Tag Archives: Biology

Do We Have to Sleep This Much?

Sleep is a universal behavior for many species on earth. Almost all mammals spend a fair amount of time sleeping every day. Adult humans, specifically, normally spend eight hours per day sleeping, and most of us will sleep over 175,000 hours in our lifetimes. Imagine how much more we could have achieved if we don’t have to sleep. Therefore, it is pretty intuitive to ask the question, do we need this much sleep? This famous study of sleep reduction may give the answer.

howstuffworks.com

Average Daily Sleep Totals of Different Animals (credit: @HowStuffWorks)

 

In 1977, Freidman et al. conducted a long experiment based on a gradual sleep reduction. During the study, participants were asked to gradually reduce their nightly sleep until they reached 6.5 hours per night. Then, the participants were asked to reduce their nightly sleep further until they no longer desired to reduce their sleep. The shortest duration of sleep was maintained by the participants for one month, and for the following two months, a sleep duration of 30 more minutes was allowed for each participant. The health of participants were recorded throughout the experiment.

Sleep Reduction/Deprivation (credit: smallbusiness.uk)

 

After sleep reduction for such a long period of time, we would expect to see a reduction in participants’ physical and psychological health. However, contradict to our common sense, although all of the participants display an increase in daytime sleepiness after they have reduced their sleep below 6 hours per night, there was actually no change in their mood, physical healthy or performance on tasks of vigilance or memory. Overall, their daytime activities were not influenced by the long-term sleep reduction.

 

The most interesting part of this study is probably that multiple participants reported daytime discomforts and reduced performances at work or school, although their performance was not actually influenced based on objective/physical measures. For example, some participants felt more distracted, depressed and sick (symptoms like having a cold) during sleep reduction, but when they were asked to perform tasks that require attention and efficiency, there was no noticeable change.

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Feeling Sick (credit: Aleksandra Sabelskaia)

 

Return to our original doubt, do we have to sleep as much as we do now? Based on this famous example, if subjective feelings were set aside, the answer is probably no. Sleep reduction only has a minimal impact on one’s performance during daytime, probably because that sleep deprivation increases the efficiency of sleep as recent researches have shown. However, more profound influences of sleep reduction and the physiological basis behind may need more studies for us to safely reduce the amount of sleep.

Does time flies?

The clock was invented by human beings to keep track of time. The atomic clock is one of the most accurate clocks in the world,  it will not gain or lose one second in 15 billion years. Therefore, the time will not fly. However, sometimes we do feel that the time pass by quickly when we are having fun. The time seems to crawl when we are having a boring class.

 

Ytterbium Lattice Atomic Clock took by National Institute of Standards and Technology https://commons.wikimedia.org/wiki/File:Ytterbium_Lattice_Atomic_Clock_(10444764266).jpg

Some people suggest that when we are having fun, we are paying attention to what we are doing. Therefore, we can not notice that the time pass by. However, when we are feeling bored, we will focus on time and notice that the time crawls.

 

Dr. Michael Shadlen said that “Every thought has various horizons”.Time flies according to these horizons. When we are really focusing on doing something, our mind can see the near horizons and the distant horizons. This makes the time goes by fast. In contrast, when we feel bored then we can only notice the near horizons and the horizons are not link to each other. As a result, time crawls.

It can also be related to the cells in the brain. Neuroscientist Joe Paton found out the neurons in our brain will release neurotransmitter dopamine which is a type of chemical that impacts how the brain feels about the time. When we are having fun, the neurons will release much more chemicals than usual. These chemicals make us feels that less time goes by. On the other hand, if we release lesser this type of chemicals, the time will go slowly in our mind.

In conclusion, time does not fly in reality. However, it does fly in our mind when we are having fun.

Is Genetic Editing the Future?

Genetic editing, is it good or is it bad?

Many people have been debating about this for a while now. One recent news that came out in November talked about a scientist who genetically edited a pair of twin girls. The scientist, He Jiankui, used CRISPR-Cas9 to edit the babies genome which he claims would allow the babies to have a better resistance to HIV and AIDS.

Human egg cells. Image by Виталий Смолыгин. Retrieved from https://www.publicdomainpictures.net/en/view-image.php?image=42719&picture=cell

What the scientist did was that he disabled the gene, CCR5. This disables the HIV virus from entering the cell because the gene forms a protein pathway. With it disabled the virus cannot get in since there wouldn’t be a pathway. The problem with disabling the gene is that people without this gene has a greater chance of being infected by other viruses.

An image of DNA structure. Image by Виталий Смолыгин. Retrieved from https://www.publicdomainpictures.net/en/view-image.php?image=31530&picture=structure-of-dna

There have been many concerns on how this genetic modification can affect the babies because of the fact that this method hasn’t been truly tested. A professor in the University of Oxford, Julian Savulescu, said, “Gene editing itself is experimental and is still associated with off-target mutations, capable of causing genetic problems early and later in life, including the development of cancer.”

Many people condemned the scientist for his seemingly unethical way of human experimentation. But gene editing has been happening for a while and have been proven to heal genetic diseases, it is just that it hasn’t been experimented enough to know for sure that it is safe to be used on humans. One example would be a team of researchers that was led by Gerald Schwank. They were able to successfully correct the mutated genes in the liver cells of mice thus healing the mice from the metabolic disorder phenylketonuria.  Another example is that gene editing was used to reduce cholesterol levels in mice that were still in their mother’s womb. This is done by targeting the gene that regulates cholesterol. The experiment was successful and the mice born were healthy.

So, would you consider gene editing the future?

This video talks about genome editing using CRISPR-Cas9. Published by McGovern Institute for Brain Research at MIT.

This video is about the scientist, He Jiankui, and his experiment on the two twin girls. Published by The He Lab.

Gloria Chan