Category Archives: Science Communication

Can Exercise Help Fight Drug Addiction?

Drug Abuse Worldwide

Image of various types of drugs. Source credit: Pixabay

Drug addiction affects the lives of millions of people worldwide. Drug-abuse can leave lasting physiological and psychological effects on users. In Canada, there are 47,000 drug-related deaths every year and the number continues to grow.

Drug-addiction is a life-long battle because it is a relapsing, chronic illness. Even after successful rehabilitation, one of the triggers that is known to cause a relapse in users is environmental cues related to their drug-use. These cues include places where they have taken the drug before or people they have taken the drug with. However, it is found that drug-addicts that exercise are less vulnerable to these environmental cues and thus less likely to relapse because of them.

Current Research

Initially, the mechanism behind the decreased vulnerability to drug-use associated environmental cues in exercisers was unknown. However, a recent article published by researchers at the University of Illinois studied this mechanism in mice and found differences in the peptides their body produced.

The mice were given cocaine injections for 4 days in chambers that had distinctive floor textures so that the mice would learn to associate that texture with their drug-use. Essentially, they created drug-associated environmental cues. The mice were then split up into two groups and kept in different cages for 30 days. One group of mice were kept in cages that had access to running wheels while the other group did not.

Mouse exercising on a running wheel. Source credit: Wikimedia Commons.

At the end of the 30-day trial, the researchers found that the mice that had access to a running wheel for exercise displayed a reduced preference for the cocaine-associated environment than the mice that did not exercise during that period.

They found that the exercising mice had less peptides related to myelin (a substance in the brain associated with fixing memories) and peptides related to actin (a substance involved in learning and memory) but higher peptides derived from hemoglobin (associated with cell-signalling in brain).

The results of the study conclude that changes related to peptides can help identify markers for drug dependence and relapse.

 

Why is this important?

 The findings from the study can be incorporated into drug rehabilitation for people with any type of addiction. There is an increased value of including some sort of exercise or physical activity in rehabilitation therapies. Moreover, this discovery sets stage for potential new drugs that can be used to treat drug addictions by incorporating different peptides.

Watch this video that goes over some of the early warning signs of a relapse:

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-Reshmin Randhawa

Killing the Ghosts: Beating Drug-Resistant Cancerous Cells

Rapid expansion of molecular biologists’ knowledge of how cancerous cells with damaged DNA sustain a long lifespan has helped us find new aggressive ways to wipe out cancer cells such as more effective chemotherapy. One key obstacle to tackle is the fact that cancerous cells quickly become resilient to DNA-harming medications. This leads to many chemotherapy failures.

A new research just appeared in Nature Structural and Molecular Biology  introduced an innovative method of dealing with death-evading cancerous cells by stripping these cells of their drug-resistance developing capabilities, more vulnerable to DNA damaging drugs hence.

Pancreatic cancer cells deficient in the expression of the human gene known as Schlafen 11 and resistant to chemotherapy (left panels) were re-sensitized to chemotherapeutic treatment (middle and right panels) by inhibiting the expression of the transfer RNA known as tRNA-Leu-TAA through specially designed antisense oligonucleotides. [Manqing Li, Michael David Lab, UC San Diego] (Genetic Engineering & Biotechnology News (GEN))

Built upon their prior works on HIV immunology, Professor Micheal David and Emeritus Professor Jean Wang from University of California (San Diego) say that a protein called Schlafen 11 stops the normal functions of the two vital proteins of cancerous cells, ATM and ATR. They explain that DNA damaging drugs activate Schlafen 11 which leads to cancerous cells death, and those cancerous cells which do not express Schlafen 11 simply survive the chemotherapy.  This study has a great potential for applications in immunology and virology, including HIV therapies, due to molecular mode of action of Schlafen 11.

David’s Lab further found out that, similar to the transfer RNA molecules of Schlafen 11, transfer RNA molecules of several gene families involved in DNA repair systems are encoded by transfer RNA gene rich in leucine amino acid. This provides a clue for making drug-resistant cancerous cells sensitive anew by attacking the transfer RNA molecules of DNA repair genes.

The findings show that disruption of normal functions of both ATR and transfer RNA could kill the cancerous cells combined with chemotherapy even though this technique could compromise whole DNA repair system. The paper also shows the role of cellular adjustments made in levels of transfer RNAs in survival or death of a cell with damaged-DNA for the first time.

by: Jamaledin Adel

https://www.nature.com/articles/s41594-018-0142-5?_ga=2.70392784.117150651.1540857600-2063335005.1540857600

 

The Americanization of Gut Bacteria in Immigrants

When immigrating to America everything becomes westernized, including the bacteria in your gut.

The green highlights the large intestines where the majority of the gut bacteria lies. Image credit: Mikael Haggstrom

Previous studies showed that living in the United states increase the risk of obesity and chronic disease among immigrants to the US relative to those who stayed in their country of birth. Researchers from the University of Minnesota, Dan Knights and Pajau Vangay, thinks that this increase in obesity and chronic diseases may be caused by the decrease in biodiversity in the gut of immigrants.

People in developing countries have more diverse microbiomes, while people living in industrialized countries like the United States have lower microbiome diversity. However the study found that when moving from a developing country to an industrialized nation would actually cause the biodiversity of the gut bacteria to decrease.

The Effect of Immigration on Gut Bacteria

The study focused on the Hmong and the Karen who are the most at risk for Obesity in Asian populations in Minnesota. The study studied the immigrants of different residency length and second generation immigrants and compared the biodiversity of the gut bacteria in these populations.

When immigrants move to the United States, their gut microbiome rapidly Americanizes within 6 to 9 months and becomes less diverse. The gut is invaded by with a rise in the population of bacteria of the genus Bacteroides which is associated with an American diet, while replacing the hey began to replace those of the genus Prevotella from the immigrants home countries diet.

When studying immigrants who have been in the US for years, they found the bacteria in the gut has become less diverse also the American genus Bacteroides have become more prevalent. The change of Bacteria is a long process and it starts immediately but it continues for many decades after and  those who have immigrated longer much more at risk for obesity and other chronic diseases.

As Immigrants reside in the US longer, the chances of obesity increases. Image Credit: Pharos

Bacteria Diversity Change with Long Term effects

The researchers also observed the second generation immigrant who have very similar diet as their parents with ten times the amount of rice as the average American. However even with a different diet the diversity of gut microbiome in these second generation immigrants very closely resemble the average American. Meaning the decrease in gut bacteria diversity does not only compound over time but across generations.

Know this decrease in gut bacteria diversity increases obesity and chronic illnesses, maybe it is worthwhile to find how to maintain or increase gut bacteria diversity to maybe help fight obesity and chronic illnesses.

Virtual Reality as Therapy for Mental Disorders

While many of us have heard of virtual reality (VR), we are likely less familiar with its applications. While VR can be an immersive gaming experience, it can also be used to confront your biggest psychological fears. In fact, some psychologists currently use this technology as treatment for patients with psychotic disorders and paranoid ideations. People with paranoid ideations believe they are being harassed and are suspicious of other people’s motives. As of 2013, more than 6.7 million people in Canada were living with mental conditions and Canadians with bipolar disorder and Schizophrenia, which both involve paranoia, each made up 1% of the population.

What is virtual reality?

Virtual reality creates the illusion of reality within different scenarios. The VR program is set up through a computer system, to which headphones and glasses are often attached. The recreated sights and sounds allow total immersion into the environment being experienced.

Samsung Gear VR virtual reality glasses

Specialized glasses for virtual reality
Image Source: flickr
Photographer: jocelynbird

 

Virtual reality as therapy

People with psychotic disorders often have similar responses to social interactions. Specifically, public settings and social activities tend to be avoided and time spent alone is higher than for an average person. One approach to treating patients and helping them reduce their social anxieties is through exposure. While therapeutic exposure-treatments are widely used, they present limitations for psychologists. Specifically, the therapist does not have control over the environment in which the patient is placed, which includes other peoples’ responses. Another difficulty is the willingness of a patient to undergo exposure to their fears in the real world. Virtual reality allows therapists to use exposure-treatments in a more controlled setting and therefore overcoming these limitations.

Virtual reality is used to treat paranoia
Posted By: Department of Psychiatry, University of Oxford

 

The effects of VR-assisted therapy were further explored in a study published in March 2018, which was conducted at seven Dutch mental health centres. The study consisted of outpatients between the ages of 18-65, who had been diagnosed with psychotic disorders and paranoid ideation, being randomly assigned to one of two groups: a control group (traditional therapy treatment) or VR-CBT (traditional therapy treatment with addition of VR). Patients within the VR-CBT group attended 16, one-hour VR-therapy sessions and were subjected to experiences such as busy streets, buses, cafés, and supermarkets. As mentioned earlier, the advantage to this treatment is the range of control that the therapist obtains. In this study, the number of human avatars in proximity to the patient, their sex and ethnicity and their responses to the patient, such as eye contact or hostile behaviour were all controlled by the therapist. The study found that momentary paranoid ideation and momentary anxiety were both decreased in patients. Their trigger-response behaviour was also reduced in the VR group compared to the control.

Supermarket virtual reality for paranoia patients
Posted By: Science News

 

Virtual reality can be used as a powerful tool in the treatment of mental illnesses. By exposing patients to their psychological fears in a controlled environment, we can decrease the anxiety and paranoia they would otherwise experience during real-life social activities.

-Shadi Elmi

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