Tag Archives: allergy

What triggers Allergies?



Some of the things that we’re allergic to – such as peanuts and pollen, for example – carry compounds that resemble proteins found in parasites. It is found that allergic reactions are actually miscommunicated immune responses: For our own protection, our bodies produce antibodies, which attack similar but harmless compounds. The action of an antibody on a harmful compound can be described through the following video:

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Various environmental and food proteins called allergens are recognized by an immune system antibody called immunoglobulin E (IgE). This part of the mammalian immune system is thought to have evolved as an additional rapid response mechanism to combat parasitic arthropods and worms called helminths. If IgE-mediated immune responses evolved to provide extra protection and not to cause allergic reactions,  then environmental allergens such as pollen should share key molecular properties with the parasite antigens that are specifically targeted by IgE in infected humans.antibodz

To test this, a team led by Nidhi Tyagi from the EMBL-European Bioinformatics Institute identified epitopic-like regions in 206 parasitic proteins and as the first example, it was found that a plant protein (BetV1) has similar binding sites for anti bodies, as it is found for allergens such as pollen in a worm. This confirms that the immune system targets allergens (Both plant protein and harmful parasites) via IgE antibodies and causes immune responses which fail to differentiate between useful and harmful compounds.

Their research also helped them to list 2,445 parasite proteins that show significant similarity in both sequence and structure with allergenic proteins, which can cause immune response against useful proteins. The research team then measured antibody responses in blood collected from 222 people living in the fishing village of Namoni on the shores of Lake Victoria in Uganda. These community members were suffering from schistomsomiasis which is caused by the worm Schistosoma mansoni(pictured below). The blood was collected immediately before anti-schistosomiasis treatment and five weeks afterwards.


It turned out that a plant protein called BetV1 – the commonest allergen in pollen – is a target of IgE in humans infected with schistosomiasis.

Tyagi’s research adds to one of those definitions: environmental and food proteins that are similar to those parasite proteins against which IgE is an observed marker of protective immunity. Defining allergen-like molecules in parasites and understanding their link to the unregulated IgE response, will help with the discovery and design of molecules for future treatment of allergic conditions.


Peanut allergy

Image courtesy of: flicker.com

There are different types of food or substances that create allergies in humans. One of the most common allergies is peanut allergy.                                                                                                                   

According to MedicineNet.com, peanut allergy is the allergy which is common among adults and kids, but it usually occurs in children under 3 years old. This kind of the allergy has 80-90% of symptoms are related to skin, for example, skin rash and itching ;despite of that it has some severe symptoms; it affects the respiratory system, gastrointestinal and cardiovascular system; therefore, it might be fatal.

In order for doctors to diagnose patients with peanut allergy, there is a test called skin prick test (SPT). However, if the result is positive, it does not mean that you have peanut allergy and doctors need to take a blood test (peanut specific lgE levels) to make sure that it is peanut allergy.

Good news is that recently, scientists find a cure for this allergy that might save people’s life. In this study, scientists achieve that probiotic treatments will have a positive effect on people who diagnosed with peanut allergy and in the most cases it will protect people from having this allergy reactions.

 Same study shows that probiotics and peanut allergies have negative correlation. Probiotic is a type of bacteria that is beneficial for our health. It will make our immune system strong and has positive effect on our gastrointestinal system and therefore, probiotic treatment is most likely to prevent people from food allergies and more specifically peanut allergies.

watch the following video to find out the details about the effects of probiotic on the peanut allergy.YouTube Preview Image

source:One Post youtube channel

To conclude, if you have already diagnosed with peanut allergy or your kid has this kind of allergy ,instead of being worried about the reactions of your kids to peanuts put probiotics in their daily diet; by using probiotics not only you will save them from fatal reactions to peanuts but also you will make their immune system stronger and therefore, more protective to other diseases. 

Sogand Goharpey