Stem Cells Remember Past Injuries of Tissues

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“What are stem cells? – Craig A. Kohn”  Video Source: TED-Ed Youtube Channel

What are stem cells?

Stem cells are your body’s internal repair system and seemingly remember past injuries of tissues by retaining memories of old injuries for improvement of  healing in the future. Studies have indicated that stem cells also have behavioral roles of responding to the environment and sensing it.

As living beings, there are times we encounter various kinds of injuries through some traumatic events. These can be simple from paper cuts to serious injuries like the loss of limbs infarction. The body has a mechanism of healing these damaged tissues. Some organisms like earthworms have the ability of regrowth of complete body parts after an injury but human beings have no such ability. Stem cells are known to replenish such types of injuries by focusing on the healing of other cell types.

” What is a Stem Cell“ Source:Relievus

How can stem cells repair injuries?

In the healing context, repair refers to restoring tissue function and architecture after an injury. This is based on the processes of replacement and regeneration. Research has indicated that these stem cells also have the ability of remembering past inflammation and wounds. The suggestion from studies of the gut, airways and the skin is that together with the immune system, stem cells use the memories for the improvement of tissue responses to later assaults by pathogens which are bacteriums, viruses that can cause disease.

“VESC system in the liver” Source: MedicalExpress

The repair of tissues can lead to restoration of some of the original structures of the tissue damaged like epithelial layers but in complex healing of organ functions. Additionally, when the responses of the stem cells fail to go in the right way, they can lead to various enduring health problems based on chronic inflammation. It thus means that stem cells directly communicate with the immune system to facilitate healing but the stem cells have a central role of making tissues adapt to preservation.

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Wenyu Zhao

Signs of a super-Earth discovered around Barnard’s star

 

Where is Barnard’s Star? What is Super-Earth?

“Barnard’s star may have a super-Earth”      Source: SciNews YouTube Channel

On November 14th, 2018, astronomers claimed that a super-Earth named Barnard’s star b was discovered in one of the orbitals of Barnard’s star which is a red dwarf star. This indicates that Barnard’s star is faint and has a low mass. It is approximately six light-years away from the solar system, and it is the second closest to the Sun. A super-Earth is an extrasolar planet which has a larger mass than Earth: Barnard’s star b is 3.2 times heavier than Earth and lies in the snow region where liquid water barely exists.

Why Is this finding important?  

The method used to detect Barnard’s star b is called the radial velocity method. It detects the wobbles in a star which are likely to be caused by the gravitational pull of an orbiting planet. This is because wobbles affect the light coming from the star: as it moves towards the Earth, its spectrum appears slightly shifted towards blue, and as it moves away, it is shifted to the red.

“Effect of wobbles on lights”           Source: ScienceNordic

 

 

 

 

 

 

 

The discovery of the planet is vital because it is the first time using this technology to detect a planet having such a small size and such a long distance from its host star. This newly applied radial velocity method adds extraordinary accuracy for identification of a planet. According to Dr. Ignasi Ribas, the research team is over 99% confident that the plant does exist. In the future, however, further data collection is still needed to minimize uncertainties. In addition, the technology is useful and easy to directly observe similar planets and obtain vital info such as the properties of the planets to extend current understanding.

 “Radio Velocity Method for Finding New Planets”      Source: cosmos YouTube  

Why do we keep searching for new planets? 

Due to the explosive growth of population, we are facing the problem brought by the limitation of resource on Earth. Astronomers keep searching for new planets that are Earth-like in the hope of obtaining the signs of liquid water. Moreover, we are all curious about the answer to the question which states “Are we closer to not being alone”.

“Earth-like Exoplanets”                         Source: NASA

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Olivia Zhou

Can Exercise Help Fight Drug Addiction?

Drug Abuse Worldwide

Image of various types of drugs. Source credit: Pixabay

Drug addiction affects the lives of millions of people worldwide. Drug-abuse can leave lasting physiological and psychological effects on users. In Canada, there are 47,000 drug-related deaths every year and the number continues to grow.

Drug-addiction is a life-long battle because it is a relapsing, chronic illness. Even after successful rehabilitation, one of the triggers that is known to cause a relapse in users is environmental cues related to their drug-use. These cues include places where they have taken the drug before or people they have taken the drug with. However, it is found that drug-addicts that exercise are less vulnerable to these environmental cues and thus less likely to relapse because of them.

Current Research

Initially, the mechanism behind the decreased vulnerability to drug-use associated environmental cues in exercisers was unknown. However, a recent article published by researchers at the University of Illinois studied this mechanism in mice and found differences in the peptides their body produced.

The mice were given cocaine injections for 4 days in chambers that had distinctive floor textures so that the mice would learn to associate that texture with their drug-use. Essentially, they created drug-associated environmental cues. The mice were then split up into two groups and kept in different cages for 30 days. One group of mice were kept in cages that had access to running wheels while the other group did not.

Mouse exercising on a running wheel. Source credit: Wikimedia Commons.

At the end of the 30-day trial, the researchers found that the mice that had access to a running wheel for exercise displayed a reduced preference for the cocaine-associated environment than the mice that did not exercise during that period.

They found that the exercising mice had less peptides related to myelin (a substance in the brain associated with fixing memories) and peptides related to actin (a substance involved in learning and memory) but higher peptides derived from hemoglobin (associated with cell-signalling in brain).

The results of the study conclude that changes related to peptides can help identify markers for drug dependence and relapse.

 

Why is this important?

 The findings from the study can be incorporated into drug rehabilitation for people with any type of addiction. There is an increased value of including some sort of exercise or physical activity in rehabilitation therapies. Moreover, this discovery sets stage for potential new drugs that can be used to treat drug addictions by incorporating different peptides.

Watch this video that goes over some of the early warning signs of a relapse:

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-Reshmin Randhawa

You might be able to blame your coffee or tea addiction on your genes!

  Image1 .      Are you a coffee lover(left) or a tea lover(right)?   

Coffee, Tea, or Alcohol?

As university students, we spend a good chunk of our money on coffee, tea, and alcohol. These 3 drinks have been controversial topics as they have both beneficial and adverse health effects.

We all have a preferred drink among these 3, and there’s no guarantee that 5 of your closest friends will have the same preference as you. You might have noticed that one of your friends is less sensitive to caffeine’s bitter taste than you. Or, you are a heavier tea drinker than your friend. Well, there is no need to sweat it anymore, because a new study, led by Jue-sheng Ong and Daniel Hwang and published in Scientific Reports, examined around 400,000 people in the UK to see if there is a correlation between a person’s bitter taste perception, drink of choice and their genetic markers.

Image2 .        A new study explains why some people love coffee but others think it tastes disgusting.

Coffee!

There’s some good news from their findings. If you are a heavy coffee drinker (>4 cups/day) and the bitter taste of coffee doesn’t bug you, then you can thank or blame your genes. So the next time someone points out that you drink too much coffee, you can tell them that it isn’t your fault that your genes have an increased sensitivity to the bitter flavour of caffeine, thus making you 20% more likely than the average person to be a heavy coffee drinker.

Tea!

Do you drink more than 5 cups of tea per day? Do you prefer tea over coffee? That is because you are more sensitive to the two chemicals (quinine and propylthiouracil) common in tea. This sensitivity is a result of the presence of receptors for those chemicals on your genes. Which makes you 4-9% more likely than the average person to be a heavy tea drinker.

So what?

The researchers suggest that coffee drinkers enjoy the bitterness of caffeine because of the buzz the chemical provides, but tea drinkers do not enjoy the bitterness of the chemicals in those drinks. Therefore, heavy tea drinkers are technically those whose genes have rejected coffee.

What about alcohol?

Unlike tea, for alcohol, a higher intensity of the propylthiouracil chemical reaction resulted in a lower consumption of alcohol. Ignoring the other side effects of alcohol consumption, alcohol’s elicit bitterness in humans might explain why our daily consumption behaviour of coffee and tea doesn’t apply to alcohol (i.e. why we don’t drink alcohol like we might drink coffee and tea daily).

Controversial Topic

While this 2018 paper looked at the underlying genetic reason(s) for our coffee, tea, and alcohol consumption preferences, coffee and tea have always been controversial topics. Their pros and cons have lead to numerous scientific articles, videos, and news articles being published.

An example of a YouTube video on the pros and cons of coffee and tea. (Video: https://www.youtube.com/watch?v=csSq4emMwGk)

The coffee vs. tea debate is so big that even famous YouTubers are now discussing it. (Video: https://www.youtube.com/watch?v=lOGXe7GN2eQ)

 

 

What Is Computer Vision?

Have you ever imagined a robot being able to rebuild crime scenes using the clues and pieces of evidence it sees at the sites of crimes just like the character in the sci-fi game Detroit: Become Human? This is possible if the technologies of computer vision are developed and mature. Computer vision is the process that lets computers recognize, understand, and analyze pictures and videos. Computer vision is important because it provides the foundation for many science and engineering applications which will benefit humans in many aspects of their lives.

How does computer vision work?

The basis of computer vision is simple: computers transform an image into a set of pixels. Each pixel has a set of values which are used to represent the color of this pixel. Transforming images into data is easy, but it is hard for computers to categorize data in order to recognize objects. For example, it is hard for computers to recognize and understand which set of pixels represents a human face, a box, or a car. Therefore, computer scientists design different computer vision algorithms to help computers recognize objects in the pixel sets. Recently, in order to make computerized devices able to find similar patterns that allow them to recognize objects, computer vision scientists have trained their devices with numerous sets of images using machine learning technologies. (You can refer to my previous blog post to understand how machine learning works: click here).

“The future of computer vision with the TensorFlow Object Detection API from Google. You won’t have to describe any photo….” by ShashiBellamkonda is licensed under CC BY 2.0. Source: flickr.com

What are some real-life applications of computer vision?

“Face Recognition Software Recognizes Animals Now Too” by terrykimura is licensed under CC BY-SA 2.0. Source:  flickr.com

You have probably already used a computer vision application in your life. For example, after you upload photos that contain your friends to Facebook, Facebook recognizes your friends and tags them automatically without asking you to tag your friends. This is done using Facebook’s facial recognition technology.

There are also a lot of other computer vision applications, such as barcode scanner and handwriting recognition. Also, check out the TED talk video below to see how we can use computer vision to transform our cities into smart cities.

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Video: “How to use computer vision to improve cities | Nikhil Naik | TEDxYouth@BeaconStreet” by TEDx Talks. Source: youtube.com

Conclusion

Computer vision is a sub-branch of Artificial Intelligence because it studies the methods that provide computers with sight so that these computers can see the world just like humans. Nowadays, computer vision is a very hot research area in computer science. If you would like to take a computer vision course online, I recommend the Introduction to Computer Vision course by Georgia Tech on Udacity.

 

-Baihao Luo

Transfer Your Photo To An Artistic Work!

Can you imagine that you can change any photo you want into a piece of art on your own? It is made possible now! Recently, researchers from University of Tubingen, Leon A. Gatys and his colleagues have found a new way to automatically transfer an image to any style while preserving the original content.

Actually, there are many methods in previous studies used to do the style transferring work. However, resultant images are not statisfiable because only low-level image features are transferred, leading to unnatural images. This time, the researchers applied convolutional neural network (CNN), a kind of neural network popularly used in photo manipulation, in style transferring. As a result, new styles could be fit in photos more perfectly without any abrupt feelings.

The image synthesized with Van Gogh’s The Starry Nigtht

Credit: Leon A. Gatys, Alexander S. Ecker and Alexander S. Ecker

Before the transferring stage, their study is mainly focused on separating content representation and style representation of images, which are features extracted from images for further recombination. Usually, the semantic content and style are hard to separate. Even for artists themselves, it is really hard to tell which part is exactly content and which is exactly style. In this study, both of them are caught by the CNN, which captures object information accurately so that both the content and the style could be used independently to synthesize new meaningful images.

Style Represetation extracted from The Starry Nigtht

Credit: Leon A. Gatys, Alexander S. Ecker and Alexander S. Ecker

The final step is not easy either. The synthesis is not simply combining representations got from the previous step, you need to decide which, original content or new style, to be dominant in the new image. Naturally, we want the new style to dominate, but in fact, a strong emphasis on style could result in images matching the appearance of artwork but losing the original content.

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The presentation of the study

Viedeo Credit: Leon A. Gatys, Alexander S. Ecker and Alexander S. Ecker

Finally, their work paid off. The synthesis images using their method show a high perceptual quality. Thanks to their study, some image style transferring services based on the study, such as deepart.io, allow everyone to upload any image to produce a new artistic picture. Now, everyone can enjoy what the new technology brings to us.

Style Transferred picture from deepart.io

Credit: deepart.io

There are still some limitations in this study, the major one is about resolution. The speed of production heavily depends on image resolution. So, costumers need to wait a long time before getting synthesis picture if they want a high-quality picture, which influence customers’ experience with the online service. Further studies could find ways to speed up the whole process so that all customers could get instant feedbacks with high quality. I believe it will popularize the service further so that more people can join in!

New tracking system could show-at last- how pesticides are harming bee colonies

We see the use of insecticides all around the world because it is something that is necessary for our own population. Insecticides is something that we depend on for the survival of our crops. However, as much as humanity may need them, not all of them are beneficial for the world. There is one type of insecticide that harms the important bee pollinators – the neonicotinoids. At high doses, the chemicals that make up insecticides can enter the pollen and nectar of flowers and harm bees’ memory, which consequently affect the bees’ ability to harvest nectar.

Neonicotinoid Pesticides Affects Bees’ Social Behaviour
Source: Organic Authority

To further investigate how this happens, researchers have come up with a tracking technique that makes note of how neonicotinoids reduce and affect the activity of bees. Previous research studied the damaging effects of neonicotinoids on the environment as a whole, but most of them did not extend towards how pesticides could specifically harm bee colonies.

Video down Below.

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To see how pesticides were affecting bee colonies, James Crall, an animal behaviour biologist at Harvard University, glued small tags to the backs of bees from approximately a dozen colonies. He then used tracking software to capture their movements as they were given sugar syrup coated with a small amount of a common neonicotinoid called an imidacloprid. As a result, the bees’ activity level, including their social interactions, decreased as the bees cared less about their brood.

Source: Wired
Tags on the back of bees to track their behaviour and movement

This was a notable finding as collectivism and working for the brood is integral to the survival of a bee colony. Crall also noted that the bees’ level of lethargy increased during the night and that their abilities to regulate temperature also hindered. Despite the potential benefits that insecticides may bring to our agriculture, they are undoubtedly harmful for some of our species, including the bees.

Source: Phys.org
Bee colonies collapsing as they are decreasing in numbers. Less social interactions.

As such, the question arises as to whether our need for pesticides is greater than our need for our natural pollinators, which is something that cannot be answered so easily.

-Christina Lee