Category Archives: Uncategorized

Mother Nature: The Ultimate Bioterrorist

Global Pandemic.
Source (Flickr)

There are three things that are certain in life: death, taxes and pandemics. While it may seem that humanity is making great strides in the medical sector in terms of advanced vaccines, therapeutics, diagnostics, and devices for primary health care, you would be surprised to find that the risks of millions dying due to pandemics are higher than ever. Bill Gates, an American businessman and philanthropist is one of the believers that a global pandemic is coming and the world is severely underprepared.

“People rightly worry about dangers like terrorism and climate change (and, more remotely, an asteroid hitting the Earth). But if anything is going to kill tens of millions of people in a short time, it will probably be a global pandemic,” Bill Gates wrote in his annual “What I learned at work this year” letter.

To understand why Bill Gates and an international panel of experts assembled by  the World Bank and the World Health Organization (WHO) warned that viral diseases like Severe Acute Respiratory Syndrome (SARS) and flu would potentially kill millions and destabilize economies as well as national security according to the  Global Preparedness Monitoring Board(GPMB), it is essential to have an  idea of how pandemics start and spread.

How pandemics start and spread globally

Types of Microbes. Source vecton

Pandemics start at the microscopic level where among the major types of microbes, bacteria and viruses cause the deadliest infections. The ability for a bacteria and virus to move from one living organism to another makes them candidates for the cause of  an inevitable pandemic.

In particular, viruses that infect animals may spillover to humans becoming new types of viruses known as zoonotic viruses. For instance, the H1N1 virus that caused the Spanish flu pandemic which killed an estimated 20 million to 50 million victims in 1918, is a zoonotic virus that resulted from the combination of influenza A virus from birds and from humans in a pig. What makes zoonotic viruses more lethal than other infectious viruses is that they contain parts (specific to animal immune response system) that the human immune system would not be able to detect hence enabling them to evade immune responses by the human body. In addition, their ability to mutate fast only worsens the human immune system’s situation as a losing side in this life or death microscopic warfare.

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In our modern world, technology has been the primary facilitator for the spread of these viruses globally. For instance, SARS spread to over 17 countries on three continent within a few week due to fast globally widespread air travel. Although SARS outbreak did not end up becoming the worst pandemic that humanity has seen, it was surely a clear sign that the next pandemic will be able to spread in a few days.

Is there anything that can be done to prevent the impending doom?

While it may be impossible to stop global human movement and improvement of transport technology, the best chance to preventing a pandemic would be controlling the spread at its source. For instance, the CDC deployed detectives  to caves in Uganda to understand how bats could spread Ebola related viruses to humans directly or through other animals. In addition, governments around the world should invest in the innovation for prevention early even when everything seems fine now!

By Flipos Tadese.

 

The Bilingual Brain

Bilingua

How many languages do you speak? Chances are, in our SCIE 300 class, more than half of the students speak at least two languages fluently. Most studies and statistics show that 50%-60% of the world population can speak at least two languages. If you were required to learn your mother tongue at home, or forced to go to language classes against your will, or put through French Immersion at school, you’re in luck—here are three interesting scientific facts about bilingual brains!

 

  1. Different brains.

srireddy, Flickr Commons

Even if you don’t realize it, being fluent in two languages requires a lot of skills, including: being more sensitive to tones, knowing when and where to use which language, quickly switch between languages, and remembering a wide vocabulary in each language. These all require many different parts of the brain to communicate with each other. Therefore, studies suggest that bilinguals have a much more interconnected neural system in the brain that results in better cognitive control (which will be discussed later). The same paper linked above also notes that certain parts of a bilingual’s brain are denser than that of monolinguals (people that can only speak one language), which have implications on a concept called “neuroplasticity”. Neuroplasticity is the ability of the brain to physically rewire and restructure itself either when learning something new or after taking damage, in order to allow an individual to continue to function properly.

  1. Improved executive functions.

    Stroop Colour Test. mediocre2008, Flickr Commons

As human beings, and particularly as university students, skills such as planning, prioritizing, multitasking, goal-setting, focusing, and filtering distractions are essential in everyday life. These processes can be referred to as “executive functions,” and require specific parts of the brain to carry out. Although it is still an area that requires further research, many studies have shown that there is a positive relationship between bilingualism, and enhanced executive function abilities. Current evidence suggests that bilinguals have better conflict resolution skills, which was tested by measuring the response times of bilinguals and monolinguals for three different tasks—one of which is the infamous Stroop colour task: where a participant has to say the colour of the word presented to them, rather than the word it self (for example, if the word “red” is coloured yellow, participants have to say “yellow” and try not to read the word provided; if you try it out yourself with the link below, it is quite difficult!). The study showed that bilinguals consistently did better than monolinguals.

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  1. Bilingualism has potential positive effects on cognitive aging, and could delay the onset of dementia.

The effect that it has on the executive functions of the brain also have beneficial effects in the long run. The cognitive abilities mentioned above tend to decline over time, but evidence suggests that the advantage that bilinguals have in this area helps to slow down the decline of these abilities. Although further research needs to be done to determine exactly how this works, researchers think that it could also be due to the changes in brain structure mentioned in number 1.

Many of these studies also emphasize that the benefits of knowing a second language are still apparent even if you learned it later in life. So, whether you have been practicing a second language since birth or acquired it later on, you have quite the set of advantages not just from a social perspective, but also cognitively! Perhaps this will help motivate you to learn a new language, or stop complaining about your French professor.

Written by Annica Eustaquio

Sleep Mysteries: The Ideal Sleep Threshold, Short Sleepers, and Early Risers

How much sleep do you get on a nightly basis? With all of the commitments that a student must subject to, one can expect that number to be quite low. Much of Western society has been raised on the knowledge that 7+ hours of sleep is the most ideal for an adult. But what happens to us if we don’t reach this threshold of “enough” sleep? How do some people seem to get by comfortably on much less? And how are individuals able to wake up easily in the morning while others have to hit snooze quite frequently? The answer to the latter 2 questions can be attributed to none other than our own genes. 

An image of a baby sleeping.
Retrieved from https://pixabay.com/photos/baby-sleeping-sleep-childish-cute-1941745/

It is common knowledge that reduced amounts of sleep leads to a variety of negative effects. Growth hormones are released during this time, which is why many adults blame lack of growth to not getting enough sleep. You may have also heard about how sleep affects your rate of metabolism, and that sleeping increases weight loss. This is due to the fact that while asleep, your body secretes appetite-reducing chemicals, which are meant to decrease the chances of hunger interfering with your rest. Studies have shown that our body’s DNA repair mechanisms are heightened when we’re asleep, because this is the time in which we undergo the least amount of chemical and mechanical stress from outside forces.

A graph of the sleep cycle, showing the stages of sleep corresponding to time. Retrieved from https://www.flickr.com/photos/37583694@N04/3457948158

For a subset of the population, a shorter average sleep cycle is actually enough to carry on their daily lives feeling energized. Each gene in our DNA is converted into one protein through intricate biological processes. A study by Ying-Hui Fu’s lab focused on the DEC2 gene, which codes for a certain protein that is an important regulator for the protein orexin. The diagram below explains the the DEC2 mechanism in detail. The study also uncovered that short sleepers (those with the DEC2 gene mutation) had 6.25 hours of sleep while others (those without the DEC2 gene mutation) had 8.06. This shows the natural difference in the amount of sleep that short sleepers felt was necessary to feel refreshed.

DEC2 mechanism in a graphic representation. Image source: Francine Flores, made with Canva

Another mystery in the sleep world pertains to “night owls” vs. “early birds”. A study by Samuel Jones’ lab has found that variation at 351 locations in the genome affects the waking patterns within different people, termed as one’s chronotype. The fluctuation in expression of these genes has shown a 25 minute difference in the waking times of the most extreme early risers and the most extreme late risers.

An image of DNA. Retrieved from https://www.publicdomainpictures.net/en/view-image.php?image=31530&picture=structure-of-dna

There are many questions up in the air concerning sleep and sleep patterns. With our knowledge of the reasons behind occurrences such as short sleepers and waking tendencies, we can further our understanding of why we need sleep and how much sleep is enough to sustain our day-to-day systems. Using the information from current and future studies, we can address issues that individuals have regarding sleep and take a step toward solving more of our sleep mysteries. 

Written by Francine Flores