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New Treatment for HIV

HIV and its Implications

The HIV global pandemic was once a major killer in the 20th century. HIV causes mental panic, social apprehension mortality when left untreated and miseducated. Due to the fact that diseases transmitted from sexual contact or drug usage cause social stigma, the HIV global pandemic became a fight not only against the virus itself but the perception of that from the general public. Though no form of illness should be conceptualized from that of a negative connotation, HIV long has had a conception coming from promiscuity, drug addiction, and carelessness. Treatment for HIV and better education continues to be a global battle.

HIV is described as a virus with no cure but treatable. Proper treatment of HIV can allow an infected individual to live a normal lifespan. Source: HIV.gov

How HIV is Transmitted

HIV is transmitted through sexual contact, needle sharing, contaminated blood transfusion as well as birth. HIV is a virus that attacks the body’s immune system. The latent stage of HIV is AIDS when the CD4 cell count in the body lowers to rates that cause infections to be prone.

HIV is transmitted through four major ways: sex, blood transfusion, needle sharing and mother to baby. Source: avert.org

Treatment History

HIV treatment first began with Zidovudine, which became available in 1987. Zidovudine causes side effects such as low blood cell count, liver damage. More importantly, Zidovudine stops working as the virus mutates. In 1996, antiretrovirals became available for public use. The combination of antiretrovirals made it difficult for enzymes in HIV to replicate. In 2007, Raltegravir became available as an HIV integrase inhibitor. In 2010, Truvada became an available option for pre-exposure prophylaxis for the public.

New Injection Treatment

Treatment for those infected with HIV requires a daily oral pill. Until 2021, one of the oral pills had to be taken by someone HIV positive. A daily pill makes it difficult to adhere to treatment. Moreover, oral pills are difficult for those with swallowing difficulties, poor drug absorption, and gastrointestinal problems. Cabotegravir and rilpivirine are taken as integrase inhibitors and non-nucleoside reverse transcriptase inhibitors. These two medications are taken in injection form once every one or two months. The result is that injection forms require much less dedication to HIV treatment, as these forms don’t require a daily treatment plan. The key to HIV treatment to allow those living with the virus to lower transmission and keep the virus under control is to have an undetectable viral load. An undetectable viral load allows an infected person to live a normal lifespan and be HIV non-transmissible.  Injection treatment works equally as well as the oral pill.

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HIV injection Treatment Description

New Treatment Plan

In the UK, injection treatment for HIV will begin in 2022. Other European countries are soon to follow this plan. Another treatment plan for HIV is a solution and alternative to approach a virus in modern society.

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The Development of Bacteria Eating Plastics

Discovery of plastics

A century ago, the discovery of plastics brought the convenience of a strong and affordable structure. However, finding something so strong and easily disposable creates environmental concerns. Science is rapidly developing to accommodate issues caused by the developments. Science has now permitted the development of bacteria to decompose the plastics that have long contaminated Earth. Using bacteria to destroy plastics may be a long-term sustainable way to preserve the planet.

Plastics and their damage

Plastics are continuing to plague and damage Earth’s environment. Single-use plastics are wasteful and environmentally unfriendly. More than 8.3 billion tons of plastics were manufactured since the 1950s, and over 60% have been buried in landfills. Plastic waste ends up in rivers, dumps, and oceans. Plastics harm aquatic life, increase disease spread, and may lie in waste for centuries. Scientifically, there needs to be a method to destroy PET’s (Polyethylene terephthalate). PET’s common uses include water bottles and plastic containers, many of which are consumed once then immediately disposed of. PET’s are not biodegradable.

Source: rsscience.com

The chemical composition of PET allows bacteria to decompose the structure. The bacteria are capable of decomposing the polyester bond. The C, H, and O bonds are capable of being decomposed by the bacteria.

Bacteria: a solution?

In March 2016, there was a breakthrough scientific discovery. Japanese scientists found that bacteria could consume PET plastics. The idea of bacteria eating plastics empowers the thought of opening industry scale to demolish plastics. The plastic-eating bacteria could open doors to many other forms of waste that would end up in landfills. In 2017, the fungus Ideonella Sakaiensis was seen to be able to decompose plastics. In 2020, strains of bacteria were seen as capable of eating polyurethane plastics.

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Implications

Researchers and industry are far from determining measures to implementing bacteria that will safely and quickly decompose plastics. Further research must be done to seek if the measures are truly environmental. There are unknowns of the side effects of bacteria decomposing plastic. There are uncertainties if toxins to the environment will harm the environment in the long run. Moreover, the rate of decomposition of plastics is currently too slow. There needs to be genetic engineering for faster industrial processes.

Source: Beautiful News Daily

The different forms of bacteria decompose different plastics. Bacteria mainly break down Polyurethane, and bacterial enzymes mainly break down Polyethylene. Mealworms are capable of decomposing Polystyrene. These are all plastics that contaminate the planet.

Developments moving forward

Scientists are currently working on implementing the enzymes of bacteria to break down plastics at a rate six times faster than the current rate. Recently, 12000 new enzymes having the capability of breaking down plastics were discovered. 60% of these newly determined enzymes are unclassified. These enzymes have the potential for industrial use to break down environmentally harmful plastics. With the progress of science, there are many adaptable forms of preserving the environment.