Author Archives: Shayan Abbaszadeh

Will Artificial Intelligence Save Humanity Or End It?

Artificial Intelligence, or AI for short, is the broad idea that machines can make decisions and perform tasks without being explicitly programmed to. AI uses machine learning, deep learning, and other techniques to learn how to solve problems beyond its understanding just like a human child. In some ways, AI is very similar to the neurons in the human brain, because it relies heavily on neural networks which are huge interconnected algorithms that process information by responding to different inputs. Since AI is a very new topic in our era, there are many different perspectives on its impact on humanity. Some consider AI a potential threat to humanity that will one day dominate the Earth, while others believe that AI is the savior that will solve most of humanity’s problems.

    A drawing of a small neural network. A neural network starts with input or multiple         inputs and processes that information until it releases the output or the response.                               Image taken from a public domain.                         https://www.shutterstock.com/image-vector/neural-network-graphic-scheme-artificial-intelligence-1583864422

How dangerous is AI?

Many people who dislike AI claim that AI’s knowledge is superior and beyond the human level. Just like a calculator, AI is very good at taking numbers and multiplying or adding them. However, AI itself isn’t too smart, as it lacks the ability to solve problems larger than its scope of intelligence. When AI reaches a problem beyond its scope, it simply produces error messages and fails. On the other hand, when humans reach a difficult problem, they look for other ways to solve the issue. Unlike humans, AI can’t perform complex divergent thinking, at least not yet!

Over the past few years, many jobs have been replaced by automated machines and artificial intelligence. As a result, there have been many concerns about the threat of AI taking over human occupations. Fortunately, unlike many science fiction movies, AI cannot take over human jobs and permanently replace us because humans are inherently needed to create the training data AI is created based on. Additionally, unless the tasks are on an enormous scale, it is much cheaper and more efficient to use humans instead of AI.

In many large companies, jobs are being replaced by AI for the long-term interest of the                   company. This graph shows the most vulnerable jobs in the US.                                                      Photo from CBINSIGHTS                                 https://www.cbinsights.com/research/jobs-automation-artificial-intelligence-risk/

Is AI perfect?

So by now, you might be thinking that AI is perfect. Not at all! AI is used around the world for many important tasks and decision-making processes. Some of these include Amazon’s hiring process, iPhone’s Siri and facial recognition, and Tesla’s self-driving cars. With the advancement of technology, many companies are trying to create their own AI system at a fast pace, which leads to many bugs going through without being fixed. In a worst-case scenario, an AI programmer’s bias could subconsciously affect the algorithms that make up the AI. These algorithmic bugs and biases can create dangerous racial and gender bias during important decisions such as hiring, loan application, and criminal justice, leading to discrimination of certain groups within the society. Such problems can only be solved by humans looking over and supervising the AI.

In Conclusion

Overall, AI is a huge development and it has helped humanity in many ways, but it is also important to acknowledge that AI will never replace humans and our decision-making. At the same time, the concept that AI will one day terminate our world is recognized within the public eye, due to a lack of understanding of how artificial intelligence and algorithms are created and used. Therefore, our goal should be to resolve the issues in artificial intelligence and work towards perfecting the algorithms, so that we can build a better future for all of us!

First Genetically Modified Pig Heart Transplant

If due to an unfortunate accident, you were on the National Organ Waitlist for a heart transplant, would you consider receiving a heart from an animal?

Since the first organ transplant, there has been a shortage of healthy organ donors all around the world. For example, last year in Canada, about 280 people died while waiting for an organ transplant. This shortage is much greater in more populated countries such as the US, where on average ten people lose their lives every day. To resolve this shortage, doctors have tried to transplant animal blood and organs to humans. Unfortunately, they have not been very successful until recently, due to the complexity of the human body and the anatomic variations between different species. However, using genetic engineering, scientists have been able to transplant a few animal organs to humans, including the first pig heart! 

Human Body & Organ Transplant

The human body is like a very complex machine, with microscopic vessels and delicate tissues. A slight change or injury to an organ can be disastrous. When a vital organ, such as the heart is damaged beyond recovery, doctors have to replace it with a donor’s organ, which is usually a deceased person. 

Organ transplant has saved countless lives over the decades but it can commonly result in complications, especially if there is low blood type compatibility between the recipient and the donor. If the recipient’s blood type does not match the donor’s blood type, the recipient’s body will reject the organ. During organ rejection, the transplanted organ is nothing more than a foreign object to the body, like bacteria. The body’s defense mechanisms will try to remove the transplanted which usually results in death.

Dark green represents the number of transplants, light green represents the number of patients on waitings lists and the dashes green represents the number of dead patients while waiting for a transplant. Image by Canadian Organ Replacement Register https://www.cihi.ca/en/organ-transplants-in-canada-2020-donations-and-need-infographic

Genetically Modified Pig Heart Transplant

However, on January 7th, 2022, scientists and doctors made a huge advancement in this field. They were able to transplant the first-ever genetically modified pig heart into a 57-year-old man, who was suffering from life-threatening heart disease. David Bennett has been recovering from the operation and is currently healthy and stable.

Why use a genetically modified pig heart?

There are many reasons why scientists used a pig as the donor, mainly because pigs are very anatomically similar to humans. In both adulthood and childhood, their organs are similar in size and function to humans, making them well suited for transplant. Additionally, pigs reproduce at a fast pace and can be bred at high health standards in labs. There are labs in the world that breed and clone pigs for organ transplants.

Eckhard Wolf with pigs in at the Badersfeld bog test farm in Oberschleissheim, Germany. Photographed by Lukas Barth/Reuters https://www.theguardian.com/science/2022/feb/03/german-researchers-to-breed-pigs-for-human-heart-transplants

Using advanced technology, scientists were able to edit parts of the DNA of a pig and turned off genes (the building blocks of DNA) that resulted in organ rejection. This eliminated the need to find a compatible blood type donor.

In Conclusion:

The use of animal organs for transplant is not a simple matter, since there is still a lot of controversy around the topic. Many believe that genetic engineering is a technology that humans should not explore. Others bring up the issue of animal welfare and question the practice entirely. However, if more research is completed on genetically modifying animals for organ transplants, we might be able to solve the organ donor shortage entirely. Patients will not have to wait on long lists to receive organs to live and we could minimize the risks of organ transplants significantly, saving thousands if not millions of lives.

 

By Shayan Abbaszadeh

First Genetically Modified Pig Heart Transplant

If due to an unfortunate accident, you were on the National Organ Waitlist for a heart transplant, would you consider receiving a heart from an animal?

For decades, doctors have tried to transplant animal organs in human bodies, but have not been successful. Partly, because of how complex the human body is.

Human Body & Organ Transplant

The human body is like a very complex machine, with microscopic vessels and delicate tissues. So complex that if one part of the body is injured, the rest of the body will be affected by it. This becomes fatal if the injured body part happens to be a vital organ, such as the heart.

Since the dawn of medicine, scientists and doctors have researched and studied techniques to perfect human organ transplants. Due to the complexity of the human body, organ transplants can commonly result in complications and possibly death. 

One of the biggest challenges of organ transplants is finding a matching blood type. If the recipient’s blood type does not match the donor’s blood type, the recipient’s body will attack the organ. During organ rejection, the transplanted organ is nothing more than a foreign object to the body, like bacteria, it will try to remove it which usually ends in the death of the patient.

Another side of the problem is finding organ donors because there is a shortage of healthy organ donors all around the world. For example, as you can see from the image below, last year in Canada, about 280 people died while waiting for an organ transplant. This shortage is much greater in more populated countries such as the US. 

https://www.cihi.ca/en/organ-transplants-in-canada-2020-donations-and-need-infographic

Genetically Modified Pig Heart Transplant

However, on January 7th, scientists and doctors made a huge advancement in this field. They were able to transplant the first-ever genetically modified pig heart into a 57-year-old man, who was suffering from life-threatening heart disease. David Bennett has been recovering from the operation but is currently healthy and stable.

Why use a genetically modified pig heart?

There are many reasons why scientists used a pig as the donor, mainly because pigs are very anatomically similar to humans. In both adulthood and childhood, their organs are similar in size and function to humans, making them well suited for transplant. Additionally, pigs reproduce at a fast pace and can be bred at high health standards in labs. There are labs in the world that breed and clone pigs for organ transplants.

https://www.theguardian.com/science/2022/feb/03/german-researchers-to-breed-pigs-for-human-heart-transplants

Using advanced technology, scientists were able to edit parts of the DNA of a pig and turned off genes (the building blocks of DNA) that resulted in organ rejection. This eliminated the need to find a compatible blood type donor.

In Conclusion:

If more research is completed on genetically modifying animals for organ transplants, we might be able to solve the organ donor shortage entirely. Patients will not have to wait on long lists to receive organs to live and we could minimize the risks of organ transplants significantly.

 

By Shayan Abbaszadeh