Category Archives: Biological Sciences

Go exercise!…to be smarter?

Image from Men's Health - "How to lace your running shoe"

Want to improve your memory and study more efficiently? Then drop your pen and lace up your sneakers! Recent studies show that exercising not only builds muscles, but it also boosts memory.

Researchers from University of Dublin  investigated the correlation between exercise and memory where they asked group of sedentary students to take part in a simple memory test. After the initial baseline test,  half of the students went through vigorous exercise and the other half just sat quietly. Then both groups took the test again. (specific procedures can be found in Physiology & Behavior Journal). Remarkably,  the exercised students performed significantly better on the memory test scores (compared to their baseline test), while the students who had rested showed no improvement.

Image of BDNF - from Wikipedia provided by Protein Data Bank

Interestingly, the researchers have collected the students’ blood samples throughout the experiment to give a biological explanation to their results. They have found that the students had significantly higher levels of a protein called  brain-derived neurotrophic factor, or BDNF, immediately after the strenuous activity, whereas the student who had sat quietly showed no change in BDNF levels. Thus these finding suggest that increases in BDNF prompted by exercise may play a particular role in improving our ability to memorize and recall on something.

Image of Hippocampus - from Wikipedia by user Looei496

In supporting this idea, other studies also reached similar conclusion even with animals. In one particular experiment from Universidade Federal de Santa Catarina (Federal University of Santa Catarina), Brazil, the researchers made sedentary elderly rats ran for 4-6 minutes, 4-5 days per week for five weeks (specific procedures can be found in Mechanisms of Ageing and Development Journal). This physical activity seemed to ignite some biochemical process in the memory center (hippocampus) of their brains, resulting in increased production of BDNF molecules there. As a result, these exercised elderly rats performed as well as much younger rats on rodent memory tests.

Although more needs to be studied on this topic and BDNF, these studies do indicate that exercising does help in improving memorization. So it would be a good idea to go for a walk or get any sort of physical activity in between study breaks, not only to get some fresh air, but to get some BDNF in our brains to study more efficiently. This may sound a bit bizarre but, we should go exercise to become smarter! It’s just too bad that I cannot make “studying” as an excuse for not getting any exercise anymore.

References:

Aerobic exercise improves hippocampal function and increases BDNF in the serum of yong adult male:
http://www.sciencedirect.com/science/article/pii/S0031938411003088

Brain-derived neurotrophic factor (BDNF) :
http://en.wikipedia.org/wiki/Brain-derived_neurotrophic_factor

Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: Involvement of hippocampal plasticity via AKT, CREB and BDNF signaling:
http://www.sciencedirect.com/science/article/pii/S0047637411001564

Hippocampus:
http://en.wikipedia.org/wiki/Hippocampus

 

The FUTURE is here! Skin-cell Gun

skin-cell-gunThe skin is our body’s first protective barrier from germs and viruses. Every year, thousands of victims from major effects of skin burns survive but some die while waiting for the skin to fully recover.In the past, burns have been treated with skin grafts which take skin sections from uninjured parts of the patient’s body, or grow sheets of skin artificially, and graft them over the burn. During the recovery period, the exposed flesh gives a greater chance for harmful pathogens to invade the human body.

Professor Jorg C. Gerlach and colleagues of the Department of Surgery at the University of Pittsburg’s McGowan Institute for Regenerative Medicine have been working on a way to minimize the healing time for burn victims, so that the chance of infection is reduced. The concept was first introduced shown in 2008. The good news is that they devised a tool to cut recovery time drastically and save lives. This method is called the Skin-Cell Gun.

The Skin-cell Gun is more like an airbrush gun that holds healthy stem cells that were isolated from a burn victim’s healthy part of skin. Using the device, these healthy stem cells are sprayed onto the burned area of a patient’s body. The surprising thing is the next part which is the recovery time. Instead of a burn wound in the past that normally takes weeks or months to heal, the same wound can be cured a lot faster. Dr Gerlach said the device takes only an hour and a half in total.

At the moment the technique can only be used on second-degree burns, but Dr Gerlach hopes it will later be able to tackle third-degree burns as well.

This video contains scenes that some viewers may find disturbing. This clip will also air on National Geographic‘s Explorer: How to Build a Beating Heart. The skin cell gun is a wonderful work!
References:
Spray-on Skin Is a Reality:
“Skin cell gun” regenerates cells in days

Make your dreams come true… in your dreams

The November/December 2011 issue of the Scientific American Mind has an interesting cover story about sleep and dreaming. I was especially intrigued by its article about lucid dreaming.

Lucid dreaming‘ is a term coined by the Dutch psychiatrist Frederik Willem van Eeden in 1913. It happens when the dreamer is aware that he or she is dreaming. Most people (8 out of 10) can recall having at least one lucid dream in their life, but sleepers who frequently experience lucid dreaming (once or twice a week) are rare. There are different degrees of lucidity in a lucid dream: from the realization that one is dreaming to having volitional control over the course of the dream.

Benzene molecule

In 2009, Dr. Ursula Voss and her team investigated sleepers’ brain activity using electroencephalography (EGG). The researchers found that the frontal lobes seem to perform very similarly in a lucid dream and in the waking state. On the other hand, the patterns of activity in the parietal and temporal lobes have more resemblance to those of REM (rapid eye movement) sleep. These results allowed them to conclude that lucid dreaming is a hybrid state of consciousness in between waking and REM sleep.

It has been shown experimentally that sleeping can lead to insights. Many scientific discoveries were made based on an insight that happened during a dream, such as Loewi’s theory of chemical neurotransmission, Mendeleyev’s periodic table of chemical elements, and Kekule’s discovery of the structure of benzene. Recent studies have shown that lucid dreams can have practical uses as well. People can learn to increase their chance of having a lucid dream to decrease their frequency of nightmares. Athletes have been found to learn complex motor sequences more quickly after targeted lucid-dream training. Finally, lucid dreams can also boost creativity, such as finding metaphors.

Below is a video with tips on how to increase your likelihood of having a lucid dream.

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A lot more needs to be found about lucid dreaming still, but we can already imagine many other potential applications. Who knows, maybe one day university students will be able to get more sleep while still learning everything they need. But for now, I am just dreaming.

References:

Consciousness in Dreams

How Can You Control Your Dreams?

Unlocking the Lucid Dream

Will SAV001 Save Us from AIDS?

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Video from University of Ontario : Media Conference on FDA Approval for SAV001

Acquired immune deficiency syndrome, better known as AIDS, was introduced to human race only a few decades ago but has since become a worldwide problem. Our society faces an AIDS pandemic. Millions of lives were taken by the disease, and more are to be lost if nothing is done to help. Vigorous researches attempt to develop a better understanding of the disease and ways to fight it. Recently, Professor Chil-Yong Kang and his colleagues at the University of West Ontario announced that they have come up with SAV001, a promising vaccine for HIV, and was approved by the FDA to proceed to human testing. Although this is enlightening news, some remain skeptical as HIV vaccines did not turn out successful in the past.

To understand why HIV vaccines are so hard to design, one must understand the mechanisms of vaccines and the nature of the HIV virus.

Image from Wikipedia by Fvasconcellos : Lock and Key Mechanism of Antibody and Antigen

Vaccines promote production of antibodies by white blood cells. Antibodies physically attach to antigens, foreign, potentially harmful molecules, or cells infected by antigens. This allows the immune system to target the tagged cells and destroy them to prevent further spread and damage. Antibodies allow such high level of specificity by recognizing epitopes which are unique and characteristic parts of antigens. In short, vaccines  introduce harmless epitopes and the body produces antibodies which can be used if the real disease infects the individual later on.

 

 

Image from National Institute of Health : Mature and Immature HIV

The difficulty associated with designing an HIV vaccine is related to the fact that the epitope for this virus is very variable. There are many subtypes of HIV and a vaccine designed for specific one of them is not likely to be effective for another. The virus also has a high rate of mutation, meaning that it is possible for a virus that has been genetically modified to be harmless to mutate back to a harmful form. For such reasons previous HIV vaccine candidates either had low efficacy or actually increased the rate of infection in some of their subjects.

 

Dr. Kang explained that SAV001 works by infecting cells with HIV to produce more virus, collecting them, and purifying them with chemicals and radiation. The dead virus as a whole is injected to elicit antibody production and activation of associated immune responses. If all goes well, the vaccine may be commercialized within a few years.

Human testing consists of 3 phases where the vaccine is tested for its safety and efficacy. Phase I for SAV001 is to begin in January 2012. Will SAV001 turn out to be a success or leave us in another disappointment? Whatever the result may be research for AIDS prevention and cure must continue. It is not likely that SAV001 will be effective for all people and subtypes of the virus. And will it be accessible in terms of cost and availability for all the people who need it? Probably not. More work needs to be done to fully fight off the disease and the misery it brings throughout the world.

 

Further Reading :

http://www.vancouversun.com/health/Canadian+researchers+start+clinical+trials+vaccine+January/5887090/story.html

References :

http://communications.uwo.ca/media/hivvaccine/

http://en.wikipedia.org/wiki/Hiv_vaccine

http://www.fiercebiotech.com/topics/fda_approval_process.asp

A cure for the common…hangover?

        

Image from Flickr: silent(e)

Recent scientific investigations  have led to the findings of an ancient Chinese herb that is able to remove the painful effects that are known to follow the consumption of alcohol; a college student’s dream!  Yes, this chinese extract from the raisin tree Hovenia dulcis, has the sobering effects on a person after excessive drinking, can relieve the symptoms of a hangover and also may provide a lifetime cure for those suffering from alcoholism.   
 

Hovenia dulcis, Japanese Raisin Tree ; this tree may be the cure to problems involving alcohol. (Image on Flickr by Tie Guy II)

For years, many Chinese people have been  using this extract in their tea to reduce any uncomfort that is associated with a hangover. The compound from the ancient raisin tree that has been found as the source of the cure, is Dihydromyricetin (DHM). It has been recently studied  by Dr. Jing Liang of the University of California on lab rats (as mentioned in NewScientist).  The results included a quicker recovery from intoxication on the rats when they were given alcohol containing DHM (only 5 minute recovery time!), versus alcohol by itself (around  a 70 minute recovery time).  Liang also found through her research, that the addiction for rats that were constantly consuming alcohol began to decrease over time after given small doses of DHM weekly.  

 For the Future
The goal of this research, is ultimately to gain the ability to have it eventually be tested on humans.  Once this is achieved, the affects could be ground-breaking. As more alcoholics are “sobering-up”, they will more likely be able to keep a job and increase the economy.  It is also predicted that the safety of living may increase in regards to drunk driving.  With the help of this “new drug”, one could essentially have an evening of drinks and fun, and still be able to drive home after without being a drunken liability to themselves and others on the road.

But…
Ideally, all of the above outcomes would be true and the drug would be perfect.  However, humans as a race are unpredictable.  Personally, I do not agree that the drug will cure many people, and instead might cause people to drink more.  If there was no consequence of drinking (a hangover etc) then it would just be more appealing.  Other scientists like Marcus Heilig have also voiced their concern regarding the bad outcomes that may occur from use of the drug and whether or not it would be beneficial or harmful to the population. 

Image from Flickr by sfllaw

Dr Liang is on the path to something that could change the lives of many people.  With no side effects currently being seen on their studies thus far, let’s hope she gets approval to begin testing on humans in the near future.

 

 

References:

NewScientist article:
http://www.newscientist.com/article/dn21337-chinese-tree-extract-stops-rats-getting-drunk.html

Hovenia Duclis Journal:
https://www.thieme-connect.com/ejournals/pdf/plantamedica/doi/10.1055/s-0030-1249776.pdf

Link to Dr. Marcus Heilig:
http://www.niaaa.nih.gov/RESEARCHINFORMATION/INTRAMURALRESEARCH/ABOUTDICBR/LCTS/Pages/Chief.aspx

Dihydromyricetin blog:
http://alcoholreports.blogspot.com/2012/01/dihydromyricetin-as-novel-anti-alcohol.html