Category Archives: Issues in Science

Pareto’s Distribution – A Real Problem

If you have ever been in a statistics class, you might have heard of the “Normal Distribution”. This distribution tells us that most things fall within the middle  and the extremes exist in small quantities. You can think of IQ following this pattern. The average person has an IQ of 100, less people have an IQ of 130 and even fewer people have Albert Einstein’s IQ of 160 – don’t we all wish we did. There are many variations of this and the distribution looks like a mountain, looking something like this:

Image result for normal distribution

photo credit: Wikipedia

This distribution describes many types of observations such a student’s grades, people’s heights, people’s blood pressure, shoe size and much more. It is a natural occurrence we observe in society and more importantly in the characteristics of people, such as people’s heights. This is important for society because it helps to understand what people need.  Imagine if the average height of Canadians were 2.3m tall, we would definitely have much higher doors!

DOES the Normal Distribution RELATE TO OUR LIVES?

Seemingly, the word “normal” in normal distribution supposes that all occurrences in nature and society would display this pattern. However, this might not be the case. In fact, many cases in physics, biology, earth and planetary sciences, economics, computer science, demography and social sciences follow a different distribution – the Pareto distribution. The Pareto distribution is quite the opposite of the normal distribution and tells us that most of the data exist in the extremes. It is therefore more commonly known as the “80-20” law which means 80% of what is measured exists in 20% of the population. Examples of the Pareto distribution is the sizes of cities, earthquakes, and forest fires.

To look at this more closely, let’s look at the sizes of cities and towns in the United States of America. There are around 20,000 cities in the country. If the population of these cities followed the normal distribution then we would expect most of the cities to have an equal population size and only a few extreme cities to have a high amount of people and a low amount of people. However, we see that most people live in big cities such as Las Vegas and New York and the overwhelming majority of people live in a small number of cities. The following graph shows the percentages of cities in USA and the population of those cities.  

Image result for pareto distribution population

photo credit: Newman, MEJ

The graph to the right displays a simpler display of the population of the US cities by doing some math. We can think of it as there being ten small suburbs surrounding a big city and ten of those cities surrounding a metropolitan city. We can also see it in Canada where metropolitan cities such as Vancouver, Montreal and Toronto are few in number but hold the majority of the population, while there are many more smaller cities spread across Canada with a small population.

Some other things that are interesting that follow this distribution is the numbers of citations to scientific papers, the numbers of copies of bestselling books sold, the diameter of craters on the moon, the length of relationships between couples, the frequency of family names, and people’s incomes.

Why should we care?

The Pareto distribution is particularly interesting because it shows that the natural state of things in a society can differ immensely. Even with books, although there are many authors that write books, only a handful make it on to the top-seller list. And in relationships, couples who are great with relationships last for decades, while couples who are poor with relationships can never break past one year. There is another topic that is widely debated about in society that follows the Pareto distribution which is wealth distribution. When we hear politicians blame the rich for poverty and income inequality – a big problem in society – one should wonder what a scientist’s perspective to the problem would be. We know in a more capitalistic society like America, 85% of the income is owned by the top 15% of the population.

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Interestingly enough, this is the reality of how wealth distributes itself in a free society. You might have heard the term “the rich get richer while the poor get poorer.” Through out history, societies have tried to rectify this phenomena and failed. But politics aside, a reality that we must face is the purple elephant in the room named Pareto.

5 ways to eat eggs bad for your health

Why people need to eat eggs

Eggs are one of the healthiest and the most commonly consumed food in the world. 

They have a high nutritional value because they contain various trace elements and kinds of essential vitamins needed by the human body, such as protein, vitamin D, B vitamins, minerals, and so on. 

 

Recent news about eating eggs

With the improvement of living conditions, people’s requirements on diet have been gradually improved. In today’s society, people are more and more about their health. As part of a balanced diet, people like to eat eggs to supplement nutrition. However, recent news on newspapers shows eats eggs can cause heart disease because of the high protein. Therefore, whether eating eggs bad or good to human health has caused concern.

High protein in eggs

The protein required for people is 0.8g per kilogram of body weight.

According to the dietary reference intake for protein, we can find:

  1. 56g protein required by the average sedentary man per day
  2. 46g protein required by the average sedentary woman per day

One large egg can provide about 6g protein, which makes up over 10% of the average sedentary man required per day and 12.5% of the average sedentary woman required per day.

To prevent side effects of eating eggs, people should pay attention to the following ways of eating eggs.

1. Eating raw eggs

Some people think that if food is cooked, it would lose its nutritional value. Therefore, many people like to eat raw vegetables and seafood, and they think that raw eggs have a higher nutritional value than cooked eggs.

However, eating raw eggs are more likely to carry bacteria, such as coli into the stomach, which can cause gastrointestinal discomfort and Diarrhea. In addition, the raw egg white contains Avidin, which only can be destroyed by high temperature. The Avidin can affect the absorption of the biotin in food, and cause many unpleasant symptoms, such as inappetence, muscle ache, skin inflammation, eyebrow fell off, and so on.

2. Cooking eggs for a long time

Some people think that more time used to cook eggs, it is better for human health. However, it is also wrong because if the egg is cooked for a long time, the ferrous ions in the yolk would combine with the sulfur ions in the egg white to form the insoluble ferrous sulfide, which is difficult to be absorbed. 

Also, fried eggs would be too old and the edges would be scorched when they are cooked for a long time. The polymer-protein in the egg white can form low molecular amino acid, which could form harmful chemicals to human health under high temperature.

3. Eating too many eggs in a day

If people eat too many eggs, the metabolites and the burden on the kidneys would increase, which can cause kidney failure symptoms. 

Here are a few effective tips:

For the elderly people, they can eat 1~2 eggs per day.

For the young and middle-aged people who engage in mental work or light manual labor, they can eat 2 eggs per day.

For people who engage in heavy manual labor, they need to consume more nutrition. So they can eat 2~3 eggs per day.

For young children, they can eat 2~3 eggs per day because of their fast metabolism.

For Pregnant women, lying-in women, breastfeeding women, individuals with weak immune systems and the patient that undertakes postoperative convalescence, they can eat 3 ~ 4 eggs per day because they need to get enough protein.

4. Eating eggs with sugar or soy milk

Many people like to cook eggs with sugar, but eggs can react with sugar under high temperature, and produce a substance called Glycolysis, which can destroy the amino acids in eggs. It is important to note that glycolysis has side effects on blood coagulation, which can harm human health. Therefore, people should leave eggs cool down before adding sugar.

In addition, many people like to have an egg, a bread, and a cup of soy milk for breakfast. In fact, the Trypsin in soy can combine with the egg pine protein in the egg white, which can cause nutrient loss and reduce their nutritional value.

5. Eating excess eggs on an empty stomach

If people consume excessive food with high protein, such as milk, soy milk, eggs and meat, the protein would be conversed forcedly into energy consumption, which cannot provide nutrition to people.

What’s more, when human body accumulates excess protein in a short period, the protein decomposition process can produce a variety of harmful substances that can bad for human health, such as urea, ammonia compounds, and so on.

In brief, if people pay attention to ways to eat eggs, eating eggs can help people meet their demand for protein, and it can bring many advantages to human health.

Information Attribute from:

Denise Hill: https://www.lifehack.org/488728/10-foods-to-eat-and-avoid-on-an-empty-stomach-for-better-digestive-health

Estherjane13: http://www.thewholesomefork.com/2017/02/23/how-many-eggs-is-it-safe-to-eat-per-day/

Haley Hernandez: https://www.click2houston.com/health/is-eating-eggs-good-or-bad-for-you-

Healthline: https://www.healthline.com/nutrition/eating-raw-eggs#section3

Healthline: https://www.healthline.com/nutrition/eating-healthy-eggs

GirlsTalkinSmack: http://women.girlstalkinsmack.com/Food/foods-you-should-not-eat-with-eggs.aspx

Jayne Leonard: https://www.medicalnewstoday.com/articles/323251.php

 

 

Zhou LU

Advances in medicine with technology: is it all good?

Having any experience in the biomedical sciences,  the phrase “microscopy is a lost art” must have some meaning to you. It means biotechnology is taking over the medical sciences. Biochemistry and molecular biology have become so prominent that techniques of old are being replaced by all things molecular.

Recent advancements in biotechnology have revolutionized science. DNA experiments not only conduct replication, they incorporate automatic interpretation of the results. Protein science has been simplified to pouring samples in vials and running them in a machine, no further skills or education required. Even medical diagnostics are “going molecular”, using DNA and protein experiments to diagnose patients rather than the traditional interpretation of labs. But while molecular experiments sure make our lives (as a scientist) easier, haven’t we been taught that shortcuts are never the answer?

What’s wrong with going molecular?

A perfect example to illustrate this point is with the blood infection: malaria. Annually, an estimated 600 million people globally still suffer from this parasitic disease and over a million die from it. Current diagnostic methods involve blood smears under microscopy as shown in the photo below; the purple specks representing malaria parasites.

Picture by Teresa Lo, BCCDC

However, when presented to pathology residents of UBC’s Faculty of Medicine, not a single one of them could identify the illness. Even more astonishing, they actually thought that the patient was perfectly healthy. This incident occurred at the BC Centre for Disease Control, where technicians of the Parasitology department tested medical residents with confirmed-diagnosis patient samples.

How did this happen?

With advancements in science and technology, biotech companies have developed molecular tests for diagnosing patients. For malaria, a well-known device is called the Rapid Test shown below. Functioning like a pregnancy test with urine, the Rapid Test simply requires a drop of blood and some time before a positive or negative result is given. You might be asking “where’s the problem?”. While the Rapid Test IS very convenient, it has a relatively low success rate. This is further discussed on the CDC website for malaria diagnosis.

Picture by Benjamin Chang, BCCDC

For patients where the malaria parasite is not prevalent or perhaps has not replicated enough, detection via Rapid Tests would fail. This is why microscopy is so important in the field of parasitology, it can detect parasitemia at low enough concentrations that early intervention would be possible. A paper published in the Journal of Malaria found microscopy was a better method for diagnosis compared to molecular techniques:

Biomedical scientist Emmanuel Biney further demonstrates in this video that while the skill required for microscopy is high, it is most definitely required:

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Unfortunately, microscopy is truly a lost art as our generation is geared towards molecular techniques. Training in microscopy takes numerous years of practice and an experienced technician as an instructor. As the previous generation retires and our generation begins to enter the workforce, we will have to find some way to compensate for the loss of their skills.