Category Archives: Biological Sciences

Cooking with Fire

Big Brained Freaks

Evolution has produced a bunch of peculiar and downright freaky organisms (Purple Frog, anyone?). However, as the BBC so delicately puts it, “[h]umans are possibly the weirdest species to have ever lived”. Although this is likely true for quite a few reasons, what really sets us apart are our massive brains.

A big brained freak.
Source: Flicker, submitted by Martin Quiroz.

In fact, humans have the largest brain to body weight ratio of any Great Ape. And we can thank these hefty brains for our unique cognitive abilities. For example, unlike other animals, we are able to solve problems by recombining old information in novel ways, we can easily understand symbolic representations and we can even think about our own thoughts objectively. But how did our brains ever get large enough to give us these impressive powers?

Fueled by Fire

Dr. Richard Wrangham poses that the answer lies in his Cooking Hypothesis. Specifically, Wrangham argues that the reason modern humans ended up with big brains is because the Homo sapien line learned how to control fire, and importantly, how to cook with it.

Dr. Richard Wrangham on his Cooking Hypothesis. Source: Youtube, uploaded by TheLeakeyFoundation.

The logic for how cooked food equals bigger brains goes like this: cooking makes a food’s calories and most of its nutrients more bio-available, meaning they are absorbed more readily by our bodies than they would be from raw foods. This happens because heat alters the structure of foods, by unwinding proteins and opening up starches, so that our bodies can expend less energy in the enzymatic breakdown (ie. digestion) of these molecules. This is to say that cooked food packs in more calories than raw food (per gram), thereby allowing the early humans who cooked to take in more energy than their bodies required to function. The Cooking Hypothesis theorizes that this energy surplus was put towards unprecedented brain growth.

Fitting Facts

While the hypothesis can’t be tested outright, Wrangham offers several pieces of evidence in its support. Perhaps the most convincing is archaeological evidence of controlled fires in sub-Saharan Africa. The fires date back to approximately 1.8 million years ago, coinciding with fossil records showing increases in early human cranial capacity (ie. brain space).

Modern day human skull.
Source: Flickr, submitted by Internet Archive.

This convergence of events supports the idea that cooking lead to the big brains we think with today. So the next time someone tells you not to play with fire, you might want to think twice.

Contributor: Hayley Carolan

 

Caffeine: A Health Benefit or Risk

Caffeine has become a part of everyday life.  It’s there from the moment we wake up to our first cup of coffee, to the late nights of intensive studying.  It is the most commonly consumed psychoactive drug worldwide, but does your everyday consumer really know how they’re being affected by the substance?

Image result for caffeine

First, let’s look at the action mechanism of caffeine in the body.  Caffeine is a central nervous system stimulant and acts on adenosine receptors in neurons and other areas throughout the body.  The adenosine receptor is activated by a breakdown product of ATP, known as adenosine, and slows down neural activity to increase relaxation and fatigue.  Caffeine binds to and inhibits adenosine receptors, leaving fewer receptors available to bind with adenosine, therefore decreasing its sleep-inducing activity.

The majority of people consuming caffeine are aware of its stimulating and energizing effects, however, many are not familiar with other benefits or risks associated with caffeine.  Since 80 percent of caffeine consumed is primarily as coffee, fewer studies have been carried out on the effects of caffeine alone, as opposed to coffee as a caffeine source.  In a recent article, it states that consuming coffee, amounting to around 200mg of caffeine, has been found to increase brain health and enhance short-term and possibly long-term memory.  It has also been found to decrease the risk of death caused by heart disease and stroke as well.  Those who were associated with drinking coffee daily were at a lower risk of developing cancer, liver disease, and type 2 diabetes.  Also, it is possible that coffee or caffeine may delay dementia for those who have mild cognitive impairment.  On the other hand, studies have correlated coffee/caffeine consumption with increased blood pressure, tachycardia, and sometimes arrhythmia.  It can also result in migraines, sleep deprivation, nervousness, and irritability.

Image result for coffee

Caffeine consumption has some appealing benefits as well as some deterring negative effects.  Although studies show there to be reduced risk percentages for certain chronic diseases, many of these studies are observational and look for parallels between coffee drinking and diseases, rather than prove a cause and effect.  With that being said, it is difficult to conclude whether or not the health benefits outweigh the risks, and to be honest, it probably doesn’t matter all that much.  Those who are regular coffee consumers will continue to be, and those who have never tried it before are never going to. However, it is still sensible to be familiar with how a substance may affect you, before it is consumed.

David Infanti

Will 2019 Be the Year of the Transgender Fish?

Birth-control pills containing the primary female sex hormone, estrogen, have been highly successful in preventing unwanted pregnancies since the 1960s. As these hormone-containing pills started to become both more readily available and socially accepted in recent years, male fish have suffered the consequences of abnormal levels of estrogen in marine environments, turning them into so-called transgender fish. Exposure to increased levels of estrogen in sexually reproducing male fish can cause them to acquire female traits. The loss of male individuals can have detrimental effects on the marine ecosystem as a whole. As a society, we are impacted by these changes due to the fact that over 3 billion people worldwide rely on seafood, including fish, as their primary source of protein. If species of fish are unable to properly reproduce due to the lack of sexually reproducing males, the entire food-web will be disrupted, directly impacting humans, who lie at the top of the web. Not only will society lose a vital food source, but the third-hand intake of estrogen through the consumption of infected fish will undoubtedly have repercussions on the human body.

Estrogen-containing birth control pills. Source: Flickr Credit: Brianna Laugher

Where Does the Estrogen Come From?

When females take birth-control pills, the synthetic estrogen that is consumed will not stay in the human body forever; it will eventually be excreted through the process of urination. Approximately 68 percent of the original dose of birth control is excreted from the human body every time a pill is consumed. In addition, the disposal of unused, unwanted birth-control down sinks and toilets will contaminate waste-water with abnormal levels of estrogen. When this waste-water gets dumped into marine environments, the female sex hormones will also be washed away into lakes and oceans in relatively high doses, inflicting many unwanted consequences on marine organisms.

Feminizing Male Fish

Many male fish are severely impacted by estrogen-contaminated waters. Source: Wikimedia Commons Credit: Firos ak

When male fish are exposed to increased levels of estrogen in their marine habitats, studies have found that they begin to show many feminine traits, rendering them transgender fish. This includes egg production, a decrease in sperm count, and signs of less aggressive behaviour. Certain studies have found that some male fish have even begun to develop ovaries in place of testes when exposed to estrogen. The entire ecosystem can be impacted by this, as a decrease in sexually reproductive male fish can eventually drive an entire species into extinction. A drop in species diversity can lead to serious ramifications, including an increased susceptibility to disease outbreak.

What Can Be Done?

Waste-water treatment plants can remove estrogen from waste-water early on. Source: Flickr Credit: eutrophication&hypoxia

As the primary and most influential contributor of estrogen to waterways is caused by the disposal of hormone-containing waste-water, better waste-water treatment methods can easily be established to prevent this from continuing to occur. Although this simple fix can make a big difference in the reproductive abilities of male fish, the impacts that estrogen has already had on many organisms can nonetheless be passed on to future generations.

Written by Kelsey Wong

Parkinson’s Disease: mystery solved by a protein?

Source: Army US

Parkinson’s disease is a lifelong disease with no cure. According to this website, out of all the diseases associated with the brain, Parkinson’s is the second most common. Parkinson’s is characterized by problems with movement, such as uncontrollable shaking and difficulty walking.

Unexplained Cell Death is the cause of Parkinson’s Disease

On a cellular level, Parkinson’s is the result of nerve cell death. Neurons are the cells that make up our nervous system. Since the nervous system is responsible for our ability to think, feel and move, neurons are pretty important. Especially, since, after a certain age, we stop producing new neurons.

Essentially, Parkinson’s Disease is caused by the massacre of these precious neurons. Specifically, Parkinson’s is caused by the nerve cell death in a specific part of the brain,  the Substantia Nigra. Nerve cells in this region produce dopamine, a chemical signal involved in producing movement.

As of now, we have yet to find a clear culprit responsible for the cell death in Parkinson’s. However, active research has shed some light on the matter.

Relative location of the Substantia Nigra. Source: Wikimedia Commons

Lewy Bodies’ association with Parkinson’s Disease

Lewy bodies are essentially clumps of broken protein, of different types and sizes. According to this study, Lewy bodies are especially common in the dopamine-producing cells belonging to patients with Parkinson’s. Because they have such a strong association with the disease, Lewy Bodies and their protein contents have piqued scientists’ interests.

One protein of note, is alpha-synuclein. In the healthy body, the function of this protein is unknown. In diseased state, however, scientists have found they make up a large portion of Lewy Bodies. With this, we turn to another study that investigated alpha-synuclein’s role in hereditary Parkinson’s Disease.

Example of a Lewy Body (the dark red circle). Source: Wikimedia Commons

Alpha-Synuclein’s role in Hereditary Parkinson’s

There are two broad categories of Parkinson’s: hereditary and non-hereditary. The hereditary type is rare and, like most hereditary disease, the cause can be found in the patient’s genes. Specifically, researchers have found a mutation in the gene that codes for alpha-synuclein. The mutation ended up producing proteins with the wrong shape. The correct proteins should have what is called an alpha helix shape; meanwhile, the defective protein had a beta sheet shape instead (refer to diagram below). Unlike alpha helices, beta sheets have the ability to stack on top of each other to form an amyloid fibril. These structures start to pose a problem because they are hard to degrade and are useless, just hanging around inside the cell. Amyloid fibrils have the potential to kill neurons and explains the cell death seen in this particular type of Parkinson’s.

The researchers for this study feel that the same mutation is probably no the cause for the more common, non-hereditary version of this disease. However, they also feel that a similar process may be at play here and their findings have provided groundwork for future research.

Is Eastern Wolf a Distinct Species?

The top-down regulation of ecosystems requires the action of top carnivorous predators like wolves. However, due to human activities, there has been a large reduction in the number of wolves in North America, which requires our immediate conservation. It is urgent to save endangered species because protecting endangered species like wolves from extinction is protecting ourselves from extinction. To be specific, without wolves in the ecosystem, the conditions of other animals and plants will be disturbed and altered unpredictably, and the disturbance may result in a more wide-spread collapse of species, including human beings.

 

Wolves in Yellow Stone National Park affect many aspects of the ecosystem (credit: National Park service)

 

Eastern wolves, native to North America, are one of the wolves/coyotes that have been disappearing, and are claimed to require protection by the law. The origin of eastern wolves (Canis lycaon) has been the subject of an ongoing debate and controversy. Specifically, while some claimed that eastern wolves are a distinct species, others argued that they are the hybrids from other wolves.

 

Eastern wolf (Canis Lycanon) (credit: Michael Runtz)

 

As the debate proceeds, scientists have found controversial evidence, including morphological and genetic analysis of wolves, giving inconsistent interpretations of the origin of eastern wolves.

 

Different canis types, eastern wolves (second from left) (credit: ScienceNews)

 

According to the law, only endangered species are qualified for protection, while hybrids are not. Therefore, the mysterious origin of eastern wolves creates problem for the government because whether eastern wolves are qualified for protection by law cannot be determined currently.

In conclusion, the most urgent act is for scientists to solve the mystery of the origin of eastern wolves, and then the government can determine whether eastern wolves should be saved as a top predator.

A Scoop of Creatine a Day Keeps the Muscles on Display

 

 

Looking to add more exercise for your 2019 New Year’s resolution? Studies show that taking creatine can increase your stamina and strength. People who ingested creatine while weight training increased their strength by an average of 8%.

What is it?

Creatine is a natural, non-protein amino acid that helps make energy for muscle contractions. It is commonly found in red meat and seafood. The human body requires about 1-3 g of creatine a day to replenish its creatine levels. Since creatine is found in various everyday foods, it is not a prohibited substance in professional sports.

What does it do?

Multiple studies have supported that creatine increases the efficiency and recovery of muscles. In a 2017 review, Kreider et al update creatine findings in the Journal of the International Society of Sports Nutrition (ISSN). They reported that numerous studies have supported the fact that consuming creatine will help with faster recovery, increased strength and increased endurance. In fact, the ISSN recently stated in 2017, “creatine monohydrate is the most effective ergogenic nutritional supplement currently available to athletes in terms of increasing high-intensity exercise capacity and lean body mass”.

Is it safe?

Creatine has undergone many short-term and long-term studies involving varied dosages of creatine. In a 2011 study by Jäger et al, they found that there were no significant negative side effects. In addition, we make creatine in our liver and kidneys naturally. It does sound like a magical substance with all positives and no negatives, but in reality, it doesn’t have anywhere near the rapid effects of anabolic steroids. So, taking creatine won’t turn you into the Hulk, but it might give you an added bit of strength when you lift in the gym.

How much to see the effects?

As previously mentioned creatine can be ingested by consuming foods like red meat and seafood to see the same effects. For instance, one pound of uncooked beef or salmon provides 1-2 g of creatine. However, using a creatine supplement is more economical and practical for replenishing creatine levels effectively. Scientists recommend that people who want to take creatine, would see the effects after reaching their creatine level saturation. This can be obtained by increasing creatine consumption to about 5 g four times a day for one week. Then to replenish that level you only need to ingest about 5 g per day.

Closing remarks

Although not everyone is a professional athlete, everyday people can take creatine supplements to assist their endurance and strength. If you are trying to meet your “New Year, New Me” weight goal in the gym or training up for a marathon, adding a creatine supplement to your diet is a safe and easy way to give you an edge.

Christopher Lam

 

 

 

 

 

 

 

A Critique on the Static Nature of Cancer-research Articles

(Cancer, Source: Alpha Stock Images)

Recent statistics released by the Canadian Cancer Society estimate that one in every two people will be diagnosed with cancer in their lifetime. Statistics that if accurate, implore the general public and scientists alike to ask what progress is being made on the front of finding a cure for cancer. Enter “The State of Cancer: Are we close to a cure?” by Maria Cohut, an article published in Medical News Today written with the intention of answering this question.

pros of the Prose

In the current epoch of ‘fake news’ where inaccurate claims are shamelessly made, this article employs the use of a ‘fact checker’. A useful method that should become an industry standard. This coupled with the utilization of hyperlinks to the literature referenced, facilitates an opportunity for readers to critically appraise significant claims. Such as the compelling statistic that a staggering 1 in 6 deaths globally are cancer related. A statistic that emphasizes the timeliness of the article, whilst offering the reader a tool to confirm the compelling results for themselves and instilling confidence that a month later it will not be debunked as inaccurate. When concerning a topic and data that impacts so many people not only nationally but internationally, and on which hope is so quickly built upon; it is imperative that such articles are transparent in their conclusions.

COns of the Content

A pathological issue in the cancer-article genre is the writer’s inability to connect the research and breakthroughs to the readers beyond an informative description. Cohut breaks down the frontiers of cancer research; but, falls short of informing the reader (and possible patient) on ways to get involved in the study in either a volunteer or donor capacity. Often the topics of such articles are still in a research and development phase or preparing to enter hum

(Lost, Source: Pixabay)

an trials. The need for both volunteers and donors may exist, but too often fails to be addressed. The target audience for these cancer treatment articles have recently received a life-changing diagnosis or heartbreaking news and are in search of hope. When articles such as Cohut’s become fixated on describing the ‘latest and greatest’ in cancer research, they fail to pay off on what interested the reader in the first place, the hope to engage in a mutually beneficial opportunity to improve their chances of beating the diagnosis.

Is ‘ok’ okay?

Cohut’s article identifies the current state of knowledge in cancer research, but ultimately fails to leave any lasting impact, which is disappointing considering that involving a reader in such research is as simple as a hyperlink. In Canada, where individuals have a 50% chance of receiving a cancer diagnosis in their lifetime, should the medium evolve to equip and involve their readers or settle with a catchy title, an ‘ok’ article, and no practical takeaway message?

(Hope, Source: Alpha Stock Images)

By: Jonathan Kraft

“Vessel Baby” on the Way?

You probably have seen it more than once in Sci-fi movies: human babies are incubated in large fluid-filled vessels growing and waiting to come alive. I am not a big fan of such movies, but a recent study has made those scenes one step closer to reality.

A paper published on Nature  caught public’s attention in 2017. Scientists at the Children’s Hospital of Philadelphia kept eight premature lambs in an “artificial womb” system to allow those lambs to continue growing outside mother lambs’ body up to four weeks. The “artificial womb” looks a lot like a plastic bag filled with solution which mimics amniotic fluid in the real uterus. The baby lamb’s umbilical cord (containing blood vessels) was also connected to a bunch of tubes which provide oxygen and remove carbon dioxide at the same time.

Credit: Nature Communication

Schematic and Real Setup of Artificial Womb

Scientists of this study think such extra-uterine supporting system would be extremely beneficial for preterm human babies in the near future. Statistics show that infants have lower than 50% survival rate and may face lifelong health issues if they are born at or before 25 weeks. It is also one of the leading causes of new-born death and illness in the U.S. “These infants have an urgent need for a bridge between the mother’s womb and the outside world,” says  Alan W. Flake,  also the leading researcher of this study. With “artificial womb” like this, doctors and caregivers could keep a premature baby in a “uterus-like” environment longer enough for its important organs to grow and thus significantly reduces the rate of mortality and the risks of other complications.

Although this technology seems incredibly promising and considered as “a pretty momentous achievement” by  other researchers in the field, some people also raise ethical concerns about it. Can people abort a “vessel baby”? Who is going to raise the baby if both parents abandon it before it is born? They argue if artificial uterus further extends human’s ability to grow embryos and fetuses, such action would challenge our laws around issues like abortion and reproductive rights. However, other people embrace this technology which may become an option for homosexual males to have their own kids without the use of surrogate and allow women to have children without going through painful labour. Fortunately, we probably won’t see human babies “popped” out of such artificial system very soon since scientists need more time to tackle many technical issues and perfect the “womb”. This leaves the general public and policy makers some time to discuss all the ethical and legal considerations behind it.

Xin Dong