Monthly Archives: March 2022

New Treatment for HIV

HIV and its Implications

The HIV global pandemic was once a major killer in the 20th century. HIV causes mental panic, social apprehension mortality when left untreated and miseducated. Due to the fact that diseases transmitted from sexual contact or drug usage cause social stigma, the HIV global pandemic became a fight not only against the virus itself but the perception of that from the general public. Though no form of illness should be conceptualized from that of a negative connotation, HIV long has had a conception coming from promiscuity, drug addiction, and carelessness. Treatment for HIV and better education continues to be a global battle.

HIV is described as a virus with no cure but treatable. Proper treatment of HIV can allow an infected individual to live a normal lifespan. Source: HIV.gov

How HIV is Transmitted

HIV is transmitted through sexual contact, needle sharing, contaminated blood transfusion as well as birth. HIV is a virus that attacks the body’s immune system. The latent stage of HIV is AIDS when the CD4 cell count in the body lowers to rates that cause infections to be prone.

HIV is transmitted through four major ways: sex, blood transfusion, needle sharing and mother to baby. Source: avert.org

Treatment History

HIV treatment first began with Zidovudine, which became available in 1987. Zidovudine causes side effects such as low blood cell count, liver damage. More importantly, Zidovudine stops working as the virus mutates. In 1996, antiretrovirals became available for public use. The combination of antiretrovirals made it difficult for enzymes in HIV to replicate. In 2007, Raltegravir became available as an HIV integrase inhibitor. In 2010, Truvada became an available option for pre-exposure prophylaxis for the public.

New Injection Treatment

Treatment for those infected with HIV requires a daily oral pill. Until 2021, one of the oral pills had to be taken by someone HIV positive. A daily pill makes it difficult to adhere to treatment. Moreover, oral pills are difficult for those with swallowing difficulties, poor drug absorption, and gastrointestinal problems. Cabotegravir and rilpivirine are taken as integrase inhibitors and non-nucleoside reverse transcriptase inhibitors. These two medications are taken in injection form once every one or two months. The result is that injection forms require much less dedication to HIV treatment, as these forms don’t require a daily treatment plan. The key to HIV treatment to allow those living with the virus to lower transmission and keep the virus under control is to have an undetectable viral load. An undetectable viral load allows an infected person to live a normal lifespan and be HIV non-transmissible.  Injection treatment works equally as well as the oral pill.

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HIV injection Treatment Description

New Treatment Plan

In the UK, injection treatment for HIV will begin in 2022. Other European countries are soon to follow this plan. Another treatment plan for HIV is a solution and alternative to approach a virus in modern society.

First Genetically Modified Pig Heart Transplant

If due to an unfortunate accident, you were on the National Organ Waitlist for a heart transplant, would you consider receiving a heart from an animal?

Since the first organ transplant, there has been a shortage of healthy organ donors all around the world. For example, last year in Canada, about 280 people died while waiting for an organ transplant. This shortage is much greater in more populated countries such as the US, where on average ten people lose their lives every day. To resolve this shortage, doctors have tried to transplant animal blood and organs to humans. Unfortunately, they have not been very successful until recently, due to the complexity of the human body and the anatomic variations between different species. However, using genetic engineering, scientists have been able to transplant a few animal organs to humans, including the first pig heart! 

Human Body & Organ Transplant

The human body is like a very complex machine, with microscopic vessels and delicate tissues. A slight change or injury to an organ can be disastrous. When a vital organ, such as the heart is damaged beyond recovery, doctors have to replace it with a donor’s organ, which is usually a deceased person. 

Organ transplant has saved countless lives over the decades but it can commonly result in complications, especially if there is low blood type compatibility between the recipient and the donor. If the recipient’s blood type does not match the donor’s blood type, the recipient’s body will reject the organ. During organ rejection, the transplanted organ is nothing more than a foreign object to the body, like bacteria. The body’s defense mechanisms will try to remove the transplanted which usually results in death.

Dark green represents the number of transplants, light green represents the number of patients on waitings lists and the dashes green represents the number of dead patients while waiting for a transplant. Image by Canadian Organ Replacement Register https://www.cihi.ca/en/organ-transplants-in-canada-2020-donations-and-need-infographic

Genetically Modified Pig Heart Transplant

However, on January 7th, 2022, scientists and doctors made a huge advancement in this field. They were able to transplant the first-ever genetically modified pig heart into a 57-year-old man, who was suffering from life-threatening heart disease. David Bennett has been recovering from the operation and is currently healthy and stable.

Why use a genetically modified pig heart?

There are many reasons why scientists used a pig as the donor, mainly because pigs are very anatomically similar to humans. In both adulthood and childhood, their organs are similar in size and function to humans, making them well suited for transplant. Additionally, pigs reproduce at a fast pace and can be bred at high health standards in labs. There are labs in the world that breed and clone pigs for organ transplants.

Eckhard Wolf with pigs in at the Badersfeld bog test farm in Oberschleissheim, Germany. Photographed by Lukas Barth/Reuters https://www.theguardian.com/science/2022/feb/03/german-researchers-to-breed-pigs-for-human-heart-transplants

Using advanced technology, scientists were able to edit parts of the DNA of a pig and turned off genes (the building blocks of DNA) that resulted in organ rejection. This eliminated the need to find a compatible blood type donor.

In Conclusion:

The use of animal organs for transplant is not a simple matter, since there is still a lot of controversy around the topic. Many believe that genetic engineering is a technology that humans should not explore. Others bring up the issue of animal welfare and question the practice entirely. However, if more research is completed on genetically modifying animals for organ transplants, we might be able to solve the organ donor shortage entirely. Patients will not have to wait on long lists to receive organs to live and we could minimize the risks of organ transplants significantly, saving thousands if not millions of lives.

 

By Shayan Abbaszadeh

Cancer Therapy – Breakthroughs in Cancer Cell Research and Treatment

Imagine this:

You’re living your life but suddenly you lose the urge to eat. Not a big deal, maybe it’s just a phase.

A week passes and you notice that those juicy arms you’ve worked so hard to grow to seem to start looking like sticks. Your face seems a bit discolored, somewhere on the paler side. You weigh yourself, and you’re down 10 pounds. You start feeling a bit concerned but maybe it’s the keto diet that you started.

A few more weeks pass and you feel a small bump on your lower back. Now you’re freaking out and head to the hospital. After a diagnosis, the doctor says the three dreaded words: “you have cancer.”

Although it seems like it’s the end of the world, 21st-century medical advances have allowed us to investigate and create new types of cures to combat cancer. One of these advances is chimera antigen receptor (CAR) T-cell therapy, which will be discussed more in-depth later in the post.

What is cancer?

In the most general sense, cancer is a disease that causes cells to rapidly divide and grow uncontrollably and spread to different parts of the body. Cancer cells can also aggregate in certain areas and disrupt bodily functions, also known as tumors.

Current CANCER TREATMENTS:

Currently, there are three main types of treatment: surgery, chemotherapy, and radiation. As surgery suggests, it is the physical removal of a tumor. Chemotherapy uses drugs to target rapidly growing cells, even healthy cells such as hair. Finally, radiation uses x-rays, particles, or radioactive seeds to kill cancer cells. Of course, there are other types of treatment such as targeted therapy but it is less used in the medical industry.

Example of Cancer Treatment (Chemotherapy) – Image by VeryWell

A newer type of treatment, car t-cell therapy:

Chimera antigen receptor (CAR) T-cell therapy is a newer type of treatment that was tested back in 2010. Essentially, T-cells from a patient are extracted, genetically modified with CAR, and reintroduced into the patient. These modified T-cells are more adept at targeting only cancer cells. In a 2022 study by Melenhorst et al., it was found that two patients suffering from lymphocytic leukemia entered remission (signs that the cancer has reduced) right after treatment and after a decade, still continue to be in remission and even contain detectable CAR T-cells. This study shows that CAR T-cell therapy has its merits as being a legitimate treatment.

CAR T-cell Therapy Cycle – Image by Genetic Engineering & Biotechnology News

Side effects of treatment:

Like all types of cancer treatments, there are some side effects associated. In a 2022 New York Times article by Gina Kolata, some side effects include high fevers, comas, and dangerously low blood pressure. However, some of these symptoms were resolved given time.

Overall takeaways:

Recent studies showing the results of CAR T-cell therapy have given it a chance to display the potential of it being a legitimate cancer treatment. Although some nasty side effects are associated with treatment, we cannot deny the positive effects it has shown. However, further research and testing would be crucial in developing this medical knowledge.

– Jimmy Huang

 

Exciting New UBC Research Could Provide A Cure For Spinal Cord Injuries

Introduction

Yearly, there are between 250,000 to 500,000 people who suffer a spinal cord injury (SCI) worldwide. In Canada, an SCI will cost on average $1.5 to 3 million per person over their lifetime. Also, people with SCIs are 2 to 5 times more likely to die earlier than a person without an SCI. The significant amount of SCIs and the cost associated with this traumatic event has researchers eager to find a cure, but there has not been a successful solution so far. However, UBC researchers think they may have found a potential solution.

What is The Spinal Cord?

The spinal cord is a column of nerves that runs down the middle of your back. It functions to carry sensory information from your body to your brain, motor signals from your brain to your body and controls an individual’s reflex responses. The spinal cord is an essential part of the human body and allows us to sense and interact with our surrounding environment. Therefore, it can have profound implications when the spinal cord gets damaged. 

Cause of Spinal Cord Injuries

The most common cause for SCIs is from trauma to the back: motor vehicle accidents for younger individuals and falls for those over 65 in the USA. Over 50% of spinal cord injuries occur in individuals between the ages of 16-30 years, with most being males. 

Statistics associated with SCIs show the significance of this injury to society.
Source: https://mendthegap.ubc.ca/approach/

EXCITING NEW UBC RESEARCH

UBC researchers just received a $24 million grant for their “Mend the Gap” project working on spinal cord regeneration. The UBC scientist Dr. John Madden leads this project and works with engineers and researchers from Canada, the United States, Europe and Australia. The projects have 32 researchers from many disciplines, including electrical engineers, material chemists, microbiologists, neurobiologists, and neurosurgeons. Dr. Madden and his team hope to have the project completed in seven years. 

UBC’s Mend the Gap teams unimaginable breakthrough in the world of SCI research. Source:  Project Video By UBC Applied Science 

The team’s research aims to use a soft gel containing small magnetic pieces that will help guide and reconnect the nerves damaged in the spinal cord. “Mend the Gap” has had success doing this in an artificial environment and is now working toward how this concept can be applied to the human body. The soft gel can modify itself to perfectly fit different shapes and sizes of gaps within the spinal cord in a non-invasive way. Furthermore, the gel contains medication that could help reduce scar tissue and help speed up the regeneration process. 

The research method has complex procedural steps that rely on the use of a magnetic field. Source: https://mendthegap.ubc.ca/approach/

Importance of the Research 

There are many people with SCIs globally; thus, they have a higher risk of mortality, demonstrating just how important this potentially life-saving research is and the impact it can have. Ultimately, this research has vast potential for impacting the lives of those with SCIs and provides hope for the future of spinal cord injury research.