Monthly Archives: February 2019

A Two-Enzyme Pathway Links L-Arg to Nitric Oxide in N-Nitroso Biosynthesis

N-nitroso compounds are carcinogenic molecules previously thought to be made only through non-enzymatic routes. We investigated how the N-nitroso natural product streptozocin is constructed, and we revealed a new two-enzyme pathway that links L-arginine to production of nitric oxide. Congratulations to Hai-Yan and coauthors for their recent publication inĀ JACS!