Current Position:
Assistant Professor, Zhejiang University
Email: yldu@zju.edu.cn
B.S. in Biotechnology, Zhejiang University
Ph.D. in Biochemistry and Molecular Biology, Zhejiang University
Michael Smith Foundation for Health Research Trainee Award, 2013-2015
Representative Publications:
Du, Y.-L., Higgins, M.A., Zhao, G., Ryan K.S. Convergent biosynthetic transformations to a bacterial specialized metabolite. Nat. Chem. Biol. DOI: 10.1038/s41589-019-0331-5.
Du, Y.-L., He, H.Y., Higgins M.A. & Ryan, K.S. A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazate. Nat. Chem. Biol. 13, 836-838 (2017) .
Du, Y.-L., Singh, R., Alkhalaf, L.M., Kuatsjah, E., He, H.-Y., Eltis, L.D. & Ryan, K.S. A pyridoxal phosphate-dependent enzyme that oxidizes an unactivated carbon-carbon bond. Nat. Chem. Biol. 2016 12: 194-199.
Du YL, Alkhalaf LM, Ryan KS. (2015) In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2717-22
Du YL, Ryan KS (2015) Expansion of bisindole biosynthetic pathways by combinatorial construction. ACS Synth Biol 4(6):682-688.
Du YL, Shen XL, Yu P, Bai LQ, Li YQ (2011). Gamma-butyrolactone regulatory system of Streptomyces chattanoogensis links nutrient utilization, metabolism, and development. Appl Environ Microbiol. 77(23):8415-26