Author Archives: sajni shah

Indestructible Water Bears

Water Bears. Courtesy of Wikimedia Commons.

Tardigrades, also known as water bears, are microscopic animals that have intrigued scientists for many years. What about them is so captivating? The fact that they are nearly indestructible.

Water bears have been treated to extreme environments, and against all odds, their survival has been astounding. They can survive temperatures ranging from -328 – 300 degrees Fahrenheit, pressures of up to 6000 times our atmosphere, and even…10 days in space!

The question though, is how do they do it?

Theories have gone as far as to suggest that the reason water bears can survive these extremes, is that they came from other planets. Personally, this idea seems impossible, but could it hold a glimmer of truth?

Scientists conducted further research and found a reason for their survival. The reason is anhydrobiosis. Anhydrobiosis is a dormant state where an organism reduces their metabolic activity significantly and becomes almost completely dehydrated. As it turns out, water bears in extreme environments tend to curl up into a dehydrated ball called a tun. In this form, water bears can survive for decades or longer.

If most living organisms were to enter this state of desiccation, they would not be able to come back from it, but water bears can. According to Thomas Boothby, a Life Sciences Research Foundation Postdoctoral Fellow at the University of North Carolina:

“[T]ardigrades have evolved unique genes that allow them to survive drying out. In addition, the proteins that these genes encode can be used to protect other biological material—like bacteria, yeast, and certain enzymes—from desiccation.”

Water bears seem like very interesting creature to study, and it makes sense for scientists to be captivated by their incredible survival rates in extreme conditions. More intensive research on these water bears could lead to amazing discoveries in the future.

~ Sajni Shah

Zika Virus…a Cure for Brain Cancer?

 

A summary of ZIKV Photo from: Google Images

ZIKV is a virus that is spread by daytime-active Aedes mosquitoes. The infection mostly causes very mild symptoms similar to Dengue Fever. Babies in the womb can have slightly more adverse effects such as brain malformations and birth defects. Researchers studied how ZIKV was causing these problems for babies. One main concern that arose was that ZIKV was causing the death of stem cells which are in high abundance in babies.

Recently experts have been studying how to use ZIKV to treat brain cancer, specifically glioblastoma. Glioblastoma is a type of brain cancer that is very common in adults and can grow and spread quickly. Due to its rapid growth, glioblastoma is tricky to treat and the common treatments, radiotherapy, chemotherapy and surgery, are unable to fully remove it.

Taking the knowledge that ZIKV targets stem cells in babies, researchers investigated whether or not ZIKV would target cancer cells in adults as they have relatively few stem cells. An article published in The Journal of Experimental Science reports the findings of this experiment. In living mice and donated human brain tissue samples, ZIKV was seen to kill the cancer cells. This is a huge step forward in the research.

Human trials are still some way away but so far the results look promising. The next step before human trials is to try and modify the virus to make a tamer version with the same effect on the cancer cells. This ensures that patients will be safe from other symptoms when treated.

For a general summary of the research conducted, the following YouTube video is informative:

YouTube Preview Image

Although the research is still in its early stages, I feel that it could have a lot of potential once human trials begin. This could lead to a treatment for cancer that is more effective than what we have today.

~ Sajni Shah

References:

1) Zhe ZhuMatthew J. Gormanet al. “Zika virus has oncolytic activity against glioblastoma stem cells.”  

2) Roberts, Michelle. “Zika virus used to treat aggressive brain cancer.” BBC News, BBC, 5 Sept. 2017, www.bbc.com/news/health-41146628.

A Glass of Wine a Day Keeps the Doctor Away?

Picture from Google Images

Since the 1990’s scientists have wondered whether red wine has any potential health benefits for the average consumer. Studies have shown that a polyphenol known as resveratrol in the wine does help to reduce the risk of cardiovascular diseases, in particular atherosclerosis.

How did scientists know in the first place that red wine could potentially help? It all has to do with the French Paradox. The French paradox looks at how the French have a lower risk of cardiovascular diseases despite consuming a diet that consists mainly of fats. What’s the main difference in these diets from others around the world? They drink a lot of wine.

Studies looking into red wine discovered a polyphenol known as resveratrol. Resveratrol comes from the grapes that make the wine. It was noticed due to its anti-oxidant and anti-inflammatory properties. Scientists believed that this may have something to do with the health benefits of the wine.

Resveratrol was first tested on mice models by feeding them resveratrol supplements and in the end it showed a decrease in the risk of cardiovascular diseases, specifically atherosclerosis. Atherosclerosis is when the arteries harden and narrow making it difficult for blood to flow through the body. The question scientists then wondered was how exactly did resveratrol help with this?

Some ways resveratrol helped is by increasing the amount of high density lipoprotein cholesterol, also known as the ‘good’ cholesterol in our body as well as decreasing platelet aggregation. This coupled with its antioxidant abilities made resveratrol a very helpful polyphenol in red wine.

Benefits of Red Wine (From :Saleem, T. S. M. & Basha, S. D. (2010). Red wine: A drink to your heart. J Cardiovasc Dis Res., 1(4), 171-176.)

The research was more recently extended to human trials and similar results were found as was with the mice. However, to this day doctors are hesitant to encourage patients to drink as the consequences from drinking alcohol are too high for the benefits of resveratrol. Non-alcoholic red wine is available with all the benefits of the polyphenol without the worry of the alcohol.

The idea that red wine can help with our health is interesting, however I believe that the risk of alcohol is too great. You can never be sure how much wine is too much and it varies from person to person. To be on the safe side I would recommend other forms of resveratrol supplements other than red wine to help with any cardiovascular problems. However, it is great to know that drinking red wine isn’t all that bad. Thus in conclusion, the polyphenol resveratrol does help to reduce our risk of cardiovascular diseases, so a glass of wine a day, does keep the doctor away!

~Sajni Shah

 

References:

Chiva-Blanch, G., Arranz, S., Lamuela-Raventos, R. M., & Estruch, R. (2013). Effects of Wine, Alcohol and Polyphenols on Cardiovascular Disease Risk Factors: Evidences from Human Studies. Alcohol and Alcoholism, 48(3), 270-277.

Gilford, J. M., & Pezutto, J. M. (2011). Wine and Health: A Review. American Journal of Enology and Viticulture, 62(4), 471-486.

O’Keefe, J. H., Bhatti, S. K., Bajwa, A., Dinicolantonio, J. J., & Lavie, C. J. (2014). Alcohol and Cardiovascular Health: The Dose Makes the Poison…or the Remedy. Mayo Clinic Proceedings, 89(3), 382-393.

Smoliga, J. M., Baur, J. A., & Hausenblas, H. A. (2011). Resveratrol and health – A comprehensive review of human clinical trials. Molecular Nutrition & Food Research Mol. Nutr. Food Res., 55(8), 1129-1141.

Saleem, T. S. M. & Basha, S. D. (2010). Red wine: A drink to your heart. J Cardiovasc Dis Res., 1(4), 171-176.