Category Archives: Biological Sciences

Why Stop at Just Organs?! The Human Head Transplant Project

Sergio Canavero, an Italian surgeon and neuroscientist, has proposed that his team will be ready to transplant the head of a 30 year-old man with muscular dystrophy onto another body by 2017. Sergio intends to use this process to better the lives of only those who have no other option left (such as those with muscular dystrophy), and has no intention of using this method for cosmetic purposes.

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Source: Redorbit.com

Helen Thompson from New Scientist summarized the process: the body would first be cooled down to help the cells live longer without oxygen and then the head would be severed. After connecting the major blood vessels, the new head would be fused to the spinal cord of the other body; a solution containing polyethylene glycol would be used which would help mesh the two parts together. A coma would be induced for about a month to allow the cell growth to continue undisturbed, and electrodes would be implanted to help stimulate nerve growth. Anti-rejection drugs would also be given to ensure a successful transplant.

Canavero has asked the help of Ren Xiaoping, a surgeon from China who has already done roughly 1000 head transplants on mice. Although the mice did not survive for more than a few minutes, Xiaoping will soon be moving on to operating on primates and told The Wall Street Journal that he hopes they will live “for at least a little while”.

 

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Above: Dr. Ren Xiaoping (left), and Dr. Sergio Canavero (right).

Source: images.china.cn

Personally, I think all of this is nuts. I understand the benefit to those receiving the transplant that truly are in need of it however I cannot accept that as justification for the implications of such a procedure.

First off, there is no guarantee that this procedure will work. However assuming the operation proceeds without major complications, what is there to stop this from eventually being performed for cosmetic purposes? Of course there are regulations in place that would not allow bodies to be donated for solely cosmetic purposes, but what is there stopping the black market from simply creating a new niche for head transplants?

Another point to consider is if the donation of an entire body for the benefit of one individual is fair. The wait time for transplants for different organs varies from five years for a kidney to four months for a heart. One organ donor can help provide life for up to eight people and help improve the lives of another 50 people! Is it really fair to use the entire body for the benefit of one person versus potentially benefiting up to 58 people?

Personally, I don’t believe I would agree with the body of  a deceased family member or friend being used for a head transplant. At the same time however, if a friend or family member was in a position where a head transplant might benefit them, I might be forced to reconsider.

Below is a news clip from RT covering the topic:

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Let me know where you guys stand on this issue, in the comments below!

Motion Sickness: Where does it come from?

Ever been excited to go on that road trip to your favourite destination, only to find yourself sprawled onto the seat unable to look outside because nausea hits you unexpectedly? Not to mention, this phenomenon takes place only a quarter of the way there, making the journey even longer and unbearable. From personal experience, I know exactly how that feels. But the main question is, why does this take place?

Roadtrip by Stig Nygaard (https://commons.wikimedia.org/wiki/File:Eriks_airconditioned_road_trip_car.jpg) License available under the Creative Commons Attribution 2.0 Generic (https://creativecommons.org/licenses/by/2.0/deed.en) via Wikimedia Commons

Roadtrip by Stig Nygaard via Wikimedia Commons

There have been many hypotheses regarding the cause of motion sickness, however, scientists are not exactly sure what the main reason is. Symptoms of motion sickness, such as nausea, vomiting, sweating, headache, dizziness, hyperventilation, drowsiness or general feeling of discomfort, are common regardless of which mode of transportation is taken. According to the British Medical Journal, a common theory of why motion sickness takes place is mismatched sensory signals between the visual and vestibular systems. The vestibular system provides balance and spatial orientation in our body by sending signals of motion to the central nervous system. In a moving vehicle, your eyes see that you are immobile because nothing in the car is moving, while your ears, which hold the vestibular system, sense that you are in fact moving. This mismatch in visual and sensory systems causes the syndrome of motion sickness.

Vestibulární systém by VestibularSystem.png (https://commons.wikimedia.org/wiki/File:VestibularSystem_la.png) CC BY-SA 3.0 ( http://creativecommons.org/licenses/by-sa/3.0/) via Wikimedia Commons

The Vestibular system by VestibularSystem.png via Wikimedia Commons

Another reason why nausea is induced as a result of motion sickness is because of an evolutionary trait to keep the body safe from ingestion of neurotoxins. This happens when someone is sitting still, while watching a movie perhaps, and the screen is showing movement. The eyes can be deceived into believing that the body is moving while the vestibular system senses no movement. This results in an abrupt signal being sent to the central nervous system, which the body counteracts with vomit.

Although not everyone is susceptible to motion sickness, it does affect about 66% of people when they are put in more severe conditions. There are a few things you can do to decrease the severity of motion sickness. Firstly, look out the window of a moving vehicle towards the horizon of the direction you are going. To acquire optimum results, sit in the front seat since doing so visually confirms that you are moving. Secondly, chew something like gum because this can restore the balance within your body. Thirdly, close your eyes and, if you able to, nap as it is great for reducing the conflict within the visual and vestibular system. Lastly, ginger has been found to reduce motion sickness quite effectively.

For a deeper understanding of motion sickness, take a look at this video:

YouTube Preview Image Credit: TED-Ed

So next time you’re going on that long drive or vacation on a that cruise ship, use this as a guide to make sure motion sickness does not ruin your trip!

–  Ravjot Ahluwalia

It’s All in Your Head-Men and Women Wired Differently for Emotions

Joy, Sadness, Fear, Anger, Disgust- these five characters from Inside Out are emotions that we know all too well. Sometimes, we experience them more often than we would like to. However, have you noticed how emotions affect each person differently, especially between men and women? I came across this question while I watched this video, which is part of a project called “The And”. A couple sat down for the first time in two years after their break up and asked each other a series of intimate and emotional questions.

As my friend and I watched this couple revisit their past relationship I experienced a roller coaster of emotions. I found myself fluctuating from being on the brink of tears to hysterical laughter. As for my friend, he seemed amused yet unaffected by the emotions. In fact, he was very concerned that the girl had not moved on since the break up. Seeing this difference made me think: is it possible that men and women simply process emotions differently?

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Credit: http://www.mybraintest.org/

We already know that the human brain consists of a left and right hemisphere. The left hemisphere is considered the logical side, whereas the right hemisphere is the creative side. We also have parts of the brain that help respond externally, and others that respond internally. So how might this affect the processing of emotions between men and women?

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Picture of the brain. Credit: The Thinking Business

In Robin Lloyd’s article, he states that scientists have found evidence that men and women were wired differently for emotions. Studies have found that when overwhelmed by fear, men tend to respond physically while women respond more emotionally. This difference is the effect of the communication between different regions of the brain and the cluster of neurons, which are found in both men and women.

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Picture of a network of neutrons. Credit: http://wespeakscience.com/scientist-transform-blood-cells-into-neurons/

If that’s not interesting enough, Larry Cahill and his team from University of California Irvine did a study on a particular group of neurons, called amygdala.This team of researches found that while the more energetic group of amygdala neurons in men are located in the right hemisphere, the more active group of amygdala neurons for women are located in their left hemisphere.

So females aren’t just more emotional, they are also wired differently from men to begin with. It’s fascinating how the same group of neurons in human beings can affect them in completely different ways, making each of them a unique individual. Inside Out illustrates this interesting scientific theory in an unique standpoint, making it easier to visualize and understand. The short trailer from Inside Out gives a quick glance into the differences between the emotional wiring of men and women. If you haven’t watched it, I strongly recommend that you do:

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-Stephanie Lam

“Asian Glow”: More than Embarrassment

Have you ever gone out to the bar or had a couple of drinks with friends of East Asian heritage (Chinese, Japanese, and Korean)? If so, you would have probably noticed that at least one of their faces turned red after only a few sips of alcohol. This is called the “Asian Glow”. As the name suggests, it refers to the common reaction of Asians turning red after drinking alcohol.

Asian Glow: Before and After | Image: Brooks PJ, Enoch M-A, Goldman D, Li T-K, Yokoyama A

According to U.S. Department of Health & Human Services, our body breaks down alcohol in two steps, facilitated by two enzymes that speed up the break down process. The enzyme alcohol dehydrogenase (ADH) converts alcohol into a toxic intermediate called acetaldehyde (C2H4O), then the second enzyme aldehyde dehydrogenase (ALDH2) turns it into acetate (CH3CO-2) and releases the toxic compound out of the body.

Breakdown of Alcohol in Two Steps | Credits: ethanol, acetaldehyde, acetate molecules from Wikimedia | Edit: Even Zheng

Unfortunately, about 80% of all East Asians are born with overactive ADH in their stomach and liver, breaking down alcohol up to 100 times faster into the toxic acetaldehyde. In addition, about 50% of East Asian have a deficiency in ALDH2 enzymes, which means it takes much longer for the body to clean out the residues of alcohol. Simply put, their body skips right past the pleasant effect of alcohol and experiences body rash, nausea, dizziness, and all the “hangover symptoms” much faster. Now we know who to blame, it’s all because of genes!

I remember a time I was at my friend’s place for a small gathering. It was only half an hour into the chitchat when my friend pointed at me and said, “Your face looks like a stop sign!” followed by everyone’s laughter. At that time, I literally had half a can of beer. If anybody can relate, someone has probably also told you to practice and increase your tolerance level, but you might want to give that a second thought.

What most people don’t know is that the toxic acetaldehyde is actually a cancer-causing agent. An article published by The New York Times revealed that researchers believe the condition of turning red after drinking alcohol may link to increased risk of throat, stomach, and esophagus cancer, which are some of the most deadly types of cancer. This is especially dangerous for people who have developed a high tolerance to acetaldehyde and became heavy drinkers.

A Time Magazine article suggested that the hereditary trait may have evolved in the ancient Chinese population as a survival strategy to allow people to drink alcohol made from fermented rice, while protecting them against alcoholism. Regardless of its credibility, there is indeed a lower rate of alcoholism among people with the deficiency, for obvious reasons. Before we find any way to replace the inactive enzyme or develop safe medications, it is the best to just avoid drinking altogether. It might make your parties a little “lame” on Friday nights, but on the bright side, you now have a good excuse to tell your friends when they want to go out for a drink right before your exam.

Here is a video to help you understand the metabolism of alcohol: YouTube Preview Image

Credit: Science of Nutrition

-Even Zheng

ALS, Still Incurable?

About this time last year, you may have seen millions of videos on social media: people were pouring buckets of ice water over them, nominating others to either take the challenge itself or financially to help fight ALS. Until I saw one of those videos, I, personally, didn’t have any clue what they were doing. Yet, I had no scientific knowledge about ALS.

Normal nerve cell (left) and damaged ALS nerve cell (right) (Source: Mahesh Kumar - via Flickr - https://www.flickr.com/photos/maheshmedindia/7182628151/in/photolist-bWGR7p-8x8Vhw-mrehCZ-mrg65y-mreikk-b8j56g-bSpVqD-oXmggM-bu1MUH-JkXVq-dSh244-paFp4a-sbRLs-9ycT8J-s71EA-9jCphF-6ixrC8-jnEixn-nEAfpf-pGGChv-jnEiDK-bxmLCd-bxmLDj-bLgssZ-bxmLAu-bxmLBd-5vaBWM-5AqpP1-pqic1f-6d5Ebb-6d5Cfh-8TBvE4-8TBvVD-8DJYEE-8DJYDG-8DFSjD-5AqpJw-6d5Kch-8TF1qb-91VyCH-8TF2L3-8TBX4v-8TBY46-8TF5xW-3pJCp3-3pE4Pz-91YFdu-8TBZVF-8TF7Mo-6d5Bom

Normal nerve cell (left) and damaged ALS nerve cell (right) (Source: Mahesh Kumar – via Flickr)

ALS (Amyotrophic lateral sclerosis), often called as Lou Gehrig’s disease, is a progressive neurodegenerative disease which causes motor nerve cells in the brain and spinal cord to degenerate. Eventually, the brain becomes impossible to initiate and control muscle movement. Patients in the beginning stage may experience difficulties with breathing, swallowing, and speaking. Later in the stage, patients become completely paralyzed. Stephen Hawking, one of the most recognizable scientists, was diagnosed with slow-progressing form of ALS in his early age. Most people who develop ALS are in between the age 40 and 70, but there are cases occurring in twenties and thirties. For more information of how it is like living with ALS, check the video below:

Credit: Roundabout U

According to an article from Johns Hopkins Medicine, ALS affects nearly 30,000 people in the United States. Every year about 5,000 people are diagnosed with ALS. Through the Ice Bucket Challenge, one of the most powerful examples of social media movement, the number of people, politicians, celebrities, and CEOs participated in this challenge, luring attention to the society. There was one of the key important message embedded in the ice bucket challenge. The idea of challenging people to douse themselves in cold water help them indirectly experience muscle contraction, just like how the ALS patients are going through.

Ice bucket (Source: Mauviel M30 Ice bucket - license available under the Creative Commons Attribution 2.0 Generic license via Commons - https://commons.wikimedia.org/wiki/File:Mauviel_M30_Ice_Bucket.jpg?uselang=en-ca )

Ice bucket (Source: Mauviel M30 Ice bucket via – Wikipedia Commons)

According to the article from Time magazine, ALS Association (ALSA), has received over $115 million in donations. ALSA allocated towards a number of research, community services and patients to improve the quality of lives. So far, it has spent about $47 million. Two-thirds of them were spent toward various researches of gene discovery, drugs and disease model development, and identification of biomarkers. 20% of the donations have been spent on patients and community services, and 11% on fundraising and education. According to ALSA, 79% of their budget was spent toward services and programs, and 28% of that was on research.

Recently, researchers have found a protein, TDP-43.  This is what ALS patients fail to have in their cells and if they repair this protein, the damaged cells in ALS can restore. Researchers are hoping to see if this method can be applied to many diseases that weaken muscles, such as  Alzheimer’s and Parkinson’s diseases. Without those funds, it would have been difficult to demonstrate this high-risk-high-return experiment. Through social media, ALSA has been able to draw the attention to this “incurable” disease for further research and education. Hopefully soon in the future, TDP-43 becomes a key to many neuromuscular disorders and therefore cure many patients.

 

Posted By: Josephina (KyungBin) Kim

Should I invite “coffee” and “Red Bull” to my late night study sessions?

We all know the feeling. After working into the night on a term paper, sipping coffee and dazing into the backlight of your laptop screen, your head finally makes its way to the pillow. You lie in your pitch dark room but you just cannot fall asleep. Why? You did have that coffee a mere three hours ago which is the cause of your wakefulness but could that really delay your entire circadian rhythm?

Your circadian rhythm is a natural body cycle that runs over a 24 hour period to match up with the hours in a day. Generally, this cycle controls your wakefulness and sleepiness by regulating the hormone melatonin. For more information about your circadian rhythm, please check out the video below:

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Credit: SciShow

Just a few days ago, the Journal of Science Translational Medicine published an article that stated what happens inside and outside of you when you consume caffeine just before bed. After approximately 49 days, scientists at the University of Colorado in the Sleep and Chronobiology Laboratory discovered that individuals who consumed the equivalent of one double espresso three hours before bed caused a delay of approximately 40 minutes in their circadian rhythm. They found that the hormone melatonin which is normally at a high level before bed, was abnormally low in these individuals. Additionally, they assessed the effect of bright light exposure on the individuals and similar disruptions in the circadian rhythm were documented. In fact, it was found that bright light exposure had about twice the negative impact on the circadian rhythm than caffeine, delaying it by over an hour. 

According to Science Daily, caffeine is a psychoactive drug and we now know that it alters the natural circadian rhythm. Below is a list of common beverages and the amount of caffeine in each. It makes me wonder why so many individuals consume these beverages on a regular basis and why are there no regulations in place to monitor consumption?

Caffeine drinks graph

Credit: https://smithlhhsb122.wikispaces.com/Gabriel+S.

I think that if our generation started consuming caffeinated beverages as early as high school, the disruption in the circadian rhythm cycle could accumulate and cause long term issues such as chronic sleep deprivation, insomnia and other sleep maladies. This could cost millions of dollars in pharmaceutical drugs and other treatments to fix so it is important for us to take a stand now for our own well-being.

In conclusion, I believe that next time you are up late to study, it is best to choose beverages without caffeine. I think that the emerging research about caffeine consumption is incredibly important since caffeine is consumed on such a frequent basis. I would like to see some further research advising individuals of the best time of day to consume caffeine in order to minimize the impact on the circadian rhythm.

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Credit: geobeats

Rosalyn Desa