Tag Archives: Public Health

Almost there! Universal blood for all.

Researchers of The Centre for Blood Research and The Chemistry Department in University British Columbia (UBC) have been experimenting to generate an enzyme that makes eight different blood types to be the safe universal blood for everyone.

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Blood transfusion (source: Flickr Commons)

As it is generally known, our blood type lies into four major groups: A,B, AB and O. Also, there are positive types and negative types on each four types. Overall, eight different blood types differentiate from each other by additional sugar structure that lies on the surface of the red blood cells which decide presence or absence of antigens. Failure in performing correct blood transfusion can bring life-threatening situation due to immune responses to patients. The importance of correctly identifying the blood type and its transfusion to the patient in need is absolutely critical in the matter of life and death. An example of wrong blood type transfusion can be found in the link.

Drawing from the above importance of identifying blood for patients, the blood type O is known as universal blood because type A and B share the same core sugar structure as type O.  More specifically, only type O negative can be called universal blood because type O positive can not be transfused to patients who have negative blood type. Blood type O negative can be donated to patients with negative blood types as well as positive blood types. The universal blood type O negative is the key to blood transfusion; one which is in need, but not enough of.

Above diagram indicates blood type O as universal donor due to absence of antigen.

Therefore, David Kwan (UBC Chemistry department), Jayachandran Kizhakkedathu (UBC the Centre for Blood Research) and others are in process of finding a way to create an enzyme that can cut off the additional sugar structure (antigen) on surface of the blood cell so that all blood types can be donated and transfused safely as blood type O. Such research is the breakthrough in the clinical use of blood transfusion in saving the lives of critical patients.

Researchers used a new technology called directed evolution to generate the “sugar(antigen)-cutting” enzyme. Through directed evolution technology, researchers were possible to insert mutation gene into the gene that codes for the enzyme. Currently, thanks to their efforts, the enzyme under research became 170 times more effective at cutting majority of antigens in type A and B.

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[Credit to: City]

Since the enzyme cuts majority of antigens but not all, the research is still underway. Human immune system is critically sensitive to even tiniest of antigens; adding to the importance of the successful research. This study needs further improvement before the enzyme can be used for clinical use.

by Grace Kim.