Category Archives: Science Communication

Pareto’s Distribution – A Real Problem

If you have ever been in a statistics class, you might have heard of the “Normal Distribution”. This distribution tells us that most things fall within the middle  and the extremes exist in small quantities. You can think of IQ following this pattern. The average person has an IQ of 100, less people have an IQ of 130 and even fewer people have Albert Einstein’s IQ of 160 – don’t we all wish we did. There are many variations of this and the distribution looks like a mountain, looking something like this:

Image result for normal distribution

photo credit: Wikipedia

This distribution describes many types of observations such a student’s grades, people’s heights, people’s blood pressure, shoe size and much more. It is a natural occurrence we observe in society and more importantly in the characteristics of people, such as people’s heights. This is important for society because it helps to understand what people need.  Imagine if the average height of Canadians were 2.3m tall, we would definitely have much higher doors!

DOES the Normal Distribution RELATE TO OUR LIVES?

Seemingly, the word “normal” in normal distribution supposes that all occurrences in nature and society would display this pattern. However, this might not be the case. In fact, many cases in physics, biology, earth and planetary sciences, economics, computer science, demography and social sciences follow a different distribution – the Pareto distribution. The Pareto distribution is quite the opposite of the normal distribution and tells us that most of the data exist in the extremes. It is therefore more commonly known as the “80-20” law which means 80% of what is measured exists in 20% of the population. Examples of the Pareto distribution is the sizes of cities, earthquakes, and forest fires.

To look at this more closely, let’s look at the sizes of cities and towns in the United States of America. There are around 20,000 cities in the country. If the population of these cities followed the normal distribution then we would expect most of the cities to have an equal population size and only a few extreme cities to have a high amount of people and a low amount of people. However, we see that most people live in big cities such as Las Vegas and New York and the overwhelming majority of people live in a small number of cities. The following graph shows the percentages of cities in USA and the population of those cities.  

Image result for pareto distribution population

photo credit: Newman, MEJ

The graph to the right displays a simpler display of the population of the US cities by doing some math. We can think of it as there being ten small suburbs surrounding a big city and ten of those cities surrounding a metropolitan city. We can also see it in Canada where metropolitan cities such as Vancouver, Montreal and Toronto are few in number but hold the majority of the population, while there are many more smaller cities spread across Canada with a small population.

Some other things that are interesting that follow this distribution is the numbers of citations to scientific papers, the numbers of copies of bestselling books sold, the diameter of craters on the moon, the length of relationships between couples, the frequency of family names, and people’s incomes.

Why should we care?

The Pareto distribution is particularly interesting because it shows that the natural state of things in a society can differ immensely. Even with books, although there are many authors that write books, only a handful make it on to the top-seller list. And in relationships, couples who are great with relationships last for decades, while couples who are poor with relationships can never break past one year. There is another topic that is widely debated about in society that follows the Pareto distribution which is wealth distribution. When we hear politicians blame the rich for poverty and income inequality – a big problem in society – one should wonder what a scientist’s perspective to the problem would be. We know in a more capitalistic society like America, 85% of the income is owned by the top 15% of the population.

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Interestingly enough, this is the reality of how wealth distributes itself in a free society. You might have heard the term “the rich get richer while the poor get poorer.” Through out history, societies have tried to rectify this phenomena and failed. But politics aside, a reality that we must face is the purple elephant in the room named Pareto.

What are Telomeres?

Telomeres are like the plastic tips at the end of the shoelaces; they are the caps at the end of each strand of DNA and they protect our DNA from becoming damaged.

Telomeres were first distinguished in 1933 by Dr. Barbara McClintock. Recent research lead Dr. Carol Greider, and Dr. Jack Szostak to be awarded the 2009 Nobel Prize in Physiology or Medicine for the discovery of how chromosomes are protected by the enzyme telomerase and telomeres.

Diagram of Chromosome Showing Telomeres in Green Credit: Beauty Black Book

Telomeres Shorten as We Age

Each cell in our bodies replicates DNA and divides. DNA polymerase is the enzyme in charge of DNA replication, but it is incapable of replicating the entire chromosome strand.  Telomeres serve as a “scape goat” of dispensable DNA not needed for vital functions, so when DNA polymerase is ready to fall off the chromosome some of this dispensable DNA is lost.

How Much Telomeres Do We Lose in a Lifetime?

To put it in perspective, we are born with about 11 kb of telomeres, that’s 11,000 base pairs of DNA. By old age, we have approximately 4 kb or 4,000 base pairs.

This significant decrease in telomeres suggests that each cell has a maximum number of cell divisions before it must induce its own cell death. Dr. Leonard Hayflick extensively studied this phenomenon and concluded that each cell can only divide up to 60 times. The maximum number of cell divisions is now known as The Hayflick Limit.

Diagram Showing Decrease of Telomere Length with Age Credit: Defytime

Promising Study on Progeria Cells

Scientist are in hot pursuit to find the fountain of youth. Dr. John Cook and his team conducted an experiment with promising results and with the intentions of helping children with progeria, a rare genetic condition which speeds up aging.

In the study, the participants, aged 1 to 14 years-old, had telomeres lengths of a 69-year-old. Telomeres length was significantly increased in progeria cells as measured by expression of telomerase.

Video on Study on Progeria Cells by Dr. John Cook Credit:  Vimeo

Although this study is very promising, other scientists believe delaying the natural decline of telomere length could be harmful. Dr. Peter Lansdorp from the University of British Columbia explains that telomere shortening is a defense mechanism built within our cells to decrease the chances of developing cancers. Shortening telomere length of cancerous cells causes them to die. Halting this mechanism would allow cancer cells to continue to divide to create tumors.

What Speeds Up and Slows Down Aging?

Studies have shown that following a healthy diet, regular exercise, managing stress, and increase sleep is associated with longer telomeres, whereas higher body mass index, high stress, and smoking are associated with shorter telomeres.

Table of Factors that Affect Telomere Length Credit:  Indian Journal of Medical Research

https://soundcloud.com/sciencetoday/telomere

Podcast on Telomeres as Marker of Aging Credit: US Science Today SOUNDCLOUD

Stress Less Live longer!

Studies suggest that any type of stress will have an effect on your telomeres and will in turn speed-up the aging process. It also shows that taking good care of yourself will  delay the aging process. So next time you feel stressed out, take a second to breath. Your biological clock will thank you.

Video of The Science of Aging Credit: ASAP Science YouTube

Maria-Fernanda Arcila