A mini-Moore lab reunion at the Marine Natural Products GRC.
Category Archives: Uncategorized
Biosynthesis of non-proteinogenic α-amino acids
Our new review article on the biosynthesis of non-proteinogenic α-amino acids is now online at Chemical Reviews. Congrats to Jay on this work.
Congratulations, Haruka!
Haruka received an Overseas Postdoctoral Fellowship from The Uehara Memorial Foundation.
Congratulations, Haruka!
Alanosine biosynthesis
Congrats to Menghua, Haru, Hai-Yan, and Phillip on their work on alanosine biosynthesis.
Taylor Parkkila joined the lab
Welcome, Taylor!
Congratulations to Alyssa
Alyssa is the 2019 winner of the Sandra Morris and Richard Tillyer Scholarship in Chemistry.
Congratulations to Jay
Jay is the winner of the 2019 Brian and Jane James Graduate Scholarship in Catalysis Research
Convergent biosynthetic transformations to indolmycin
In a new paper in Nature Chemical Biology, we report that a convergent biosynthetic transformation leads to the bacterial specialized metabolite indolmycin in marine gram-negative Pseudoalteromonas luteoviolacea, when compared to a terrestrial gram-positive Streptomyces species.
Read about it here.
Congratulations to Yi-Ling, Mel, and Guiyun on this work!
An asymmetric reductase for acyclic imino acids
Acyclic imines are unstable in aqueous conditions, but acyclic imino acids can exhibit transient aqueous stability. Here we report the X-ray crystal structure and mechanism of Bsp5, an asymmetric acyclic imino acid reductase that intercepts acyclic imino acids produced by a partner oxidase and then converts them into D-amino acids. To read more, check out our recent paper in JACS!
In vitro reconstitution of azomycin biosynthesis
In this work reported in Angewandte Chemie, we reconstitute the biosynthetic pathway to the nitroimidazole antibiotic azomycin, revealing some interesting new enzymology. Congrats to Jay on this work!