Category Archives: Issues in Science

Caught in the Act: Partners in Crime behind Brain Diseases

Posted on April 10, 2015 by | Leave a comment

The first step to treating a disease is to catch the culprit behind it. Researcher Jingfei and her team set out to do just that and discovered that hypoxia (a lack of oxygen) and inflammation act as partners in crime to cause damage to the brain.

hypoxia plus inflammation

The main result of Jingfei’s research. (Image: credits to Sean)

 

Jingfei’s recent publication from the University of British Columbia (UBC), highlighted the key role that hypoxia plays in brain damaging diseases such as Alzheimer’s, something that has been overlooked in past studies. They found that hypoxia and inflammation combined is what causes long term damage to the brain.

“This is a never-before-seen mechanism among three key players in the brain that interact together in neurodegenerative disorders,” says Jingfei’s supervisor, Brian MacVicar, from the Djavad Mowafaghian Centre for Brain Health at UBC. The three key players that he is referring to are hypoxia, inflammation, and microglia (the immune cells of the brain).

By manipulating the brain slices of rodents using various techniques, the researchers tracked the movement of microglia and found that the two factors, hypoxia and inflammation, work together to permanently weaken the connections between brain cells. Furthermore, the damaging effects of the two factors may worsen people’s memory, which is one of the early symptoms of brain diseases like Alzheimer’s.

Pictures (or rather videos) are worth a thousand words so watch below to see exactly how they went about conducting this exciting research and what they found.

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 (Video: Credits to Ian, Siana, Shikha, and Sean)

So, who will benefit from this research? Jingfei said, “Well I think right now it still will be researchers, because this paper is more like a new finding of something people didn’t know before, so hopefully […] they can build more realistic model on top of it.”

Moreover, some researchers have already built upon her research in the short  time that has passed since her paper was published. Researchers at Cambridge University have broadened our understanding of microglia in a recent study. They found that microglia are not just important after injury to the brain, but also for daily functioning.

In another study, researchers looked at human brain diseases like Alzheimer’s and Parkinson’s to see if they’re related to inflammatory conditions in multiple sclerosis (MS). They found that the type of inflammation found in brain diseases is completely different from the inflammatory conditions in MS.

At the rate that research around the world is being conducted, we can only hope to see clinical applications in the near future that hopefully bring us a step closer to finding a cure for brain diseases.

We can do our part in helping researchers gain more support in their studies by raising awareness of brain diseases. It’s important for people to be aware of these diseases and realize how devastating they can be to the patient, and their  loved ones.

Participants of Walk to End Alzheimer’s 2014

Participants of Walk to End Alzheimer’s 2014. (Flickr Image: Yooperann)

Below is our “Myth or Fact” podcast that aims to raise awareness for Alzheimer’s, which affects over 15% of Canadians over the age of 65. Listen to find out just how much some of the brightest students at UBC know about Alzheimer’s.

 

https://soundcloud.com/e-thereal-1/so-project-podcast

(Podcast: Credits to Ian, Siana, Shikha, and Sean.
Music: Credits to House Theme Song from YouTube User: Damaster00777)
No copyright infringement intended

– Written by Ian, Siana, Shikha and Sean

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Posted in Biological Sciences, Issues in Science, Outreach Project

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Clearing Up The Smoke Around E-Cigarettes in Vancouver

Posted on March 23, 2015 by | Leave a comment

Late last year, Vancouver made the controversial move to ban the use of  electronic cigarettes (e-cigarettes) in public places where smoking is prohibited as well as their sale to minors. The controversy behind the ban was evident by the results of a poll by Metro News, where out of over 2500 of its readers, 65% of people opposed the ban.

This may be because many people think of e-cigarettes as a less harmful alternative to smoking cigarettes, similar to that of products such as nicotine patches or nicotine gum. However, it is worth noting that in Canada, only e-cigarettes that do not contain nicotine can be legally sold which means that e-cigarettes may not curb cravings as well as the aforementioned nicotine containing products. Regardless, when it comes to their safety in comparison to cigarettes, opponents may be on the right track. When the Canadian Cancer Society was asked whether e-cigarettes were less harmful than cigarettes, they said, “Yes, because the products contain no tobacco, nor tobacco smoke.”

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E-cigarette and Cigarettes Side By Side Source: Flickr Commons                             Credit to: TBEC Review

So if e-cigarettes appear to be less harmful than cigarettes, why the big fuss? An article in the Vancouver Sun about the topic made it clear that one of main causes of concern is the effect of e-cigarettes on youth. In the article, Dr. Meena Dawar, a medical health officer with Vancouver Coastal Health, says that although e-cigarettes aren’t proven to be linked to any cancers, they are quite new and the vapour they produce may still contain certain carcinogens, cytotoxic chemicals and heavy metals present in tobacco smoke. Moreover, a study published in The New England Journal of Medicine found that high levels of formaldehyde, a cancer causing agent found in cigarettes, was present in some varieties of e-cigarettes which is a concern as it would eventually be inhaled by the user.

Lastly, an article in the Metro adresses the concern that e-cigarettes are normalizing the concept of smoking  and are diminishing the work that has gone into making smoking ‘taboo’ in our society. Additionally, proponents for the ban argue that advertising for e-cigarettes often seems to be targeted to youth in terms of the different flavours available and the ‘fun’ packaging.

The YouTube video shown below is a great summary of the potential health risks of e-cigarettes.

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Credit:  CNN on Youtube

In summary, although there is not much conclusive evidence out there on the dangers of using e-cigarettes compared to what is out there for cigarettes, I personally support Vancouver’s decision to go ahead with the ban because e-cigarettes are relatively new and it is hard to evaluate their long term effects. Additionally, when it comes to the health of our society, I don’t think it’s ever a bad idea to err on the side of caution.

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Laboratory nurseries could save Coral Reefs

Posted on March 22, 2015 by | Leave a comment

A natural underwater Atlantis is found beneath the crystal clear waters of the Caribbean; clustered corals of all shapes and colours create the home of a vibrant array of fish species. But these reef ecosystems are declining and are threatened with destruction unless the corals can be saved. Marine researchers have uncovered the secret to breeding pillar corals in the laboratory with the hope that these can be transplanted to reefs to reverse such trends.

A Caribbean coral reef ecosystem (copyright - Ken Clifton)

A Caribbean coral reef ecosystem (copyright – Ken Clifton)

Corals are soft-bodied organisms which associate with algae, they form a hard limestone base which forms the structure of reefs. These cover less than a quarter of one percent of the ocean floor yet support 25% of all marine life. That equates to 2 million species whilst also acting as a nursery to a quarter of the oceans fish. In addition to the beauty of an ecosystem rivalling the diversity of the Amazon rainforest, coral reefs are vital fisheries. If sustainably managed, one square kilometre can yield 15 tonnes of fish per year whilst the total commercial annual output of coral fisheries is valued at $5.7 billion. Furthermore, coral reef fish species are a significant food resource for over a billion people worldwide and are the principle protein source for 85% of this total. Therefore, it is of paramount importance that we conserve these ecosystems.

Pollution from oil depots enters the ocean and poisons coral reefs (copyright - Kris Krug)

Pollution from oil depots enters the ocean and poisons coral reefs (copyright – Kris Krug)

However, one quarter of coral reefs are considered damaged beyond repair whilst the remainder are under serious threat. The warming ocean temperature has disrupted their associations with algae; this is known as bleaching and leads to the death of corals. Climate change has increased CO2 levels; this has raised the acidity of the ocean which then dissolves the coral limestone skeleton. Moreover, pollution from oil, industry and agriculture has poisoned the corals thus furthering their decline. Overfishing also poses a threat through disordering the complex food webs of the ecosystem whilst fishing practices such as trawling can directly damage the reef.

Pillar corals of the Caribbean reef (copyright – BioMed Central)

Marine researcher Kristen Marhaver and her team are hoping to reverse these effects through raising juvenile pillar corals in the laboratory environment. Coaxing the corals into reproduction was a difficult task; Dr. Marhaver drew the “analogy to in vitro fertilization in humans.” Pillar corals build single gender colonies and spawn eggs or sperm on very few nights annually. The offspring then grow at just half an inch per year. However, the team succeeded and learnt of the optimal conditions of water, bacteria and other species that help them to grow in the wild. Furthermore, there is hope that these laboratory grown juveniles could be transplanted back to the Caribbean reefs to regenerate the ecosystems. Marhaver added, “We do see that coral juveniles can survive in places where the adults are suffering badly, so we are thinking that some reefs can recover in places we have given up on.” Such research can only help to protect and potentially regenerate these crucial coral reef ecosystems upon which so much is dependent.

Toby Buttress

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Posted in Biological Sciences, Issues in Science, Science Communication, Science in the News

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Can Vegetarians Say Goodbye to Some Cancers?

Posted on March 15, 2015 by | 4 comments

Cut the meat, cut the crap? It appears this is the case when considering colorectal cancer, a cancer of the large intestine and rectum, and its reduced risk in vegetarians. This cancer is the second leading cause of cancer death in the United States. A new study found that a vegetarian diet may cut ones risk of colorectal cancer by 20%! In a society that’s obsessed with weight loss, a vegetarian diet seems to be increasing in popularity. What is it about the vegetarian diet that may be causing this association?

Vegetarian diet: Flickr Commons by Ano Lobb

Vegetarian diet: Flickr Commons by Ano Lobb

Vegetarian diet: Flickr Commons by bangdoll

Vegetarian diet: Flickr Commons by bangdoll

 

 

 

 

 

The biggest reason for the association between a vegetarian diet and reduced risk of colorectal cancer is little to no consumption of red and processed meat. A nutrition report addressed the relationship between consumption of red or processed meat and risk of colorectal cancer. Examples of red meat include, beef, goat, lamb and pork. On the other hand, examples of processed meats are ham, bacon, sausage and hot dogs. It was stated, in this nutrition report as well as a review, that studies from 2007 to 2011 continued to support and strengthen the finding that as consumption of red or processed meat increases, the risk of colorectal cancer does as well. However, this has not been concluded as a cause-and-effect relationship. It is this association that seems to be the biggest reason why vegetarians appear to have a reduced risk of colorectal cancer.

Red meat: Flickr Commons by Jeff Attaway

Red meat. Source: Flickr Commons by Jeff Attaway

Processed meat: Flickr Commons by Steven Depolo

Processed meat. Source: Flickr Commons by Steven Depolo

 

 

 

 

 

It is important to remember that a vegetarian diet is a lifestyle choice and there may be other reasons why it is associated with reduced colorectal cancer risk. Not only does this diet include a decreased meat intake, it also includes decreased consumption of unhealthy foods, increased consumption of many healthy foods and healthier activities. For example, vegetarian diets show a reduced sugar intake especially through decreasing caloric beverages. Increased fruit and vegetable consumption is also a key aspect of vegetarian diets. This diet has also been demonstrated to include healthy activities such as, not smoking and avoiding/moderate consumption of alcohol, both of which are linked to reduced cancer risk. Therefore, as was mentioned in the previously talked about nutrition report, it is necessary to clearly understand how different aspects of a vegetarian diet may be influencing cancer risk.

You may be wondering, don’t these diets also result in decreased consumption of other essential nutrients and protein, which could increase cancer risk? As Professor Marion Nestle addresses in the following video posted by Big Think, vegetarians don’t lose out on much.

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Towards the end, Professor Nestle talks about how being a vegetarian plays a positive role in the environment. Therefore, not only is vegetarianism thought to be benefiting the individual, by appearing to reduce risk of colorectal cancer, it has broader implications on the world around us.

Source: Flickr Commons by QuotesEverlasting

Source: Flickr Commons by QuotesEverlasting

It seems Einstein believed it too, in many ways, cutting the meat is cutting the crap.

– Surekha Gangar

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Posted in Biological Sciences, Issues in Science, Outreach Project, Science in the News

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Saying Goodnight to Bed Bug Bites

Cimex lectularius

Cimex lectularius, the most common bed bug           Source: Gilles San Martin on Flickr

Many of you may not think that bed bugs pose a significant threat in your life. Several believe that only cheap motels and hostels became infested with these parasites, and that I was never at risk of coming into contact with them. It turns out this issue may be closer to home than we think. According to the British Columbia Ministry of Health, there have been increased reports of infestation, particularly in Downtown Eastside Vancouver, but also throughout British Columbia. Houses, apartment buildings, hotels and university and elderly residences across Canada have fallen victim to infestation.

Scientists at Simon Fraser University have recently come up with a concoction of pheromones that attract and trap bed bugs. After years of investigating this issue, they found the right balance of pheromones that causes bed bugs to be drawn to the source of the chemical attractant. The key is histamine, which bed bugs interpret as “safe shelter”. As soon as they come into contact with the histamine, they stay there, despite whether or not they have recently fed. This essentially helps stop their reproduction and spread. This mixture of pheromones has already proven extremely effective, and has even been tested in bed bug infested areas in Metro Vancouver.

Here is a video by Simon Fraser University introducing the scientists responsible for this research:YouTube Preview Image

 

Bed bugs were basically eradicated in the mid-20th century due to widespread use of pesticides such as DDT. However, in recent decades they have been making a global comeback, likely due to increased international travel and pesticide resistance. Reaching epidemic proportions, bed bugs are returning in higher abundances, distribution and intensity of infestation. For this reason, it has become imperative to find more effective methods of early detection and extermination of bed bugs.

Bed bug bite

An example of a bed bug bite                                   Source: hiroo yamagata on Flickr

Bed bugs have not been proven to carry infectious diseases, but their bites can be itchy, cause rashes, and some people can suffer severe allergic reactions. Moreover, their presence can be irritating and distressful, causing loss of sleep, anxiety and paranoia. Many people go to great lengths to minimize the effects, including the use of pesticides and radical cleaning.  Pheromones are a much less harmful way to get rid of the parasite. Finding the right combination of histamine and other chemicals could have huge implications for the global eradication of bed bugs. Low-income areas are usually unable to afford professional extermination, and since the cost of the pheromone method is low, these regions will have better opportunity for monitoring and preventing infestation.

So, if you ever have the misfortune of getting bed bugs in your home, hopefully it happens after next year, when the pheromone treatments should be widely available.

– Anne Persson

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Posted on March 9, 2015 by in Biological Sciences, Issues in Science, Science in the News

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Mars One, project to colonize Mars. Is it achievable?

Posted on March 9, 2015 by | 2 comments

Interstellar travel or interstellar colonization have been cores to many science fiction stories. There’s nothing more exciting to see something in science fiction to exist in the real world. Now, it seems the dreams of many science fiction fans have a chance of becoming true.

Concept of Mars Colony (Image from Wikimedia Commons, credit to NASA Ames Research Center)

In 2012, a project of sending humans on a one-way trip to colonize Mars, the Mars One project, was announced. According to Mars One, a rover will be send to Mars to search for optimal location for a settlement in 2020. In 2022, cargoes for building a settlement will be sent, and a settlement will be established in 2023. The first crew of colonists will depart Earth in 2024 and will arrive in 2025, while the second crew will depart in 2026. Below is a video of a brief description of Mars One.

https://www.youtube.com/watch?v=n4tgkyUBkbY

Youtube video uploaded by MarsOneProject

Criticisms have never stopped since the day of the announcement. One of the criticisms is on the funding of the project. Different from major space projects supported by governments, Mars One receives no funding from any government agencies but from company partnerships, sales of broadcasting rights, crowd funding, and more. NASA chief Briand Muirhead said that he has very little confidence in such project being publicly funded.

Also, the cost of the project received many criticisms. The project was estimated to cost 6 billion USD, but Austere Human Missions to Mars, a similar project proposed by the National Aeronautics and Space Administration (NASA), was estimated to cost 100 billion USD. The difference in cost raised skepticism on the Mars One project. In an assessment by MIT on the Mars One project, establishing a settlement on Mars would cost 4.5 billion USD alone, meaning only 1.5 billion USD will be left for building of spacecrafts, transporting the crews to Mars, or any other costs.

As for technology required for the project, no detailed information has been released yet. The Mars One project only has brief descriptions of the technologies required for the project on the website, and they stated that the existing technology is sufficient carry out the project. However, according to the same assessment by MIT, one of the technology essential to the project (In-Situ Resource Utilization) is currently immature to be used on Mars. In-Situ Resource Utilization is required to convert raw resources on Mars into usable resources.

At this point, the project receives many doubts. However, the future is unpredictable. Maybe a new technology is currently in development and will make the project possible in the future. Whether the Mars One project will be successful or not, only time will tell.

-Daniel Hsiao

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