Tag Archives: Genetics

Hiding Beneath our Noses: A New Subspecies of Goshawk

Could there be a new subspecies of bird hiding beneath our noses?

Researchers at the University of British Columbia (UBC) have recently discovered a new subspecies of Northern Goshawks  living on Haida Gwaii.  They looked at DNA of Northern Goshawks and found the birds on Haida Gwaii were different from those found anywhere else. This stunning discovery will help improve current policy and conservation efforts for these endangered birds.

Courtesy: Flickr | Photo Credit: Aleksander Cocek | A Northern Goshawk.

Northern Goshawks are native to British Columbia. These medium sized birds have sharp beaks, large talons, and live in British Columbia’s (BC) mature forests.  They are birds of prey and feed on other birds, small mammals, and even insects.  To learn more about these amazing birds, check out this interesting Scie 300 Podcast.

For decades, the birds along the coast have been seen as one species.  However, recent evidence suggests the birds on Haida Gwaii, an island archipelago off the coast of central BC, may be a subspecies of their own.  Kenneth Askelson is one of the researchers behind this study.  Kenneth explained the 433 samples they had was one of the largest collections of its kind and relied on contributions from museums and collectors.  “To collect all these samples by hand would have taken 30 years,” he explained.  Kenneth and his team analyzed the genetic samples and found differences not found in samples from other locations.

Goshawks numbers have been falling around the province, and the species along the coast is officially listed as endangered. There may only be about 1200 of these birds left in BC.  The population on Haida Gwaii is even smaller and estimated to have only 50 individuals. This small population is also at risk of inbreeding. Inbreeding is when closely related birds mate with each other. This can produce children that are more susceptible to changes in the environment or have genetic defects. It is not known for sure why these birds have remained isolated for so long.

Courtesy: Flickr | Photo Credit: Nick Goodrum | A Northern Goshawk spreads its wings.

This begs the question, are we doing enough? Human population growth has caused many species around the globe to disappear, and many more are at the verge of disappearing.  The Goshawk is seen as an important indicator of forest health. If the Goshawk species is struggling, the forest may also be struggling.  Current efforts to prevent further loss of this species include the creation of Wildlife Habitat Areas. The government of BC hopes to have 90 such areas set up by 2020, with many of these being created on Haida Gwaii.

However, effective conservation depends on knowing where species live and the  issues they face.  Mr. Askelson prides himself on, “being someone who can provide the most information to make the best management decisions possible.”  This study will help policy makers make informed decisions that could save the Haida Gwaii Goshawks from disappearing.

Goshawks are pretty cool, aren’t they? Check out this short video for more information.

 

 

-Sukhman Bhuller, Farhan Muhib, Janet Lee

Help! I can’t stop eating!

A child eating pizza. Image from Wikimedia Commons

One slice of pizza turns into five boxes of pizza and twenty hours later… you’re still eating! Imagine an insatiable hunger and a love for food turned deadly. When eating becomes your worst enemy, Prader-Willi Syndrome may be the culprit.

What is Prader-Willi Syndrome?

Prader-Willi Syndrome (PWS) is a rare genetic disorder in which an individual feels hungry all the time. So much to the point where they are found constantly eating, and can continue eating even after they’re full. These individuals can literally eat to the point of death.

PWS was first described in 1956 by Swiss doctors Andrea Prader, Alexis Labhart, and Heinrich Willi. Anyone can develop PWS, and it was found that this disorder affects nearly 1 in every 15,000 births. As a result, PWS is one of the leading causes of childhood obesity.

Symptoms of a Deadly Appetite

The most common symptom of PWS is chronic hunger. Other symptoms can include: poor muscle tone during infancy, early-onset obesity, limited growth, delayed motor and verbal skills, behaviour and mental disorders, and curvature of the spine.

A 15-year-old child with typical PWS facial features. Note the presence of mild truncal obesity. Image from Wikimedia Commons

How does this happen?

PWS is a genetic disorder, which means that children inherit this disorder from their parents. Specifically, from an abnormality in a chromosome that comes from the father. This abnormality arises when a part of the gene is missing or malfunctioning. When this occurs, the hypothalamus (the part of the brain that controls hunger and thirst and releases hormones that promote growth) stops working which results in an inability to regulate food intake.

Is there a cure?

Unfortunately, there is no known cure for PWS. In fact, most of the research to date has only been targeted towards developing treatments for the disorder. For example, doctors may prescribe a growth hormone to treat PWS that not only increases height, but also decreases body fat, increases muscle mass, improves weight distribution, increases stamina, and increases bone mineral density.

Ultimately, the inability to regulate food intake remains one of the biggest obstacles that prevent individuals with PWS from living independently. There is still no effective medication that aids in regulating appetite. Nevertheless, those with PWS can still live a long and fulfilling life with the right guidance and support, as seen with Katie in the video below. Her documentary on living life with PWS gives us a better insight into the disorder, and presents a new meaning to the saying “you are what you eat”:

Documentary of Katie, a child living with PWS. Video from Youtube.

-Christina Rayos

Can Sharks Help Us Cure Cancer?

There are very few things in this world that are more terrifying to humans than sharks are. After all, with their intelligence, size, agility and ideal anatomical features, they really are the perfect predators. They have dominated the ocean for over 400 million years, instilling fear in other animals and humans alike. But what if these fierce hunters actually hold the key to surviving some of our deadliest diseases?

A great white shark in Dyer Island. Courtesy of Wikimedia Commons (Olga Ernst).
Source: https://commons.wikimedia.org/wiki/File:Great_white_shark_Dyer_Island.jpg

Recently, scientists at the Save Our Seas Foundation Shark Research Center characterized the full genome of a great white shark, essentially the genetic blueprint that maps the structure and function of the animal. Their studies revealed that sharks are just as resilient on the inside as they look on the outside.

Their research, published in the Proceedings of the National Academy of Sciences of the United States, found that sharks can repair and alter their DNA, the material in our bodies that carry genetic information, in order to fight diseases and heal wounds efficiently as they age. Their built-in resistance to DNA damage increases their genetic stability and health, which is how they are able to thrive for millions of years.

A 3D-model of DNA strands.
Courtesy of Flickr Commons (Helen Carmody).
Source: https://flic.kr/p/R8JhxZ

Healing progression of a lemon shark over a three year period. Courtesy of YouTube (Ramon Llaneza Technical Diving). Source: https://www.youtube.com/watch?v=-lrn5AHipp8. 

Our cells, the building blocks of our body, along with our DNA, which provide the layout for the cells to function, breakdown as we age. This damage, termed genomic instability, is what makes humans so vulnerable to serious age-related diseases like cancer.

By studying the shark genome, the scientists hope to understand the mechanisms behind how these animals are able to preserve its stability, information that may potentially help us fight cancer and other serious human diseases. It may also help improve current flesh-healing treatments.

There is still so much to learn from sharks, both from a biomedical perspective and from an environmental perspective. Hopefully, this newfound research will heighten our appreciation for these evolutionary superheroes instead of feeling the need kill them.

– Justine Law

Recording the Cell? New technologies further uncover mysteries surrounding the cell.

Does anyone really know what life is like inside of a cell? Sure, we can all say that the mitochondria is the powerhouse of the cell, and we’ve learned mitosis more time than we can count, but do we really know about the intricacies of day to day cellular processes? Historically, answer has been an overwhelming no, but that is something the researchers behind CAMERA are hoping to change.

CAMERA, or CRISPR-mediated analog multievent recording aperture is a tool developed by David Liu and Weixin Tang of Harvard university to record the molecular interactions within a cell, all of which are stored on the cell’s DNA. This new discovery allows scientists to observe and therefore clarify the processes that contribute to such things as the emergence of cancer, aging, environmental damage, and even embryonic development. CAMERA is only one of the many developments based off of the gene cutting technology known as CRISPR-Cas9.

Thyroid Cancer Cell Line. Courtesy of NASA’s Marshall Space Flight Centre and Flickr Commons. 

What is CRISPR-Cas9 you ask? Well, it’s basically a really small pair of scissors, so small that it can even cut DNA. CRISPR-Cas9, or CRISPR for short, is a technology based off of the natural defence mechanisms found in bacteria that have been reengineered for editing genomes. It has the ability to cut the double helix strand of DNA allowing for researchers to easily alter DNA sequences and modify gene expression. Some of the major implications of this include the possible correction of genetic defects, and the treatment and prevention of cancer and other diseases.

Video recreating a CRISPR-mediated genome editing. Courtesy of McGovern Institute for Brain Research at MIT .

So how did scientists develop a cellular recording device from this cutting tool? When CRISPR cuts a DNA strand to alter the sequence, the strand will naturally repair itself but in doing so can occasionally add in errors that make the targeted gene inactive. These random errors can sometimes be used as markers, mapping out the cell’s pattern of differentiation. Liu and Tang took this information and set out to regulate it thereby creating a more detailed, continuous record of a cell’s life, documenting not only its responses to external factors but the severity of the response and how long it lasts.

Flowchart of CRISPR mediated gene alterations. Image courtesy of Flickr Commons

At this point in time, CAMERA, is able to document cellular responses to light exposure, antibiotics, viral infections, and internal molecular interactions in as few as 10 cells. As well, it can record multiple events at once making it an impressive candidate for future medical technologies involved in screening embryos for a wide variety of mutations during development. Despite these impressive feats, Liu and Tang are still working towards pinpointing the recording down to one cell, allowing scientists to one day observe the processes of each cell individually and efficiently isolating any mutations. Another big step is proving it works to the same detailed extent when placed in the body of a living mammal as it does in a small cell group in a petri dish. There is still a lot to be done before we can confidently say we know how cells operate but CAMERA is a step in the right direction.

-Tenanye Haglund

I agree to all terms and conditions … Or do I?

In this day and age so much of what we do is shared on different platforms of social media that the notion of privacy is limited to having a private account. We open an account by providing a name and a picture and once we are in the system, one by one we begin adding more insight into who we are and what we do. We snap a picture of our outfit, take google recommendations for where to dine out and post a story of the meal we eat. Our urge to participate so actively on social media isn’t solely rooted in our desire to share but stems from us being innately social creatures who are inherently curious.
It didn’t take long for corporation to cultivate our curiosity and take data collection to a whole new level. Genealogy and ancestry companies, in the name of providing us with medical information and lineage tracing, now have access to what’s most personal to us, the code to our being.
It has now become posh and trendy to pay $100 to companies such as 23andme to find out what diseases we are prone to and where we have originated from. What we get as a result may not necessarily add much significance to our lives, but it provides those companies with pools of golden data. I stress the word “necessarily” as tendencies do not translate to definite diagnosis and a long list of places we get, does not provide us with much insight of where we originate from. On the other hand, companies like 23andme now have access to data that once took researchers years to gather.

How it works by 23andme

One might argue that having a DNA bank has in fact facilitated research by providing more detailed data. Additionally, DNA banks have revolutionized solving of murder and rape crimes. It is also illegal in Canada for such companies to sell this data to insurance and employment companies. However, the controversy does not lie in what is done to the data once collected, but whether or not the selling of it is considered an invasion of our privacy. We might have quickly scrolled down to check the “agree with the terms” button; or have even read the terms fully and agreed- which I highly doubt- but does that provide them with jurisdiction to use such personal knowledge in a research I did not consent to? How does DNA sequencing deidentifies a subject and how is my anonymity preserved? I can delete my Facebook account, get a new credit card, change my name, but I can never reclaim my DNA data.

Recording the Cell? New technologies further uncover the mystery of the cell

Does anyone really know what life is like inside of a cell? Sure, we can all say that the mitochondria is the powerhouse of the cell, and we’ve learned mitosis more time than we can count, but do we really know about the intricacies of day to day cellular processes? Historically, answer has been an overwhelming no, but that is something the researchers behind CAMERA are hoping to change.

CAMERA, or CRISPR-mediated analog multievent recording aperture is a tool developed by David Liu and Weixin Tang of Harvard university to record the molecular interactions within a cell, all of which are stored on the cell’s DNA. This new discovery allows scientists to observe and therefore clarify the processes that contribute to such things as the emergence of cancer, aging, environmental damage, and even embryonic development. CAMERA is only one of the many developments based off of the gene cutting technology known as CRISPR-Cas9.

Thyroid Cancer Cell Line. Courtesy of NASA’s Marshall Space Flight Centre and Flickr Commons.

What is CRISPR-Cas9 you ask? CRISPR-Cas9, or CRISPR for short, is a technology based off of the natural defense mechanisms found in bacteria that have been reengineered for editing genomes. It has the ability to cut the double helix strand of DNA allowing for researchers to easily alter DNA sequences and modify gene expression. Some of the major implications of this include the possible correction of genetic defects, and the treatment and prevention of cancer and other diseases.

So how did scientists develop a cellular recording device from this cutting tool? When CRISPR cuts a DNA strand to alter the sequence, the strand will naturally repair itself but in doing so can occasionally add in errors that make the targeted gene inactive. These random errors can sometimes be used as markers, mapping out the cell’s pattern of differentiation. Liu and Tang took this information and set out to regulate it thereby creating a more detailed, continuous record of a cell’s life, documenting not only its responses to external factors but the severity of the response and how long it lasts.

CRISPR mediated DNA splitting. Courtesy of Flickr Commons.

At this point in time, CAMERA, is able to document cellular responses to light exposure, antibiotics, viral infections, and internal molecular interactions in as few as 10 cells. As well, it can record multiple events at once making it an impressive candidate for future medical technologies involved in screening embryos for a wide variety of mutations during development. Despite these impressive feats, Liu and Tang are still working towards pinpointing the recording down to one cell, allowing scientists to one day observe the processes of each cell individually and efficiently isolating any mutations. Another big step is proving it works to the same detailed extent when placed in the body of a living mammal as it does in a small cell group in a petri dish. There is still a lot to be done before we can confidently say we know how cells operate but CAMERA is a step in the right direction.

-Tenanye Haglund