Tag Archives: Medical Technology

New Wireless Pacemaker Offers Treatment for Parkinson’s Disease

In Canada, over 10,000 people currently live with Parkinson’s disease with an additional 6,600 new cases being diagnosed every year. The disease is caused by a loss of dopamine producing nerve cells. Without dopamine, the nerves are unable to control body movements efficiently. As Parkinson’s advances, movements such as walking and talking become heavily affected. Due to the complexity of this disease, the reason behind the nerve damage is very difficult to determine. Thus, researchers are focusing on ways to alleviate patients’ difficulty in movement. Most recently, UC Berkeley scientists have discovered a new neurostimulator, WAND, that could change the course of neurological disorder treatment, especially Parkinson’s.

What is a neurostimulator?

The most effective method of Parkinson’s treatment is the implantation of a neurostimulator device to the brain. This is very similar to a cardiac pacemaker, since it is able to maintain appropriate circuits in the brain. The dysfunctional areas of the brain are targeted by electrical signals that block any irregular brain waves.

What is Deep Brain Stimulation?

The most used neurostimulator is the deep brain stimulation (DBS) device. As seen in the video below, the DBS electrode is implanted near target areas, with wires passing under the skin down to the shoulders and connected to the neurostimulator in the chest. The patient after recovery is provided with a remote or magnet that allows for the stimulator to be turned on and off at home. While this treatment has been seen to be mostly effective, the surgery process and control of the device can be very strenuous, especially considering the advanced age of most Parkinson’s patients. Therefore, UC Berkeley researchers have developed a new neurostimulator, called WAND, that is smaller and much more advanced in capabilities.

Video of How Deep Brain Stimulation Works. Courtesy of The Wall Street Journal

What is WAND?

WAND or wireless artifact-free neuromodulation device, contains wireless and autonomous capabilities. This means that the device once trained to recognize signs of tremors or seizures, is able to adjust the stimulation parameters and apply electrical signals on its own. WAND is also able to record brain wave activity while applying the treatment. These recordings would allow doctors to see how the patient is reacting during and after the treatment. This is a large advancement from the typical DBS treatments which either stop recording or record away from the target region.

Newly Developed WAND Device. Source: Rikky Muller, UC Berkeley

Has WAND been tested?

To test its effectivity, researchers applied the device in a study that taught subjects to use a joystick to move a cursor. WAND was able to detect the neural signatures that preceded the joystick motion, and delay it by applying electrical stimulation. Thus, showing that the closed-loop system and neurological recordings worked more effectively in a demonstration done by previous DBS devices.

In all, WAND is a brilliant new technology that is cost-effective, time-effective, and saves patient’s the worry of having to apply their own electrical stimulations. The device is able to treat and record simultaneously, which builds an up-to-date record of treatment. While there is still much research needed to look at potential side effects, this technology gives hopes to Parkinson’s patients of returning to their former, healthy selves.

          Arrthy Thayaparan

Recording the Cell? New technologies further uncover mysteries surrounding the cell.

Does anyone really know what life is like inside of a cell? Sure, we can all say that the mitochondria is the powerhouse of the cell, and we’ve learned mitosis more time than we can count, but do we really know about the intricacies of day to day cellular processes? Historically, answer has been an overwhelming no, but that is something the researchers behind CAMERA are hoping to change.

CAMERA, or CRISPR-mediated analog multievent recording aperture is a tool developed by David Liu and Weixin Tang of Harvard university to record the molecular interactions within a cell, all of which are stored on the cell’s DNA. This new discovery allows scientists to observe and therefore clarify the processes that contribute to such things as the emergence of cancer, aging, environmental damage, and even embryonic development. CAMERA is only one of the many developments based off of the gene cutting technology known as CRISPR-Cas9.

Thyroid Cancer Cell Line. Courtesy of NASA’s Marshall Space Flight Centre and Flickr Commons. 

What is CRISPR-Cas9 you ask? Well, it’s basically a really small pair of scissors, so small that it can even cut DNA. CRISPR-Cas9, or CRISPR for short, is a technology based off of the natural defence mechanisms found in bacteria that have been reengineered for editing genomes. It has the ability to cut the double helix strand of DNA allowing for researchers to easily alter DNA sequences and modify gene expression. Some of the major implications of this include the possible correction of genetic defects, and the treatment and prevention of cancer and other diseases.

Video recreating a CRISPR-mediated genome editing. Courtesy of McGovern Institute for Brain Research at MIT .

So how did scientists develop a cellular recording device from this cutting tool? When CRISPR cuts a DNA strand to alter the sequence, the strand will naturally repair itself but in doing so can occasionally add in errors that make the targeted gene inactive. These random errors can sometimes be used as markers, mapping out the cell’s pattern of differentiation. Liu and Tang took this information and set out to regulate it thereby creating a more detailed, continuous record of a cell’s life, documenting not only its responses to external factors but the severity of the response and how long it lasts.

Flowchart of CRISPR mediated gene alterations. Image courtesy of Flickr Commons

At this point in time, CAMERA, is able to document cellular responses to light exposure, antibiotics, viral infections, and internal molecular interactions in as few as 10 cells. As well, it can record multiple events at once making it an impressive candidate for future medical technologies involved in screening embryos for a wide variety of mutations during development. Despite these impressive feats, Liu and Tang are still working towards pinpointing the recording down to one cell, allowing scientists to one day observe the processes of each cell individually and efficiently isolating any mutations. Another big step is proving it works to the same detailed extent when placed in the body of a living mammal as it does in a small cell group in a petri dish. There is still a lot to be done before we can confidently say we know how cells operate but CAMERA is a step in the right direction.

-Tenanye Haglund

New Wireless Pacemaker Offers Treatment for Parkinson’s Disease

In Canada, over 10,000 people are currently living with Parkinson’s disease with an additional 6,600 new cases being diagnosed every year. The disease is caused by a loss of dopamine producing nerve cells. Without this vital neurotransmitter the nerves are unable to control body movements efficiently. As Parkinson’s advances, movements such as walking and talking become heavily affected. Due to the complexity of this disease, the reason behind the nerve damage is very difficult to determine. Thus, researchers are focusing on ways to alleviate patients’ difficulty in movement. Most recently, UC Berkeley scientists have discovered a new neurostimulator, WAND, that could change the course of neurological disorder treatment, especially Parkinson’s.

The most effective method of Parkinson’s treatment is the implantation of a neurostimulator device to the brain. This is very similar to a cardiac pacemaker; in which it is able to maintain appropriate circuits in the brain. The dysfunctional areas of the brain are targeted by electrical signals that block any irregular brain waves.

The most used neurostimulator is the deep brain stimulation (DBS) device. As seen in the video below, the DBS electrode is implanted near target areas, with wires passing under the skin down to the shoulders and connected to the neurostimulator in the chest. The patient after recovery is provided with a remote or magnet that allows for the stimulator to be turned on and off at home. While this treatment has been seen to be mostly effective, the surgery process and control of the device can be very strenuous, especially considering the advanced age of most Parkinson’s patients. Therefore, UC Berkeley researchers have developed a new neurostimulator, called WAND, that is smaller and much more advanced in capabilities.

WAND or wireless artifact-free neuromodulation device, contains wireless and autonomous capabilities. This means that the device once trained to recognize signs of tremors or seizures, is able to adjust the stimulation parameters and apply electrical signals on its own. WAND is also able to record brain wave activity while applying the treatment. These recordings would allow doctors to see how the patient is reacting during and after the treatment. This is a large advancement from the typical DBS treatments which either stop recording or record away from the target region.

Newly Developed WAND Device. Source: Rikky Muller, UC Berkeley

To test its effectivity, researchers applied the device in a study that taught subjects to use a joystick to move a cursor. WAND was able to detect the neural signatures that preceded the joystick motion, and delay it by applying electrical stimulation. Thus, showing that the closed-loop system and neurological recordings worked more effectively in a demonstration done by previous DBS devices.

In all, WAND is a brilliant new technology that is cost-effective, time-effective, and saves patient’s the worry of having to apply their own electrical stimulations. The device is able to treat and record simultaneously, which builds an up-to-date record of treatment. While there is still much research needed to look at potential side effects, this technology gives hopes to Parkinson’s patients of returning to their former, healthy selves.

          Arrthy Thayaparan

Wearable Stickers: The New Life-Saving Medical Device

What if a sticker could save your life? Sometimes, the scariest part about being sick is not knowing whether you are taking all the correct measures to monitor and treat your illness, even after the doctor prescribes medication. A number of wearable devices such as wristbands have been created to monitor our physical activity and ensure that our health is on the right track. However, these devices are typically very expensive.

Recently, a team from Purdue University in Indiana published their research in ACS Advanced Materials and Interfaces on an electronic wearable sticker. These smart stickers are a simpler and more cost- efficient version of existing electronic wearable devices available for personalized medicine.

University Hall at Purdue University. Courtesy of Flickr Commons (Bill Badzo)
Source: https://flic.kr/p/suXmh8

 

Both the electronic devices and the stickers can alert users of any health risks or warning signs in real time. They contain sensors that record electrocardiograms, electromyograms and electrooculograms, which measure the electrical activity produced by the heart, the skeletal muscles, and the corneas respectively. They can also provide thermotherapeutic treatments, or heat therapy, to joints.

EPEDs demonstration video. Courtesy of YouTube. Source: https://www.youtube.com/watch?v=IuKbx3xyPIk

Purdue’s new epidermal, paper-based electronic device (EPED) can also be used as implantable sensors that monitor sleep, as they can adapt to internal organs without any serious effects. They are inexpensively paper-based and made out of cellulose. Lined with serpentine shapes, which make them more flexible and stretchable, they are coated with molecules that protect them from sweat, oil, water and bacteria as well. Each sticker costs about 5 cents to produce, and only require cheaper printers likened to those used to print books quickly and efficiently.

EPED Stickers designed by Purdue University. Courtesy of Youtube.
Source: https://www.youtube.com/watch?v=IuKbx3xyPIk

Book Printer. Courtesy of Wikimedia Commons.  Source: https://commons.wikimedia.org/wiki/File:On_demand_book_printer_2.jpg

As wearable devices become increasingly popular in this technological era, these stickers are a cheap and effective solution that makes personal health monitoring more accessible to all. Since they are so easy to implement and test, with growing research, they can be developed to accommodate a range of other healthcare needs in the very near future.

– Justine Law