Author Archives: jake wong

Human Brains in Rats?

Picture of neurons. Source: https://commons.wikimedia.org/wiki/File:GFPneuron.png#/media/File:GFPneuron.png

The idea of a human-animal hybrid has long been a part of science fiction, but so far has been a highly impossible task. However, recent studies have resulted in the first steps taken towards doing this in reality, involving implanting a miniature human brain into a lab rat.

This miniature human brain is called an organoid, which previously were created in petri dishes made from human stem cells, and grew new neurons similar to how full-size human brains do. Prior testing on these organoids were focused on researching how brain diseases such as Alzheimer’s and Zika virus develop, however this research was limited as the organoids were not attached to any biological system.

This is where researchers, such as Dr. Isaac Chen, came up with the idea of implanting the organoids into rats. Chen’s team had attached the visual cortex portion of the organoid to rats, which was shown to have connected properly as neurons in the organoid were fired when light was shined into the rat’s eyes. A separate lab also successfully connected blood vessels of rats to the organoids, allowing blood flow and growth.

Picture of a lab rat. Source: https://commons.wikimedia.org/wiki/File:Albino_Rat.jpg#/media/File:Albino_Rat.jpg

However, there was a big problem that caused this research to come to a halt: ethics. Organoids are no where near the size of an operating human brain, nor have they shown the growth required to reach human intelligence. Even when attached to a rat, there are no signs of increased intelligence or growing consciousness. What this does imply, however, is that there is a potential for a rat to grow thoughts like a human with advancements in this process. Where can science draw the line between ethical testing on rats and testing on rats that can think like humans?

Currently, the closest thing to an ethical rule is the moratorium against implanting human stem cells into early embryos of vertebrates, but the organoids are not direct stem cells, and the test rats were fully developed. Perhaps laws need to be set to restrict organoid size before implant, or a certain development limit for the rats, as younger rats are likely to develop with the human neurons intertwined? The ethics behind these experiments are hazy, but the results of these experiments are highly beneficial for society, as it provides potential solutions for horrific neurological diseases.

While limits should definitely be set on this kind of experimentation, scientific progress should not be limited. We must continue to strive towards supporting our society and those who are diseased, and as long as the ethical boundaries of this experimentation is understood well, it deserves to be investigated.

Forget High Internet Lag and Costs: Meet Optical Access Networks

Written by: Jake Wong, Oct. 20th

The average internet speed in Canada is ~30Mb/s (which may be an inflated average), meaning that it takes average Canadians half a minute to download a 1GB movie, or about 3 minutes to download a full 5GB game. However, most people don’t have high internet speeds, or even if they do speeds get bogged down by high traffic and many users using the same site at once. There must be a more optimal way to use the internet that is cost effective and efficient. That is exactly the question Dr. Sezer Erkılınç at the University of College London thought when he began his research on optical access networks.

Traffic

Optical access networks had already existed prior to this research, as optic fibers are commonly used around the world for data transfer and Internet connection. Essentially, each fiber wire transmits data by sending light pulses. However, this does not necessarily mean that each fiber is restricted to sending information to only one receiver. By having different non-interfering wavelengths of light in each fiber, multiple receivers can be connected to a single fiber. This can be done using coherent receivers, which is highly sensitive and therefore has the precision to separate wavelengths. However, this is extremely costly and would cause fast internet to be unaffordable. Fortunately, Dr. Sezer Erkılınç’s team found a way to implement this multi-wavelength technique without the high costs. This can be done “by adopting a coding technique to fibre access networks that was originally designed to prevent signal fading in wireless communications”. Unfortunately the paper is yet to be published so the details are not clear, but you can read the article about this project here.

Fibre Optics

This technology will take advantage of the current data system we have in place today, so no new infrastructure will be needed to be built around it. Also, if each user is assigned a specific wavelength of light, other uses accessing the same information will not interfere and slow down the data transfer. Finally, this method is extremely efficient, offering up to 10Gb/s, which is 300x faster than the average speed of Canada. Further testing needs to be done, but if this technology can be put into place, we may be seeing advancing internet speeds to match our ever increasing need for high speed data transfer. This technology will revolutionize how we use the internet, whether it be to watch movies, play games, or download files. I think if this technology will truly allow us to increase internet speeds, experience less lag, AND reduce our payments, it is worth our time investigating and testing it.

New Plan for Seeking Life on Mars

Written by: Jake Wong, Sept. 24th

Many have wondered whether our neighbor planet, Mars, contains life outside of what we know of here on Earth. It would make sense, as Mars is within the proper distance away from the Sun to sustain life. However, enough research has been done to know that the stereotypical humanoid green “Martian” does not exist. Therefore, researchers are switching targets to find life: fossilized microorganisms, or “microfossil”.

Geology professor Craig Marshall and his team recently released a paper discussing how the detection of vanadium can lead to detecting life. The technique makes use of Raman spectroscopy, which reveals the cellular composition of a sample. Previously, researchers had been using Raman spectroscopy to see if a sample contains carbon chains, which all living things are made of. However, there are a lot of artificial carbon samples that may visually look like a fossil without actually being previously alive. Therefore, a new identifying factor was required, which Marshall’s team believes to be vanadium.

Example of a microfossil from Earth taken by Craig Marshall. Source

It has been previously shown that vanadium on Earth is present in things like crude oil and fossilized plants, both of which are similar to what would indicate life on Mars. This also shows that the vanadium can still be detected after extremely long periods of time and potentially under great pressure. In order to detect vanadium, Marshall is testing a technique called synchrotron micro-X-ray fluorescence, which focuses on the elemental presences in a sample.

So, if a sample has the physical characteristics of a microfossil, is shown to contain carbon material through Raman spectroscopy, and is shown to contain vanadium through synchrotron micro-X-ray fluorescence, then we can conclude that sample contains a microorganism, Marshall states. However, currently all tests on this hypothesis have been on samples from Earth. Soon, we will hopefully see this method being used on actual Martian rocks.

I believe these results are the first steps for mankind to finally make groundbreaking extraterrestrial discoveries. In the past, our testing of Martian samples was highly limited and not extremely targeted for finding life, but with these new ideas and techniques, we may find data that could lead to future colonization of Mars. I have extremely high hopes for this project and the future of our space exploration.

With investigations of Mars continuing and a Rover planned to be sent to Mars in 2020, we may find soon that we are not as alone in the solar system as we once thought.

An artist’s rendition of the Rover to land on Mars in 2020
Credit: NASA/JPL-Caltech

Read Marshall’s paper here.