Category Archives: Biological Sciences

A baby defeats HIV

Just yesterday, scientists announced that a baby who was born infected with HIV was cured of the disease. The doctors diagnosed the mother to be HIV-positive at the time of labor; the baby was at a high-risk of exposure to HIV, and later confirmed to be infected. After 30 hours of birth, the doctors treated the baby with highly active antiretroviral therapy or HAART, a combination of 3 antiretroviral drugs in order to prevent HIV from making home in the baby’s immune cells. The baby was given treatment for 18 months, and half a year later from quitting treatment, its blood showed no sign of infection.

This is the second case of curing the infected of HIV. The first person to defeat HIV is Timothy Brown who received bone marrow transplant from a donor with HIV-resistant genetic mutation, which is found in 1% of European population.

HIV via flickr user: Microbe World

HIV via flickr user: Microbe World

This “breakthrough” may bring hope to children born with HIV, whose number count to 300,000 worldwide in 2011, and comprise about 1% of HIV patients. However, mother-to-baby HIV transmission is 99% preventable if the mother is treated during her pregnancy. Given that most babies with HIV are born in developing countries where only 50% of pregnant women have access to the medicines, it is crucial to urge wealthy countries to increase their support to organizations such as UNAIDS that work for the elimination of mother-to-baby HIV transmission.

HAART is not a cure for HIV patients at later stage of infection as it can only suppress the virus from replicating rather than killing the viruses themselves. Nevertheless, the news of world’s second case of curing HIV gives hope that the virus may be conquered if actions are taken quickly.

An Origin of Schizophrenia Revealed

 

Comparing the prevalence of Schizophrenia with other diseases. From Schizophrenia.com.

Schizophrenia is a mental illness that is characterized by delusions and hallucinations. Because the symptoms affect the cognitive and social functions of an individual, and the prevalence of schizophrenia is high, psychiatrists and psychologists are doing researches to find origins of this illness in order to develop a better treatment for this illness. A recent stem cell research at University at Buffalo revealed that schizophrenia is induced by defects in an important genomic pathway in a stem cell. These defects in the pathway can be responsible for onset of the disorder later in life.  

This important genomic pathway is called the Integrative Nuclear Fibroblast Growth Factor Receptor 1 Signalling (INFS). It is a platform for the integration of signals that come from many other pathways, involving around 160 genes that are linked to schizophrenia. To study the consequences of the defects of INFS, laboratory mice are used as the model organisms.
 
Using the mouse model, the researchers found some interesting results. It was observed in embroynic stem cells that some genes that are linked to schizophrenia binded with Fibroblast Growth Factor Receptor 1 (FGFR1) protein, which is an essential protein for cell division, cell growth and cell differentiation, and also has a cascading effect on the INFS pathway. To test the relationship between FGFR1 protein and schizophrenia, a mutation of FGRR1 protein was made in the mice. This mutation created structural changes in mice’s brain, alterations in mice’s behaviour, and overwhelmed sensory processes in mice. Those symptoms in mice resembled the human disease, schizophrenia. Therefore, it can be concluded that an alteration in the transition from stem cells to neurons will result in schizophrenia. In addition, this study supported that nicotinic agonists (medications that activates the nicotinic acetylcholine receptors in neurons) could help the schizophrenics to have better cognitive functions.  
 

The picture shows that fibroblast growth factor receptor 1 (FGFR1) interacts with multiple genes that are linked to schizophrenia. Arrows point to the nuclei of human embroynic stem cells. Picture from: University at Buffalo, News Centre.

Researchers found an genomic explanation to the causes of schizophrenia using a mouse model. The head researcher, Michal Stachowiak, mentioned that this can lead to a generalized approach to treat schizophrenia if it is sure that a malfunction of a common genomic pathway is the cause for the disorder. He also proposed that possible methods that would stop the illness from developing could be created in the future. I have a high hope for the development of better treatments and even a cure for schizophrenia based on the current understanding of schizophrenia and technologies.

– (Shirley) Yu Chen

Life as a Fish

Look at the poor little fish flopping around! They must be in pain right? Actually no,  they might not be!

YouTube Preview Image

via youtube user nclspttr

Are you one of those people that feel sad for those little fish when you see them squirming in pain? If yes, then you will be happy to know that these fish may not actually be in pain at all. Research has been done that says that fish are  physically incapable of feeling pain.

On the other hand, there has been some research done that claims fish do feel pain; however, the science in this research is not always accurate. Most of this research fails to differentiate between nociception and actual pain. Nociception is basically a pain-free response to remove an unpleasant sensation. This response comes from the nociceptors. Researchers see this response and assume that it is pain when really it isn’t.

There has also been research done that says fish do not feel pain; and here is the main reason why. Fish have quite a few A-delta fibers which are responsible for the first reaction one has to avoid pain. For example, pulling your hand away from a hot object before you get burnt. They have a very small amount of C-type fibers which provide intense and lasting pain.

A photo of nerve fibers via flickr user akay

So next time you feel bad for that little fishy flopping around, maybe you should think again. That fish may be one of the luckiest organisms out there. Imagine a life where you don’t need to feel pain. Could be pretty great right? I beat you are wishing you were a fish right now. Just like this happy guy!

File:Cometap.jpg

A happy fish via wiki media user bramfab

Is your mind wandering right now?

Studies suggest that our minds wander at least 30% of the time! Mind wandering occurs when we lose focus on the task at hand and start thinking about another idea or topic. Most of the time, we are not aware that we are mind wandering since we do it quite frequently. I know that as I am sitting in class, sometimes I am actually thinking about what I should do after class. Though I am physically sitting in the chair and my professor is lecturing to the students, how much am I actually absorbing?

Picture of Brain by Liz Henry via Flickr Creative Commons

Actually, mind wandering has its positive and negative effects. Some positive effects are that it promotes creative thinking and allows us to multitask, (i.e. shift our focus from one idea to another). However there seems to be more negative effects such as causing unhappiness and affecting our immune cells! We can become unhappy when we constantly mind wander because it may produce fear,  decrease our ability to focus and blur our vision about the future. Additionally, in a recent study, researchers found that telomeres of immune cells (granulocytes and lymphocytes) shorten when the participants were mind-wandering. The length of these telomeres predicts an aging body, and affects a person’s vulnerability to diseases and clinical stress syndromes.

So how can we limit our mind wandering and stay in the present moment?

We can focus on our surroundings that are present right now such as the smell of the environment, the sounds that are projecting around us and the processes that occur in our inner body such as our breathing. Also, if there is someone around us that seems to be in the vibe of the presence, maybe we take away some of that optimism or excitement that they have. Furthermore, some things that we can do alone are reading a fictional novel, doing yoga, and doing meditation.

Yoga for beginners by synergybyjasmine via Flickr Creative Commons

Good luck in achieving an healthier mind, everyone!

To amnio or not to amnio, is that still a question?

Pregnant_woman_(2)

A pregnant woman from David Roseborough via Wikipedia Creative Commons

Since the mid-70’s, expectant mothers believed to be at high risk for giving birth to a child with a defect have been faced with a critical choice: to take a risky diagnostic procedure called an “amniocentesis” (amnio), or to forgo it and not know what to expect out of their pregnancy.

Imagine that you are an expectant mother who has been told that your future child has a high risk of having a genetic disorder, and would have to make the decision to have an amniocentesis or not. It is likely a tough call to make, because research shows that up to 1 in 100 of these procedures directly result in the loss of the baby, in addition to other risks to the mother and baby.

Luckily, expectant mothers of the future may not be faced with this dilemma. A new technology called “non-invasive prenatal diagnosis” has been recently innovated, which allows doctors to determine if a baby has some sort of genetic disorder without performing a risky procedure! All that is needed is some blood from the pregnant mother.

Fetus_and_placenta_-_journal.pbio.0060312.g001

A fetus in the womb from Wei Hsu and Shang-Yi Chiu via Wikipedia Creative Commons

The idea behind non-invasive prenatal diagnosis is that when a woman is pregnant, there is some of the unborn baby’s genetic information floating around in her blood. This genetic information can be collected from a sample of the mother’s blood, and tested for genetic disorders! Furthermore, the procedure is 99.5% accurate, so with the test results accompanying other tests which are used to detect genetic disorders, physicians can almost definitely ensure that they are correct when they tell a parent their baby will be normal!

Below, Ariosa Diagnostics Inc. explains how a mother’s blood can be used to test for a baby’s genetic disorders.

YouTube Preview Image

From Ariosa DX via Youtube.

The possibilities for the applications of this technology stretch far into the future. With the advent of machines which can find out a person’s genetic code in its entirety within the span of a couple hours, and have the ability to do it cheaply, non-invasive prenatal diagnosis could be used to test single genes!

Unfortunately, like many new innovations in the field of genetics and health care, this one has ethical issues. If the technology is not controlled carefully, someday, it may be possible for parents to test to see what their child might be like before its born. Should parents be able to get an abortion just because their child may not be a genius? Or 6 feet tall? The technology to do this is likely going to be expensive; what happens if some families cannot pay for it? I personally believe that this technology is great because it allows parents to make an informed choice about their future child; however, the government should control the application of this technology to traits that are not considered disorders.

-Shaun

Melatonin’s Effects on Sleep

Over the past reading break I decided to go on vacation rather than actually doing any reading. During this time, I messed up my sleep cycle and had a very difficult time falling asleep at night and waking up in the morning. Of course, I realized that this was partly due to my rowdy roommates and their will to stay up until the wee hours of the night. Being in the states, it was easy to go to the nearest drug store and grab some over the counter sleep aid, and in this case I chose melatonin.

 

Melatonin 3D Stick Structure via Wikimedia Commons by Sbrools

 

Light’s Effect on Melatonin Levels via Life Enhancement by Dr Rosick

Melatonin is a chemical and hormone which is naturally produced in the body to promote and control our sleep cycles. It is produced in the pineal gland within the endocrine system in humans. Melatonin is released into the bloodstream and is usually affected by light and dark surroundings throughout the day. For example, melatonin levels will tend to increase as the day goes on until night time to promote sleep. Near the end of the night, melatonin levels will start to decrease to help us wake up in the morning.

In recent years, melatonin has become increasingly popular as a natural remedy compared to the use of sleeping pills to aid people with sleeping difficulties or people suffering from Seasonal Affective Disorder (SAD). So the question is, how effective is melatonin pills in addressing these issues? According to a study published by the British Medical Journal on the effects of melatonin in cases of jet lag, results did positively reinforce our hypothesis.

YouTube Preview Image

Of course, it is recommended to take as little medication as possible if unnecessary. But this has become such a popular aid and a solution to  to seriously consider if you are experiencing difficulties sleeping. I highly recommend speaking with your physician first. I personally will definitely be able to see for myself whether or not these melatonin pills are effective after tonight.

Wishing you all a good night’s sleep,

Bonnie Tam

Uncovering the Secret Sexual Side to Our Favorite Fungus!

With Valentine’s Day only a few days away, love is definitely in the air. As it turns out, even fungi are in the mood!

Valentine’s Day Cupcakes. Sugar Daze via Flickr Creative Commons.

A recent study has discovered that Penicillium chrysogenum (P. chrysogenum) have a sexual side. While you may not recognize the name P. chrysogenum, it is likely that at some point in your life you have depended on this fungus to help you feel better. P. chrysogenum is popularly known for its production of the antibiotic penicillin, which has been used for treating bacterial infections since it was discovered by Sir Alexander Fleming in 1928.

Penicillin works by preventing bacteria from building cell walls. Lacking this external support, the bacterial cell is very fragile and bursts, resulting in death of the cell (click here to watch this process). As we do not possess the same cell wall components as bacterial cells, penicillin is an effective treatment for human bacterial infections, as the antibiotic interferes with bacterial cells but not our own cells!

Penicillium Growing on Bread. Logan Sakai via Flickr Creative Commons.

Previously, it was thought that P. chrysogenum only underwent asexual reproduction. In this reproductive strategy, fungal cells duplicate their genetic material and divide, resulting in two identical clones called daughter cells.

However, researchers suspected that P. chrysogenum would be able to sexually reproduce if provided with the right conditions, as the genetic sequences required for mating could be found within the DNA of this species. Supporting this belief, a recent experiment by Bohm et. al has shown that when proper conditions are met, P. chrysogenum fungi will sexually mate to produce new genetic strains of offspring.

Scanning Electron Microscope (SEM) Image of P. chrysogenum Fungus. Engineering at Cambridge via Flickr Creative Commons.

This discovery has been dubbed the “secret sex life” of P. chrysogenum. So, light the candles, turn on some romantic music, and spread out the rose petals?

Not quite; these fungi require a special “love potion”. After testing a variety of light and nutrient conditions, experimenters found that P. chrysogenum engaged in sexual mating when grown in darkness, in an oatmeal base supplemented with biotin (a vitamin).

Fungi Love Potion? Oatmeal! Nillerdk via Wikimedia Creative Commons.

Furthermore, researchers found that fungi engaging in sexual activity also produced more penicillin than asexual fungi. These findings are important on an industrial level, as sexual strains can be used to maximize penicillin output when synthesizing this antibiotic for medical usage. While high antibiotic-producing strains have been engineered before, they are genetically unstable and have short lifespans. However, knowing that sexual reproduction in P. chrysogenum occurs, engineered strains can be sexually mated with normal strains to produce offspring that are both genetically stable and produce large quantities of antibiotic.

While I can’t promise that oatmeal and biotin will help you get lucky this Valentine’s Day, it appears that you won’t need to worry about a penicillin shortage in the near future!

– Sydney Schnell