Category Archives: Science Communication

Melatonin’s Effects on Sleep

Over the past reading break I decided to go on vacation rather than actually doing any reading. During this time, I messed up my sleep cycle and had a very difficult time falling asleep at night and waking up in the morning. Of course, I realized that this was partly due to my rowdy roommates and their will to stay up until the wee hours of the night. Being in the states, it was easy to go to the nearest drug store and grab some over the counter sleep aid, and in this case I chose melatonin.

 

Melatonin 3D Stick Structure via Wikimedia Commons by Sbrools

 

Light’s Effect on Melatonin Levels via Life Enhancement by Dr Rosick

Melatonin is a chemical and hormone which is naturally produced in the body to promote and control our sleep cycles. It is produced in the pineal gland within the endocrine system in humans. Melatonin is released into the bloodstream and is usually affected by light and dark surroundings throughout the day. For example, melatonin levels will tend to increase as the day goes on until night time to promote sleep. Near the end of the night, melatonin levels will start to decrease to help us wake up in the morning.

In recent years, melatonin has become increasingly popular as a natural remedy compared to the use of sleeping pills to aid people with sleeping difficulties or people suffering from Seasonal Affective Disorder (SAD). So the question is, how effective is melatonin pills in addressing these issues? According to a study published by the British Medical Journal on the effects of melatonin in cases of jet lag, results did positively reinforce our hypothesis.

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Of course, it is recommended to take as little medication as possible if unnecessary. But this has become such a popular aid and a solution to  to seriously consider if you are experiencing difficulties sleeping. I highly recommend speaking with your physician first. I personally will definitely be able to see for myself whether or not these melatonin pills are effective after tonight.

Wishing you all a good night’s sleep,

Bonnie Tam

From Toy Soldiers to Convicted Criminals

Vintage Toy Lead Soldiers by USA Direct To You via Flicker

What if someone told you that if  lead is found present in your bones, you are more likely to be a delinquent? In 2007, you may have encountered a report or read an article on lead poisoning due to lead containing toy products and households.

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Following such reports, the general public understood the effects of lead poisoning as a toxin. In 1996,USA had banned the use of the element as an additive to gasoline. However, minimal amounts of lead were still used  in the production of batteries, jewelry,toys and paint products. After the 2007  Mattel recall , customers around the world looked carefully at the lead label when purchasing house and toy products. In 2008, Henry Clement, Canadian Health Minister, announced that the government would increase the number of inspections with an increase in a maximum fine of $5 million if high levels of lead were detected in children’s jewelry and other products.

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The public and government then understood  that lead has a dangerous effect whether a child was breathing or swallowing it. Children exposed to high levels of lead can suffer from kidney and brain damages. While low levels of exposure is a health hazard to all.This knowledge resulted in lead safety campaigns and sites such as www.leadfreekids.org. , which offers support and advice about lead inspections and protection techniques. In 2010, the federal government  decided to effectively ban lead from toys for children and other home products.Health hazards such  as kidney damage, brain damage,  hyperactivity, headaches,hearing problems could be prevented with precautions.However, lead exposure could result in more than these physical health problems but behavioural problems such as delinquency.

More studies have now been developed on lead poisoning. In 2013, Summer Miller pointed out data from US Centre for Disease (CDC) and suggested that high levels of lead exposure lead to juvenile delinquency. They have now diagnosed that 10 micrograms per deciliter of lead can cause lead poisoning. Subsequently, this small amount of lead can be identified with signs of headaches and abdominal pains. As informed in 2007, lead exposure impacts the human brain.Miller states that studies now find higher levels of lead in delinquents and how it affects their intelligence, communication skills and behaviour.

Kids play with toy guns – Wadi Nisnsa – by Dror Miller via Flicker

This was observed in a 2000 study  in Allegheny County. It concluded that 216 youths in a Juvenile Court had a higher high bone-lead level in comparison to 201 non-delinquents control in a Pittsburgh high school. Children with cognitive and behaviour problems are more likely to have higher blood concentrations due to lead exposure.

Sometimes it is not just about what children swallow or touch or symptoms we physically see, sometimes just that exposure can change the way things play out. 

From Toy Soldiers to Convicted Criminals

-Diane Mutabaruka

Uncovering the Secret Sexual Side to Our Favorite Fungus!

With Valentine’s Day only a few days away, love is definitely in the air. As it turns out, even fungi are in the mood!

Valentine’s Day Cupcakes. Sugar Daze via Flickr Creative Commons.

A recent study has discovered that Penicillium chrysogenum (P. chrysogenum) have a sexual side. While you may not recognize the name P. chrysogenum, it is likely that at some point in your life you have depended on this fungus to help you feel better. P. chrysogenum is popularly known for its production of the antibiotic penicillin, which has been used for treating bacterial infections since it was discovered by Sir Alexander Fleming in 1928.

Penicillin works by preventing bacteria from building cell walls. Lacking this external support, the bacterial cell is very fragile and bursts, resulting in death of the cell (click here to watch this process). As we do not possess the same cell wall components as bacterial cells, penicillin is an effective treatment for human bacterial infections, as the antibiotic interferes with bacterial cells but not our own cells!

Penicillium Growing on Bread. Logan Sakai via Flickr Creative Commons.

Previously, it was thought that P. chrysogenum only underwent asexual reproduction. In this reproductive strategy, fungal cells duplicate their genetic material and divide, resulting in two identical clones called daughter cells.

However, researchers suspected that P. chrysogenum would be able to sexually reproduce if provided with the right conditions, as the genetic sequences required for mating could be found within the DNA of this species. Supporting this belief, a recent experiment by Bohm et. al has shown that when proper conditions are met, P. chrysogenum fungi will sexually mate to produce new genetic strains of offspring.

Scanning Electron Microscope (SEM) Image of P. chrysogenum Fungus. Engineering at Cambridge via Flickr Creative Commons.

This discovery has been dubbed the “secret sex life” of P. chrysogenum. So, light the candles, turn on some romantic music, and spread out the rose petals?

Not quite; these fungi require a special “love potion”. After testing a variety of light and nutrient conditions, experimenters found that P. chrysogenum engaged in sexual mating when grown in darkness, in an oatmeal base supplemented with biotin (a vitamin).

Fungi Love Potion? Oatmeal! Nillerdk via Wikimedia Creative Commons.

Furthermore, researchers found that fungi engaging in sexual activity also produced more penicillin than asexual fungi. These findings are important on an industrial level, as sexual strains can be used to maximize penicillin output when synthesizing this antibiotic for medical usage. While high antibiotic-producing strains have been engineered before, they are genetically unstable and have short lifespans. However, knowing that sexual reproduction in P. chrysogenum occurs, engineered strains can be sexually mated with normal strains to produce offspring that are both genetically stable and produce large quantities of antibiotic.

While I can’t promise that oatmeal and biotin will help you get lucky this Valentine’s Day, it appears that you won’t need to worry about a penicillin shortage in the near future!

– Sydney Schnell

Owls; Their Amazing Head Turning Ability Solved

Owls are known for their ability to turn their heads “All the way around”, but have you ever wondered why?

Owl perching by Peter Trimming

Well first off,  contrary to popular belief, owls are not able to turn their heads the full 360 degrees. Most owl species, but not all, can turn their heads up to 270 degrees. The reason why they have adapted this ability is thought to be linked to the fact that unlike humans, with movable oval eyes, owls have tube like eyes that do not have the ability to swivel much.

If a human snapped their neck at the speed and angle that owls are able to do, there would be severe trauma to the neck and arteries, or completely stopping the blood flow to the brain. To test how this works, researchers, led by Fabian de Kok-Mercado, injected dye into the blood stream of dozens of owls, and used a CT scan to track the flow of dye throughout the bloodstreams of the owls.

After the CT scans were completed, they then injected a plastic like substance into the blood stream, let it harden, then dissected the owls to find out how the arteries were oriented.

Northern spotted owl by user USFS Region 5
Via Flickr

It was found that the owls neck bones, or vertebrae, contain holes that are much larger than those found in humans. In humans, the holes are just about as big as the arteries, whereas in owls they are about 10 times larger. These likely contain air sacks meant to cushion the twisting motion of the neck. This may explain why the blood vessels do not break during the rapid head turning motions of the owls.

The researchers also noticed that the artery slightly enlarges as it gets closer to the head. This is thought to allow blood to pool so that the brain has extra blood to work with as the head swivles.

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Above is a video explaining the details of how owls are able to turn their heads up to 270 degrees. [By user SciFri via Youtube]

And there you have it, the science behind how owls can turn their head at great angles. Wouldn’t that be cool if humans can do that to?

Okay, maybe not. Lets leave this to the owls.  

-Christina Bell

More human than just another Artificial Intelligence

Ask your (grand) parents: had they, 30 or 40 years ago, anticipated to live in an era where people carry cell phones, do face time, or shop via the Internet? Some may had imagined to witness today’s technology and some may had not. One of the most debated future technologies that many scientists feel skeptical believing we won’t ever achieve is human-like artificial intelligence. However, new software made last year may bring us closer to creating computers that operate like human brains.

So far there has been a number of artificial intelligences (AI) so smart that one of them has won the quiz show Jeopardy (IBM’s Watson) and another makes video games on its own (Angelina). Artificial Intelligences are programmed to think like people so that if one asks it and a real human a question, he cannot distinguish whether answer is from the real human or an AI. However, AIs do not at all work like human brains do; they are computers pre-programmed only to perform tasks with the data they store.

This time, a team of scientists of the University of Waterloo made an artificial brain that works more similar to ours. Its name is Spaun, acronym for Semantic Pointer Architecture Unified Network. Spaun is a supercomputer with 2.5 million simulated neurons (average human brain has 80 – 100 billion), an eye, and an arm. With its 2.5 million neurons, Spaun processes what it sees with its eye and performs tasks like a human brain would. Below is a video and a summary of some stuff Spaun can do:

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it can recognize, write, count, and remember numbers as well as forgetting them. via Youtube user: CTNWaterloo

The abilities of Spaun may not seem as impressive as AI Watson or Angelina, and even stupid in comparison, taking 2.5 hours in real time per 1 second in the video. However, the importance of Spaun’s birth is that it works like a human brain. With this, scientists can run experiments unethical to perform on human subjects such as killing neurons and observing brain degradationNow that we have an artificial model of human brain, I think we are a little closer to the future where computers will think and make decisions on its own like humans. 

Codeine: Should we continue prescribing it?

 

Little boy not enjoying his cough medicine
From Mediconews by Satish

Flu season, it’s that time of the year where everyone around you is coughing, sniffling, or sneezing. Sadly, this time around I am once again one of those victims. For me, it all started out with a cough. And now what’s the one thing that people take when they have a bad cough? That’s right, cough syrup.

I took 1.5 tsps of something labelled as Ratio-Cotridin Expectorant. In the morning it did significantly reduce my cough but the drowsiness remained. Doing some quick research showed that the cough syrup in fact contained something that stuck out to me: codeine.

Codeine’s Molecular Structure
From Wikimedia by NEUROtiker

Codeine is an opiate which is known to act as a cough suppressant and narcotic analgesic. The most common side effect of codeine is drowsiness. However, codeine is also addictive and can cause dependence, which is why its circulation is strictly controlled in certain countries.

A study  published by the Norwegian Institute of Public Health in 2009 showed that the risk of being involved in a traffic accident with personal injury was two times as high in the period after having a codeine prescription dispensed.

Cough syrup aka “purple drank”
From coughsyrup.ecoffeeonline.com

Codeine has also been known to have varying results dependent on unpredictable genetic variations. There have been attempts to restrict age distribution and the amount that is able to be consumed. However, a simple search online shows that cough syrup with codeine is easily available. There are even tutorials that teach you how to make “purple drank” or “sizzurp” online, a recreational drug consisting mainly of codeine and Promethazine.

So should such a drug like codeine be so widely available to the public? It has been shown to contain significant risks and be pretty ineffective as an analgesic  according to an editorial by the Canadian Medical Association Journal. Their solution is to phase out codeine altogether and only use morphine. This may be a good alternative for a painkiller, but what about for a cough suppressant? Recent studies using the placebo effect show that codeine is not such a necessary ingredient in cough syrups anymore. Perhaps doctors should no longer consider prescribing codeine to patients with a bad cough altogether.

–Bonnie Tam