Tag Archives: Alzheimer’s Disease

Alzheimer’s and research on a possible cure?

Alzheimer’s is a disease that has been distraught on families for decades. It starts by damaging the brain cells, eventually killing them off, and causing dementia (memory loss) as a result. Current medical resources can slow down symptoms but no cure has been found yet.

Source: https://drjockers.com/alzheimers-disease/

Recent research that points to decreasing levels of steroids in the brain (neurosteroids) and the risk of Alzheimer’s with increasing age suggests that Alzheimer’s might be related to the decreasing neurosteroids. In response to this, Dr. Daniel Tobiansky has found that the brain likely produces its own testosterone, and testosterone has been found to decrease inflammation of cells in male rat brains.

The Research of Dr. Daniel Tobiansky:

The human brain has always been thought to be a passive recipient of steroids such as testosterone and estrogen from our body. However, researchers may have found recent evidence that suggests otherwise. In particular, Daniel Tobiansky, a postgraduate doctoral fellow at the University of British Columbia performed an experiment, with gonadectomized (removal of testes or ovaries) rodents to observe the difference in sex-steroid levels of the brain in contrast to the control animals (not gonadectomized). If the brain indeed does not produce its own steroids, then, control animals should observe regular levels of steroids in the blood while others have none due to the lack of sexual organs.

What They Found:

The results of the experiment came just as hypothesized, with no signs of testosterone in the blood. Interestingly, parts of the brain such as the mesocorticolimbic system that functions as the “reward system” of the body, were found to have the same levels testosterone as it was in the control animals. This incredible in the context that further understandings to this simple discovery that the brain produces its own steroids can suggest potential cures to diseases and disorders such as depression and Alzheimer’s.

Source: https://slideplayer.com/slide/5724554/

YouTube Preview Image

Conclusion:

There is currently strong evidence suggesting that brain damage is related to the regression of neurosteroids. If Alzheimer’s is indeed associated with decreasing neurosteroid levels in the brain, then ramping up those steroid levels might help with slowing down the disease or even curing it.

The Development of Alzheimer’s Disease: Linked to the Air We Breathe?

Credit: iStockphoto/Michael Valdez
https://www.sciencedaily.com/releases/2007/11/071108135522.htm

Have you ever noticed the colour of the sky when the sun starts to set? That beautiful orange-pink colour is actually caused by the air particles of pollution, which researchers now found it to be closely correlated to the development of Alzheimer’s disease.

Research Study

Our air contains hundreds of millions of small particles, some harmless, others not so much. A new study obtained data from over 130,000 adults aged 50-79 years old (all registered to a family doctor on Jan 1st, 2005) and measured their exposure to nitrogen dioxide (NO2) levels from their homes in London. NO2 was used to measure this correlation because it is found from the emissions of burning fuels, like a coal burning stove, the cars we drive on a daily basis, power plant systems, and anything to do with fossil fuels being processed found worldwide. The results show that there was a positive correlation between high concentrations of air pollution and an increase in risk for Alzheimer’s disease.

The study couldn’t explain the effects of the variables that were hard to control but in this video narrated by Caleb Finch, professor at the University of Southern California’s Leonard Davis School of Gerontology, explains the biological aspect of how air pollution affects the brain:

Video Created by: USC Leonard Davis School of Gerontology

In summary of the video, the fine particles from fossil fuels first enter our nose, which then easily reaches the brain as well as the lungs. These particles create an effect on the brain cells, causing inflammation and swelling of the cells which accelerates the progression of Alzheimer’s. Experiments were conducted on rats that carried the Alzheimer’s gene in its DNA, called APOE e4, exhibiting a larger increase in brain amyloid (proteins in the brain that build up along the walls, causing dementia) than those without the gene.

Credit: Martin Basinger https://qph.fs.quoracdn.net/main-qimg-cd611d7893ad257d1ee98e8d6d97732a

With dementia being one of the biggest health problems in the world, if the link between air pollution and Alzheimer’s disease is fully proven, preventing it through improving our air quality might be the only solution to at least reduce the numbers. Knowing that pollution easily comes from the cars and buses used on a daily basis, should we start wearing face masks to reduce our own risk of Alzheimer’s disease?

 

Loretta Huang