Can Sharks Help Us Cure Cancer?

There are very few things in this world that are more terrifying to humans than sharks are. After all, with their intelligence, size, agility and ideal anatomical features, they really are the perfect predators. They have dominated the ocean for over 400 million years, instilling fear in other animals and humans alike. But what if these fierce hunters actually hold the key to surviving some of our deadliest diseases?

A great white shark in Dyer Island. Courtesy of Wikimedia Commons (Olga Ernst).
Source: https://commons.wikimedia.org/wiki/File:Great_white_shark_Dyer_Island.jpg

Recently, scientists at the Save Our Seas Foundation Shark Research Center characterized the full genome of a great white shark, essentially the genetic blueprint that maps the structure and function of the animal. Their studies revealed that sharks are just as resilient on the inside as they look on the outside.

Their research, published in the Proceedings of the National Academy of Sciences of the United States, found that sharks can repair and alter their DNA, the material in our bodies that carry genetic information, in order to fight diseases and heal wounds efficiently as they age. Their built-in resistance to DNA damage increases their genetic stability and health, which is how they are able to thrive for millions of years.

A 3D-model of DNA strands.
Courtesy of Flickr Commons (Helen Carmody).
Source: https://flic.kr/p/R8JhxZ

Healing progression of a lemon shark over a three year period. Courtesy of YouTube (Ramon Llaneza Technical Diving). Source: https://www.youtube.com/watch?v=-lrn5AHipp8. 

Our cells, the building blocks of our body, along with our DNA, which provide the layout for the cells to function, breakdown as we age. This damage, termed genomic instability, is what makes humans so vulnerable to serious age-related diseases like cancer.

By studying the shark genome, the scientists hope to understand the mechanisms behind how these animals are able to preserve its stability, information that may potentially help us fight cancer and other serious human diseases. It may also help improve current flesh-healing treatments.

There is still so much to learn from sharks, both from a biomedical perspective and from an environmental perspective. Hopefully, this newfound research will heighten our appreciation for these evolutionary superheroes instead of feeling the need kill them.

– Justine Law

The Fall of Sea Stars

1986-014-01: Sunflower seastar

1986-014-01: Sunflower seastar” by August Rode is licensed under CC BY-SA 2.0

Once an abundant species of sea star, the sunflower sea stars have become harder to find on the West Coast of North America. A recent study co-led by the University of California, Davis, and Cornell University claims that the combination of ocean-warming and an infectious wasting disease has led to the declined population of these large sea stars.

The sunflower sea star is one of the largest sea star species, they can grow as big as manhole covers. Commonly found in the northwest Pacific, they were once regularly found from Southern California to Alaska and some of the largest sunflower sea stars could be found in Puget Sound, British Columbia and Alaska.

In 2013 and 2014, a disease called sea star wasting syndrome affected around 40 different species of sea stars, including the sunflower sea star, to die off along the North American Pacific coast. Symptoms of the disease would be lesions and tissue decay, which the body structure of the sea star would start to breakdown. For example, their arms may twist and fall off and the sea stars would become limp. Eventually, the sea star would disintegrate and melt away into a white, mushy blob and no longer be a sea star. It is unclear where this disease originated from but researchers believe ocean-warming might be the reason why this disease continues to affect the sea stars and why the sea star population is not recovering fast enough.

Dying sea star

Dying sea star” by Oregon State University is licensed under CC BY-SA 2.0

Ocean-warming is an effect of global warming. The ocean absorbs excess heat from the atmosphere which contains greenhouse gas emissions, which leads to rising ocean temperatures. Increasing ocean temperature can affect many marine species and ecosystems. Warming of the oceans have been linked to the increase and spread of diseases of marine species.

The sunflower sea star species has been detrimentally affected by sea star wasting syndrome. The study conducted by Dr. Harvell and her colleagues collected data over eleven years to show how the population of sea stars have diminished due to this disease. In addition, scientists also found that the ocean water has warmed almost 4 oC within a four-year span in some areas. Results of the study showed the population crash of sunflower sea stars from Southern California to Alaska whilst tracking patterns of unusual warming in the Pacific Ocean. The sunflower sea star is shown to be highly susceptible to this wasting disease because they do not have a complex immune system. As a result, the data showed an 80 to 100% decline over the period of the study.

Sunflower Star Imperiled by Sea Star Wasting Epidemic” by Hakai Institute

If the sunflower sea star dies off, this should be an important indicator of the effects of ocean-warming and its impact on marine ecosystems. Sunflower sea stars are voracious predators in the deep and shallow waters of the northwest Pacific, and if these sea stars were to go away we could see an unbalanced ecosystem in our waters.

– Katherine Lam

The technological singularity: Science fiction or science future?

What would happen if we programmed a computer to design a faster, more efficient computer? Well, if all went according to plan, we’d get a faster, more efficient computer. Now, we’ll assign this newly designed computer the same task: improve on your own design. It does so, faster (and more efficiently), and we iterate on this process, accelerating onwards. Towards what? Merely a better computer? Would this iterative design process ever slow down, ever hit a wall? After enough iterations, would we even recognize the hardware and software devised by these ever-increasingly capable systems? As it turns out, these questions have extremely important ramifications in the realm of artificial intelligence (AI) and humanity’s continuing survival.

Conceptual underpinnings

In 1965, Gordon Moore, then CEO of Intel, wrote a paper describing a simple observation: every year, the number of components in an integrated circuit (computer chip) seemed to double. This roughly corresponds to a doubling of performance, as manufacturers can fit twice the “computing power” on the same-sized chip. Ten years later, Moore’s observation remained accurate, and around this same time, an eminent Caltech professor popularized the principle under the title of “Moore’s law”. Although current technology is brushing up against theoretical physical limits of size (there is a theoretical “minimum size” transistor, limited by quantum mechanics), Moore’s law has more-or-less held steady throughout the last four and a half decades.

Moore’s Law, illustrated. Source: Our World in Data

Accelerating returns

This performance trend represents an exponential increase over time. Exponential change underpins Ray Kurzweil’s “law of accelerating returns” — in the context of technology, accelerating returns mean that the technology improves at a rate proportional to its quality. Does this sound familiar? It is certainly the kind of acceleration we anticipated in our initial scenario. This is what is meant by the concept of a singularity — once the conditions for accelerating returns are met, the advances they bring begin to spiral beyond our understanding and, quite likely, beyond our control.

Losing control

As AI will almost certainly depend on some digital computer substrate, the concept of accelerating returns are readily applied to AI. However, losing control of an exponentially accelerating machine intelligence could have catastrophic consequences. In his excellent TED Talk, the world-renowned AI philosopher Nick Bostrom discusses the “control problem” of general AI and suggests that, though the advent of machine superintelligence remains decades away, it would be prudent to address its lurking dangers as far in advance as possible.

Nick Bostrom delves into the existential implications imposed onto humanity by machine superintelligence. Source: TED

 

In his talk, Bostrom makes a poignant illustrative analogy: “The fate of [chimpanzees as a species] depends a lot more on what we humans do than on what the chimpanzees do themselves. Once there is superintelligence, the fate of humanity may depend on what the superintelligence does.”

— Ricky C.

New Wireless Pacemaker Offers Treatment for Parkinson’s Disease

In Canada, over 10,000 people currently live with Parkinson’s disease with an additional 6,600 new cases being diagnosed every year. The disease is caused by a loss of dopamine producing nerve cells. Without dopamine, the nerves are unable to control body movements efficiently. As Parkinson’s advances, movements such as walking and talking become heavily affected. Due to the complexity of this disease, the reason behind the nerve damage is very difficult to determine. Thus, researchers are focusing on ways to alleviate patients’ difficulty in movement. Most recently, UC Berkeley scientists have discovered a new neurostimulator, WAND, that could change the course of neurological disorder treatment, especially Parkinson’s.

What is a neurostimulator?

The most effective method of Parkinson’s treatment is the implantation of a neurostimulator device to the brain. This is very similar to a cardiac pacemaker, since it is able to maintain appropriate circuits in the brain. The dysfunctional areas of the brain are targeted by electrical signals that block any irregular brain waves.

What is Deep Brain Stimulation?

The most used neurostimulator is the deep brain stimulation (DBS) device. As seen in the video below, the DBS electrode is implanted near target areas, with wires passing under the skin down to the shoulders and connected to the neurostimulator in the chest. The patient after recovery is provided with a remote or magnet that allows for the stimulator to be turned on and off at home. While this treatment has been seen to be mostly effective, the surgery process and control of the device can be very strenuous, especially considering the advanced age of most Parkinson’s patients. Therefore, UC Berkeley researchers have developed a new neurostimulator, called WAND, that is smaller and much more advanced in capabilities.

Video of How Deep Brain Stimulation Works. Courtesy of The Wall Street Journal

What is WAND?

WAND or wireless artifact-free neuromodulation device, contains wireless and autonomous capabilities. This means that the device once trained to recognize signs of tremors or seizures, is able to adjust the stimulation parameters and apply electrical signals on its own. WAND is also able to record brain wave activity while applying the treatment. These recordings would allow doctors to see how the patient is reacting during and after the treatment. This is a large advancement from the typical DBS treatments which either stop recording or record away from the target region.

Newly Developed WAND Device. Source: Rikky Muller, UC Berkeley

Has WAND been tested?

To test its effectivity, researchers applied the device in a study that taught subjects to use a joystick to move a cursor. WAND was able to detect the neural signatures that preceded the joystick motion, and delay it by applying electrical stimulation. Thus, showing that the closed-loop system and neurological recordings worked more effectively in a demonstration done by previous DBS devices.

In all, WAND is a brilliant new technology that is cost-effective, time-effective, and saves patient’s the worry of having to apply their own electrical stimulations. The device is able to treat and record simultaneously, which builds an up-to-date record of treatment. While there is still much research needed to look at potential side effects, this technology gives hopes to Parkinson’s patients of returning to their former, healthy selves.

          Arrthy Thayaparan

Recording the Cell? New technologies further uncover mysteries surrounding the cell.

Does anyone really know what life is like inside of a cell? Sure, we can all say that the mitochondria is the powerhouse of the cell, and we’ve learned mitosis more time than we can count, but do we really know about the intricacies of day to day cellular processes? Historically, answer has been an overwhelming no, but that is something the researchers behind CAMERA are hoping to change.

CAMERA, or CRISPR-mediated analog multievent recording aperture is a tool developed by David Liu and Weixin Tang of Harvard university to record the molecular interactions within a cell, all of which are stored on the cell’s DNA. This new discovery allows scientists to observe and therefore clarify the processes that contribute to such things as the emergence of cancer, aging, environmental damage, and even embryonic development. CAMERA is only one of the many developments based off of the gene cutting technology known as CRISPR-Cas9.

Thyroid Cancer Cell Line. Courtesy of NASA’s Marshall Space Flight Centre and Flickr Commons. 

What is CRISPR-Cas9 you ask? Well, it’s basically a really small pair of scissors, so small that it can even cut DNA. CRISPR-Cas9, or CRISPR for short, is a technology based off of the natural defence mechanisms found in bacteria that have been reengineered for editing genomes. It has the ability to cut the double helix strand of DNA allowing for researchers to easily alter DNA sequences and modify gene expression. Some of the major implications of this include the possible correction of genetic defects, and the treatment and prevention of cancer and other diseases.

Video recreating a CRISPR-mediated genome editing. Courtesy of McGovern Institute for Brain Research at MIT .

So how did scientists develop a cellular recording device from this cutting tool? When CRISPR cuts a DNA strand to alter the sequence, the strand will naturally repair itself but in doing so can occasionally add in errors that make the targeted gene inactive. These random errors can sometimes be used as markers, mapping out the cell’s pattern of differentiation. Liu and Tang took this information and set out to regulate it thereby creating a more detailed, continuous record of a cell’s life, documenting not only its responses to external factors but the severity of the response and how long it lasts.

Flowchart of CRISPR mediated gene alterations. Image courtesy of Flickr Commons

At this point in time, CAMERA, is able to document cellular responses to light exposure, antibiotics, viral infections, and internal molecular interactions in as few as 10 cells. As well, it can record multiple events at once making it an impressive candidate for future medical technologies involved in screening embryos for a wide variety of mutations during development. Despite these impressive feats, Liu and Tang are still working towards pinpointing the recording down to one cell, allowing scientists to one day observe the processes of each cell individually and efficiently isolating any mutations. Another big step is proving it works to the same detailed extent when placed in the body of a living mammal as it does in a small cell group in a petri dish. There is still a lot to be done before we can confidently say we know how cells operate but CAMERA is a step in the right direction.

-Tenanye Haglund

Microwaves: Do They Really “Give You Cancer”?

 

“Don’t stand in front of the microwave! You’ll get cancer.” Growing up, we hear this at home repetitively over and over again. In contrast to this widely believed myth however, microwave ovens do not “give cancer” to people. The mechanism that a microwave functions by is not so complex, but the assumptions made around it are questionable.

Much of our world today revolves around convenience. We often see people choosing convenience over cost, quality, conscience, and sometimes even safety. In this context, microwaves are fantastic to use in daily life – the energy efficiency, ease of use, and rapid processing time make them increasingly popular.

But how exactly do microwaves work? This is a question that needs to be addressed before we discuss anything else. Simply put, microwaves produce radiation that is absorbed by water molecules in whatever is inside the microwave. These water molecules then vibrate and produce heat, causing the food to cook. This mechanism is what allows microwave ovens to heat our food in such a short span of time, while the chemical structure of the food components are not altered in any way.

In The Journal of Agricultural and Food Chemistry, a study found that when microwaved, broccoli retained its minerals all except for vitamin C. What does this imply? Nothing much at all. It is actually easy to lose vitamin C in any type of cooking process, because of its volatility. Microwaves are not the only ones at fault. Luckily, we have raw fruits and vegetables that are abundant in vitamin C to compensate for this deficit.

So what about being physically near a microwave when it is functioning and emitting radiation? The fabrication that microwave ovens cause cancer comes from the suggestion that the energy given off by microwaves is enough to damage one’s DNA. However, Peter Valberg found little evidence to support this relationship between microwave exposure and cancer causation in his study conducted in 1997. He concluded against the existence of a relationship, and very few studies have been carried out after Valberg’s review.

Microwave ovens do not destroy all the nutrients in our food, and neither do they literally cause cancer in humans. It has never been proven that microwaves are actually harmful, whether indirectly or directly. It’s time for the public to recognize the stale saying that “microwaves give you cancer” as ignorant and untrue.

– Sarah Choi

Immune Systems in Space

Humans are getting closer to reaching their goal of becoming an inter-planetary species. NASA is under presidential orders to land humans on Mars by 2033.  However, will astronauts be able to survive such a long and grueling journey?  Little is known about the long-term effects of space travel on the human body. A one-way trip would take about seven months and a round trip could take well over three years, but the longest a human has continuously been in space is just over a year. Our bodies have adapted over millions of years to survive on earth and long-term spaceflight could weaken our immune systems, according to recent research led by the University of Arizona.

NK Cells and the Immune System

The immune system helps to fight infections and protect our bodies from illnesses. It is made up of many types of cells, including white blood cells which help destroy invaders and protect against diseases that can make us sick. One of these cells, called the NK (natural killer) cell, is especially important since it is responsible for killing infected/cancerous cells. NK cells are especially important during space travel since the body may be exposed to larger amounts of radiation and there is a possibility of increased cancer risk.

Astronauts in space will not be protected from radiation by Earth’s atmosphere. Courtesy of Wikipedia.

The research team tested the blood of astronauts who had been in space for at least six months and compared these test results to those of healthy individuals on earth. Results were taken before and after spaceflight, and even twice during the flight. What they found was shocking, the NK cells from blood taken during and after spaceflight were about 50% less effective than the NK cells from blood taken before spaceflight. Even blood samples taken 90 days into spaceflight contained NK cells that were much less effective. Richard Simpson, one of the authors of the study explained how NK cell activity decreased; “When we look at the function of the astronaut samples during flight compared to their own samples before they flew, it goes down. When we compare them to controls who stayed on Earth, it still goes down.”

Small Piece of the Puzzle

Safely transporting astronauts to Mars is no small task, and this highlights one of the many challenges faced by engineers and scientists. Problems that we consider small or things we take for granted have to be carefully thought out.  Engineers have to invent solutions for problems that we may not see as problems. It is amazing how many factors are at play and must be accounted for when planning a project of this magnitude. Nevertheless, countless individuals are hard at work tackling numerous problems such as this. Simpson and his team are actively working to find a solution, hoping that a combination of nutrition and fitness can be used to keep NK cells effective. If successful, their hard work will contribute to one of the finest achievements of the human race.

Render of an astronaut gazing across Mars.  Courtesy of NASA.

 

-Sukhman Bhuller