Category Archives: News

Scientists have created a device that produces plastic from CO2 and sunlight energy from artificial photosynthesis.

Scientists from the National University of Singapore (NUS) have created a device that imitates natural photosynthesis and uses a greenhouse gas to make ethylene gas (a primary ingredient in polyethylene, the most common plastic in the world). This method requires only sunlight, water and CO2,making for a non-destructive and eco-friendly alternative to current ethylene production methods.

Polyethylene demand and production challenges

Polyethylene is in extremely high demand for its use in everyday objects. Humans produce 10`s of millions of tonnes of polyethylene each year, and demand is increasing in correlation with the exponentially growing population. According to a study done from the Freedonia Group, demand for polyethylene will surpass 220 million tonnes by 2020.

Current methods of ethylene production require the burning of fossil fuels, which pollute the atmosphere with greenhouse gases. Producing one pound of ethylene returns two pounds of carbon dioxide [3]. Additionally, fossil fuels are a limited resource, straining its availability. These challenges have driven Professor Jason Yeo Boon Siang and his team in finding a renewable and environmentally-friendly way of producing ethylene

Artificial photosynthesis and ethylene production

Two photosynthetic by-products are crucial to our existence: Sugars and oxygen. These products make photosynthesis important to humans. Photosynthesis is defined as  the chemical process in which plants use the energy of the sun to make carbohydrates from carbon dioxide and water. This is nature`s convenient method of handling carbon dioxide in the atmosphere.

In 2015, the scientific team created a copper catalyst that could produce ethylene in the presence of water and carbon dioxide when stimulated with electricity. They then combined this copper catalyst with an artificial photosynthesis system to create a device that could create ethylene by using solar energy in place of electricity. This prototype, if up-scaled on an industrial level, could revolutionize the current eco-harming methods of polyethylene production, and could potentially decrease CO2 concentrations in the atmosphere for future years to come. Not only does this new device produce ethylene with a clean and renewable energy source, it also cleans the air we breath!

Doctor Yeo said: “Carbon capture is a key step in fighting human-driven climate change. There has been a steady increase in the atmospheric concentration of carbon dioxide, because the rate of carbon dioxide emissions exceeds that of carbon capture. This has been attributed as a major cause of global warming which leads to undesirable environmental changes. Our device not only employs a completely renewable energy source, but also converts carbon dioxide, a greenhouse gas into something useful. This could potentially close the carbon cycle.”

The future of sustainable plastic production:

 

Source:

  1. National University of Singapore. “Scientists develop artificial photosynthesis device fo greener ethylene production.” ScienceDaily. ScienceDaily, 24 November 2017      <www.sciencedaily.com/releases/2017/11/171124084755.htm>.
  2. Peng, Y.; Wu, T.; Sun, L.; Nsanzimana, J. M. V.; Fisher, A. C.; Wang, X. ACS Applied Materials & Interfaces 2017, 9 (38), 32782–32789.
  3. Posen, I. D., Jaramillo, P., Landis, A. E., & Griffin, W. M. (2017). Greenhouse gas mitigation for U.S. plastics production: energy first, feedstocks later. Environmental Research Letters, 12(3), 034024. doi:10.1088/1748-9326/aa60a7

-Sina Alavi

Earliest image of men and dogs – a brief history of our friendship

“I think my Instagram should be renamed, like the album of my Husky.” Said my friend Katrine last week. “That’s why I never post on Instagram,” I replied. “I don’t have a friend that close to me.” Humans’ fevers for dogs spread everywhere on the internet, and dogs have entitled “humans’ best friends” for a very long time. In fact, human relationship with dogs is a very long story, and we can trace it way back when the world population was only about 5,000,000.

 

A paper published in Journal of Anthropological Archaeology last month revealed that sandstone carved images of humans and dogs were discovered in northwestern Saudi Arabia. Scientists suspected the images to be world’s first images of humans and dogs.

 

earliest image of men and dogs” from paper in Journal of Anthropological Archaeology

 

In this image, the man, with an arrow in his hand, has dogs following him hunting the big mammals together. Scientists noticed that there are very obviously carved lines between the man’s waist and the dogs’ necks. Similar lines appeared in the other images at the site, and researchers stated that the lines were probably leashes, and dogs were already domesticated, trained to assist human hunting activity at the time. From the weathering condition of rocks and the sequence of drawings, scientists concluded the art is at least 8000 years old.

 

“It’s the only real demonstration we have of humans using early dogs to hunt.” Said Melinda Zeder, an archaeozoologist at the Smithsonian Institution National Museum of Natural History, Washington, D.C.

 

Scientists have hypothesized the collaboration between dogs and hunters a long ago. In fact, in an earlier study that provided a hypothesis of dogs’ domestication for hunting, evidence indicated mammoths were massively killed at a time when humans did not have compatible weapons in Europe, and dogs were likely accompanying hunters. Dogs, evolved and inherited from wolves, could identify preys by scents and growl in groups to hold preys in place. In fact, another research team also found in Japan that humans from 2,400-16,000 years ago buried their dogs with shreds of evidence that they were hunting partners.

 

Today is always the consequence of yesterday. We now consider dogs are such good friends of humans because the friendship arose since a very long time ago. In the past, humans fed and sheltered dogs while dogs assisted humans for hunting. It is domestication but also collaboration, with the common goal of survival for both men and dogs. It is the result of natural selection. Today, aside from gaining “likes” on social media, dogs are still helping men on a lot of practical aspects such as guidance for the disable, therapeutics, DEA detection. Like the carved images on the stone, our friendship with dogs never faded as time went by.

A guide dog working” by Yahoo! Accessibility lab from Flikr. CC BY-SA 2.0

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Youtube: How dogs became our best friends

-Zhou Wang

How do airbags work? Deadly poison in your car’s air bag!!!

Have you ever wondered how do airbags work? Do you know airbags are not inflated by any compress gas source but rather the product of a chemical reaction?? The reagent of the reaction is a really Toxic salt called sodium azide, NaN3, but is it gonna KILL you???

Under normal condition, this salt is really stable. However, if it’s heated, the salt will decompose immediately and give sodium and nitrogen gas as products.

2NaN3 → 2Na + 3N2

The equation above describes how sodium azide falls apart. It is noticeable that after the reaction, the total volume of the chemicals increased since there is only solid before reaction. And it can be calculated that under standard state condition, 130 grams of sodium azide produces about 67 liters of nitrogen gas which can inflate a normal airbag immediately (in 0.03 s!!) as the sensor detect a collision!

The following video shows how fast an airbag will expand!

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You may notice that nitrogen isn’t the only product of this reaction. It produces sodium, too! Sodium is a quite reactive metal and will form sodium hydroxide (click to see the hazards) which is a strong base when reacting with water. Thus it would be hazardous if it got into your nose or eyes. To minimized the risk, sodium azide is always mixed with other chemicals which convert sodium metal into less hazardous salts. The most commonly used chemicals are potassium nitrate and silica.

It can be seen from the equations above that the final products of the overall reaction are nitrogen gas and Na2K2SiO4 which is a harmless alkaline silicate (click to see the hazard).

Overall, the airbag does contain toxic substances, but it is quite stable and sealed inside your car. It will NOT kill you definitely!!! When the airbag is inflated, all the toxic chemicals will be converted into harmless substances which are nitrogen gas and alkaline silicate.

Written by Xuan Wang

Why Do Onions Make Us Cry?

Via Wikimedia Commons

While I love cooking with onions, I absolutely hate cutting them. The stinging I feel when I slice through an onion is a sensation that I am very familiar with; however, I am not as familiar with the reason why. Like me, researchers were unsure what exactly happens between slice and tears, until a recent study on the structure of the enzyme responsible for the burning sensation when cutting onions, Lachrymatory Factor Synthase.

It was known that, when chopping onions, the broken cells’ cytoplasm releases amino acid sulfoxides that the onion enzyme, allinase, converts to volatile sulfenic acids responsible for the onion’s aroma and flavor. Another enzyme that is released as the cell breaks is lachrymatory factor synthase, or LF synthase. This enzyme converts select sulfenic acids into propanethiol S-oxide, another volatile sulfur gas that, when reaches the water in our tears, produces sulfuric acid. The acid irritates our eyes, which produces the burning sensation and more tears, further increases the burning. While research on allinase, a common enzyme found in plants responsible for producing volatile compounds, is well known, LF synthase is a new idea to the process.

Before 2002, it was believed that allinase produced the tear causing gas from the beginning of cell rupture; however, when a Japanese food company tested the theory, they discovered another enzyme, LF synthase, is really responsible. In order to really understand the complete mechanism, researchers needed to know the structure of LF synthase. And now we do.

Researchers in Ohio wanted to know what LF synthase looked like to gain insight into the enzyme’s role in the onion’s volatile gas mechanism. To do this, they analyzed the structure of the enzyme through X-ray crystallography after crystallizing the enzyme.  When compared to the structure of other plant proteins, they were able to identify the enzyme’s active site and propose a mechanism of propanethiol S-oxide production.

With this new piece of the puzzle, we now have a greater understanding of why we cry when chopping onions. Perhaps, one day, they will use this information to produce onions that do not result in tears. Until then, I will continue to dread making French onion soup.

Perhaps you could also try this man’s trick to cutting onions without tears. YouTube Preview Image

 

Lori Waugh

 

A Clear Perspective wins Nobel Prize

Joachim Frank, Richard Henderson, Jacques Dubochet have claimed this year’s Nobel prize in chemistry taking biochemistry and medicine to a new era. The trio earned the prize for cryo-electron microscopy which is an imaging technique that allows researchers to see proteins and other large bio molecules with atomic precision. Knowing where all the pockets are in molecules helps chemists to get drugs to fit into them which makes imaging techniques vital to understand in order to treat diseases. However, researchers have had really powerful tools for imaging bio molecules for a while. Specifically, X-ray crystallography and nuclear magnetic resonance spectroscopy.

So why this one is so important is because the most decorative methods have short comings. NMR spectroscopy works best for small bio molecules – which is a drag if you want know what a virus looks like for example and if you want to use X-ray crystallography the bio-molecules you are interested in has to crystallize which not all bio-molecules do. Cryo-electron microscopy gets around these problems without sacrificing resolution. Generally speaking, electron microscopy, uses an electron beam rather than light to magnify samples to atomic resolution. But plain old EM isn’t optimized for living things and their molecules. Hitting bio molecules with an electron beam which can damage or destroy them. And electron microscopes work in vacuum which can also damage or destroy bio molecules. Today we are seeing virus and proteins and other structures like never before thanks to cryo-EM.

Cryo-electron microscopy of proteins has advanced from the low resolution image on the left to the detailed image on the right. Attribution: National Institutes of Health

Understanding how Cryo – em overcomes this challenge relies on the fact that the proteins stay in a very thin layer of liquid nitrogen and then they are frozen. The thin layer of nitrogen that they are frozen in allows them to be protected from the beam of electrons that hit them and hence they are not damaged.

Although freezing the samples protect them an electron microscope, ice crystals actually interfere with imaging. In 1982, Jacques Dubochet and his team found they could vitrify water by adding ethane that had been chilled by liquid nitrogen. Vitrify water is a glass like structure and randomly ordered rather than crystal like and hence it doesn’t interfere with imaging. Another obstacle for Cryo-em was image processing power. Early stages of the technology resulted in fuzzy images of proteins and averaged to a whole protein. In the coming years, computers get better and researchers get better in using the technology.

Presently there is an avalanche in Cryo em technology leading to sharper and better images.

Comparison of X-ray Crystallography to Cryo-Electron Microscopy Attribution: Nature

We talked about biology, medicine and a little bit of physics, you must be thinking how does this all fit in with chemistry. Allison Campbell, the president American chemical society states: “To me this is all about chemistry because this enables us as scientists to look at molecules and the arrangement of atoms in molecules and the resulting structure. And that’s all about chemistry”.  I believe the Nobel prize has mostly to do with biochemistry and less about chemistry. Although, the imaging technique can be used to design new targeted drugs for certain proteins it is still mostly a biological advancement rather than a chemical advancement. Maybe a chemistry advancement will win a prize on grounds of biology in the future. Till then we can enjoy crisp images that were only part of a fantasy decades ago.

 

Garvit Bhatt

Dangers of Artificial Food Colouring

Artificial food dyes are additives that are used to enhance the colour of various foods. The food industry has used food colouring as a tactic for many centuries to make food look more appealing to consumers. Would you rather eat a colourless lollipop, or a rainbow coloured lollipop? Although artificial colouring is widely used, it is linked to a number of health problems such as cancer in animals and increased hyperactivity in children.

Lollipop (By Graham and Sheila)

For many of us, it is almost impossible to go a day without consumption of artificial colouring. Colouring agents are found in beverages, candies, cereals, and in most processed foods. Health Canada has permitted 13 colouring agents that are considered safe, including Brilliant Blue (or Blue #1), Allura Red (or Red #40) and Tartrazine (or Yellow #5), the 3 most common colouring agents.

In “Food Dyes: a Rainbow of Risks”, CSPI (Center for Science in the Public Interest) revealed health issues linked to nine food dyes. For instance, Citrus Red 2, which is used for colouring the skins of oranges, is toxic to rodents and is linked to bladder tumor. Yellow 5, which is used in beverages, cereals, and yogurts, may be contaminated with cancer-causing chemicals and is linked to hypersensitivity reactions in children.

A study published in 2007 also found that artificial colours increased hyperactivity in children. The results were achieved from 267 studies in 3 year old and 8/9 year old children. The children were given a placebo drink, or a drink containing artificial colouring equivalent to the amount of colouring found in two bags of sweets. The children consumed the drink everyday for a total of 6 weeks. During the study period, three measures of behaviour, the ADHD rating scale, the hyperactivity scale and the classroom observation code were used to study the hyperactivity in children. The researchers found that the results were consistent with those from other studies.

Top: Chocolates coloured with Brilliant Blue. Bottom: Chocolates coloured with natural spirulina (By John Penton)

Although there are potential health effects linked to artificial food colouring, I still want my M&M’s chocolate and Jell-O to be coloured. Thankfully, more companies are looking for natural alternatives to replace artificial colours and meet the public’s desire for natural products. Natural colour sources such as cyanobacteria Spirulina can replace Brilliant Blue, curcumin from turmeric can replace yellow, and chlorophyllin from chlorella can replace green. Furthermore, Health Canada has set many restrictions to limit the amount of food colours that can be used, and the types of food the colours can be added to. However, if you are concerned and want to limit artificial colours in your diet, look for food labels that say, “no artificial colours”, or shop at grocery chains that do not sell food with artificial colouring, like Whole Foods Market.

An interesting video that talks more about the potential health effects of artificial food colours is shared below.

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Carmen Chu

Did We Forget Fukushima?

The Fukushima Daiichi Nuclear Power Plant. Attribution: Google Maps

You may recall, in March of 2011, the magnitude 9.0 undersea megathrust Tōhoku Earthquake that devastated the coast of Japan by tsunamis and killed tens of thousands. You may also recall the nuclear disaster when the Fukushima Daiichi Nuclear Power Plant’s emergency generators shut down, causing meltdowns, hydrogen gas explosions, and radioactive release into the ocean. While, like me, you may remember the constant focus by the news on the disaster and the failure of the Tokyo Electric Power Company in adequate preventative measures leading to the plant’s inability to manage during a tsunami.

That being said, you, also like me, may have put your focus on other, more recent topics, and forgotten about the entire situation. News is constantly updating and to think of what is happening now and what has ever happened is simply too much for the brain. So, let me remind you.

The nuclear plant is still leaking. According to the Japanese government, 300 tons of radionuclide-containing water is released to the surrounding ocean daily, particularly, cesium. This radioactivity is being found in fish, contaminating the fisheries market, and will take decades to clean from oceans or decay.

The Tokyo Electrical Power Company aims to have collected and treated the water pooled around the reactors by 2020 ; however,  to collect all would be impossible and the consequences of the event will remain. Without even considering the everyday struggle that Japanese radioactive refugees are still dealing with, ocean pollution is everyone’s problem.

For more information, watch the following video by Microsoft Research, YouTube Preview Image

 

 

-Lori Waugh

 

 

 

Komodo dragon’s blood could be the key to new antibiotics

Antibiotic resistance has been spreading faster and stealthier than ever. At least 23,000 people in the U.S. die every year from infections that are resistant to even the strongest antimicrobial drug. The increasing prevalence of resistant drugs demands new antibiotics before life-threatening infections cannot be treated.

In Feburary, a study was published in The Journal of Proteome Research that offered a glimpse to a new antibiotic. Researchers from George Mason University found that the blood of Komodo dragons (Varanus komodoensis) could counter antibiotic resistance.

Komodo Dragon (Source: By Bahnfrend)

Komodo dragons are the largest living lizards, growing up to 3 metres in length. They have thrived on Indonesian islands despite competition with other venomous reptiles and harsh conditions. Scientists began to study Komodo dragon because of the dragon’s resistance to their own poisonous bacteria. The dragon has 57 deadly bacteria in their saliva.

Staphylococcys aureus Bacteria (Source: By NIAID)

The scientists identified 48 antimicrobial peptides in the blood of a Komodo dragon that have germ-killing abilities and could be used to develop new drugs. They isolated eight of the antimicrobial peptides found in the dragon’s blood to test them against Pseudomonas aeruginosa and Staphylococcus aureus, two superbugs that are in urgent need of new antibiotics according to the World Health Organization. Seven of the peptides had antimicrobial activity against both microorganisms, while one was only effective against P. aeruginosa.

The antimicrobial peptides in the dragon’s blood inspired researchers to create a synthetic version in the lab called DRGN-1. It was tested on mice with skin wounds infected by P. aeruginosa and S. aureus. When treated with DRGN-1, the wounds healed significantly faster than wounds treated with other antimicrobial drugs or untreated wounds. DRGN-1 broke apart colonies of bacteria on the surface of the wound which accelerated the migration of skin cells to close the wound.

Scientists hope to find more peptides in the dragon’s blood with antimicrobial activity. They believe that this could potentially lead to the development of new antibiotics that will help us fight superbugs.

The discovery of antimicrobial activity in Komodo dragon’s blood is important because we need new antibiotics. Currently, research and development of  new antibiotics is lacking because companies are not willing to invest in developing drugs that are only used for the short-term. The government and the World Health Organization need to manage and encourage drug research better. They need to provide financial incentives like raising the prices of antibiotics or offer companies more money so that antibiotic development is worth the investment. An infected cut could be life-threatening if no more antibiotics are available. Our future relies on more research on Komodo dragon’s blood and the development of new antibiotics.

An interesting video of how “Dragon’s Blood Could Save Your Life” is shared below.

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Carmen Chu

The Magic of Aspirin: Uncovered

Ever have a headache ? fever ? you’ve probably have taken  aspirin or acetyl salicylic acid in your life. Aspirin has been used by humans for more than 2500 years ever since someone had discovered that chewing willow leaves treat the discomfort. This is because of salicin which is turned into salicylic acid in the body allow for the discomfort to be treated. Chemists such as Charles Frederic Gerhardt and Felix Hoffman experimented with salicylic acid to make it last longer and make it less toxic in the body which lead to the creation of aspirin or acetyl salicylic acid. Most people have taken aspirin and enjoyed the comforts it brings in terms of fevers or headaches. But how does aspirin actually work in the body ?

 

Salicin the compound found in Willow leaves initially used to treat headaches , fevers and inflammation Attribution: Wiki Images (https://upload.wikimedia.org/wikipedia/commons/a/ab/Salicin-2D-skeletal.png )

 

The body has many ways to fight an infection it could cause a fever by raising the temperature and allow the pathogens to die , it can generate immune cells to generate chemicals in order to fight pathogens and infections or they can generate other chemicals recruiting other immune cells as backup. The body has natural ways of dealing with pathogens and bacteria. Hence , aspirin should only be used when the fever is lasted longer than expected or the body temperature is fairly high. In 1971 , the discovery of the chemical prostaglandin was found to be responsible for fever , pain and inflammation. Aspirin treated these symptoms by preventing the release of prostaglandin. Prostaglandins are produced in various forms and their functions include but are not limited to  increase of body temperature , stimulation of immune cells , initiation of blood clotting and much more. Prostaglandins are released from an enzyme known as Cyclooxygenase or COX. An enzyme is a chemical substance which increases the speed of a reaction. Most enzymes require a missing piece , known as a substrate , this substrate binds to the enzyme and activates it in order to speed up the reaction taking place. Cyclooxygenase’s substrate is known as Archidonic acid , when this substrate binds to the enzyme it releases prostaglandins so they can act on the body and cause inflammation , pain and a rise in temperature.

The production of prostaglandin from the enzyme COX Attribution: Wiki images  https://upload.wikimedia.org/wikipedia/commons/thumb/0/07/Prostaglandin_E1.svg/1486px-Prostaglandin_E1.svg.png

When you take aspirin or acetyl salicylic acid , it binds to the enzyme COX              (cyclooxyengease) and prevents its substrate (Archidionic acid) to bind. The acetyl salicylic acid binds irreversibly , meaning that it does not unbind easily and requires energy for it to unbind from the enzyme. The loss in production of prostaglandins results in less inflammation , pain and fever.

However , prostaglandins are also responsible for blood clotting and if they are blocked from being produced , blood clotting will not occur as effectively. Aspirin should be taken with care and only when required. Other medication such as acetaminophen (Tylenol) or ibuprofen (Advil) are a better substitute in the case of the fever or body temperature not being as high. Some people might think an alternative to medication are “natural” remedies that directly arise from plant based foods. They tend to forget that medication is synthesized from plants. I believe that medication is the way to go for the best treatment of most type of illness. So next time you take an aspirin you can be thankful for that willow plant someone ate a few thousand years ago !

– Garvit Bhatt

Psychedelics… Not Just for Hippies Anymore

“Never do drugs!” Constantly, throughout childhood and adolescence, it is drilled into our brains that drugs will ruin our lives. However, new research is indicating that some drugs may be a positive influence in many aspects of our mental health. No, I’m not trying to tell you that shooting heroin or snorting cocaine will cause you any benefit. But, when clinically mediated, use of hallucinogenic (psychedelic) substances such as lysergic acid diethyl-amide, LSD (colloquially known as acid), and psilocybin, the active chemical in “magic mushrooms”, may lead to a healthier perspective on life. But how can illegal drugs offer any benefits?

An artist’s rendition of the mindfulness experienced during an acid (LSD) trip

Can you tell me a time that you’ve felt not as a human, but as an internal cog in a non-definitive life force that extents through you? Experiencing an unfathomable connection between your soul and each fibre of every living thing on the Earth. For an instance, you understand that your reality is a nothing but a tribute to life itself. The answer for most: “of course not, I’m not crazy..?”. This is how I would best describe the awe-inspiring  experiences I have had with the mind-reviling effects of psychedelics. No, I’m not insane. But these experiences have changed the way I view the world, amplifying my appreciation of life, and allowing me to see existence in a new and humbling way.

Now my claims may seem outlandish, but studies at Imperial college London have illuminated the therapeutic mind-expanding effects of psychedelic drugs for those with depression, addiction, death anxiety, PTSD, and even for the general public. As world renowned psychedelic drug researcher Dr. Robin Carhart-Harris explains in interviews with CNN and presentations with TEDx: “This experience is sometimes framed in a religious or spiritual way — and seems to be associated with improvements in well-being after the drug’s effects have subsided”.

With the use of modern brain-imaging technology, Dr. Carhart-Harris is attempting to reduce the public stigma on these kinds of drugs.  MRI brain imaging scans, when compared to a placebo, have displayed a mind ‘lit up’ with unified activity under LSD conditions. Results of mindfulness questionnaires, taken by LSD users in the same study, emphasize a sense of openness and optimism while experiencing the drug’s effects.

MRI scans from Dr. Carhart-Harris’ study. This image reveals that, with eyes closed, much more of the brain contributes to a unifed visual experience under LSD conditions than with a placebo.

 

This area of study is young. Extensive research is required before LSD and psilocybin are removed from the dangerous drug index. Education is vital for people to understand the benefits these drugs can offer. I believe the improved respect for Earth and all its organisms may be the key for peace for those effected with mental illnesses and a cure for the hate that is far too present in society today. Through my personal experiences, I can assure that psychedelics facilitate beneficial reshaping of your way of thinking. In turn, these substances could create a more positive, harmonious world with acceptance and contentment through revised perspectives.

Joey Krahn