The OTHER Foreign Accent Syndrome : I do not understand nor believe you !

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As shown in the video above, humans love to imitate accents from around the world. Studies from the University of Manchester  believe that  if you talked to someone in their accent, you would understand  them better. Our brain is  an accent discriminator and tends to doubt foreign accents.The moment we hear an accent we diagnose the person as foreign and unfamiliar.

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An accent is defined as a  distinctive way of pronunciation, inflections, tones and emphasis patterns. In 2010, University of Chicago psychologists Shiri Lev-Ari and Boaz Keysar studied how the brain processes non-native accents in a report entitled ” Why don’t we believe non-native speakers?:The influence of accent on credibility”. This would prove that our brain doubts foreign accents therefore the credibility of one’s words is lost behind one’s accent. People were asked to judge the truthfulness of trivia statements received from either native and non native English speakers. Lev-Ari and Keysar hypothesized that if the subject found the statement less believable when the messenger had an accent then credibility  was associated to the ease of processing the speech known as cognitive fluency.

Experiment 2 : Truth ratings as a function of accent by Lev Ari and Keysar

In the second part of the experiment, Lev-Ari and Keysar tested if the doubt would be observed if subjects were aware that they were doubting foreign
accents. Therefore, this time, the psychologists informed the participants about  the purpose of their study on cognitive fluency and credibility. Nonetheless, the same conclusions were observed in which statements were less believed when the messenger had a heavy accent. The psychologists suggested that instead of perceiving their speech as harder to understand, it was thought as less truthful.

Listen, Understand, Act via Flicker by highersights

This research was then compared to  the University of Michigan ‘s study on the impact of a decreased font size when asking subjects :  “How many animals of each kind did Moses take on the Ark?” [Answer: None – Moses wasn’t on the Ark, Noah was].  Font size like accents decreases cognitive fluency.Researchers now go on to say that one should practice analyzing small fonts more carefully and do likewise with non-native accents.

See How Nigerians pronounce…

However, Pavel Trofimovich, applied linguist at Concordia University, believes that one should listen beyond the accent and judge credibility with grammar and vocabulary, hence, comprehensibility. Similarly, his British colleague, Talia Isaacs highlights the importance of identifying aspects of speech that don’t actually affects listener’s understanding  but enhance stereotypes. Upon researching about accents, it is easy to come across these stereotypes with imitations.

Ultimately , we should be aware of both accents and comprehensibility.Imitation  may help to adapt to one’s  accent. However, there is a risk of falling into offensive stereotypes . Similarly, one must be aware and parse the brain’s discrimination towards unfamiliar and foreign accents.   Therefore, refocus on judging the messenger’s credibility with both their actions and words not just their accents.

– Diane Mutabaruka

Bloody Sunscreen

As summer rapidly approaches, it brings with it the hot sun, dark tans, and skin burns. As undesirable as skin burns are, many people use things like sunscreen to combat this, while those who do not, become susceptible to things like skin damage. Now, Imagine a world in which there was no need for sunscreen. This is the world of the Hippopotamus, more commonly known as the Hippo.

Wikimedia commons via Micha L. Rieser

Hippos puzzled people for many years, as they appeared to sweat out blood. Studies have busted this myth, revealing that the Hippopotamus releases a sticky secretion from its skin, which is originally colourless. This colourless substance later changes its colour to red, giving rise to the idea of “bloody sweat”. This occurs due to two little pigments in its skin, which polyerize.  One of them is orange (called: “norhipposudoric acid” ) and the other red ( called: “hipposudoric acid”). Both of these pigments absorb Ultraviolet (UV) Radiation, offering protection from the suns harmful rays, whereas the red pigment specifically, has anti-bacterial properties. This helps the hippo fight disease-causing agents like bacteria and viruses, as well has helping it recover from wounds. This is very important as hippos tend to fight a lot , leaving lots of wounds, scratches, and cuts.

Wikimedia Commons via William Warby

This amazing sweat not only protects the hippopotamus from the sun, but also helps keep its skin moist, which is crucial for this large animal. This is because it sticks onto the hippos skin – wet or dry, which is very convenient as the hippo spends a large portion of the day in the water.

Wikimedia via BS Thurner Hof

Great interest has been generated from this perspiration, as scientists and entrepreneurs a like, marvel at the idea of producing a similar product for humans, with the properties of sunscreen, sunblock,as well as being an antiseptic. No such product has yet been synthesized, but the future looks promising!

 

-Tabish Khan

 

A Gene for Skinny Jeans!

The person sitting beside you in your morning lecture is slurping down an extra-large iced cap, with whipping cream AND chocolate drizzle. Those french fries in the cafeteria at lunchtime are looking deliciously tempting, and when you get home from your long day your roommate has a fresh batch of chocolate chip cookies sitting on the counter.

Chocolate Chip Cookies! Christie @ Love From the Oven via Flickr Creative Commons.

Oh the temptations, but with “beach season” soon approaching, it makes for a hard choice between those deliciously fattening foods and a trim waistline. What if I told you that soon, you may be able to indulge in all of your favorite foods, never hit the gym, and still turn heads in your swimsuit this summer?!

Miguel Angel via Flickr Creative Commons.

Genetics researchers at the University of Colorado’s School of Medicine, led by Professor James McManaman, have recently discovered a gene that appears to be directly related to obesity. This gene, called Perilipin 2 (Plin2), produces a protein that plays a key role in regulating fat storage and metabolism. When mice lacking this gene were fed an obesity-inducing diet, they were observed to be resistant to becoming obese!

In fact, not only did these mice stay lean, they appeared to be much healthier than the mice with a functional Plin2 gene. Compared to normal mice, their fat cells were 20% smaller, they showed an absence of fatty-liver disease, they had lower triglyceride levels, and they were more insulin-sensitive. When both normal mice and mice lacking the Plin2 gene were placed on an obesity-inducing diet, the Plin2-lacking mice showed surprising restraint when eating their food (normal mice will eat until all food is gone!), and were also more active.

Obese mouse and normal mouse. Bigplankton via Wikimedia Commons.

What does this mean for us?

Obesity is quickly becoming a dominant health concern throughout North America (see famous chef Jamie Oliver discussing the obesity trend here), indirectly causing a long list of medical complications such as type 2 diabetes, hypertension, coronary heart disease, and stroke.

Obesity, an increasing trend in North America. Malingering via Flickr Creative Commons.

The interesting thing is, humans also have a Plin2 gene. If researchers can find a way to target the Plin2 gene, these findings may result in an effective treatment for obesity. This would lead to a slimmer, healthier nation, and reduce the financial strain  that obesity-related complications place on our health care systems!

However, don’t book your reservation at the neighbourhood all-you-can-eat buffet just yet. Before any human applications can be made, we must better understand what other roles the Plin2 gene may play, and how removal of this gene will influence health and behavior on a long-term scale.

– Sydney Schnell

The Science Affairs of Mice and Men

You may not have worried too much about Pinky and The Brain actually taking over the world in the past, but with a new procedure that transplants human brain cells into mice, the 90s cartoon may not be too far off.

Humans have two major types of cells in their brain. Neuron cells are responsible for sending electrical and chemical signals throughout your nervous system. Until now, the other type of cell has been largely ignored in regards to communication and learning. These glial cells have been thought of as structural cells that provide protection and support for neurons. The typical jobs of glial cells (purple, green and blue cells), supporting and protecting the neurons (yellow cells), are pictured below.

Via Anmats on Wikimediacommons

Researchers from the University of Rochester performed an experiment in which they transplanted human glial cells into newborn mice. When these mice reached adulthood, human glial cells had replaced a large percentage of the mice brain cells in the front areas of their brains.

Via Rama on Wikimedia commons

Testing of these mice revealed that they had an enhanced ability to learn. Analysis of their learning abilities was done using a variety of techniques, such as the Barnes maze test (pictured below). In this test mice are placed on a circular surface with visual cues on the board and many holes around the edge. The mice must locate and remember, based on the visuals provided, the hole that it can use as an escape route from the circular platform. Mice with transplanted human cells demonstrated a shorter time in completing this task. As well, they made fewer errors (choosing the wrong hole to try and escape) when completing the task.

Example of a Barnes maze setup
Via Marcoesiste on Wikimedia commons

This experiment indicates that human glial cells enhance learning and the brains ability to make new connections (neuroplasticity) in mice. In addition to creating super smart mice, this procedure also shed some light on the potential functions of glial cells in humans.

You can go to NPR and listen to an interview about neurons, glial cells and this research by clicking here

What does this mean for the human brain? The human brain is creating new connections and pathways every time you remember something or have a new thought. How much of this is strictly because of neurons, and how much relates to glial cells?

Glial cell: superstar of the brain
Via Methoxyroxy on Wikimedia commons

The evidence from this experiment supports the idea that the evolution of the human brain may be dependent on glial cells, and not just neurons. With this new information researchers need to evaluate what they believe the functions of glial cells actually are. Are they lowly structural cells or much more than that?

– Miranda Marchand

Camels in the Arctic?!

Traditionally, when we think of camels, we associate them with their signature humps for water storage, extreme endurance abilities and most importantly with hot desert environments. However, the most recent groundbreaking discovery on March 5th by fellow Canadian paleobiologist, Natalia Rybczynski of the Canadian Museum of Nature in Ottawa suggests otherwise.

‘Our camel’ by Neil and Kathy Carey. Retrieved from Flickr Creative Commons.

At the Fyles Leaf Bed site on Ellesmere Island in Nunavut, Rybczynski discovered 30 “wood-like” fragments that were in fact part of the lower leg bone of a camel dated to be at least 3.4 million years old! These fossil remains were collectively retrieved over a span of 3 summer excavations (in 2006, 2008 and 2010). Furthermore, several state of the art techniques were used to verify the authenticity of these fossil remains including “3D laser scanning” and “collagen fingerprinting”.

In fact, the actual alignment and assembly of the fossil fragments were conducted with the help of the 3D laser scanner which uses infrared light to record the distance between each fragment and allow detailed reconstruction of the overall leg structure. On the other hand, collagen fingerprinting technique analyzes the collagen content within samples as this protein seems to be able to survive long periods of burial time. This portion of fossil analysis was carried out by expert Dr. Mike Buckley at the University of Manchester in England.

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It is estimated that the ancient camel is about 29% bigger than our average modern camel which may have been beneficial for their survival but more research has yet to be done. Now that even camels have been found to have lived in the Arctic, what more farfetched discoveries still awaits for scientists to uncover?

-Megan Nien-I Lin

Fact or Fiction?

Now, I’m sure many of us have fallen for some very untrue facts in science.
Here I’ve collected just a few commonly believed myths, and their real explanations!

Myth #1 
People explode in space
Here, we are assuming being unprotected in space, such as a leak in a space suit or some other hazardous accident.

Astronaut
From DeviantArt, User ~Master-Fri

So to clarify,

No, no people do not explode in space and their blood does not boil (unlike what we’ve seen in various SciFi movies). The containing properties of your skin and circulatory system prevent this. 

There would be some swelling of course, loss of oxygen leading to unconsciousness  There would also be skin burns due to being unprotected closer to the sun.

An incident which occurred at NASAs Manned Spacecraft Center (now renamed Johnson Space Center) in 1965 gives us a better idea of what would happen if one was exposed in a pure vacuum, much like space. A test subject was in a  near-vacuum condition, when his space suit started to leak. After about 14 seconds, he fainted. After the chamber was re pressurized  he regained consciousness.  Now obviously we can not be sure exactly what happens, as I’m sure no one would offer to be the test subject, but based off of what we currently understand about space and pressure, we are quite sure that we do not explode. Or boil. Sorry SciFi fans.

Myth #2
Five Second Rule!

Hand Sanitizer
From Wikimedia, User Sean Narvasa

Okay, even I have admitted to doing this. Dropping a piece of food on the ground, picking it up and yelling five second rule, as a way for me to justify eating whatever it is I had dropped without having to worry about germs. This is terribly wrong.

As soon as a piece of food hits the floor, it will stick to whatever germs happen to be there. Now, this doesn’t mean you can’t eat the food, it just means that you may possibly be ingesting a harmful bacteria. And get sick. Up to you.

Myth #3
Brain Cells Can’t Regenerate

Brain
From Flickr.com, User digitalbob8

This was thought to be true for a very long time, until a discovery in 1998, by Sweden and at the Salk Institute in La Jolla, California. The learning and memory center of the brain can regenerate new cells!

Now you can’t be fooled into thinking brain cells can’t regenerate,  but that does not stop you from lightly bopping a friend on the head and saying “Uh oh, you’ve just lost brain cells!”. Not that anyone did that to me as a kid, causing me to worry that I would grow up not knowing anything because I lost all my brain cells… *cough*

And that’s it folks! Want to know some more neat myths? The video down below mentions some of the most common scientific myths

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Video found on Youtube from user alltimetens

-Christina

A baby defeats HIV

Just yesterday, scientists announced that a baby who was born infected with HIV was cured of the disease. The doctors diagnosed the mother to be HIV-positive at the time of labor; the baby was at a high-risk of exposure to HIV, and later confirmed to be infected. After 30 hours of birth, the doctors treated the baby with highly active antiretroviral therapy or HAART, a combination of 3 antiretroviral drugs in order to prevent HIV from making home in the baby’s immune cells. The baby was given treatment for 18 months, and half a year later from quitting treatment, its blood showed no sign of infection.

This is the second case of curing the infected of HIV. The first person to defeat HIV is Timothy Brown who received bone marrow transplant from a donor with HIV-resistant genetic mutation, which is found in 1% of European population.

HIV via flickr user: Microbe World

HIV via flickr user: Microbe World

This “breakthrough” may bring hope to children born with HIV, whose number count to 300,000 worldwide in 2011, and comprise about 1% of HIV patients. However, mother-to-baby HIV transmission is 99% preventable if the mother is treated during her pregnancy. Given that most babies with HIV are born in developing countries where only 50% of pregnant women have access to the medicines, it is crucial to urge wealthy countries to increase their support to organizations such as UNAIDS that work for the elimination of mother-to-baby HIV transmission.

HAART is not a cure for HIV patients at later stage of infection as it can only suppress the virus from replicating rather than killing the viruses themselves. Nevertheless, the news of world’s second case of curing HIV gives hope that the virus may be conquered if actions are taken quickly.

An Origin of Schizophrenia Revealed

 

Comparing the prevalence of Schizophrenia with other diseases. From Schizophrenia.com.

Schizophrenia is a mental illness that is characterized by delusions and hallucinations. Because the symptoms affect the cognitive and social functions of an individual, and the prevalence of schizophrenia is high, psychiatrists and psychologists are doing researches to find origins of this illness in order to develop a better treatment for this illness. A recent stem cell research at University at Buffalo revealed that schizophrenia is induced by defects in an important genomic pathway in a stem cell. These defects in the pathway can be responsible for onset of the disorder later in life.  

This important genomic pathway is called the Integrative Nuclear Fibroblast Growth Factor Receptor 1 Signalling (INFS). It is a platform for the integration of signals that come from many other pathways, involving around 160 genes that are linked to schizophrenia. To study the consequences of the defects of INFS, laboratory mice are used as the model organisms.
 
Using the mouse model, the researchers found some interesting results. It was observed in embroynic stem cells that some genes that are linked to schizophrenia binded with Fibroblast Growth Factor Receptor 1 (FGFR1) protein, which is an essential protein for cell division, cell growth and cell differentiation, and also has a cascading effect on the INFS pathway. To test the relationship between FGFR1 protein and schizophrenia, a mutation of FGRR1 protein was made in the mice. This mutation created structural changes in mice’s brain, alterations in mice’s behaviour, and overwhelmed sensory processes in mice. Those symptoms in mice resembled the human disease, schizophrenia. Therefore, it can be concluded that an alteration in the transition from stem cells to neurons will result in schizophrenia. In addition, this study supported that nicotinic agonists (medications that activates the nicotinic acetylcholine receptors in neurons) could help the schizophrenics to have better cognitive functions.  
 

The picture shows that fibroblast growth factor receptor 1 (FGFR1) interacts with multiple genes that are linked to schizophrenia. Arrows point to the nuclei of human embroynic stem cells. Picture from: University at Buffalo, News Centre.

Researchers found an genomic explanation to the causes of schizophrenia using a mouse model. The head researcher, Michal Stachowiak, mentioned that this can lead to a generalized approach to treat schizophrenia if it is sure that a malfunction of a common genomic pathway is the cause for the disorder. He also proposed that possible methods that would stop the illness from developing could be created in the future. I have a high hope for the development of better treatments and even a cure for schizophrenia based on the current understanding of schizophrenia and technologies.

– (Shirley) Yu Chen