A New Dawn of Early Detection of Sepsis

A new method developed by researchers at the University of British Columbia could help clinicians predict sepsis within an hour using an endotoxin tolerance signature (endotoxin tolerance is defined as a reduced responsiveness to a lipopolysaccharide, also known as LPS, following a first encounter with endotoxin).

Sepsis is one of the most deadly diseases around the world. People should get awareness of  it. This image shows some symptoms of sepsis as well as the cause of sepsis. ( Image Credit: Medical Device)

Sepsis is an inflammatory disease triggered by bacterial infections. There are 18 million cases every year around the world. Diagnosis of sepsis is a race against time because for every hour delay in sepsis diagnosis, there is an eight percent increased risk of death. However, sepsis is difficult to diagnose. A basic diagnosis will take 24 to 36 hours, but with this method, proposed by Professor Bob Hancock’s research group, clinicians can start a therapy immediately.

Check out the following podcast on the background information about sepsis.

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The new method defined a gene expression signature characteristic of endotoxin tolerance. Researchers correlated this gene signature with early sepsis and determine whether this signature was associated with development of confirmed sepsis and organ dysfunction. Overall they found that the subsequent development of confirmed sepsis and suspected sepsis patients with new organ dysfunction are significantly associated with an endotoxin tolerance gene signature. All 593 sepsis patients presented an expression profile strongly associated with the endotoxin tolerance signature (p<0.01). “We could differentiate between guys who are sick but went on to sepsis and guys who did not go on to sepsis”, says Hancock, “also could differentiate guys who could go onto organ failure and guys who would not go onto organ failure.”

Equipment Professor Hancock and his research team used in the research. Photo credit: Xindi Wang

Equipment Professor Hancock and his research team used in the research. Photo credit: Xindi Wang

In the following video, Professor Hancock demonstrate techniques used in his research to find the early detection of sepsis.

A potential misunderstanding about sepsis has also been revealed in the article. Sepsis had been treated as an inflammatory disease; however, many anti-inflammatory drugs failed to treat sepsis. The gene signature, used in this new method found by Hancock’s research team, relates to cellular reprogramming which is a special type of immune-suppression. Hancock emphasizes, “If we can reverse that immune-suppression then we have a really good chance of a new therapy”.

For future research, Professor Hancock suggests that larger clinical trials should be done to confirm these findings. He also expects to increase test functionality in order to  have a fast and accurate diagnostic test for sepsis in the early stage.


 

Reference

Cavaillon, J., & Minou, A. (2006). Bench-to-bedside review: Endotoxin tolerance as a model of   leukocyte reprogramming in sepsis. Critical Care, (10)


 

By Group 2

Harsheen Chawla, Erik Johnson, Lincoln Li and Xindi Wang

To Bee or Not to Bee

Can you imagine a world without honeybees? At first glance, bees can be quite frightening, especially if you are allergic to them.  However, honeybee populations are currently on a steady decline and a loss of these insects can have serious effects on our society.  As it is these small pollinators that have a hand in providing us with a third of what you see in all produce departments. Not to mention, the delicious honey that they provide us.

honey-bees

A group of honey bees. Image credit: Pixabay.com

Pollination is an incredibly important step in producing new healthy plants, some of which are used as food by humans and other species. There are two types of pollination: cross-pollination and self-pollination. Cross-pollination is the process of plant reproduction that requires an external mechanism, such as insects or wind, to transfer the pollen of one plant to another plant of the same species. On the other hand, self-pollination only needs the pollen produced by itself to reproduce.

If pollinators, such as bees, are not in abundance, it can put pressure on plants to self-pollinate, which can lower genetic diversity in plants. A decrease in genetic diversity in one species can lead to a decrease in biodiversity among species’ which can be very harmful to an ecosystem.  Some plants can self-pollinate without penalty, but for others, pollinators are crucial to maintaining genetic diversity in the species.

P1080306 Bombus Rhinanthus

A bumblebee and Rhinanthus minor. Image credit: Dr. Hargreaves

In research led by Dr. Anna Hargreaves, a herb called Rhinanthus minor was studied in the Rocky mountains of Alberta. Interestingly, this herb is able to self-pollinate successfully, but also produces flowers that attract bees to promote cross-pollination. She investigated how a reduction in bee visitations might affect the distribution of the plant. Watch the video below for more details on her research.

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As mentioned earlier, honeybee populations are quickly declining. This is a problem because honeybees are considered to be the primary pollinator of the majority of human food crops. There are several causes thought to affect honeybee populations, including several chemicals contained in pesticides used in agriculture. For this reason, it is important to take immediate action to prevent a decline in the honeybee population.

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Image credit (from podcast) : www.flickr.com

Next time you’re eating peaches, honey, or receiving flowers as a gift, think about how bees have contributed to your life, and what you can do to make sure these products and the bees are available in the future.

Stay buzzy as a bee,

Group 3
Candace Chang, Dixon Leroux, Dorothy Ordogh, & Rafael Alfaro

3-D Printer Changes Building Industry

Have you heard about the new innovative technology, the 3-D printer? Well, the 3-D printer is a printer which has been recently developed and is presumed as the “ultimate builder” for practically anything. From medical equipment to bones and body parts, the 3-D printer is capable making of countless things.

Mojo 3D Printer Photocredits: Wikimedia Commons

Until recently, the 3-D printer was only able to print small objects. The 3-D printer has now been designed for larger scaled objects, such as printing houses and other infrastructures. A Chinese company calleded Winsun has claimed to have built 10 houses in 24 hours (see video below). While in other places, such as Amsterdam, there is a company, DUS Architect, that is replacing cement and mortar with bio-based renewable resources to build houses using 3-D printers. (A link to the DUS Architect Video story)

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Video credit: New China TV

The new technology will be much safer than the conventional method of building and will be cheaper. Alternative materials can be used instead of cement and other common building materials, which are be environmentally threatening. This idea of a machine replacing thousands of construction workers may not sound appealing, but there are some places in the world where there are not enough workers. For example, in developing countries, the working conditions are harsh and workers may not have the correct tools to build a safe house. If a house can be built in 24 hours, people will have a much sturdier and safer house with minimal labor and can be much more affordable.

Photo Credits: Wikipedia

3-D printers may just be the starting point of a completely different lifestyle for the future. With the countless number of uses it has, 3-D printers can replace many machines and potentially reduce harmful actions such as pollution.

-Tommy Kim

To Sip Or To Not Sip? The Benefits of Coffee on Health

Image Courtesy of: Flickr Commons

Image Courtesy of: Flickr Commons

After water, coffee is the most popular beverage consumed worldwide. There are countless reasons that people consume coffee on a day-to-day basis. Many people drink it to stay awake during a long day. Some people drink it in the morning to wake themselves up. According to the National Coffee Association, in 2012 over 64% of U.S. adults over the age of 18, regularly drank coffee. Many people wonder if this number is something to worry about – what kind of effect does coffee have on our overall health? Luckily for all those coffee drinkers out there, there are numerous health benefits for drinking that morning cup of joe.

In a recent study, coffee has been found to have a positive effect on Parkinson’s disease. Parkinson’s disease is a disorder caused by progressive impairment of neurons in the brain, usually occurring in the aging population. When these neurons function normally, they produce dopamine; a transmitter that serves as a messenger between parts of the brain. This lack of dopamine seen in Parkinson’s disease causes poor coordination and muscle motion, ultimately leading to loss of control of body movements. The caffeine in coffee helps prevent the dopamine deficits that are characteristic of Parkinson’s. Therefore a higher intake of coffee is associated with a lower incidence of Parkinson’s disease.

Both Alzheimer's and Parkinson's Effect the Aging Population Image Courtesy of: Flickr Commons

Both Alzheimer’s and Parkinson’s Effect the Aging Population
Image Courtesy of: Flickr Commons

According to this same study, coffee may prevent the onset of Alzheimer’s disease as well. Alzheimer’s disease is a type of brain disorder that causes problems with behavior and memory, occurring more frequently in the aging population and those with damaged neurons in the brain. A component of coffee beans called Trigonelline showed regeneration of nerves in the brain, significantly improving memory in Alzheimer’s patients. To be clear, coffee consumption does not cause a decline in the symptoms of Alzheimer’s disease, it is associated with reduced risk of Alzheimer’s, and a reduction of some of the common symptoms of Alzheimer’s patients.

Additionally, another study showed that coffee drinking is inversely associated with mortality, meaning coffee consumption is associated with living a longer life. A comparison was done between men who drink coffee and men who don’t, and it was seen that coffee drinkers had a 10% lower risk of death. When comparing females, a 15% lower risk of death was seen in those drinking coffee. Coffee consumption was also found to be inversely related to major causes of death such as heart disease, respiratory disease, stroke, diabetes and infections.

These studies have shown that coffee consumption has an inverse relationship with death and disease of many causes. All in all, coffee is surprisingly found to have an overall positive effect on people’s health. So welcome that morning coffee, and know that it is having a positive effect on your health!

Check out this video on the positive effects of coffee!

YouTube Video Courtesy of: Natural Foods Diet

Posted by: Alex Ensing

 

Hydrothermal Vents: Home Sweet Home?

One of the most wildly debated and difficult to answer questions in any field of science is the origin of life. From where did we come? One of the most widely accepted hypotheses of our origin points to hydrothermal vents, fissures deep within the ocean that spew water heated by geothermal activity. The water these vents exude is filled with minerals and as a result dense communities of deep sea life congregate around them, as seen in the video below uploaded by Youtube user MrCoxyWoxy.

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What makes some researchers believe this is where it all began? The alkaline hydrothermal vents interact with the carbon dioxide-rich seawater in a bunch of redox reactions, in which electron acceptors, in this case the carbon dioxide, receive electrons from electron donors such as molecular hydrogen. These reactions are exothermic and release a lot of energy, meaning that hydrothermal vents are a source of sustained chemical energy from beneath the sea floor. Such an environment, ideal for the redox reactions, is a great candidate for the origin of life. It’s even been demonstrated that deep sea vents can create the same type of proton-motive force seen in living organisms.

Redox reactions are how life harnesses chemical energy. When we digest food, our cells carry out redox reactions in order to extract the nutrients in it. Since hydrothermal vents are full of the building blocks required for redox reactions involving hydrocarbons like the ones we utilize for food today, it seems possible that the chemical processes our bodies use originated in hydrothermal vents.

By Erik Johnson