Category Archives: Biological Sciences

A New Dawn of Early Detection of Sepsis

A new method developed by researchers at the University of British Columbia could help clinicians predict sepsis within an hour using an endotoxin tolerance signature (endotoxin tolerance is defined as a reduced responsiveness to a lipopolysaccharide, also known as LPS, following a first encounter with endotoxin).

Sepsis is one of the most deadly diseases around the world. People should get awareness of  it. This image shows some symptoms of sepsis as well as the cause of sepsis. ( Image Credit: Medical Device)

Sepsis is an inflammatory disease triggered by bacterial infections. There are 18 million cases every year around the world. Diagnosis of sepsis is a race against time because for every hour delay in sepsis diagnosis, there is an eight percent increased risk of death. However, sepsis is difficult to diagnose. A basic diagnosis will take 24 to 36 hours, but with this method, proposed by Professor Bob Hancock’s research group, clinicians can start a therapy immediately.

Check out the following podcast on the background information about sepsis.

Audio clip: Adobe Flash Player (version 9 or above) is required to play this audio clip. Download the latest version here. You also need to have JavaScript enabled in your browser.

The new method defined a gene expression signature characteristic of endotoxin tolerance. Researchers correlated this gene signature with early sepsis and determine whether this signature was associated with development of confirmed sepsis and organ dysfunction. Overall they found that the subsequent development of confirmed sepsis and suspected sepsis patients with new organ dysfunction are significantly associated with an endotoxin tolerance gene signature. All 593 sepsis patients presented an expression profile strongly associated with the endotoxin tolerance signature (p<0.01). “We could differentiate between guys who are sick but went on to sepsis and guys who did not go on to sepsis”, says Hancock, “also could differentiate guys who could go onto organ failure and guys who would not go onto organ failure.”

Equipment Professor Hancock and his research team used in the research. Photo credit: Xindi Wang

Equipment Professor Hancock and his research team used in the research. Photo credit: Xindi Wang

In the following video, Professor Hancock demonstrate techniques used in his research to find the early detection of sepsis.

A potential misunderstanding about sepsis has also been revealed in the article. Sepsis had been treated as an inflammatory disease; however, many anti-inflammatory drugs failed to treat sepsis. The gene signature, used in this new method found by Hancock’s research team, relates to cellular reprogramming which is a special type of immune-suppression. Hancock emphasizes, “If we can reverse that immune-suppression then we have a really good chance of a new therapy”.

For future research, Professor Hancock suggests that larger clinical trials should be done to confirm these findings. He also expects to increase test functionality in order to  have a fast and accurate diagnostic test for sepsis in the early stage.


 

Reference

Cavaillon, J., & Minou, A. (2006). Bench-to-bedside review: Endotoxin tolerance as a model of   leukocyte reprogramming in sepsis. Critical Care, (10)


 

By Group 2

Harsheen Chawla, Erik Johnson, Lincoln Li and Xindi Wang

To Bee or Not to Bee

Can you imagine a world without honeybees? At first glance, bees can be quite frightening, especially if you are allergic to them.  However, honeybee populations are currently on a steady decline and a loss of these insects can have serious effects on our society.  As it is these small pollinators that have a hand in providing us with a third of what you see in all produce departments. Not to mention, the delicious honey that they provide us.

honey-bees

A group of honey bees. Image credit: Pixabay.com

Pollination is an incredibly important step in producing new healthy plants, some of which are used as food by humans and other species. There are two types of pollination: cross-pollination and self-pollination. Cross-pollination is the process of plant reproduction that requires an external mechanism, such as insects or wind, to transfer the pollen of one plant to another plant of the same species. On the other hand, self-pollination only needs the pollen produced by itself to reproduce.

If pollinators, such as bees, are not in abundance, it can put pressure on plants to self-pollinate, which can lower genetic diversity in plants. A decrease in genetic diversity in one species can lead to a decrease in biodiversity among species’ which can be very harmful to an ecosystem.  Some plants can self-pollinate without penalty, but for others, pollinators are crucial to maintaining genetic diversity in the species.

P1080306 Bombus Rhinanthus

A bumblebee and Rhinanthus minor. Image credit: Dr. Hargreaves

In research led by Dr. Anna Hargreaves, a herb called Rhinanthus minor was studied in the Rocky mountains of Alberta. Interestingly, this herb is able to self-pollinate successfully, but also produces flowers that attract bees to promote cross-pollination. She investigated how a reduction in bee visitations might affect the distribution of the plant. Watch the video below for more details on her research.

YouTube Preview Image

As mentioned earlier, honeybee populations are quickly declining. This is a problem because honeybees are considered to be the primary pollinator of the majority of human food crops. There are several causes thought to affect honeybee populations, including several chemicals contained in pesticides used in agriculture. For this reason, it is important to take immediate action to prevent a decline in the honeybee population.

YouTube Preview Image

Image credit (from podcast) : www.flickr.com

Next time you’re eating peaches, honey, or receiving flowers as a gift, think about how bees have contributed to your life, and what you can do to make sure these products and the bees are available in the future.

Stay buzzy as a bee,

Group 3
Candace Chang, Dixon Leroux, Dorothy Ordogh, & Rafael Alfaro

The Cure to Cancer May Only Be a Sip Away

The Oral Cancer Foundation reports that oral cancer is responsible for over 8,000 deaths per year in the United States alone. That is an average of one death per hour. Oral cancer can target many areas of the mouth and neck, such as the tongue, lips, and lymph nodes (oval-shaped organs). Fortunately, researchers have been studying the effects of a very popular drink that could lead to promising treatments for oral cancer.

13080645805_b03a5045e9_o

Mitochondria in a Cell, Source: Flickr Commons

The article, Green tea ingredient may target protein to kill oral cancer cells, published in January 2015 states that a compound in green tea may be able to treat patients with oral cancer. Researchers at Penn State’s Center for Plant and Mushroom Foods for Health studied epigallocatechin-3-gallate (EGCG), a compound found in green tea. They compared the affects of EGCG on normal human oral cells versus human oral cancer cells. They grew these cells in petri dishes and exposed them to the compound. Surprisingly, they found that EGCG damages the mitochondria in only oral cancer cells. The mitochondria are vital parts of the cell that provides energy, but once they become damaged, they are unable to function correctly. This type of disruption to the mitochondria will cause the oral cancer cells to undergo programmed cell death.

Morning_cup_of_green_tea

A Cup of Green Tea, Source: Wikimedia Commons

Dr. Lambert, the co-director at Penn State’s Center for Plant and Mushroom Foods for Health, argues that the selective nature of EGCG to attack oral cancer cells and not normal cells may be applied to other types of cancers as well. He also mentions the benefits of consuming green tea over current  methods to treat cancer. For instance, chemotherapy drugs target rapidly dividing cells, but cannot differentiate between fast-growing cancer cells and normal dividing cells in your hair follicles and intestines. Unfortunately, these drugs can cause harmful and unpleasant side effects like hair loss, nausea, and vomiting. However, the selective nature of green tea may be able treat cancer patients without the presence of these terrible side effects. Overall, consuming green tea would be less harmful and also a lot cheaper than existing cancer treatments.

So, can we state with certainty that you will be able to drink your way to a cure to cancer in the future? The current research looks promising, but only through further research, like clinical trials can we really determine if a sip of green tea will in fact be the new anti-cancer treatment.

Check out the video below uploaded by iHealthTube.com for more information on green tea!

YouTube Preview Image

 

By: Navjit Moore

WHY IS IT HARD TO STOP SMOKING IN ONE SHOT?

Even though it is widely known that smoking causes serious health problems, people still do it. Centers of Disease Control and Prevention (CDC) reminds us that some of the consequences of smoking are cardiovascular diseases, respiratory problems, cancer development, and even death. Nevertheless, some people are still smoking because of good feeling nicotine leaves in the body. On the contrary, some others are trying to quit smoking. Trying. But why is it hard to do it in just one shot? Here is a video from ehowhealth YouTube channel which explains what nicotine does in the body.

Recent research at the University of Copenhagen has demonstrated that the post-smoking symptoms are what make quitting smoking really difficult. In a press-release from ScienceDaily, Professor Albert Gjedde, neuroscience researcher at the Department of Neuroscience and Pharmacology, University of Copenhagen explains “Regular smokers experience an almost dementia-like condition in the early hours after quitting, as suggested by brain scans.”

Risk from Smoking        Source: Wikipedia

According to brain scans on smokers performed by Gjedde’s research team, after having stopped smoking, the blood flow and oxygen uptake in the brain decrease by almost 20%. This is considered a stressful situation for the body, which in turn starts producing an anxiety-like reaction, which is “probably one of the reasons why it can be very difficult to quit smoking once and for all. Smokers drift back into abuse, perhaps not to obtain a pleasant effect […] but simply because the withdrawal symptoms are unbearable.” MedlinePlus  provides a comparison of the way one feels while smoking and one does after. From such list, it is evident why people have a hard time when throwing cigarettes away.

Cigarette Smoking           Source: Johanna Keppler – Flickr

 

So what could be the best method to quit smoking? Scientists have recommended that a gradual withdrawal from smoking could be less traumatic than trying to quit in a single attempt. The explanation is that the effect of the post-smoking symptom will not hit not be as overwhelming, since they will not ‘hit’ the person at once. That way quitting smoking will be more manageable.

That’s Nuts! A New Take on Allergy Treatment

Everyone knows the best way to treat allergies is to avoid what causes them, right? Well, according to a recent study that is not the case. But before we go into that, we need to know a little about what allergies really are.

food-allergies

Image credit: Salt Room Millenia Wellnes Center

Everyone has heard of them, but what are they really? Generally speaking, an allergy is an over-reaction of the body’s immune system to something that is harmless for most people, such as eggs, pollen, or peanuts. These substances are called ‘allergens’, and the immune responses they cause can do serious harm. More information on allergens can be found in the video below, credit to eMedTv YouTube channel.

YouTube Preview Image

So, why do people have allergies anyway? This question stumped scientists until DP Strachan proposed in 1989 that allergies develop primarily from the lifestyle changes of our modern society, such as increased hygiene and cleanliness. This idea has come to be commonly known as ‘the hygiene hypothesis‘. The basic principle of the hypothesis, that less exposure to certain substances causes allergies, appears to hold true under more recent analysis.

Food Allergies cause 200 000 emergency room visits each year in the U.S., with more than 15 million Americans living with food allergies. From 1997 to 2008 the number of reported peanut allergies in the U.S. tripled, breaking three million cases according to Food Allergy Research and Education (FARE). This time period coincided with increasing attempts to lower exposure of children to peanuts. Clearly something isn’t working.

Nut Free Logo Nut free school logo

Image credit: Logo-kid.com

With understanding of allergies, why they arise, and how they affect people, the importance of finding effective treatment methods becomes clear. Using logic that follows from the hygiene hypothesis, one research group may have found a strikingly simple solution.

In a paper published February 2015, Du Toit and associates studied 640 infants, 4-11 months old, that were at risk of developing peanut allergies and separated them into two treatment groups. The first group were exposed to small amounts of peanut butter routinely, while the second group completely avoided peanuts, continuing until 5 years of age. The group with peanut exposure developed peanut allergies with remarkably-less frequency than the second group(1.9% compared to 13.9%).

So what does this mean? Should people start feeding their kids peanuts to avoid a serious allergy? The answer to that is absolutely not. This study was undergone with careful scrutiny by expert physicians to ensure minimal risk. What it does mean, is that allergy treatment is going to be changing in the near future, and hopefully the rate of allergies changes too.

-Dixon Leroux

One Breath Closer…

According to the World Health Organization (WHO), the leading cause of death worldwide is cancer. More specifically, lung cancer is the most common type of cancer in the world. This terrible disease does not discriminate when it comes to victims. It afflicts both genders, and people of all ages and ethnicities. Luckily, scientists have been working on a new detection device for lung cancer that holds promising benefits for patients. We are literally one breath closer to early detection and treatment of this terrible disease.

lung-cancer-faims

The LuCID Device, Source: Google Images

The article, Ground-Breaking Lung Cancer Breath Test in Clinical Trial, published on February 14, 2015 states that a breath test shows hopeful advancements in detecting lung cancer. Scientists at the University of Leicester have begun the clinical trials of the Lung Cancer Indicator Detection (LuCID) project. LuCID is a device that detects Volatile Organic Compounds (VOC) at low concentrations in a patient’s breath. The evaluation of VOC’s in a patient’s breath can serve as a biomarker to detect lung cancer.

Dr Siddiqui, the lead researcher in this study, states that lung cancer has one of the lowest survival rates of all cancers. More importantly, he emphasizes the importance of early detection to improve a patient’s prognosis. Basically, the earlier the cancer is discovered, the greater the chance of survival for the patient. For this reason, the LuCID device may just be the missing key to early detection. The device is also cheaper, more efficient, and less invasive compared to other detection methods. For example, performing a CT scan exposes the patient to harmful radiation that could result in further health complications. Another downside to invasive techniques is that they are not suitable for everyone, especially children and pregnant women. Overall, the breath test is a safer alternative to more conventional lung cancer detection methods.

The Presence of Lung Cancer Source: Flickr Commons

The Presence of Lung Cancer
Source: Flickr Commons

Though the LuCID project is still in clinical trials, it is showing promising results in early detection for lung cancer. Catching lung cancer at an early stage can give patients a much better chance at fighting this disease. Furthermore, this new procedure may potentially lead to more safer and non-invasive detection methods for other diseases as well.

Check out the BBC News coverage on the LuCID device. The video was uploaded by the user KaFaDoKyA NEWS.

YouTube Preview Image

 

– Navjit Moore