Tag Archives: immune system

That’s Nuts! A New Take on Allergy Treatment

Everyone knows the best way to treat allergies is to avoid what causes them, right? Well, according to a recent study that is not the case. But before we go into that, we need to know a little about what allergies really are.

food-allergies

Image credit: Salt Room Millenia Wellnes Center

Everyone has heard of them, but what are they really? Generally speaking, an allergy is an over-reaction of the body’s immune system to something that is harmless for most people, such as eggs, pollen, or peanuts. These substances are called ‘allergens’, and the immune responses they cause can do serious harm. More information on allergens can be found in the video below, credit to eMedTv YouTube channel.

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So, why do people have allergies anyway? This question stumped scientists until DP Strachan proposed in 1989 that allergies develop primarily from the lifestyle changes of our modern society, such as increased hygiene and cleanliness. This idea has come to be commonly known as ‘the hygiene hypothesis‘. The basic principle of the hypothesis, that less exposure to certain substances causes allergies, appears to hold true under more recent analysis.

Food Allergies cause 200 000 emergency room visits each year in the U.S., with more than 15 million Americans living with food allergies. From 1997 to 2008 the number of reported peanut allergies in the U.S. tripled, breaking three million cases according to Food Allergy Research and Education (FARE). This time period coincided with increasing attempts to lower exposure of children to peanuts. Clearly something isn’t working.

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Image credit: Logo-kid.com

With understanding of allergies, why they arise, and how they affect people, the importance of finding effective treatment methods becomes clear. Using logic that follows from the hygiene hypothesis, one research group may have found a strikingly simple solution.

In a paper published February 2015, Du Toit and associates studied 640 infants, 4-11 months old, that were at risk of developing peanut allergies and separated them into two treatment groups. The first group were exposed to small amounts of peanut butter routinely, while the second group completely avoided peanuts, continuing until 5 years of age. The group with peanut exposure developed peanut allergies with remarkably-less frequency than the second group(1.9% compared to 13.9%).

So what does this mean? Should people start feeding their kids peanuts to avoid a serious allergy? The answer to that is absolutely not. This study was undergone with careful scrutiny by expert physicians to ensure minimal risk. What it does mean, is that allergy treatment is going to be changing in the near future, and hopefully the rate of allergies changes too.

-Dixon Leroux

Thymus: A Lab-Grown Organ

They are in the air we breathe and on the objects we touch. Germs, such as bacteria, viruses and parasites, are all around us. The thymus, an important structure of the immune system, is responsible for the production and storage of a vital cell called the T cell. T cells help to recognize and defend the body from various infections and foreign invaders. In a recent study, led by Professor Clare Blackburn from the Medical Research Council Centre for Regenerative Medicine at the University of Edinburgh, scientists were able to construct a fully functioning thymus in the lab.

 
This was done by collecting fibroblast cells, which play a role in making collagen and the extracellular matrix for tissues, from the mice embryos. The collected cells were then genetically altering to express a particular gene not normally present in the fibroblast cells.  As a result, these modified fibroblast cells began to function like regular thymus cells. The study had shown that when scientists transplanted the altered cells back into the mice, the cells had organized themselves into a functioning thymus organ

Youtube Video Courtesy of: Medical Research Council

Thymus Image Courtesy of: Google Images

Thymus Image Courtesy of: Wikipedia http://en.wikipedia.org/wiki/Thymus

This important study will have a major impact on the healthcare field as this opens a potential opportunity for lab grown thymus’ to be transplanted into human patients who suffer from immunodeficiency.  For example, bone marrow transplants patients are more easily at risk of infections due to a decrease in the number of granulocytes, which are a type of white blood cell, and elderly patients as the thymus naturally deteriorates with age.  In addition, patients who are born without a thymus, also known as DiGeorge Syndrome, who suffer from many complications such as low levels of calcium, heart defects and a poor functioning immune system will also benefit from this finding.  Therefore, a lab grown thymus is such a new and exciting finding as it could be the key to protecting these patients from various health concerns and even death.

Although it would be nice to begin using this process  immediately, Blackburn stated that this study had, so far, only been conducted on mice and there are plenty more steps that need to be taken, such as applying this technique to human cells and testing their functions in models, before we can apply this technique on human patients.

Nonetheless, this is an exciting finding as we can hopefully apply this technique in the future to human patients who suffer from weaken immune systems. Not only will this study help patients who suffer from immunodeficiency but this can also reduce the challenges that come with finding a correct match between an organ donor and organ recipient!

– Candace Chang