Author Archives: mparmar

The Role of Genetics in Athletic Ability

What exactly are genes?

A gene is a segment of DNA located on specific areas of the chromosomes that functions to control the production of proteins and directs the activities of cells. Every person has two copies of each gene; one copy comes from the father, and the other from the mother. Genes determine an individual’s characteristics such as hair color, eye color, and even ones athletic abilities. Specifically, genes have a large influence over strength, muscle size, muscle fiber composition, lung capacity, and flexibility.

Diagram of a gene. Showing a gene is a segment of DNA on a chromosome. Source: J.Craig Venter Institute

Moreover,  research indicates two specific genes, ATCN-3 and the ACE gene, have a very close relationship to the athletic performance of an individual.

What is the relationship between the ATCN-3 Gene and athletic performance?

The ATCN-3 gene is responsible for producing a protein called α-actinin-3. This protein is found in fast-twitch muscle fibers. The main function of this protein to generate intense muscle contractions during high velocity movements such as sprinting and weight lifting. There are two variants of the ACTN-3 gene. One is the R variant and the other is the X variantPower athletes usually have the R variant whereas endurance athletes have the X variant. Moreover, researchers have concluded that every Olympic level power athlete has a minimum of one copy of the ACTN-3 gene, and that it is impossible for someone to achieve top ranks in power sports without the gene. Also, another specific gene that determines an individual’s athletic potential is called the ACE gene.

This video by GeneTechPI explains in more detail the influence of ACTN-3 on physical performance:

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What is the relationship between the ACE Gene and athletic performance?

The basic function of the ACE gene is to regulate the rate of blood that flows throughout your body. The way in which this is accomplished is by first activating a hormone called angiotensin. Once this hormone is activated, it regulates the constriction of the blood vessels, and hence regulates the rate of blood flow. Individuals that have this gene are better endurance athletes, and respond a lot better to endurance training due greater efficiency of blood flow regulation. Moreover,  two variants exist, called the I and D variants. Rowers and long distance runners usually have the I variant, whereas power athletes like sprinters and weight lifters have the D variant.

So without the right genes, is it still possible to become a really good athlete?

With proper training and nutrition, you can get to a certain level but in the end genetics determine if you are capable of being an superstar athlete. It has been concluded by researchers that roughly 20-80% of athletic performance is related to genes. In fact, many Olympic level coaches believe that genetic testing should be an important component of the selection process in order to choose the very best athletes for their teams.

-Mandip Parmar

Hearing Loss and Earphones

The IPod and MP3 player revolutionized the way we listen to music. It is possible to carry thousands of high quality songs in a super portable device. Everywhere you look, whether it is at a gym, at a school campus, in a library, or even on the street, you are bound to see numerous people with their earphones in their ears, listening to their music. Through observation, you will notice many people spend hours listening to music with the music so loud that others are able to hear the music clearly around them. People that are listening to their music loud and for prolonged periods of times are damaging their hearing. In order to understand how loud music from earphones damages hearing one must first understand how hearing works in the first place.

How does hearing work?

Diagram of the structure of ear. Shows external, middle and inner ear. Source: Temporal Bone and Ear Anatomy – Kevin Kavanagh MD

First sounds are picked up by the external ear. The sound wave pitches are then increased as the sound enters the ear canal. Next, the sound enters into the middle ear. The middle ear contains an important delicate bone structure called the ossicles. The function of the ossicles is to intensify the sound vibrations. Once the ossicles has done its job, the sound waves are moved into the inner ear. Tiny hair cells are then activated and are set in motion by the movement of fluid. These tinyhairs convert the vibrations into impulses. The impulses are then sent down the auditory nerve and the brain processes the sounds.

How do headphones harm your ear? 

The main location in the ear that hearing loss occurs is the inner ear. The high energy sound waves produced by loud music in earphones or prolonged earphone use, overstimulate the fluid, causing an over stimulation in the hair cells, which results in many of these cells to die. When these hair cells die,  certain frequencies of sound are no longer heard and processed by the brain. This is called hearing loss.

So how can you protect your ears?

If you regularly use your IPod and want to prevent hearing loss here these are the best preventative measures:

  • The most obvious is to control the volume of the device, don’t go over 60% of the maximum volume.
  • Use noise cancelling headphones so you don’t adjust the volume louder just because you are hearing background noise
  • Finally, limit the use of your IPod to only one hour a day, as this the time limit stated by researchers as the optimal time for use, considering the fact that your ears are exposed to  other high sound level factors such as traffic every day.

In the NBC news report below, Dr. Kourosh Parham, a ear specialist, describes preventative techniques in order to help people avoid hearing loss from earphones:

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-Mandip Parmar

Increasing a Kids Height with Human Growth Hormone

In today’s image-conscious society, researchers have concluded that people are often treated differently based on their height. Specifically, children that are short in stature have reported that they are constantly teased, whereas taller individuals have reported that they are well respected among their peers.

To help boost their confidence, numerous vertically challenged children are undergoing growth-hormone treatment to increase their height. There is a steady increase of children being prescribed the main drug in this treatment, as the number of prescriptions of this drug has increased from 19,000 to 23,000, from the years 2007 to 2011.

The children undergoing this treatment are referred to as idiopathic short stature patients (ISS). ISS patients are deemed as being the shortest 2% of the population. Males are projected to reach an adult height of 5’3 and females a height of 4’10. These short heights have no correlation to deficiencies such as low growth hormone levels, or diseases such as turner syndrome that are related to below average height. In Canada, growth hormone treatment is only available for medical reasons and not cosmetic. Therefore, parents cannot simply ask for this treatment just because they want there child to be a few inches taller. The doctor must deem their child as being a suitable candidate.

For ISS patients to undergo the growth hormone therapy, the synthetic lab made growth hormone Humatrope, which was approved by Health Canada in 2006, must be used.

The side effects of Humatrope are very low. The most common side effects are: headaches, muscle pain, joint pain, high blood sugar, and hypothyroidism. In my view, the benefits of the drug out way the common side effects.

The video below from King5 news provides a child, parent, and a doctors view on benefits of growth hormone therapy and describes how the benefits out way the risks.

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So exactly how does Humatrope work?

When Humatrope is injected it acts like normal growth hormone in the bodyGrowth hormone is hormone secreted by the pituitary gland and then quickly converted in the liver into Growth Factor- Type 1 or simply IGF-1. IGF1 is what causes the height growth in children. The height increase in children is attributed to the fact that IGF-1 stimulates bone growth and cell reproduction.

Effects of Growth Hormone- IGF-1 increases bone size. / Source: Vanderbilt University

Overall, I believe that growth hormone therapy using Humatrope is a great way to help short children grow. Someone who I knew from high school had a wheat allergy and was very short in stature. He was often picked on for being short. He decided to undergo this treatment and within a year he had grown to the height of many of the other students without any side effects. Ultimately, I believe this treatment will help many kids that suffer negatively from their short stature as my friend did, and will help give them an extra boost in their confidence.

Mandip Parmar