Author Archives: adilcader

The sweet solution to antibiotic resistant bacteria

It has been known for some time now that honey has several antibacterial properties, having been employed by many ancient civilizations as a topical treatment for wounds. Honey is an effective treatment against antibiotic resistant bacteria because it effectively attacks bacteria on multiple levels having hydrogen peroxide, acidity, osmotic effect, high sugar concentrations and polyphenols in its arsenal to kill bacterial cells. This makes it very difficult for bacteria to develop resistance to all of the effects of honey simultaneously.

Honey (Image Source: Wikimedia Commons)

Dr. Rowena Jenkins and her team from the University of Wales Institute – Cardiff looked at the antibacterial properties of honey on bacteria that infect wounds. They determined that it wasn’t only the sugar present in honey but other factors that helped kill the bacteria. In their experiment they noticed that one particular protein, called FabI, was entirely missing after the honey treatment. This protein was particularly responsible for fatty acid biosynthesis and without it bacteria couldn’t produce the lipopolysaccharides that are essential to build bacterial cell walls. However they could not isolate which particular element of the honey was responsible for completely destroying the protein.

Another research paper, published the year following Dr. Jenkins work, in the Federation of American Societies for Experimental Biology (FASEB), isolated the protein which was responsible for most of the antibacterial properties  of honey as defensin-1. This protein, the researchers proposed, is added to the honey by the bees that make it and is part of their immune system. Further research into this protein could pave the way to finding treatments that bacteria cannot develop resistance to and even kill antibiotic resistant bacteria.

Honey Bee (Image Source: Wikimedia Commons)

Additionally, Professor Rose Cooper from the University of Wales Institute Cardiff has experimented on the interactions between three types of bacteria and honey, concluding that honey could even have an effect that reverses antibiotic resistance. One of the bacteria she was studying, Meticillin-resistant Staphylococcus aureus (MRSA), was shown to become more sensitive to the antibiotic oxacillin when used together with honey. This brings about the proposition that antibiotics should be coupled with honey in treatments to increase their potency and also decrease the chances of bacterial resistance developing.

The research invested into the antibacterial properties of honey show that it is a very effective treatment that should be included into modern medicine in a larger scale. Currently certain medical grade honeys are used in the treatment of infectious wounds. These honeys are handled very differently to conventional honey to avoid contamination as they come in contact with exposed body tissue.

YouTube Preview Image

Further research should be carried out to determine ways in which to administer antibiotic-honey coupled treatments for a greater, less risky effect that has the potential to eradicate antibiotic resistant bacteria.

~Adil Cader.

Naked Mole Rats And Cancer

Cancer is the reality that haunts the forefront of society’s mind and one of the greatest killers that we fear today. It comes as no surprise that we would expect a great deal of research to be invested in its prevention. When researchers are looking into every possible opportunity that may yield a solution, it peaks our curiosity that a bizarre  animal such as the naked mole rat may hold the key.

The Naked Mole Rat (Source: Flickr.com)

Although this not very visually appealing creature doesn’t seem to stand a chance against something as notorious as cancer, scientists at the University of Haifa in Israel believe that the cells of these mole rats secrete a substance that could be linked to the prevention of cancer. In addition to this the naked mole rat lives for a much longer period than your conventional species of rats, up to around thirty years, and hasn’t yet been detected to have any form of tumours. These features of this animal allowed it to win vertebrate of the year in the science magazine.

So how does this seemingly insignificant animal keep cancer out? Scientists from the University of Rochester in New York along with scientists from The University of Haifa in Israel have suggested that the substance responsible is a super sugar called high-molecular-mass Hyaluronan (HMM-HA). The proposed mechanism is that when secreted by cells it decreases cell overcrowding and the formation of tumours. This substance is also secreted by humans into the extracellular matrix of cells, but the sugar in these rats are ‘much heavier’. The evolution of these rats deep underground may have lead to the formation of this advanced version of the sugar. Additionally, this sugar secreted by mole rats allows their skin to be very much more elastic.

Research conducted on these creatures include, inducing cancers via carcinogens on them, however, it was found that the mole rats didn’t appear to develop any tumours. This differs from an experiment in which the mole rats were exposed to these same carcinogens in the absence of the secreted sugar (Hyaluronan). In this case, tumours developed, which lead researchers in the direction that this was, in fact, the substance responsible for the mole rats cancer free record.

YouTube Preview Image

The research into this substance is still progressing slowly, like all things in science and medicine. There are still several problems that researchers face, such as; how can it be harnessed and administered to humans? Will the substance cure already existing tumours and how can this be tested safely? Unfortunately several news articles that have been published are misleading to people who are looking for current cancer treatment as this research is in no way a current treatment and still needs several years of work to be of substantial use for human applications. That being said it is a significant door that has been opened in the field of cancer research and should be pursued.

~Adil Cader.