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Who’s afraid of germs? Apparently, plants are.

Researchers at UBC’s Michael Smith labs have identified a crucial gene that regulates the immune response in plants. Yes you heard correctly, the plant immune system.

Because we live the majority of our lives in cities, where the only thing we see wrong with plants is the burnt lawns in August, we could be excused for not knowing that plants can ‘get the flu’. But it’s true, plants get sick much like we do, with similarities down to the molecular scale.

Source: Wikimedia Commons

 This is the expertise of Dr. Li’s lab; paving the way to mapping the immune system of plants. This is no easy task. Teasing out the relationships between the dozens of genes responsible for plant immunity a like trying to put together a jigsaw puzzle blindfolded, not knowing what the assembled picture will look like. Recently however, they have published a paper that puts a piece solidly into place.

They have identified the gene that regulates the immune response by adjusting how NLR’s (an important class of immune receptors) are regulated. The gene, called CPR1, is part of a class of proteins that is involved in ubiquitination, which is the way all multicellular organisms ‘tag’ the proteins that need to be disposed of.

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This unfolding field of research is being spearheaded right here in UBC as well as in collaboration with teams from Beijing’s National Institute of Biological Sciences and Duke University. And although plant pathology is often overshadowed by its more charismatic, better-funded cousin, the study of the animal immune system, it’s by no means less important.

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 Music: Ergo Phizmiz – Papageno Drunk. Creative Commons.

So if we can get the plant to do the heavy lifting by making a protein that could adjust how hard the plant fights against a certain pathogen, we may eventually move away from using chemical control techniques that are often toxic to farmers and consumers alike.

Although it’s nice to imagine a bright tomorrow where all food crops will be perfectly immune against any blight that comes their way, we have to face the facts. In order for us to have our “Jetsons” dream come true, basic research must come first.

After all, as Dr. Li notes, even Albert Einstein didn’t realize that research on the atom could someday lead to atomic weaponry.  So we have no sound way to tell what fruits this research will bear in the future. Let’s hope that the next generation of scientists will only weaponize our crops metaphorically speaking.

 

 

Who’s afraid of germs? Apparently, plants are.

Tomato Leaves Provide Insight to Natural Selection

By looking at differences that are found in domestic and wild tomato leaf DNA and traits, Dr. Chris Muir, from UBC Biodiversity Research Center, can confirm that the driving force behind all changes observed in physical traits are due to natural selection. Genetics account for various differences observed, and are responsible for making all organisms unique from one another.  Naturally, some differences are more fitted for survival in the environment than others. Thus, some traits tend to dominate, and organisms with these traits have a higher survival rate. The video below examines the concept of natural selection:

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Dr. Muir’s research builds on top of previous research experiments, as it uses genetic data collected by the Tomato Genetics Resource Center to determine where mutations lie. The Tomato Genetics Resource Center provides visualizations, which maps out where mutations are located. These images are known as introgression lines as pictured below. Each line is a different gene, and the shaded regions account for different types of mutations.

Image 1: Introgression Lines Courtesy of Tomato Genetics Resource Center

Determining which mutations are responsible for physical traits in the leaves is like doing a puzzle.  Dr. Muir would look at which differences could be found in physical traits of the tomatoes, and where the mutations were in that particular tomato. If the same physical traits were constantly being altered, such as leaf thickness, and the same regions of genes were affected, the two are likely to be correlated.

Instead of focusing on the entire tomato, Dr. Muir focused on leaf traits. He looked at several different types of leaves, which physically looked quite different from one another.

Image 2: Different variations of leaves in various types of tomatoes courtesy of Dr. Muir

The traits that were measured included leaf surface area and weight, as well as density and location of stomata and trichomes. Both stomata and trichomes appear to be rather complex terms, but they are merely scientific terms used to describe the pores and hairs, respectively, present on leaf surfaces. Both are responsible for regulating transpiration, leaf temperature, and other crucial cellular activities.

Although commonly overlooked, leaves are important to each plant’s survival. Leaves are responsible for growth stimulation of plants (Lam and Leopold 1966), and for photosynthesis – the harvest of energy. The size of the leaves, and the amount of stomata or trichome would influence the plants’ ability to survive in different environments.

Dr. Muir’s work was tedious, but rather simple. Using scanners, he measured the surface area, and using a scale, he measured the weight.

Image 3: Describing the Role of Stomata courtesy of Berkeley Education

He used an interesting application to examine the stomata and trichome. He applied clear nail polish, and look at the hardened impressions underneath the microscope.

The results were clear. Different types of tomatoes had distinct, unique traits that helped it to survive in the environment. Natural selection played a role in making these changes happen.

Dr. Muir’s work can be applied to many industries, and used in a variety of applications. To learn more, listen to the interview with Dr. Chris Muir below:

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Science 300 Group 3 – Christy Kwok, Sophia Hu, Claire Curran, and Felix Tang

Literature Referenced:

Lam, S. and Leopold, A.C. 1966. Role of Leaves in Phototropism. Plant Physiology. 41:847-851

Moyle, L.C., Muir, C.D. and Pease, J.B. 2014. Quantitative genetic analysis indicates natural selection on leaf phenotypes across wild tomato species (Solanum sect. Lycopersicon; Solanaceae).

New Survey Methods Give Hope for More Accurate Estimates of Antarctic Minke Whale Populations

In a breakthrough report on March 13th, Dr. Williams and his team of experts surveyed Antarctic minke whales in the Southern Ocean using a never used before technique integrating helicopters.

Surveying in Antarctica is not an easy task. “Not only is a minke whale’s habitat a challenging place to work, it is also a changing place to work”, said Dr. Williams, a marine mammal conservation biologist, “as the climate is warming, it is changing the ice.”  He adds that the changing ice conditions could influence the amount of Antarctic minke whales that are available for surveying while on the icebreaker, which would therefore skew the data every year according to the amount of ice present.

The Antarctic Minke Whale: they have grey pectoral fins and their baleen colour is different from the Northern species of Minke Whales (Photo by Dr. Williams)

As we all know, polar regions are experiencing huge yearly variations in sea ice that are being linked to climate change. This greatly affects the organisms that live in those regions, such as the Antarctic minke whale.

Previous estimates by the International Whaling Commission (IWC) of the minke whale population showed a 30% decline. This decrease prompted Dr. Rob Williams and his team to test a breakthrough method that uses helicopters to determine a more accurate population estimate. They wanted to know if this population was really decreasing or if it was due to the inability of previous investigators to sample near the sea ice without using helicopters.

The use of helicopters makes this study so revolutionary (Photo by Dr. Williams)

Previous surveys were thought to be hindered by what they couldn’t see near the ice. Additionally, Dr. Williams believes that icebreaker ships could make large noises, scaring the whales away from their natural habitat, preventing the counting of the whales that would have been there. Hence, bringing helicopters to assist in surveying the Antarctic minke whale population is revolutionary and adds to the surveys from icebreakers.

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The population of Antarctic minke whales could be essential to understanding the impact of climate change on their ecosystem.

Antarctic minke whales belong to a larger family of whales called baleen whales and are well adapted to the sea ice, but not much is known about them such as their diving capabilities. They are much larger than their northern counterparts and have significantly different skull forms. “The whales are there [by the ice] because that’s where the krill is”, said Dr. Williams. Naturally, minke whales move in toward the sea ice edge, where the krill thrive. Also, minke whales are hunted by the carnivorous killer whale, making them part of a complex ecosystem. Therefore, their response to the changing sea ice is very important in predicting how other organisms in the ecosystem will respond.

An interview with Dr. Williams reveals his passion for the Antarctic Minke Whales: Click HERE

Dr. Williams hopes that the attention from this study will help bring additional funding to support more research.

Dr. William states: “It is not about not only how many minke whales are there now, but how many minke whales do we think there are likely to be 50-100 years from now”.

By Cynthia Lung, Maria Benard, Dani Marcoux and Cindy Liang

References & additional sources:

 

New Glue Could Fix that Wounded Heart!

Ever watched the TV show Star Trek, where Captain Jean-Luc Picard is stabbed in the heart but yet survives due to a device that stitches wounds in the heart? Now, researchers have found an adhesive of similar function where rather than using stitches or staples, this glue repairs heart wounds which are as strong as the alternatives while avoiding complicated procedures.

A new glue could be used to seal tears in heart tissue or blood vessels.

Inventors, Jeffrey M. Karp, an associate professor of medicine at Harvard Medical School, andDr. Pedro del Nido, a cardiac surgeon at Boston Children’s Hospital explains how staples and stitches can cause problems. Each pass of a suture (stich) needle, the tissue needs to be realigned and staples can damage the tissue and moreover, it requires the process of removal. In order to solve these problems, the researchers aimed to design a water-repellent glue that could harden quickly and create a seal that could withstand the stress in a beating heart.

The liquid glue is applied either on a patch and then placed on to the hole in the tissue (shown below) or directly to the tear of the blood vessel or the intestinal wall until the glue is hardened.

The glue is used with a patch to repair a wound in the heart tissue.

The surgeon then shines ultraviolet light onto the glue which results in a rubbery substance that merges with the heart’s collagen due to the glue molecules binding with the collagen fibres creating strong chains.

This adhesive has been tested on rats and pigs and have successfully shown that it helps seal the wound quicker than other adhesives that exist. In addition, “some of those adhesives require that the tissue be dried for the adhesive to stick, while others aren’t compatible with certain types of tissue,” Karp says.

Human trials are still necessary in order for use in the clinic but the researchers are optimistic that they will be able to utilize this in Europe by the end of 2015.

– Yuri Tomura

Home Away From Home?

At the recent Search for Life Beyond the Solar System conference in Arizona, it was announced that an Earth-sized planet had been found orbiting a star’s habitable zone. Thomas Barclay, a NASA astronomer, looked at data collected by the Kepler telescope to determine the characteristics of this planet. However, he’s been quiet about the details, waiting until his research is published.

Area in Kepler Telescope’s Range of View (Source: NASA)

At least we know the important part: it orbits in the habitable zone. Many scientists believe that liquid water is necessary for life to exist and while this may an Earth-centric view to take, so far it seems like liquid water is most associated with life.  While we don’t know if there is water on this planet, we know that its distance from its host star means that it’s cool enough for water to condense yet warm enough for it to not freeze.

The second most important part is its size: its relatively small size (1.1 times the radius of Earth) among all the exo-planets detected means that it’s the first Earth-sized planet to be found orbiting a star’s habitable zone. While we are not exactly sure how dependent life is on gravity, it bodes well for the possibility of life if a planet has the similar characteristics as that of the only planet known to host life.

While a minimal amount of details are known to those outside of the conference, we do know that the star the planet orbits an M1 Dwarf, also known as a Red Dwarf.

Artist’s depiction of a Red Dwarf (Source: Wikipedia)

These stars are very small and their masses range from the bare minimum needed for star formation to half that of the Sun. They are also the most common star in the Milky Way.

We also know that there are at least five other planets that are in orbit around this dwarf.

However, it’s probably best to ease up on the speculation and wait until the research is published: when we know more about the planet, then we can continue to consider what this discovery means for the search for life on other planets.

– Nicholas MacDonald

Are you Emotionally Intelligent?

Drawing by Roy Blumenthal on Flickr

Some people may argue that emotional intelligence (EQ) is more important than one’s intelligence (IQ). In fact, psychologists generally agree that among the ingredients for success, IQ counts for roughly 10% (at best 25%); the rest depends on everything else — including EQ. EQ allows for people to read other’s physical or emotional signals and react to it appropriately. This is particularly important in the twentieth century, where being able to empathize, understand, negotiate with others and understanding yourself.

Your EQ is the level of your ability to understand other people, what motivates them and how to work cooperatively with them,” says Howard Gardner, the influential Harvard theorist.

Evidence has been shown that trait EQ predicts job performance and job satisfaction and other career success. Fear not, unlike IQ, EQ can be improved over time so long as one actively understands the basis of EQ.

Your EQ can be measured by 5 different categories: self-awareness, self-regulation, motivation, empathy and social skills.

1) Self-awareness is the ability of knowing what kind of emotion you are experiencing as it “happens,” it relies heavily on how you evaluate your emotions. Not only is it important to know your emotions, but knowing yourself; your self-worth and capabilities.

2) Self- Regulation is has a mutual partnership with self-awareness because once you’ve identified what emotions you are feeling, the next step is: how do you deal with the situation effectively? Emotionally intelligent people have the ability to alleviate emotions such as anger, anxiety or depression by looking at the brighter side of the situation, taking a long walk, meditation, praying…etc. Self-regulation involves being able to manage impulse disruptive emotions, maintaining standards of honesty and integrity, taking responsibility, being flexible of the situation and being innovative.

3) Motivation is driven by setting clear goals to negate disruptive emotions. Write your goals down on a piece of paper, make it visual and make a conscious effort to strive for change. Motivation consists of having determination, committing to your goals, and having a positive attitude despite obstacles and setbacks.

4) Empathy is the ability to understand how people feel. Being able to read the feelings behind someone’s signal will allow you to control your thought and feelings as well. An empathetic person is able to anticipate sense and recognize needs, they have political awareness – able to read a group’s emotional currents and power relationships, and most importantly, they understand what others need.

5) Social Skills are important in our society because it allows you to effectively negotiate, understand and empathize with others. Social skills focus on: effective persuasion, clear communication, leadership, initiating or managing change, resolving disagreements, nurturing relationships, being a team player, creating group synergy.

How emotionally/socially intelligent are you? Take a test:

http://kgajos.eecs.harvard.edu/mite/

– Cynthia Lung