Category Archives: Uncategorized

It’s in the Blood

Breakthrough research was published on March 9th 2014 by Dr. Howard Federoff and a team of researchers in Washington DC. They developed a blood test that identifies 10 biological markers which has been shown to determine if healthy individuals will develop Alzheimer’s Disease within two or three years. This amazing stepping stone could help individuals receive treatment before developing symptoms of this horrible neurodegenerative disease.

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35 million people all over the world have been diagnosed with Alzheimer’s, the most common form of dementia, and this number is rising rapidly. The ripple effect of this disease touches many family members by having to care for them or put them in care-homes. Individuals with onset Alzheimer’s disease become confused, frustrated, and forgetful and eventually progress to where they cannot talk, feed, or even dress themselves. Alzheimer’s is a horrible disease affecting many innocent elderly people and hopefully in the near future, there will be tremendous progress in the treatment of Alzheimer’s; it may just start before symptoms even begin.

Visual representation of Alzheimer’s (Shuttershock)

“This is a very exciting time,” says Federoff, who leads the team. He states that the test could help patients at risk of developing Alzheimer’s disease and perhaps delay or even stop the progression. “We don’t really know the source of the ten molecules,” admits Federoff, but he suggests that they reflect the destruction of neurons in the brain, which ultimately leads to cognitive impairment and Alzheimer’s disease. When neurons are destroyed in the brain, they cannot come back online or be built again.

Simon Lovestone, a University of Oxford neuroscientist is also excited about the findings in this study. “We desperately need biomarkers which would allow patients to be identified – and recruited into trials – before their symptoms begin”, says Lovestone, who is also a coordinator of a European public-private partnership that searchers for new biomarkers for Alzheimer’s.

Blood Vials (Flickr: loscheiner)

Previous studies have emphasized treatment after diagnosis of Alzheimer’s disease, but no one has ever been completely cured. This new and important research uses blood that is easily accessible, and it has the ability to identify potential risk factors before any symptoms arise. Stopping the disease before it even happens could be an incredible advancement in this field.

Federoff highlights that larger studies must be done exploring a more diverse range of individuals including different races and ages. When these large-scale studies show positive results, perhaps early diagnoses can prevent the disease from becoming aggressive and debilitating to controlled and stable. Overall, this is very promising research that I see possibly flooding the medical field.

By Danielle Marcoux

Sources:

  • http://www.nature.com/news/biomarkers-could-predict-alzheimer-s-before-it-starts-1.14834
  • http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3466.html
  • http://www.alz.org/alzheimers_disease_what_is_alzheimers.asp
  • http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-medications-fact-sheet
  • http://www.webmd.com/alzheimers/guide/treatment-overview

What’s my title again?

A new study by Howard J. Federoff and his team of researchers has been released, and they have discovered a new way of identifying people who are at risk of having Alzheimer or other mental brain impairments within three years. This five year study took place at Georgetown University Medical center,  and the study states that their discovery is capable of predicting the presence of the disease with 90% accuracy, by identifying ten specific  lipids (fats) in your blood that are believed to present disease onset.

Alzheimer is a life altering degenerative disease that is one of the more common types of dementia, a loss of cognitive ability, and it is affecting an estimated 40 million people worldwide, with the World Health Organization stating that the number will double every 20 years.  By 2050, the numbers are expected to rise to over 115 million, a staggering number for something with no cure.

But our current way of predicting Alzheimer is not useful in preventing or treating the disease. At this time, Alzheimer is typically diagnosed when the various symptoms of Alzheimer starts showing up, such as memory loss. However, this comes at a time where there is already irreversible damage to the brain, and as there is presently no cure, the damage is already done.  Although there are various drugs presently available to try and combat these effects, they have all failed and Federoff believes this is due to the drugs being used far too late into the disease timeline.

Comparison of a normal brain and one with Alzheimer’s.
Photo by: National Institutes of Health (Source: Wikimedia Commons)

However, this study gives us a cheap and effective basis for diagnosing the disease, so while it only predicts with 90% accuracy, this is an improvement over the previous method of waiting for the first stages of the disease. Howard J. Federoff explained “We consider our results a major step towards the commercialization of a preclinical disease biomarker test that could be useful for large-scale screening to identify at risk individuals”.

Although this method is not clinically ready yet, this study is a step in the right direction of finding an effective way to combat Alzheimer.

Here is a link to the original study:

http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm.3466.html

-Jeffrey Chen

Don’t Let the Bed Bugs Bite….

What if you were told that there were thousands of bed bugs crawling in your mattress at night? The common bed bug, Cimex lectularius, is one of the most widely recognized insects in the world.

“Size of bed bug compared to dime “by Medill DC on Flickr

Bedbugs are tiny wingless insects that feed on the blood of people and animals , reproduce at a terrifying rate and are hard to get rid of. Bed bugs are attracted by the carbon dioxide (usually when we sleep) that are exhaled by us (and our pets too), they are typically found in areas really small such as: in mattress pads, backpacks, night tables, electrical outlets, behind wallpaper… etc.

The bed bug reproduction cycle is pretty horrifying. Bed bugs mate in a process called traumatic insemination. This basically means that the male injects its genitalia into the female’s abdomen, and the sperm is inserted through the wound, travels through the female’s abdominal fluid till it reaches her ovaries. The process of traumatic insemination causes a risk of infection and diseases in females, so she tends to isolate herself to avoid mating again, this also means… your backpack clothes, or even your pets, make a perfect home for a pregnant female.

The female bed bug can store sperm to fertilize her eggs for up to six weeks, and typically they can lay up to 12 eggs per day, and a female can lay anywhere from between 200-500 eggs in her lifespan, so long as both female and male have a blood meal every 14 days. With a little math, a single pregnant female can raise up to 5,000 bed bugs in six months.

Once the eggs are laid, it takes 6-17 days to be able to feed. The need for blood is apparent immediately for young ones to molt. Baby bedbugs are born they can live up to a year and a half without feeding.  After 5 molting periods the baby becomes an adult, this process if affected by temperature, from around 21 days to 120 days. Adult bed bugs, can typically live around 10 months to up to a year or more, if the environment for these critters are good for reproduction (approximately 21°C and 28°C)

“Bed bug eggs mattress corner” photo taken by Bulwark Exterminating on Flickr

If you start getting rashes or little bumps on your skin after a nights rest, start making the assumption that there might be bed bugs. Start looking for signs of bed bug: dried blood or feces, carcasses or white spots (eggs – very hard to see), or live bedbugs, in small tight areas around the house, once signs mentioned are spotted, start inspecting your pets and call pest control immediately. Bed bugs die at 50°C, and it is recommended that everything be washed or steamed, or thrown out to prevent spread and further invasion of the species.

Written by Cynthia Lung

P.s. Good night, don’t let the bed bugs bite.

Airplane Colds

Airplane riding into the sunset. Source: Flickr Commons Kuster & Wildhaber Photography

If you were to walk into my room right now you would see cold medication, chicken noodle soup and a still unpacked suitcase from the trip I took over reading break. I rode an airplane twice in the past week and now I am getting a cold. Coincidence? I think not. And neither does science. According to a study done, a person’s chances of contracting a cold on an airplane are significantly higher than when on the ground (Hocking & Foster, 2004) .

There are several reasons of why people are more susceptible to colds and respiratory diseases after flying. Surprisingly, studies have proven that lack of air circulation is not to blame (Zitter, Mazonson, Miller, Hulley, & Balmes, 2002) . A common misconception is that the air on a plane is stagnant and not fresh, therefore letting airborne bacteria sit there longer. In reality, air in an airplane is cycled through very sophisticated filters 15 to 20 times an hour. (Lang et al., 2007) This is much higher than the number of times air is cycled in homes and offices, 5 and 12 respectively. (Lang et al., 2007)

So if stagnant air isn’t the culprit, what is? Dry air is the main culprit according to one source (Hocking & Foster, 2004) . When you’re flying, the relative humidity drops to levels around 10%. This drop in relative humidity is a very big difference from on the ground levels, where for example, in Vancouver on February 24, 2014 is 96%. These low levels of humidity due to highflying elevations cause people’s first line of defense to not function properly. Mucous in the nose cannot form and bacteria can therefore pass.

Other culprits include the ratio of people to space. Since person-to-person interactions are very high (think of climbing over someone to get up to go to the bathroom), there is an even higher number of possible infectants in the air. Although airplanes are cleaned regularly, high-traffic areas  that may not necessarily be cleaned thoroughly are thought to be possible bacteria rich areas. These areas include overhead bins, armrests, aisle seats and the seat-tray.

Here people can be seen touching the aisle seats. Source: Flick Commons Matt Hurst

One last reason that could contribute to getting sick after travelling is stress. A lot of people find travelling stressful and higher levels of stress can affect your immune system’s ability to ward off sickness (Glaser & Kiecolt-Glaser, 2005) .

So what can you do to ward off a cold when travelling by airplane? This article  has several great suggestions. The most important being staying hydrated and keeping your hands clean. Next time I travel by plane, I will definitely be taking better advantage of the free beverages offered inflight.

~Claire Curran

References

Glaser, R., & Kiecolt-Glaser, J. (2005). Science and society – stress-induced immune dysfunction: Implications for health. NATURE REVIEWS IMMUNOLOGY, 5(3), 243-251.

Hocking, M. B., & Foster, H. D. (2004). Common cold transmission in commercial aircraft: Industry and passenger implications. Journal of Environmental Health Research, 3(1), 7-12.

Lang, M., Amit, M., Cummings, C., Feldman, M., Ponti, M., Grabowski, J., & Community Paediat Comm. (2007). Air travel and children’s health issues. PAEDIATRICS & CHILD HEALTH, 12(1), 45-50.

Zitter, J. N., Mazonson, P. D., Miller, D. P., Hulley, S. B., & Balmes, J. R. (2002). Aircraft cabin air recirculation and symptoms of the common cold. JAMA : The Journal of the American Medical Association, 288(4), 483-486.

Move Your Hands – The Importance of Gesturing

Over the past month, all of us in the Science 300 course have learned quite a lot about making an effective presentation. One of the most important questions we asked ourselves was whether or not to hold a script while we speak.  Well, many research studies have suggested that it might be beneficial to ditch the script.

The reason behind not holding something in your hands during your speech is so that you can leave the hands free to make gestures. A research study by (Hubbard et al., 2009) suggests that there is a common neural substrate for processing speech and gesture, likely reflecting their joint communicative role in face-to-face interactions. What does that mean?  To put it simply, using hand gestures when giving a presentation enhances the comprehension and perception of the spoken material by your audience.

This is also very important in the early development of speech and language as well. Before babies are able to speak multi-word phrases, they rely heavily on hand gesturing to help communicate their thoughts. Hand gesturing is observed between the babbling period at approximately 8 months to the one-word stage at approximately 12 months. At 8 months, most babies start to use proto-declarative pointing, which is pointing to draw attention to a certain object. Later on at 12 months, babies start to combine speech and hand gestures such as pointing to enhance their communication (Esteve-Gibert, and Pireto, 2014).

The researchers even found that the babies’ multi-modal coordination is much like ours when prominence is taken into account. I can’t agree with this finding more as I am often fascinated by the adult-like and sophisticated hand-gestures made by my 12 month-old nephew. For those of you who are not as well-acquainted with babies, here’s a video of two babies babbling and gesturing in an adult-like fashion. It really looks like the matters are pressing.

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Speaking of pressing matters, let’s go back to the many important presentations that we will be making as science students. Many of  you will still opt for the script because you are afraid of not being able to remember your speech. Don’t be afraid!  We all have moments where we just can’t seem to find the right word  or moments where we just can’t recall that one thing we had on our mind two seconds ago. Dr. Elena Nicoladis from the University of Alberta recommends that we start moving your hands around to help us remember. Her research done on bilingual children suggests that gesturing while you speak may improve your access to language area in the brain. In this study, bilingual children were asked to tell the same story in two different languages. Researchers first thought the children would be more inclined to use gestures to help them communicate in their weaker language. To their surprise, these children used gestures significantly more when telling the story in what they considered to be their stronger language. Based on their results, it is believed that gesturing plays an important role in accessing language in the process of speech production.

Whether in  adults or infants,  we know how important gesturing is in the communication process. Numerous research studies are under way to study its connection to speech and language. For example, an on-going study at Alberta Children’s Hospital is trying to observe gesture development as a way to detect language problems at an early age.

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More and more evidence are being discovered to solidify the importance of gesturing. So next time you make a presentation, remember to trust yourself: practice your speech, lose the script, and make hand gestures with your now-free hands. If these chimpanzees can use hand gesture to communicate, you can definitely do it too.

Keep those hands in motion.

Cindy Liang