Category Archives: Uncategorized

Walking Dead Syndrome!?

Photograph: Lionel & Heidi (statelyenglishmanor) on flickr

With the second part of season four of  The Walking Dead premiering next week, It has got me thinking whether or not it is possible for someone to have similar characteristics of those we see in zombies: lifeless, brainless, and  decomposing.

Ever feel like you’re dead? Or imagine that you’re decomposing? If so, you might be suffering from Cotard syndrome. Cotard syndrome (or Cotard’s Delusion, also literally known as Walking Corpse Syndrome) – named after Dr. Jules Cotard (1840-1889) was a Parisian neurologist who discovered this  rare neurological condition in which one believes that they have lost their organs, blood body parts, or their soul, making them believe that they are dead.

Photograph: Sam Howzit on Flickr

“When I was in hospital I kept on telling them that the tablets weren’t going to do me any good ’cause my brain was dead. I lost my sense of smell and taste. I didn’t need to eat, or speak, or do anything. I ended up spending time in the graveyard because that was the closest I could get to death.” 

 A British man named Graham woke up one day and believed he was dead. The syndrome was agitated by severe depression (anxious melancholia) when he tried to take an electrical appliance with him to bath. He sought medical attention, and told the doctors that his brain did not exist anymore when he attempted suicide previously. The doctors found it hard to rationalize, as he was still breathing, talking and living. However it was different story on Graham’s end, he stopped wanting to talk to people, stopped wanting to eat, didn’t want to see people, didn’t find pleasure doing anything, even his addiction to cigarettes did not interest him anymore. It was a shock to the doctors that despite his intellect and his ability to talk and converse, his PET scans revealed that there was little to no activity in Graham’s frontal and parietal brain, this resembled that of someone in a vegetative state – talk about being the “walking dead.”

Graph produced by Cynthia Lung based on information from study by Charland-Verville et al., 2013: Read related article here

Not to worry, the Cotard Syndrome an extremely rare malfunction of the fusiform gyrus, a part of the brain that recognizes the face and the amygdala, a set of neurons that are shaped like an almond that process your emotions. Usually this syndrome targets people of an older age, however there are at least 7 other journal recorded incidences that resemble the Cotard Syndrome. The combination malfunction of these two processes make the person feel really disconnected with reality.  Currently there is no real cure to this syndrome treatment, the way to combat this would be to focusing on the symptoms of depression and loss of meaning to life with anti-depressants and anti-psychotics.

– Cynthia Lung

Dolphins Doing Drugs?

Dolphins getting high…..did you read that right? BBC recently made a documentary called “Spy in the pod” depicting a peculiar and controversial topic: dolphins getting high on puffer fish. You may be doubting your own mind’s consciousness, but it’s true according to series producer and zoologist Rob Pilley, “it was the first time dolphins had been filmed behaving this way”.

The footage that has been making international headlines, show the dolphins in a trance-like state. It’s the first time being documented that dolphins are apparently partaking in recreational drug use. Hanging around with their noses at the surface of the water and seemingly fascinated by their own reflection: a result of intoxication from puffer fish?

Take a look at a video clip from the documentary: YouTube Preview Image

The toxin secreted by an attacked pufferfish is known as tetrodotoxine. 1000 times as potent as cyanide, exposure to this neuro-poison causes numbness in small doses, paralysis in medium doses, and death in high doses. A dose of 1-2 mg of purified toxin is deemed to be fatal.

Intoxicated Dolphins? Image: U.S. Navy photo by Photographer’s Mate 2nd Class Veronica Birmingham. (Wikimedia Commons Images)

We know what this toxin can do to humans, but does it have the narcotic effect on dolphins as claimed and what do the critics think? Freelance science writer Justin Gregg stated on his blog that “there are no observations of this behavior reported in the peer-reviewed literature”. The evidence showing that the dolphins’ behaviour is linked to the tetrodotoxin is weak. Dolphin researcher Diana Reiss stated “I can tell you that when they’re not intoxicated, they are also fascinated by their reflection.” So all these actions are not at all unusual nor necessarily attributed to being “high”.

In my opinion, the wild behaviour of these dolphins can easily be explained by the psychoactive inducing tetrodotoxin. However, there is no strong evidence that there is a causal link between the dolphins chewing the puffer fish and getting intoxicated. Their response pattern preceding the chewing of the fish, although peculiar to humans, is nothing outlandish to these dolphins.

Pufferfish: Drug of Choice. Image: Amanda (Wikimedia Commons)

At this point, we cannot confirm whether these astonishing marine mammals are getting high off their toxic chew toy. Perhaps future research on dolphin behaviour will enlighten us further on the tetrodotoxin’s effect. But if the dolphins are really getting a little high, we now know that spiky lethal creatures would be their drug of choice.

-Sophia Siyao Hu

 

Other Sources:

 http://www.ndjglobalnews.com/15478/dolphins-get-high-puffer-fish.html

http://www.nbcnews.com/science/dolphins-getting-high-fish-toxin-or-just-load-puff-2D11849410

http://scienceblogs.com/lifelines/2014/01/02/dont-miss-this-episode-dolphins-using-puffer-fish-toxins-to-get-high/

http://scienceblogs.com/lifelines/2014/01/03/more-throughts-on-dolphins-and-puffer-fish/

Printing the Sum of Our Parts

You don’t have to know anyone with a failed organ to understand what kind of stress they must go through while they’re on the organ transplant waiting list.  Many don’t live to see the end of that line-up and heartbreakingly, the ones who make it are still at danger from organ rejection. Thankfully, a solution is on the horizon. In the near future, all a patient has to do is wait for their kidney or liver to be printed, 3D printed that is.

You may have heard a thing or two about 3D printers, the method of manufacturing an object, layer by layer, guided by a digital model of what you wish to print.  While it may seem complicated enough to print plastics or metal into complex shapes, scientists and engineers are now working on creating ways to print fully functional organs.

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We’ve had the ability to print tissues (hyperlink) made of a single type of cell for some time now, but the possibility of producing entire organs is now on the horizon, most notably, the human liver.

Organovo-3D-Printed-Liver

However, there are still many major milestones to reach before the first printed organ can be transplanted to a donor.  Currently, the greatest tissue thickness that can be printed is about a centimeter; adding more layers causes the tissue to suffocate from lack of oxygen and nutrients. Only once a way to incorporate blood vessels into the tissue is developed will there be serious talk of transplantation.

Nevertheless, we are already beginning to reap the benefits of these techniques. The thin pieces of functioning liver tissue are being used as ‘organs on a chip’  in testing new drugs. This means we can finally begin moving away from animal testing, without sacrificing reliability of animal models. In fact, such ‘organs on a chip’ save money and resources for medical research. Finally, something both PETA and pharmaceutical companies can be happy about.

As for clinical applications in humans, the current state looks rather disheartening; so far, only 3D printed implants have been used. However, for the thousands currently in line for a transplant, this technology offers reason to hope.

 

Published by Alena Safina

 

Chocolate: Dogs’ secret enemy

Chocolate being bad for you? How could that be, but it turns out that chocolate can be quite dangerous for you and man’s best friend, the dog. This could be bad news with Valentine Day’s coming up, but exactly how much of a danger is it?

Chocolate (picture taken by: Andre Karwath)
(Source: Wikipedia commons)

 

Chocolate is a very common treat due to their sweet and addicting taste. Chocolates can come in a variety of flavours but typically contains cocoa, produced from cocoa beans. This cocoa contains one ingredient that turns out to be very harmful to dogs yet typically fine to humans.

Researchers have shown that this one substance is the key factor to a chocolate’s potency. An alkaloid known as theobromine is the nemesis of dogs, but why exactly does it turn out to be toxic to your dog when it appears that your dog can eat almost anything? The reason is that Dogs and many other animals metabolize theobromine at a very slow rate.  As theobromine affects the central nervous system as well as the heart muscle, this inability to metabolize or break it down quickly can cause death. Humans are capable or metabolizing theobromine much more readily, thus the toxicity of theobromine doesn’t play as much of a factor, although it can still be dangerous if one engulfs roughly a gigantic amount of chocolate.

Dog at Vet Photo by: Ildar Sagdejev (Source: Wikipedia Commons)

 

The lethal dosage, the amount that someone can digest before it being fatal has been studied by researchers to determine how dangerous chocolate is to dogs. Studies have shown that the LD50, the point at which 50% of the subjects who go over this limit die, of theobromine is roughly 300 milligrams per kilogram. The amount of theobromine in chocolate also varies with type. White chocolate contains very little theobromine, a Kit-Kat contains only 49mg, while dark chocolate such as Scharffen Berger 82% Cacao Extra Dark Chocolate contains 1100 milligrams per bar. So a 20kg dog would be able to consume 6 bars before reaching the LD50 point.  While 6 bars might be a lot for a human, that isn’t much for a dog.

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So as long as you keep chocolate high in theobromine away from your dogs, everything should be fine. Typical levels of chocolate bars do not have exceedingly high levels of theobromine, but it is important to be aware of the dangers on certain days like Valentines and Christmas.

One other interesting tidbit is that theobromine doesn’t actually contain any bromine, isn’t science confusing at times?

-Jeffrey Chen