Tag Archives: Antibiotics

The Invisible Cold War: Bacteria Vs. Humanity

We are in a constant war and we don’t even realize it. No, it’s not the recent development in Ukraine or the crisis in Syria some time ago. It’s something much more subtle and dangerous. As you may have guessed it from the title, we are constantly fighting against bacteria with a type of weapon called antibiotics. Antibiotics are natural products used to kill bacteria by interfering with bacteria growth or replication. Unfortunately, we have been using our weapon inappropriately and now we are steadily losing this fight against bacteria.

Face of Danger (antibiotic-resistant bacteria, MRSA, at work. Image source: wikimedia)

However, researchers from the division of Healthcare Quality Promotion at the U.S. Centers for Disease Control and Prevention (CDC) found something we can do to fight against bacteria. According to the study done in 2013 by Fridkin, S.K. and Srinivasan, A. (associate director for Healthcare Associated Infection Prevention Programs), by fusing antimicrobial stewardship with their strategies, hospitals in the U.S. is able to create a sort of benchmark for all hospitals to follow (2014). This is necessary as there is no clear guideline about how much of antibiotics is “too much.” In order to do this, they went through a trial and error of implementing sound decisions and comparing outcomes within 200 hospitals in U.S..

Now, here is why you might be asking why this is necessary at all when antibiotics can kill bacteria and have been doing so for the longest time. That is only half right. While we have been killing bacteria with antibiotics, they have been evolving through exposure of antibiotics and have become immune to them. As they become immune to the only weapon we have against them, we are forced to create or modify the antibiotics. This is called, “evolutionary arms race.”

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While manufacturing new antibiotics would be good and all, there has been reports of misuse of antibiotics in hospitals and other medical centers as early as late 1950’s which resulted in rise of antibiotic-resistant bacteria (Fridkin, S.K. & Srinivasan, A., 2014). If this faulty practice continues, all the effort and money went into producing antibiotics would be in vain as they would develop immunity again due to overexposure. Therefore, a new practice of controlling distribution of antibiotics called, “antimicrobial stewardship,” has been developed.

Just like how it is not wise to show all your cards in your hand during a poker game, it is not wise to show every antibiotics we got by misusing them. While this study proves that we can set a guideline for all hospitals to follow, it also supports further improvements over their strategies. To prevent a certain future where no cure exists to fight against lethal bacteria, I believe there should be more improvements on the guidelines and if possible, we as citizens should also be smart about our usage of antibiotics.

References

Fridkin, S. K., & Srinivasan, A. (2014). Implementing a strategy for monitoring inpatient antimicrobial use among hospitals in the united states. Clinical Infectious Diseases, 58(3), 401-406.

– Jong Hwan Seo

 

The sweet solution to antibiotic resistant bacteria

It has been known for some time now that honey has several antibacterial properties, having been employed by many ancient civilizations as a topical treatment for wounds. Honey is an effective treatment against antibiotic resistant bacteria because it effectively attacks bacteria on multiple levels having hydrogen peroxide, acidity, osmotic effect, high sugar concentrations and polyphenols in its arsenal to kill bacterial cells. This makes it very difficult for bacteria to develop resistance to all of the effects of honey simultaneously.

Honey (Image Source: Wikimedia Commons)

Dr. Rowena Jenkins and her team from the University of Wales Institute – Cardiff looked at the antibacterial properties of honey on bacteria that infect wounds. They determined that it wasn’t only the sugar present in honey but other factors that helped kill the bacteria. In their experiment they noticed that one particular protein, called FabI, was entirely missing after the honey treatment. This protein was particularly responsible for fatty acid biosynthesis and without it bacteria couldn’t produce the lipopolysaccharides that are essential to build bacterial cell walls. However they could not isolate which particular element of the honey was responsible for completely destroying the protein.

Another research paper, published the year following Dr. Jenkins work, in the Federation of American Societies for Experimental Biology (FASEB), isolated the protein which was responsible for most of the antibacterial properties  of honey as defensin-1. This protein, the researchers proposed, is added to the honey by the bees that make it and is part of their immune system. Further research into this protein could pave the way to finding treatments that bacteria cannot develop resistance to and even kill antibiotic resistant bacteria.

Honey Bee (Image Source: Wikimedia Commons)

Additionally, Professor Rose Cooper from the University of Wales Institute Cardiff has experimented on the interactions between three types of bacteria and honey, concluding that honey could even have an effect that reverses antibiotic resistance. One of the bacteria she was studying, Meticillin-resistant Staphylococcus aureus (MRSA), was shown to become more sensitive to the antibiotic oxacillin when used together with honey. This brings about the proposition that antibiotics should be coupled with honey in treatments to increase their potency and also decrease the chances of bacterial resistance developing.

The research invested into the antibacterial properties of honey show that it is a very effective treatment that should be included into modern medicine in a larger scale. Currently certain medical grade honeys are used in the treatment of infectious wounds. These honeys are handled very differently to conventional honey to avoid contamination as they come in contact with exposed body tissue.

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Further research should be carried out to determine ways in which to administer antibiotic-honey coupled treatments for a greater, less risky effect that has the potential to eradicate antibiotic resistant bacteria.

~Adil Cader.