Author Archives: TristanJeffery

Nanotechnology; size does’t matter

Just a few weeks ago the Nobel Prize in Chemistry was awarded to a group of three brilliant men, Jean-Pieree Sauvage, Fraser Stoddart and Bernard Feringa. Over the past few decades, these three have developed molecular machines that can do a variety of work,  allowing for infinite applications.

To begin, the sizes of the machines are amazing, being measured on the scale of nanometers. To put this into perspective these machines would be 1000 times smaller than a single strand of human hair! It is quite mind-boggling to imagine how humans could build such tiny machines and this was one of the biggest obstacles in designing the molecular tools.

There had been many methods attempted to build the machines, from building small machines that would be used to build smaller machines repeating this process until a macroscopic end product had been created. Another method was  layering individual atoms and dissembling in various parts to shape a molecular machine. Finally the method used by the Nobel Prize winner’s consists of forming a new mechanical bond that allows linkages to occur without any chemical interactions. Further manipulation and these interacting molecules can be rotated, spun and twisted independently of each other.

An explanation of molecular machines. Video from https://youtu.be/vELfuiUpKM0.

The applications are immense. Molecular computer chips are one of the many things being created with the molecular machines. The computer chips are able to store data in them and compared to today’s computers hardware are miniscule. With further developments I would imagine that one day the entire computer’s hardware will be of molecular size. The computers will likely be even more compact and lightweight too!

One unique invention by researchers is the creation of a nano-car. These tiny vehicles consist of chemicals that build its chassis and rotating molecules as wheels. When I read about this I imagined researchers combining this molecular car with the molecular computer that could be use to sense and see the surrounding environment. Doctors could use this machine to travel the human body, patrolling for diseases in humans by programming the computer to sense the changes in the body. This isn’t too far fetched as the idea of tiny machines travelling through the human body has been brought up before.

The nanocar. Image from https://cdn0.vox-cdn.com/thumbor/ItfIwlmbPGDqVpOXuPVErG0ygrA=/800x0/filters:no_upscale()/cdn0.vox-cdn.com/uploads/chorus_asset/file/7221875/Screen%20Shot%202016-10-05%20at%206.36.46%20AM.png

The nanocar. Image from https://cdn0.vox-cdn.com/thumbor/ItfIwlmbPGDqVpOXuPVErG0ygrA=/800×0/filters:no_upscale()/cdn0.vox-cdn.com/uploads/chorus_asset/file/7221875/Screen%20Shot%202016-10-05%20at%206.36.46%20AM.png

Novel batteries are under development as well. The molecular machines are used to roll up polymers (long strings of joined chemicals) into an unorganized mess upon radiation with light. This mess could then unravel, releasing the energy used to initially twist up the polymer. This process essentially would harness the light energy, as it was what powered the motor to coil up the previously straight polymer.

As the era of molecular machines are still in its infancy there will be many more discoveries and applications found in coming years. As Bernard Feringa said “Through natural sciences, we can go far beyond the limits imposed on nature by evolution”, what exactly these limits are, we will have to wait and see.

-Tristan Jeffery

CRISPR; A tool that can almost fix everything

CRISPR, sounds like a type of vehicle or a new gym supplement. In fact CRISPR is a new piece of technology, possibly the greatest finding of the century. CRISPR, short for Clustered Regularly Interspaced Short Palindromic Repeats, is a genome-editing tool that was first found in bacteria. Japanese scientist Yoshizumi Ishino at the University of Osaka was the first to discovered CRISPR in 1987.

CRISPR is used as part of the immune system defence in bacteria. It has the ability to sense when viruses inject their DNA into the cell; sending out proteins that recognize the foreign DNA, cutting it up into non-functioning pieces to prevent an infection. The sent out proteins are able to recognize virus genomes by incorporating the injected viral DNA into its own genetic material, using this as a template to find the invading DNA.

How bacteria use the CRISPR/Cas system against viral infections. Image from https://upload.wikimedia.org/wikipedia/commons/5/5f/Crispr.png

How bacteria use the CRISPR/Cas system against viral infections. Image from https://upload.wikimedia.org/wikipedia/commons/5/5f/Crispr.png

Many of you may be thinking, cool so the bacteria has a way of protecting itself from invading viruses but how does this effect humans? Until now there have not been accurate DNA cutting technology but with CRISPR we have one. As discovered by Doudna Lab, it is possible for scientists to create templates that match the gene they want to remove from genetic material, allowing them to cut out any gene they want. For a concise explanation check out Carl Zimmer’s, on behalf of  BI science, description of how CRISPR works in the video below.

This allows for endless possibilities. Genetic diseases, like sickle cell anemia, can be cured using CRISPR. Simply make a template that matches the mutated gene, remove it with the CRISPR  and add a functional gene. The individual will no longer suffer from sickle cell anemia. Scientists are even looking at the possibility to modify the human germ layer, allowing for ‘designer’ babies to be made. We are still a long way from designer babies though, as it is illegal to do genetic experiments that alter the germ layer in many countries, as well as the possibilities of errors arising during the procedure that have not been fixed.

Scientists are also exploring CRISPR’s applications on plants. Want to produce plants that can survive harsher climates and produce better products, modify the genome by removing and inserting genes of interest. For instance, the State University of New Jersey is working with grape plants to edit their genes to be resistant against fungus using CRISPR.

Unfortunately CRIPSR technology won’t be used for several years. Research is only being done on animal models and human cells right now, as the errors of CRISPR are still trying to be fixed along with arguments around it’s ethics. The templates made to match genes may accidentally match up with similar genes in the body, which would lead to mutations in human genes that could potentially be fatal. Although still under work, CRISPR has the potential to cure many diseases and provide a higher quality of life for everyone.

-Tristan Jeffery