Telescopes and Spacecrafts: Exploring the Great Unknown

Humankind has always been fascinated with the stars. To unveil the mysteries that could be hiding out there beyond our planet, we first invented the telescope, an optical instrument that allows us to observe distant objects, and later on, spacecrafts and rockets, the vehicles that allow us to travel through space.

THE HUBBLE SPACE TELESCOPE

In 1610, Galileo was among the first scientists to use a telescope and the discoveries he made completely changed what we knew about our world. Today, telescopes have become so advanced that they can not only observe in the visible spectrum, but in the near infrared and near ultraviolet spectra as well. One of the most famous and most useful modern telescopes is the Hubble Space Telescope (HST), which was launched into Earth’s orbit in 1990 and is still in use today. Since it is high above Earth’s atmosphere, it is unaffected by light pollution and rain clouds, which allows it to capture perfect photos of our universe.

File:Star-forming region S106 (captured by the Hubble Space Telescope).jpgStar-forming region S106 (photo from HST) Image Credit

SPACECRAFTS AND COLONIZATION

However, being able to see the stars and planets is not enough; we created spacecrafts that could take us beyond the confines of the Earth, with the dream of one day establishing a colony on another planet. This is the ultimate goal of SpaceX, an aerospace manufacturer and space transportation services company founded by Elon Musk. SpaceX intends to colonize Mars, which is the planet most habitable for humans due to similar surface conditions and solar days (the calculated time with respect to the sun). Although the temperature and composition of the atmosphere differ greatly from Earth, scientists are optimistic about colonization because of Mars’ close proximity and water has been found in the form of ice below its surface.

In order to establish a colony on Mars, SpaceX is developing an interplanetary transport system that will shuttle people and supplies between the two planets. This system, the Big Falcon Rocket (BFR), will be reusable and it will be capable of not only transportation, but orbital and interplanetary missions as well. It is intended to be the ultimate launch vehicle and spacecraft and will render all other rockets obsolete.

Additionally, to minimize the enormous costs of space travel, SpaceX has also been developing a reusable launch system. In order to explain how this works, the terms “spacecraft” and “rocket” must first be differentiated and defined. The spacecraft is the vehicle used by astronauts to travel through space and the rocket is the vehicle that propels it off of Earth’s surface. When a launch is successful and both the spacecraft and rocket exit the atmosphere, the latter is jettisoned. However, the rocket is the most expensive part of the launch, so reusing it can save millions of dollars. SpaceX has managed to create a rocket that can withstand reentry of Earth’s atmosphere without burning up and land safely before flying again.

YouTube Preview Image Video of SpaceX’s Falcon 9 Rocket Reflight from National Geographic

Lawrence Liang

DNA storage technology

1 Introduction

Do you know DNA?  The gene which could store information of  inheritance.DNA has a double-helical structure with four chemical groups, nucleobases, which are arranged in a specific order to form genetic information that guides the growth and development of the organism.DNA storage technology is the use of synthetic DNA to store data such as text documents, pictures and sound files, followed by a complete reading technique.

2 Advantages

One of the significant advantages of DNA storage technology  is its large capacity. DNA molecules are an incredibly dense storage medium, and 1 gram of DNA can store about 2 pats, which is equal to 300GB.
Using DNA to store data can save to thousands of years. Unlike storage media such as hard disks and tapes, DNA does not require frequent maintenance. As far as reading is concerned, DNA storage does not involve compatibility issues

 

Now the DNA storage

 

Picture 1 DNA structure

(cite: https://www.technologynetworks.com/genomics/lists/what-are-the-key-differences-between-dna-and-rna-296719)

3 Method

Therefore how could it be possible for storage process?

Picture 2 DNA storage progress

(cite:https://gss3.bdstatic.com/-Po3dSag_xI4khGkpoWK1HF6hhy/baike/c0%3Dbaike80%2C5%2C5%2C80%2C26/sign=651b5cbd8694a4c21e2eef796f9d70b0/4e4a20a4462309f723c110a0730e0cf3d6cad6d2.jpg)

(1)The DNA digital storage system developed by the researchers also uses these four-base “letters” to develop custom code that is completely different from the “language” used by the organism.

(2)When copying a computer file, the DNA digital storage system first translates the binary numbers in the hard disk information into custom code, and then creates the corresponding base sequence by means of a standard DNA synthesis machine. This sequence is not a long molecule, but multiple repeats, each carrying some index details, clarifying where each is located in the overall sequence.

(3)Although such a system is redundant, the advantage is that even if some fragments are destroyed, the data will not be lost. The standard device used by the Molecular Biology Laboratory (like this one)to read biological DNA can read information and present it on a computer screen.

DNA Vaccine: A New Universal Vaccine Platform

With the sudden drop in temperature as autumn comes to an end, the inevitable flu season is once again underway. For many of us, this means another visit to the doctor for a flu vaccine to last us through the winter. We have become so reliant on vaccines to protect us from disease-causing pathogens and now there is a new radical platform using DNA that will make vaccines much more accessible and cheaper.

The researchers at The University of Texas Medical Branch at Galveston (UTMB) have discovered a method of using DNA for vaccine production that is much inexpensive with longer shelf-life (80% increase) and the same effectiveness as those that are manufactured in cell culture. This new approach promises not only the treatment of common flus at the universal level, it can also treat patients with weakened or impaired immune systems including those infected with HIV.

The Current Procedure

Currently, the most common way of supplying vaccine has been through cell culture in factories where large amounts of cells are cultivated in a dish. This method of vaccine production is ineffective because vaccines are prone to contamination when not refrigerated in their optimal temperature range. Maintaining a cold enough temperature while they are delivered from factories to hospitals and clinics can cost up to 80% of the original cost of vaccine in warmer regions.

The New Platform

To eliminate the problem of storage and cost of vaccines, the researchers of UTMB were able to design a vaccine against a type of virus spread through mosquitoes called Zika in the form of DNA. DNA vaccine contains nucleotides that encode the region of a virus that contain the pathogens. When the DNA construct is taken up in the host cell, the viral gene is expressed into the corresponding antibodies. In the research by UTMB, a single-dose immunization of the Zika vaccine was shown to protect mice of the virus infection, as well as maternal-to-fetal transmission during pregnancy and testis damage in males.

Thanks to this new approach, vaccines no longer need to be manufactured in cell culture. Also with DNA molecules being much less temperature-dependent, they can now last for years without the risk of contamination, consequently making vaccines accessible worldwide no matter the climate at the cheapest cost. Adapting to this new platform will increase vaccine availability and ensure future prospects of immunization, taking us one step closer to creating a world free of disease, ensuring health and wellness to not only the privileged but to the overarching public.

Ellena Yoon

A DNA Tool to Predict the Future

A common fear among parents is the risk of their children being diagnosed with serious illnesses such as heart disease and cancer. Fortunately, a DNA tool created by Michigan State University has been shown to accurately predict people’s height and bone density. This tool could also potentially assess people’s risk for illnesses such as heart disease and cancer.

Figure1. A new tool, created by Michigan State University, capable of predicting height. Used with permission, © 2018 Science Daily.

The Potential:

This amazing tool uses an algorithm to predict human traits including height, bone density and even the level of education an individual might achieve, entirely based on one’s genome. Lead investigator of the study Stephen Hsu mentions, “This is only the beginning.” There are plans in motion to apply this tool to predict more relevant matters like heart disease, diabetes and breast cancer. These are major diseases that impact a large amount of people. Heart disease, for instance, is the second leading cause of death in Canada. About 1 in 12 Canadian adults live with diagnosed heart disease alone! Hence, this tool could greatly impact and advance healthcare. Doctors would be able to step in during the early stages of illnesses to prevent or delay them!

Creating and Testing:

Stephen Hsu and his team’s research used machine learning, where a computer learns from data, to analyze the entire genome of around 500 thousand adults in the United Kingdom. The genome’s obtained from the United Kingdom Biobank, an international resource for health information, were used to put the algorithm to work. The algorithm evaluated each individual’s DNA and taught the computer to identify unique differences. “The algorithm looks at the genetic makeup and height of each person, learns from each person, and ultimately produces a predictor that can determine how tall they are from their genome alone,” said Hsu.

The computer was able to accurately predict everyone’s height within about an inch. However, predictions for bone density and educational achievement were not as accurate. Nevertheless, they were accurate enough to identify outliers in the population who were at risk of having problems in school and low bone density, which is associated with osteoporosis.

Future Plans:

Hsu’s team plans to continue to improve the algorithm by obtaining larger, more diverse data sets for the computer to learn. This would increase the algorithm’s capability to understand and interpret the combination of genes responsible for risks against specific diseases.

With increasing technology, the bright future of healthcare is considerably closer than originally believed. “What was once thought to be 5 to 10 years out, is now a lot closer when it comes to this type of work,” Hsu mentioned.

Figure 2. Collecting DNA using mouth swabs. Used with permission, © 2015 InfoLaw.

It is quite possible in the near future that a simple swab of the cheek could save families millions of dollars in treatment costs and more importantly, the lives of their children through early interventions of genetically based diseases.

Trevor Shen

Say Goodbye to Artificial Trans-Fat: The “Great Move”

Image Cedhttp://shqip.republika.mk/?p=194461

Have you ever considered why a tub of margarine lasts for 4-5 months while a stick of butter only lasts for 1-2 months? In simple terms, margarine contains trans-fat while butter doesn’t.

As of September 17th, 2018, Health Canada has banned artificial trans-fat from all food supplies. A specific industry produced trans-fat called Partially Hydrogenated Oils (PHOs) is a health hazard and therefore, removed from all industry manufactured foods to imported goods to meals served in restaurants across Canada, taking a step forward in the “Great Move.”

The ban of artificial trans-fat in Canada will take 2 years to phase out all of the pre-existing foods containing PHOs. Through this movement, World Health Organization (WHO) is one step closer to globally eradicating artificial trans-fat. So why is WHO so determined to eliminate trans-fat?

Small amounts of natural trans-fat are found in meat and milk, but the most consumed trans-fat is the one manufactured by the food industry. Artificial trans-fat is produced from a process where liquid oil is solidified, referred to as Hydrogenation. It’s typically found in packaged snacks, baked goods, and fried foods. PHOs is the very reason why your margarine can last for 4-5 months. It provides stability that increases shelf life, while maintaining the spreadable texture and savoury taste that everyone enjoys. But at what cost?

According to numerous research papers, high intake of trans-fat has proven to increases “bad” cholesterol, and decreases “good” cholesterol. This accumulates bundles of fat in blood vessels that result in heart diseases. Excess trans-fat is associated with diabetes and heart risks.

Why is this move so crucial?

Image Credit: Krenosky, S., L’Abbé, M.R., Lee, N., Underhill, L., Vigneault, M., Godefroy, S., & Ratnayake, N. (2013). Risk Assessment of Exposure to Trans Fat in Canada.

The image above displays the average trans-fat intake (g/day) of Canadians in the years 1995, 2004, and 2008 vs. WHOs recommended limit. As the graph indicates, the consumption of trans-fat in Canada has exceeded the recommended amount. Though the intake of trans-fat has reduced over time, it is still a major health issue in Canada. The image below shows that 25% of deaths in 2016 were due to cardiovascular diseases (28% if you include diabetes). By banning PHOs in the food industry, Heath Canada is eliminating a main cause of cardiovascular diseases, along with other health concerns.

Image Credit: WHO Canada – Proportional Mortality in 2016. *NCDs stands for Non-Communicable Diseases, which includes cardiovascular diseases, cancer, chronic respiratory diseases and diabetes.

Until artificial trans-fat is completely phased out of our diet, here are some helpful tips on avoiding artificial trans-fat.

  1. Read the nutrition labels carefully – Health Canada has enforced labelling on all packaged foods. Watch out for PHOs in the ingredient section!

    Image Credit: American Medical Association

  2. Opt-out for healthier alternatives – Natural vegetable oils such as olive or avocado oils have more benefits than harm to your body. Or you could always switch back to butter!

Jinny Jang