Opportunity: A Science Win

Science often amazes us. Opportunity, a rover built by the National Aeronautics and Space Administration (NASA), has done just that by functioning 10 years after its launch. This might not seem remarkable, but when you find out it was built for a 3-month mission and yet is still making discoveries today, it becomes noteworthy.

A Lego Tribute of Opportunity. Source 

The rover mission was launched to find out more about the conditions of early Mars and if life has existed there. Ten years ago, on January 24, 2004, Opportunity landed on Mars, joining another rover, Spirit. Spirit and Opportunity are identical. They both carry several scientific investigation instruments . These include a panoramic camera, several spectrometers, a microscopic imager, rock abrasion tools, navigation camera and hazard-avoidance cameras. All of these instruments allow the rovers to provide NASA with information about the composition of rocks on Mars.

The main discovery of the rovers has been confirmation that water existed on Mars at one time.  Many journal articles have been written  about the discoveries the rovers made.

YouTube Preview Image

How do these rovers work?  The rovers get their power from solar panels. The engineers understood that Mars is a dusty planet and that the solar panels would eventually get covered in dust and stop functioning. Accordingly, the mission for the rovers was expected to last 90 days. Unexpectedly, strong winds that cause dust storms and cover the solar panels in dust also blow the dust off. This surprise has made the mission last 20 times longer than expected.

Unfortunately, Spirit is no longer actively roving.  Its last known communication was on March 22, 2010. Spirit was hibernating during the Martian Winter and was expected to wake up in the spring but didn’t. NASA tried for a year to communicate with it but has since given up.  Opportunity is still moving about and making discoveries such as mysteriously appearing rocks. Opportunity represents a science win.

~ Claire Curran

Fukushima Radiation Effects Under Control

In 2011, the tsunami that hit Japan led to discharge of radioactive isotopes from the Fukushima Daiichi Nuclear Power Plant. The venting reduced gaseous pressure from the reactor containment vessels and discharge of water from the coolant into the sea. The USS Ronald Reagan undertook a rescue mission following the nuclear plant accident. However, several months later, the US sailors started experiencing severe radiation symptoms that prompted them to file suits against the Tokyo Electric Power Company with claims that the company failed to disclose radiation details from the US Navy after the nuclear power plant accident. According to the WHO report, 70% of the people exposed to radiation are likely to develop thyroid cancer, 7% are at a risk of suffering from leukemia, 6% from breast cancer, 4% from female cancers.

Image by IAEA Imagebank (Source: flickr.com)

Traces of the radioactive particles have been detected worldwide and numerous deaths of birds, animals and sea life have been linked to the radioactive plume. However, since  the accident, the Tokyo Electric Power Company has been trying to contain the radioactive leaks and nuclear radiation levels around the Fukushima power plant. Their effort has been successful because at the worst month following the disaster, Fisher’s lab tested Tuna that had been caught off the waters of California. The radioactivity dose from the tuna was much lower than what people are exposed to from eating bananas, medical X- rays, and natural occurrence. This is because disperse of contaminants through the Pacific Ocean into the West Coast dilutes the radiation concentration reducing it several times. Additionally, the federal and state agencies have boosted monitoring of radiation after the disaster and the recorded data shows a decline in the high levels in milk and air.

IAEA experts monitoring water samples (Source: flicker.com)

On the contrary, assertions are circulating in the internet that seafood and beaches are being contaminated by radiation from the Fukushima meltdown. For example, the YouTube video titled ‘28 Signs that the West is Being Absolutely Fried with Nuclear Radiation from Fukushima’ shows a man detecting radiation levels using a Geiger counter on Half Moon Bay beach. Also, an outrageous worry in Seattle was also observed that people were afraid of eating seafood and going to the beach. This prompted the California Department of Public Health to send inspectors to test radiation levels. The analysis showed that radiation at the beach resulted from natural occurrence from minerals in the sand but not as a result of the Fukushima radiation.

Since the tsunami that led to discharge of radioactive isotopes from the Fukushima Daiichi Nuclear Power Plant, there has been tremendous improvement in the control of radiation health risks. The Tokyo Electric Power Company controlled the leaks and the same has been reviewed several times by the International Atomic Energy Agency (IAEA). In addition, numerous tests have been conducted and it has been established that fish are safe for human consumption. Also, it has been established that beaches are safe for use by the public.

Printing the Sum of Our Parts

You don’t have to know anyone with a failed organ to understand what kind of stress they must go through while they’re on the organ transplant waiting list.  Many don’t live to see the end of that line-up and heartbreakingly, the ones who make it are still at danger from organ rejection. Thankfully, a solution is on the horizon. In the near future, all a patient has to do is wait for their kidney or liver to be printed, 3D printed that is.

You may have heard a thing or two about 3D printers, the method of manufacturing an object, layer by layer, guided by a digital model of what you wish to print.  While it may seem complicated enough to print plastics or metal into complex shapes, scientists and engineers are now working on creating ways to print fully functional organs.

YouTube Preview Image

We’ve had the ability to print tissues (hyperlink) made of a single type of cell for some time now, but the possibility of producing entire organs is now on the horizon, most notably, the human liver.

Organovo-3D-Printed-Liver

However, there are still many major milestones to reach before the first printed organ can be transplanted to a donor.  Currently, the greatest tissue thickness that can be printed is about a centimeter; adding more layers causes the tissue to suffocate from lack of oxygen and nutrients. Only once a way to incorporate blood vessels into the tissue is developed will there be serious talk of transplantation.

Nevertheless, we are already beginning to reap the benefits of these techniques. The thin pieces of functioning liver tissue are being used as ‘organs on a chip’  in testing new drugs. This means we can finally begin moving away from animal testing, without sacrificing reliability of animal models. In fact, such ‘organs on a chip’ save money and resources for medical research. Finally, something both PETA and pharmaceutical companies can be happy about.

As for clinical applications in humans, the current state looks rather disheartening; so far, only 3D printed implants have been used. However, for the thousands currently in line for a transplant, this technology offers reason to hope.

 

Published by Alena Safina

 

Image

Common Misconceptions of Delayed Onset Muscle Soreness (DOMS)

Delay Onset Muscle Soreness
Source


A common barrier while attempting to persevere through an intensive long-term exercise program is having to deal with muscle soreness afterwards, which is also known as delayed onset muscle soreness (DOMS). Unlike the acute soreness that develops during the actual activity, delayed soreness becomes prominent approximately 24 hours after exercising, and is positively correlated to the duration and intensity level exerted. Although various studies have been performed regarding DOMS, the ultimate cause of the symptom is still unknown. However, there has not been any report of DOMS posing as a permanent threat to the body.

Most people unfamiliar with DOMS are often deceived into believing that there is a correlation between pain and injury, where continued exercise while experiencing DOMS leads to further injuries. As a result, many simply stop their exercise routines and turn to treatments such as taking a hot shower or using heat pads to alleviate the pain, which may take up to a week after the initial symptom. However, by that time, your muscles will have decreased its ability to adapt to the intensity level of your routine, and that hour of intensive exercise you performed earlier becomes a waste.

The main cause of DOMS still remains unknown, but many studies have investigated the mechanisms involved and suggested possible explanations. First, studies performed by Armstrong demonstrate that high intensity exercise result in greater metabolic waste, such as lactic acid, which may influence the calcium concentration gradient within the muscle tissue and stimulate neuron activity to increase pain sensation (1). Hough suggests that DOMS is related to the rate and force of muscle contraction during strenuous exercise, which leads to structural damage (2). Supporting Hough’s findings, Kumazawa et al. also suggest that elevated temperature plays a role in damaging muscle structure and promotes necrosis of muscle fibres and connective tissues (3). In brief, there is no main cause of DOMS. It is most likely caused by a combination of various factors, which leads to the difficulty in developing a treatment that can efficiently eliminate DOMS.

Compression to help reduce Delay Onset Muscle Soreness Source

There are various treatments for DOMS such as having a proper cool-down period after exercising, taking a hot shower, or wearing compression sleeves. However, continuing to exercise while experiencing DOMS is actually the only proven way to effectively eliminate DOMS. According to Armstrong, one the reasons why continued exercise can reduce DOMS is its ability to decrease the rate of muscle fibre necrosis (1). There has also been evidence for the reduction of exercise plasma enzymes, which indicates that continued exercising can reduce muscle fibre injuries (4). Lastly, lysosomal enzyme levels have been shown to decrease while exercising with DOMS, resulting in the reduction of the rate of muscle cell death (5). Therefore, although it may be difficult to motivate yourself while experiencing DOMS, the most effective way to treat DOMS is actually to continue exercising until your muscles adapt to it.

-Bailey Lei

References

1. Armstrong, R.B. Mechanisms of exercise-induced delayed onset muscular soreness: a brief review. Med. Sci. Sports Exerc. 16(6): 529-538, 1984.

2. Hough, T. Ergographic studies in neuro-muscular fatigue. Am. J. Physiol. 5:240-266, 1901.

3. Kumazawa, T. and K. Mitzumura. Thin-fibre receptors responding to mechanical, chemical, and thermal stimulation in the skeletal muscle of the dog. J. Physiol. (Lond.) 273: 179-194, 1977.

4. Schwane, J.A. and R.B. Armstrong. Effect of training on skeletal muscle injury from downhill running in rats. J. Appl. Physiol. 55: 969-975, 1983.

5. Vihko, V., A. Salaminen, and J. Rantamaki. Exhaustive exercise, endurance training, and acid hydrolase activity in skeletal muscle. J. Appl. Physio. 47: 43-50, 1979.

Chocolate: Dogs’ secret enemy

Chocolate being bad for you? How could that be, but it turns out that chocolate can be quite dangerous for you and man’s best friend, the dog. This could be bad news with Valentine Day’s coming up, but exactly how much of a danger is it?

Chocolate (picture taken by: Andre Karwath)
(Source: Wikipedia commons)

 

Chocolate is a very common treat due to their sweet and addicting taste. Chocolates can come in a variety of flavours but typically contains cocoa, produced from cocoa beans. This cocoa contains one ingredient that turns out to be very harmful to dogs yet typically fine to humans.

Researchers have shown that this one substance is the key factor to a chocolate’s potency. An alkaloid known as theobromine is the nemesis of dogs, but why exactly does it turn out to be toxic to your dog when it appears that your dog can eat almost anything? The reason is that Dogs and many other animals metabolize theobromine at a very slow rate.  As theobromine affects the central nervous system as well as the heart muscle, this inability to metabolize or break it down quickly can cause death. Humans are capable or metabolizing theobromine much more readily, thus the toxicity of theobromine doesn’t play as much of a factor, although it can still be dangerous if one engulfs roughly a gigantic amount of chocolate.

Dog at Vet Photo by: Ildar Sagdejev (Source: Wikipedia Commons)

 

The lethal dosage, the amount that someone can digest before it being fatal has been studied by researchers to determine how dangerous chocolate is to dogs. Studies have shown that the LD50, the point at which 50% of the subjects who go over this limit die, of theobromine is roughly 300 milligrams per kilogram. The amount of theobromine in chocolate also varies with type. White chocolate contains very little theobromine, a Kit-Kat contains only 49mg, while dark chocolate such as Scharffen Berger 82% Cacao Extra Dark Chocolate contains 1100 milligrams per bar. So a 20kg dog would be able to consume 6 bars before reaching the LD50 point.  While 6 bars might be a lot for a human, that isn’t much for a dog.

YouTube Preview Image

So as long as you keep chocolate high in theobromine away from your dogs, everything should be fine. Typical levels of chocolate bars do not have exceedingly high levels of theobromine, but it is important to be aware of the dangers on certain days like Valentines and Christmas.

One other interesting tidbit is that theobromine doesn’t actually contain any bromine, isn’t science confusing at times?

-Jeffrey Chen