Author Archives: Ali Lamont

Iron Deficiency: The Quiet Killer

Iron is an “essential mineral”  for humans; this means it is an element that our bodies cannot manufacture independently, and therefore, must be obtained through an external source.  The sad fact of the matter is that many individuals (approximately two-billion people world wide) do not consume an adequate amount of iron, leaving them iron deficient, which can have many adverse effects on our bodies.

Image Source: http://www.medicinenet.com/hemoglobin/article.htm

Image Source: http://www.medicinenet.com/hemoglobin/article.htm

Why is iron so important to us? Iron is essential to the circulatory system as it is a main component of hemoglobin (a compound responsible for binding to oxygen and carbon dioxide) within our red blood cells. Iron deficiency is responsible for nearly 20% of all maternal deaths during pregnancy. Mothers with low iron status can be heavily effected by the loss of blood during labour. As blood is lost, individuals already low in iron will drop to more alarming levels, resulting in an inability to provide their bodies with enough oxygen. Their hearts will begin to pump harder, eventually resulting in cardiac arrest, and subsequent death.

This begs a the question, how much iron does an individual need? The answer varies from person-to-person depending on body composition and lifestyle, however, the average male should be consuming roughly 8 mg of iron daily, and the average woman should be consuming nearly 18 mg per day. The drastic difference between men and women is due to the fact that women loose a large portion of their iron stores as they progress through their monthly menstrual cycle, forcing women to consume larger volumes of iron to compensate for their losses.

If we cant make iron ourselves, where do we get it from? Iron can either be obtained from the food we eat, or through supplementation. The iron in our diets is termed “dietary iron”, and there are two types: “heme Iron,” and “non-heme iron.”

Image source: Michael Collan, inSlideShare

Image source: Michael Collan, inSlideShare

Heme-iron is exclusively obtained through a carnivorous diet, in particular, it is found within the meat’s blood (attached to hemoglobin), and the meat’s muscle (attached to myoglobin). This type of iron is more bioavailable, meaning it is better absorbed through the gastro-intestinal tract into the blood stream. Non-heme iron is found in both animal tissue (representing 60% of the iron present), and is the only type of iron found in plant tissue (100%). This type of iron is comparatively less bioavailable. The implication here is that those who have a herbivorous diet must consume 1.8 times the amount dietary iron (as less of the iron they consume is appropriately absorbed through the GI tract into the bloodstream.) This further implies that vegetarians are more susceptible to iron deficiency.

Image Source: http://geekymedics.com/respiratory-examination-2/

Pale Conjunctiva                 Image Source: http://geekymedics.com/respiratory-examination-2/

Image Source: Rachel Casiday

Ferritin, Image Source: Rachel Casiday

 

 

 

 

 

 

How do we know if individuals are deficient in iron stores? One practical method is to track your dietary intake and calculate your iron consumption. However, a more reliable and specific mode of detection is through measuring “serum ferritin” concentrations within the blood. This is a protein that stores iron, and therefore, low levels of serum ferritin are indicative of iron deficiency. Clinically, the presence of pale conjunctiva of the eyes, or pale red inner lip colour can indicate low iron stores. The symptoms of iron deficiency are not obvious, and often go unnoticed, leading to many deaths that could have been easily avoided.

Ali Lamont

The Intelligent Elephant: An Animal too Cognitively Developed for Captivity

How can we decide what species can be taken into captivity? There are many factors to consider when assessing whether an animal can live an adequate lifestyle in captivity. Among these factors, is assessing the cognitive capacity of the animal in question.

One family of species that is well known for their intelligence, is the family Elephantidae — modern day African and Asian elephants. Sadly, these species are also well known as ” zoo attractions.”

It has been thoroughly observed, and studied, that elephants have an outstanding emotional capacity, which is an indicator of their advanced cognitive capacity. Elephants can embody a wide range of emotions: They are known to form families, and friendships with others, they are known to mourn the deaths of their kin, and most ironically, elephants are able to express the feeling of empathy– something we clearly lack, in lieu of placing the largest land mammals on the planet in captivity.

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Zoos are unable to accommodate a number of elephants great enough to provide an environment where they can form relationships that would have otherwise formed, had they not been placed in captivity. These relationships are essential to the livelihood of the animal, and govern a large role in the way that the species develops.  Essentially, zoos ignore the species inherent cognitive ability to learn from others, and deprive them of these resources.

Moreover, when taken from the wild, it must be noted that the elephant is able to actively recognize that it is being abducted from its family, and friends.

Elephants are undoubtedly an intelligent species, but it may surprise you to realize the degree of their intelligence. A study was conducted by a researcher, Diana Reiss (and colleagues), to test the insightful nature of several elephants. They tied food to branches of bamboo trees that were out of reach for the elephants. They observed that the elephants were able to problem solve, and obtained their food through the use of tools. This is an indicator of a greater level of intelligence in comparison to other species. Below is actual footage from the study, courtesy of the Smithsonian National Zoo.

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With the blatant humanistic qualities held by these animals, its baffling to realize that their are still currently around 300 captive elephants in North America alone. However, with some degree of optimism, individuals whom are advocating for elephant freedom believe that this number will reach zero in our lifetime, that is, if we can prove our own empathetic nature.

-Ali

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Clinical Depression: Its Biological Mechanisms and It’s Treatments

One in four Canadians have depression that is to a degree worthy of clinical assessment, and treatment. With a number as alarming as this, why do we see that this particular mental health issue is so infrequently spoken about?

This is because there is an enormous stigma that surrounds clinical depression. In particular, polls show that 46 percent of Canadians believe that people suffering from depression are using the diagnosis as an excuse for their behaviours. This is not the case.

This stigma (held by nearly half of the nation) can be discredited by the scientific research that has gone into deciphering the physiological mechanisms of this mental health issue.

In particular scientists at the NIMH have concluded that depression is associated with a deficiency in a neurotransmitter known as serotonin. This is a di-cyclic compound that activates neurons within the central nervous system, promoting the feeling of happiness or well-being.

https://healthpsych.psy.vanderbilt.edu/2009/StopSadness_files/image010.jpg

https://healthpsych.psy.vanderbilt.edu/2009/StopSadness_files/image010.jpg

Mechanistically, serotonin is released from the axon of one neuron, and taken up through a channel protein within the dendrite of an adjacent neuron. In individuals suffering from depression, the channel protein’s ability to accept serotonin is not optimal, and essentially the feeling of happiness, and well-being elicited by the transmission of serotonin, is lost or not optimal. How is this treated?

Antidepressants are used as a treatment for this disorder by acting directly upon serotonin’s mechanism. In particular, the administration of a class of drugs known as “selective serotonin re-uptake inhibitors”  are prescribed. Essentially, this class of drugs allows serotonin to remain in the “synaptic cleft” (the extracellular space between the two neurons) for a longer amount of time. This is done by inhibiting the axon’s serotonin re-uptake channels, which are channels responsible for allowing serotonin to flow back into the axon from which it was released. Essentially SSRI’s are compounds that chemically interact with (and physically block) these re-uptake channels.  In doing so, this provides the disabled dendritic channel proteins with a longer period of exposure to the serotonin, and consequently, are able to take up near normal amounts of serotonin.

In conclusion, the symptoms felt by those suffering from depression, such as hopelessness, sadness, lethargy, and many more; are in part, caused by a proven physiological deficiency. With no control over the processes that we have discussed today, we can also conclude that those suffering from depression are unable to control particular behaviours (to a certain degree).