Tag Archives: health

The Changing Field of Stroke Medication

Strokes are the fifth leading cause of deaths in North America. If one is fortunate enough to survive a stroke, the rehabilitation process is long and painful depending on the amount of damage done to the brain. There are two types of strokes – ischemic and hemorrhagic. Ischemic strokes are the result of a clot forming in an artery and preventing blood flow, whereas hemorrhagic strokes are the result of an artery bursting and and the brain literally bleeding out.

Many researchers have worked towards improving and developing treatments to reduce the amount of brain damage a patient suffers during a stroke. One of the events that takes place during a stroke is called excitotoxicity, where brain cells literally excite themselves to death.

Receptors like NMDA as well as calcium are key culprits in causing damage to brain tissue. NMDA is a protein that is present on nerve cells and binds to the neurotransmitter glutamate. When a stroke occurs, nerve cells release large amounts of glutamate which bind to these NMDA receptors. The binding of glutamate to an NMDA receptor causes it to open. Calcium which is present in excess on the outside of the nerve cell, enters the cell. The calcium alongside with glutamate go on to wreck havoc in the nerve cell ultimately leading to its death. 

Courtesy of Khashayar.

Dr. Nicolas Weilinger investigated what happens at a cellular level during a stroke and the mechanism which works to damage brain cells. While researching, Dr. Weilinger discovered a new signalling pathway that had broad reaching implications for brain physiology and pathology.

YouTube Preview Image Courtesy of Harnoor Shoker

The findings of this study are important because current treatments in place to protect the brain during and after a stroke are not as effective as they should be. One of the main findings of Dr. Weilinger’s paper was that another channel much bigger than NMDA called pannexin gets activated during a stroke. Pannexin is physically connected to the NMDA receptor so when the NMDA receptor opens it signals pannexin to open as well. The opening of another channel therefore allows more calcium and glutamate to enter at an even faster pace. Using this information, a new drug was designed that would prevent the NMDA receptor from communicating with pannexin – in other words it would block the physical connection between the two proteins.

The wider implications of Weilinger’s paper is to hopefully improve stroke treatment. Future research into Dr. Weilinger’s findings could potentially be the first step in discovering a new drug type that can be used to reduce brain damage suffered during a stroke.

**We would like to thank Dr. Nicholas Weillinger for his time and the SCIE 300 team for guiding us and providing feedback.**

Harnoor, Khashayar, Matthew.

The Okinawan Secrets to Longevity

The island of Okinawa, southwest of Japan’s main landmass, is home to the healthiest and largest population of centenarians in the world. In other words, people who have lived one hundred years or more and have led remarkably healthy lives. The centenarian ratio of Okinawans is 50 per 100,000 people in a given population, almost triple that of Canada’s ratio, and on average, Okinawan males live 78 years whereas Okinawan females live 86 years. Furthermore, the Okinawan people are known for having the lowest rates of age related diseases such as cancer, heart disease, dementia, and osteoporosis.

What is their secret? According to The Okinawan Centenarian Study, apart from possible genetic factors, their stress free lifestyle and nutrient dense diet plays a major role. A few of the key habits are briefly discussed below.

Always Kind

An elderly Okinawan (Image Courtesy Of: Flikr Commons)

“Whew, I’m stuffed!”. This is a phrase you’ll probably never hear on this small island due to the Okinawans having a philosophy of only eating till they’re 80% full, referred to as hara haci bu . Although there is no instinctual way of knowing if you’re 80% full, it is roughly around 1800-1900 calories, the typical amount consumed by Okinawans. It’s important to note that just as the quantity of calories is key, so is the quality of the calories. The diet of Okinawans is heavily plant based, accompanied by oily fish 2-3 times per week, and is limited in refined grains, meats, saturated fats, and dairy. 

Apart from their dietary habits, Okinawans remain active individuals throughout their life. Walking, gardening, dance, and tai chi are a few examples that the elderly partake in, which helps maintain their cardiovascular system, in addition to allowing them to maintain their muscle and bone strength.

“So the secret to a longer life is daily exercise and proper nutrition? Lame! How about telling me something I haven’t heard before?”

Not so fast.

In addition, the Okinawans embrace an ikigai. An ikigai is a Japanese concept meaning “a reason for being”. Older Okinawans can readily articulate their purpose in getting up every morning. This definite sense of purpose and a deeper understanding of one’s self provides them with a clear role of responsibility and a feeling of being needed.

It’s clear that apart from healthy eating habits and daily exercise, a positive outlook on life is just as important, as illustrated by the stress free lifestyle of the Okinawans.

Check out the short documentary below for a more in depth review of the lifestyles of the Okinawans!

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Youtube video courtesy of: TheWayPlace

Thanks for reading!

-Sahil Mann

Iron Deficiency: The Quiet Killer

Iron is an “essential mineral”  for humans; this means it is an element that our bodies cannot manufacture independently, and therefore, must be obtained through an external source.  The sad fact of the matter is that many individuals (approximately two-billion people world wide) do not consume an adequate amount of iron, leaving them iron deficient, which can have many adverse effects on our bodies.

Image Source: http://www.medicinenet.com/hemoglobin/article.htm

Image Source: http://www.medicinenet.com/hemoglobin/article.htm

Why is iron so important to us? Iron is essential to the circulatory system as it is a main component of hemoglobin (a compound responsible for binding to oxygen and carbon dioxide) within our red blood cells. Iron deficiency is responsible for nearly 20% of all maternal deaths during pregnancy. Mothers with low iron status can be heavily effected by the loss of blood during labour. As blood is lost, individuals already low in iron will drop to more alarming levels, resulting in an inability to provide their bodies with enough oxygen. Their hearts will begin to pump harder, eventually resulting in cardiac arrest, and subsequent death.

This begs a the question, how much iron does an individual need? The answer varies from person-to-person depending on body composition and lifestyle, however, the average male should be consuming roughly 8 mg of iron daily, and the average woman should be consuming nearly 18 mg per day. The drastic difference between men and women is due to the fact that women loose a large portion of their iron stores as they progress through their monthly menstrual cycle, forcing women to consume larger volumes of iron to compensate for their losses.

If we cant make iron ourselves, where do we get it from? Iron can either be obtained from the food we eat, or through supplementation. The iron in our diets is termed “dietary iron”, and there are two types: “heme Iron,” and “non-heme iron.”

Image source: Michael Collan, inSlideShare

Image source: Michael Collan, inSlideShare

Heme-iron is exclusively obtained through a carnivorous diet, in particular, it is found within the meat’s blood (attached to hemoglobin), and the meat’s muscle (attached to myoglobin). This type of iron is more bioavailable, meaning it is better absorbed through the gastro-intestinal tract into the blood stream. Non-heme iron is found in both animal tissue (representing 60% of the iron present), and is the only type of iron found in plant tissue (100%). This type of iron is comparatively less bioavailable. The implication here is that those who have a herbivorous diet must consume 1.8 times the amount dietary iron (as less of the iron they consume is appropriately absorbed through the GI tract into the bloodstream.) This further implies that vegetarians are more susceptible to iron deficiency.

Image Source: http://geekymedics.com/respiratory-examination-2/

Pale Conjunctiva                 Image Source: http://geekymedics.com/respiratory-examination-2/

Image Source: Rachel Casiday

Ferritin, Image Source: Rachel Casiday

 

 

 

 

 

 

How do we know if individuals are deficient in iron stores? One practical method is to track your dietary intake and calculate your iron consumption. However, a more reliable and specific mode of detection is through measuring “serum ferritin” concentrations within the blood. This is a protein that stores iron, and therefore, low levels of serum ferritin are indicative of iron deficiency. Clinically, the presence of pale conjunctiva of the eyes, or pale red inner lip colour can indicate low iron stores. The symptoms of iron deficiency are not obvious, and often go unnoticed, leading to many deaths that could have been easily avoided.

Ali Lamont

Sleep loss and Obesity ?

With the cold months ending and summer coming up very soon, this means cutting down for many people. People use countless methods to help them achieve that goal such as protein powder, creatine, and diet pills. Despite all this effort, a lot of people are making this one mistake that could make it much harder for them to achieve their weight loss goal. These studies below show and strengthen correlation between insufficient sleep and factors that lead to weight gain.

Lack of sleep and 2-AG

A new study published in the journal, Sleep, was carried out by a team of scientists who focused on a type of endocannabinoid. Endocannabinoid is a class of molecule that controls physiological processes in our body. They studied a molecule called 2-AG which is associated with our ability to control our appetite. When this molecule is circulating throughout our body, it decreases our ability to control instant cravings and increases the pleasure we get from eating food we would normally think of as unhealthy and feel guilty from indulging in.

They gathered 14 healthy young adults, both male and female. Half of them were allowed to get a full nights sleep which consisted of 8.5 hours compared to the other half who were restricted to 4.5 hours of sleep. What they found was that the level of 2-AG in their body was higher consistently through out the day and remained high in the evening for those who had restricted amount of sleep.

Increased level of 2-AG would make you crave junk food you normally wouldn't

Increased level of 2-AG would make you crave junk food you normally would stay away from. Image from deckofdreams

Lack of sleep and Leptin & Gherlin

Another study that supports this claim of correlation between insufficient sleep and weight gain was also done by Prinz and Taheri. Their studies looked at the level of leptin and ghrelin in participants with restricted amount of sleep. Leptin in our body serves to suppress appetite and stimulate burning energy in our body. Ghrelin on the other hand sends signal to make us feel hungry and tells the body to store more fat. By monitoring people participants who got less than 7-8 hours of sleep, they saw decreased level of leptin and increased level of ghrelin which ultimately lead to weight gain.

Example of how reduced levels of leptin produced in mouse leads to obesity (left) compared to normal mouse (right)

Example of how reduced levels of leptin produced in mouse leads to obesity (left) compared to normal mouse (right). Image from wikipedia

Just get more sleep!

In summary, when you get less than recommended amount of sleep of 7-8 hours every night, there is increased amount of 2-AG and ghrelin and decreased amount of leptin flowing through our body. This all serves to makes us less capable of controlling our appetite, and promotes fat build up. Thinking in reverse, this means that getting sufficient amount of sleep every night would help us control our appetite and have our body burning fat like usual! This should be convincing enough for anyone wanting to lose weight for the summer to spend more time in bed at night getting some shut eye.

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video – How Lack of Sleep can Cause Weight Gain. by Howcast

 

Alana Lee

Special K to treat the Blues

Ketamine is a drug that was developed in 1962 and is commonly used as an anesthetic during surgical procedures in humans as well as in animals. However, like most drugs, ketamine made its way into the party scene during the 90s due to it’s hallucinogenic as well as dissociative effects (alter a person’s perception of reality). Furthermore, it also became notorious for being a date rape drug and was eventually classified as a Schedule III drug.

A vial containing ketamine.

A vial containing ketamine. Courtesy of Wikimedia Commons

In an interesting turn of events, ketamine is now undergoing clinical trials for its potential use in the treatment of depression. Depression itself is a debilitating condition with approximately 121 million people globally affected by it. The same drug that was being used as a date rape drug is now being used to treat depression?!

Yes! Ketamine therapy is being used to treat patients with severe major depression who don’t respond to traditional antidepressant medication. The treatment consists of giving a low dose of ketamine to the patient. The most common way to administer ketamine is by injecting it or by intranasal (smelling it) use. The positive effects in mood can be seen within 24 hours and can last up to ten days. This is one of the biggest advantages of using ketamine because the effects are noticeable immediately compared to traditional antidepressants which can take up to several months to work.

A typical neuron. Courtesy of Wikimedia Commons

A typical neuron. Courtesy of Wikimedia Commons

Depression is a multi-faceted disorder with several causes, one of them being a reduction in synaptic connections – the area between two neurons. For example, picture a neuron being a tree during spring, with many branches and leaves. When depression comes along, that tree now looks shrivelled up with bare branches and no leaves. Introduce a bit of Special K at low doses, and it converts our sad looking tree into a healthy tree once again. In other words, the synaptic connections are restored. The exact mechanism behind this is still unknown and being investigated.

Like with any other treatment, ketamine therapy also has a few side effects. When patients are first given a dose of ketamine they experience dissociative effects which are only temporary. Another down side of ketamine treatment is cost. The effects of ketamine treatment are short lived so patients often have to get regular infusions and since insurance does not cover the cost of treatment, it can get expensive; a single dose can cost anywhere from $525 to $800.

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Courtesy of The Doctors

Furthermore, many opponents are concerned about the possibility of patients developing an addiction to ketamine. The dose used in clinical trials is well below the dose used by recreational users so it is very unlikely for the patient to develop an addiction. The future of ketamine therapy in treating depression looks promising and further studies should explore the long term effects of it before it becomes a standard in treating depression cases that don’t respond to traditional therapy.

Harnoor Shoker

Is What You’re Currently Doing, Killing You?

Chances are, while reading this blog post, you are seated on a chair in a posture that’s unhealthy for your body and some of you may even have back or neck pain.

Back and neck pain. Source: Flickr Commons

Back and neck pain.
Source: Flickr Commons

Sitting: An Unknown Assassin

Nowadays, it seems pretty much anything can kill you and astoundingly, this includes sitting. Sitting has become the new smoking as awareness of the adverse effects it has on our health increases along with the difficulty to ‘quit’ this subtle comfort. Unfortunately, most of us are bound by our lifestyle that revolves around a chair. Whether this is at work in an office, on a desk at school, during our daily commute, eating a meal, or relaxing at home watching television – we are bound to a habit that’s silently killing us.

Health Risks From Sitting

Sitting, termed sedentary behaviour, by the scientific community has shown to lead to cardiovascular diseases such as a heart attack or clogged arteries, type 2 diabetes, cancer, muscular pains, weight gain; all of which significantly raise your mortality rate despite exercising.

It is estimated that one loses 7 years of life expectancy if they’re sedentary compared to a physically active person. This makes anatomical sense as our bodies were not designed to be constantly stagnant as evidenced by our elastic skin, many joints and muscles, and how blood flow slows while sitting.  This is better explained by Murat Dalkilinc of Ted-Ed:

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What Can We Do?

Sit with an exercise ball. Source: Flickr Commons

Sit with an exercise ball.
Source: Flickr Commons

The solution is simple! While it may not always be practical, try to be more active if you have sat for a prolonged period of time. It’s best to get moving for every thirty minutes of sitting and there’s many different methods to try. Experiment sitting on an exercise ball; this works your core muscles giving your body a better balance. Also try yoga poses for a few minutes or a brisk walk in between commercial breaks.

As a reminder to staying healthy, why don’t you move around a bit right now. Whatever you do, just get moving!

Henry Liu

 

Ocumetics’ Bionic Lens: Prefect vision for everyone?

Are you suffering from poor vision? Do you ever complain about wearing eye glasses because they may ‘ruin’ your look? Have you ever imagined there would come a day to have perfect vision?

Recently, a new bionic eye lens named The Ocumetics Bionic Lens has got a lot of attention in media. This lens was developed by Dr. Garth Webb of Ocumetics Technology Corporation, who has dedicated his professional life to finding a way to improve and correct human vision regardless of patients’ eye conditions. This new bionic lens is able to correct human vision at all distance and give patients approximately three times vision enhancement for an entire lifetime. See the following YouTube video for a brief description of this new bionic lens.

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These specialized lenses are beneficial because they offset the risk of acquiring cataracts. This is because your eye’s natural lenses, which tend to deteriorate over time, have been replaced by these super stable bionic ones. In addition, compared to laser eye surgery, which involves corneal reshaping to improve visual acuity, this new bionic lens is perfectly safe; it does not cause any physiological changes to the eyes or other side effects that laser surgery may have, such as inflammation, astigmatism and decreased night vision.

How does it work?

According to Ocumetics’ website, this remarkable lens can be implanted into human eyes via a painless and outpatient surgery without anesthesia and hospitalization. The operation only takes 8 minutes, aiming to replace the eye’s natural lenses with the bionic ones. Ten seconds after the surgery, the bionic lenses unfold and wrap up over your eyes on its own, immediately correcting a patient’s impaired vision.

This remarkable lens looks like a small button. Image from www.cbc.ca

Is it affordable?

Dr. Webb claims the cost of the surgery is around 3000 dollars per eye. Is it overpriced? Compared to the laser eye surgery, which costs around 2000 dollars per eye, a total cost of 6000 dollars for lifelong perfect vision seems quite cheap for what is involved. In fact, this surgery may cost less than eye glasses or contact lenses in the long run because the new bionic lenses do not need to be replaced as often. Also, as the product and the technology become more mainstream in the market, the price will eventually go down.

Who can benefit from it?

The company is currently performing clinical trials on animals and blind human eyes. If the product was clinically approved to be able to cure blindness, it would be a great news for the blind. Also, for those people who are unhappy with wearing corrective lenses, this new bionic lens can provide them a better option in terms of cost, vision correction and ease of use.

Ying Yu

Link

Hospitals: More Dangerous Than You Think?

If someone suffered a heart attack or was involved in a car accident, the first place we would turn to is the nearest hospital, right? It happens almost every day; someone is carried into the ER on a stretcher and leaves smiling, walking on their own two feet. Generally, hospitals are perceived to be a safe place of medical assistance, treatment, and recovery, however, there is growing data to suggest that a stay in the hospital may actually come with risk.

Health care-associated infections (HAI), also called nosocomial infections (from the Greek word nosokomeíon, meaning hospital), are classified as infections that occur during a hospital admission and up to 3 days after discharge. They are a growing cause of lengthened hospital stays, medical complications, and even death in patients. In fact, it is estimated that these infections rack up a cost of one billion pounds for England’s National Health Service and over $35 billion for U.S. hospitals.

The intensive care unit (ICU) has one of the highest rates of HAI. Courtesy of Wiki Commons

The intensive care unit (ICU) has one of the highest HAI rates.
Courtesy of Wiki Commons

In 2011, the United States had almost 722,000 cases of HAI, ranging from surgical site infections to pneumonia. The Canadian Nosocomial Infection Surveillance Program also found an increase in the incidence of a specific bacterium, called C. difficile, from around 42 cases per 100,000 in 1992 to 160 per 100,000 in 2003. Additionally, the severity and reoccurrence also spiked, with more severe outcomes recorded, including perforated large intestines, shock, and death.

A common misconception is that only the elderly are at risk for HAI due to their weaker state of health. This is untrue, as studies find increasing numbers of these infections in children’s hospitals, maternity wards, and in the young adult population. A study published in 2014 found a more than triple increase in incidence of flesh eating disease, known as necrotizing fasciitis, in pregnant women that were admitted to hospital for delivery over the past decade. Children also experience a high prevalence of HAI, with the highest percentages recorded in intensive care (19%) and transplant units (27%).

So what can be done?
Unsurprisingly, poor hand washing has been attributed to 40% of infection transfers in hospitals, thus focusing on improving hand hygiene habits can have a positive impact. Increasing compliance of wearing protective accessories including gloves, masks, and aprons is also critical. As well, creating a system that immediately isolates patients who have contracted a severe infection is key to prevent further spreading.
Careful attention to sanitation must also be emphasized, as it was found that an antibiotic-resistant bacteria that attacks the intestinal tract can also be transferred between patients through the use of  thermometers.

The issue of HAI is a global problem, however it is not all doom and gloom when it comes to the future of patients’ well-being. Much research is currently underway to find new methods to decrease the prevalence. Take a look at the video below from the Mayo Clinic, where they tested the effectiveness of UV light disinfection. They found an impressive 30% decline in C. difficile infection in the UV-treated rooms!
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Kerrie Tsigounis

Multivitamins- A waste of money ?

It’s common understanding that maintaining adequate levels of essential vitamins and minerals is crucial for good health. For this reason, it comes to no surprise that the popularity  of multivitamins has surged over the past few decades and that they are now the most commonly used dietary supplement in the world. At the same time, there has been growing attention at the potential role these multivitamins may or may not play in improving overall health.

Multivitamins: Should You Take One?

Image Courtesy of: Flikr Commons

Like many others, I was under the notion that consuming 1-2 multivitamins a day would help satisfy any shortcomings of important nutrients my body may be lacking. “It’s reassuringly simple!” I would tell myself. ” Consume a pill and instantly have your bad diet turn into a healthy one.” Now if only that was the case…

As I look online, it’s evident that over the past few years, there have been several debates amongst scientists over the effectiveness of  multivitamins.

Do the promised claims on labels such as increased energy, increased cognitive functions and increased illness recovery hold any merit? One interesting find I came across was that dietary supplements such as multivitamins are not regulated by the FDA. This means that certain claims can be misleading since companies can imply that their products have greater capabilities than what the actual scientific evidence shows.

Recent studies have also even claimed that multivitamins may even be harmful. In particular, an editorial that appeared in the Annals of External Medicine, “Enough is Enough: Stop Wasting Money on Vitamin and Mineral Supplements“, made widespread coverage in the news media. The authors behind this research concluded with a bold statement, ““[W]e believe that the case is closed- supplementing the diet of well-nourished adults with (most) mineral or vitamin supplements has no clear benefit.” However, many scientists are arguing that the case is far from closed and that these studies completely disregarded their unique patient samples, none of which had nutritional deficiencies.

So what is the real answer? Just how effective are these pills of nutritional insurance to our overall health?

I think the best response to this question is that it is “short-sighted to think your vitamin or mineral is the ticket to good health- the big power is on the plate, not the pill”, as stated by Roberta Anding, a spokesperson for the American Dietetic Association.

So, unless you’ve discussed vitamin supplementation with your doctor, the majority of us are better off investing our time and money into acquiring nutrients the way nature intended, with a well balanced diet.

Check out this video below for another interesting take on the effectiveness of supplemental vitamins!

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YouTube video courtesy of: BrainStuff- HowStuffWorks

Thanks for reading!

Posted by: Sahil Mann