Category Archives: Biological Sciences

The Changing Field of Stroke Medication

Strokes are the fifth leading cause of deaths in North America. If one is fortunate enough to survive a stroke, the rehabilitation process is long and painful depending on the amount of damage done to the brain. There are two types of strokes – ischemic and hemorrhagic. Ischemic strokes are the result of a clot forming in an artery and preventing blood flow, whereas hemorrhagic strokes are the result of an artery bursting and and the brain literally bleeding out.

Many researchers have worked towards improving and developing treatments to reduce the amount of brain damage a patient suffers during a stroke. One of the events that takes place during a stroke is called excitotoxicity, where brain cells literally excite themselves to death.

Receptors like NMDA as well as calcium are key culprits in causing damage to brain tissue. NMDA is a protein that is present on nerve cells and binds to the neurotransmitter glutamate. When a stroke occurs, nerve cells release large amounts of glutamate which bind to these NMDA receptors. The binding of glutamate to an NMDA receptor causes it to open. Calcium which is present in excess on the outside of the nerve cell, enters the cell. The calcium alongside with glutamate go on to wreck havoc in the nerve cell ultimately leading to its death. 

Courtesy of Khashayar.

Dr. Nicolas Weilinger investigated what happens at a cellular level during a stroke and the mechanism which works to damage brain cells. While researching, Dr. Weilinger discovered a new signalling pathway that had broad reaching implications for brain physiology and pathology.

YouTube Preview Image Courtesy of Harnoor Shoker

The findings of this study are important because current treatments in place to protect the brain during and after a stroke are not as effective as they should be. One of the main findings of Dr. Weilinger’s paper was that another channel much bigger than NMDA called pannexin gets activated during a stroke. Pannexin is physically connected to the NMDA receptor so when the NMDA receptor opens it signals pannexin to open as well. The opening of another channel therefore allows more calcium and glutamate to enter at an even faster pace. Using this information, a new drug was designed that would prevent the NMDA receptor from communicating with pannexin – in other words it would block the physical connection between the two proteins.

The wider implications of Weilinger’s paper is to hopefully improve stroke treatment. Future research into Dr. Weilinger’s findings could potentially be the first step in discovering a new drug type that can be used to reduce brain damage suffered during a stroke.

**We would like to thank Dr. Nicholas Weillinger for his time and the SCIE 300 team for guiding us and providing feedback.**

Harnoor, Khashayar, Matthew.

Snap, Crackle and Pop Are the Sounds You Hear in Brittle Bones

What do you do when you drop something on the ground? Simple- you bend over and pick it up. It would never cross your mind that performing such a mindless gesture could land you in the hospital. However, if you are one of the many with osteoporotic bones, then you may be out of luck. Osteoporosis  is a condition that weakens bones and leads to fractures, affecting both men and women worldwide.

Image Courtesy Of: Flikr Commons

Surprisingly, many people are not aware of the detrimental effects of osteoporosis until it is too late.

 

 

 

 

Take a listen to the podcast below as we attempt to see how well informed the students at the University of British Columbia are of this silent disease.

As mentioned in the podcast, leading medical treatments for osteoporosis are currently limited to bisphosphonates. These are highly effective drugs aimed at limiting bone loss. However, they come with a fair share of disadvantages, including unwanted side effects and complicated dosing regimes.

As a result, alternatives are being investigated. In fact, applications using the element lanthanum have become a new area of interest. Lanthanum is a bone-seeker, as it has a high affinity for the main mineral component of bones, called hydroxyapatite. To further improve the effect of this element, suitable compounds known as chelators have also been studied to improve the targeting ability and enhance its affinity to hydroxyapatite.

In the most recently published study, a team of UBC researchers led by Dr. Chris Orvig have investigated the effect of lanthanum, along with certain chelators, in rats. In the following video, Dr. Orvig introduces the idea of using lanthanum as a potential treatment for osteoporosis and explains the overall implications of his research. Have a look!

In this video, Dr. Orvig emphasizes that this research is at the very basic level. However, he was able to elaborate on the significance and concerns of the potential role of lanthanum in the treatment of osteoporosis. One certain lanthanum complex has shown great promise, and thus will be a focus of interest for future studies.  Although the future of lanthanides in osteoporosis treatment is bright, it still needs support and funding.

Overall, we all can do our part in raising awareness of this disease, by providing people with the knowledge that it’s never too early or too late to take steps to improve your bone health.

Thank you for reading!

By Brigette Wee, Sahil Mann, Ali Lamont-Caputo, Kerrie Tsigounis

Hybrids: the good, the bad, and the … natural?

What do you think about when you hear the phrase ‘genetically engineered crops’? Do you think they’re inherently bad because they’re not ‘natural’?

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Zebroid – hybrid of zebra and donkey.  Image from Wikimedia Commons

Well, maybe you should think twice before answering, because hybridization is a process commonly found in nature. Basically, hybridization is cross-breeding between two species with different genes. In animals it’s pretty distinct in appearance, but in plants the main changes are on a chemical level. These changes are what affects the taste, smell, or defence mechanisms of the plants. Therefore, people might find a useful application to them, as hybrids may be grown as crops with better qualities, such as stronger resistance against diseases and insects. That’s why researchers are interested in exploring the genes of various plants to find the benefits, which humanity can use.

How the mystery unveiled

Dr. Celine Caseys in her lab. Photo by Alex B.

Dr. Celine Caseys in her lab at UBC. Photo by Alex B.

For example, Dr Celine Caseys and her colleagues at the University of Fribourg, Switzerland, examined the hybridization process between two types of trees from the Poplar family. Their methods involved collecting poplar leaves in three European regions and then looking for certain chemicals, responsible for defending trees from insects. More details on this research in the video below.

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Video: Benefits of Hybridization in plants by Henry Liu and Jan Jenko, Group 5

Practical use

The research revealed that hybrids are capable of creating better defence mechanisms by more efficiently producing chemicals against insects. This might have a practical application for productional growing of plants (like for biofuel) and, furthermore, for farming purposes, since the plants will require less pesticides, therefore growing crops will cost less. More on the benefits and potential drawbacks of hybridization in the podcast.

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Podcast: Benefits and drawbacks of hybridization by Alex Budkina, Group 5

As we learned from above, studying the effects of hybridization is really important, because despite all potential benefits, there are still some danger behind the artificial modification of genes, such as  endangering wild populations. Therefore, humanity must consider the  “ecological consequences”, according to Dr.Caseys, of creating genetically engineered plants. We still know too little about the process, so more studies of natural hybridization will help us to unveil the mysteries behind it.

~ Group #5: Alex Budkina, Henry Liu, Jan Jenko

Visions of a Greener Earth

Have you ever been watering plants and wondered just how much water was being absorbed by plants? Is the water you’re using to soak your garden even being put to good use by the plants? It turns out, plants contain an extensive system with complicated processes which allows them to “drink” water via osmosis. A little known fact, plants have an inner and outer layer which they use to filter water. Dr. Jetter, a researcher in the department of botany at the University of British Columbia, completed a study that aimed to figure out the function of each of those layers. He did this by examining eight different species of plants and studying the chemistry of each individual inner and outer layer.

Dr. Reinhard Jetter from UBC Department of Botany. Image courtesy of Daryl’s Camera

Our group had the pleasure of interviewing Dr. Jetter at the Biological Sciences building where he gave us further insight into his research. When our group first read his paper, we expected similar research had already been completed by scientists at other institutions but surprisingly, that was not the case. In fact, Dr. Jetter told us related research had only been done by one other group of scientists located in Germany in 2001. The video below highlights the most important components of Dr. Jetter’s research and what he found:

https://youtu.be/Ex1gqoDKbEQ

Video – Credit to Dr. Reinhard Jetter, Brian Wong, Daryl Kwok and Ying Yu

Plant cuticles were isolated. Image courtesy of Daryl’s Camera

A specially designed water chamber was used to measure how fast water passes through each layer of cuticles. Image courtesy of Daryl’s Camera

Why is this research significant? Well for one, North America suffered major droughts from 2012-2015 due to record-breaking heat waves. Acres of vegetation died off and as a result, entire ecosystems were disrupted. Additionally, water became an extremely scarce resource and states such as California were so desperate for water, they were buying it from Canada. So what are the nitty-gritty details regarding the composition of how plants control water loss? Furthermore, what are its applications to the general public? We examine this in the podcast below:

Audio –  Credit to Dr. Reinhard Jetter, Brian Wong and Ying Yu

Like all studies done in the name of science, there exist limitations. Each individual plant’s chemical components are not analogous, the water-loss barriers will vastly differ within each species. For example, in Dr. Jetter’s study, some plant species had up to 100 times water-loss prevention effectiveness versus other species. This variation is due largely to the interaction between chemical compounds within the plant itself. As a result, it would be an extremely extensive task to accurately record every individual plant species’ ability to control water-loss.

With Dr. Jetter’s research as a basis, huge potential exists in developing technologies that would drastically reduce the negative effects of drought. In the future, if scientists can fully understand and utilize the level of water loss between plant layers, vast farmlands which are highly dependent on weather conditions could be alleviated of disastrous levels of crop loss. Undoubtedly, Dr. Jetter’s research serves as the pioneering basis for a frontier of unspoken possibilities to benefit our great big green planet Earth.

-Group 3: Brian Wong, Daryl Kwok and Ying Yu

Stop smoking to make a big difference to your health

Nowadays, it’s hard to find a person who hasn’t heard about how harmful smoking is to our overall health. Each year, cigarette smoking is responsible for nearly 20 percent deaths in the United States and more than 6 million of people in the world died from smoking-related diseases. Smoking is harmful to every part of the body and can lead to serious health problems, such as cancer, heart diseases and respiratory problems.

 Smoking-related diseases

Smoking is one of the leading causes of cancer and it accounts for more than 30 percent of all cancer deaths in the U.S each year. The reason behind it is that smoking can trigger DNA mutations and damage the genes that protect us from cancers. Studies have shown that cigarette smoke contains more than 7000 chemicals and more than 69 of them are known to be carcinogens, which can cause varying degrees of DNA damage. As a result, people who smoke are more likely to develop certain types of cancers, such as lung cancer, throat cancer and liver cancer.

Additionally, cigarette smoking can cause heart diseases by damaging the function of your heart and the structure of the blood vessels. First, smoking produces carbon monoxide that can reduce the oxygen level in the bloodstream and hence increase heart rate to supply the body with enough oxygen. Second, some chemicals in cigarette smoke have been shown to cause the fatty plaque build-up inside the arteries. This will increase the risk of getting stroke, heart attack and atherosclerosis.

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The image shows how smoking can affect arteries in the heart. Image from National Heart, Lung, and Blood Institute.

Furthermore, smoking is also the primary cause of chronic obstructive pulmonary disease (COPD), which is a type of progressive lung disease that can cause respiratory problems and lung infections. The main symptoms of COPD include coughing, wheezing and shortness of breath. Cigarette smoking can also cause damage to lung tissues and reduce the airflow in and out of the lungs, resulting in many breathing-related problems.

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Youtube video – Smoking and its effects on Health. By iheedinstitute

Benefits of quitting smoking

Quitting smoking can lower the risk for smoking-related diseases and largely improve our overall health. Recent studies have shown that quitting smoking before the age of 40 can reduce the risk of early death from smoke-related diseases by 90 percent and increase the life expectancy by 10 years.The following graph shows the timeline of recovery effects after quitting tobacco.

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Timeline of health benefits after stopping smoking. Image from http://www.tobaccofreeco.org

In summary, cigarette smoking can cause negative health effects in many ways and it is also a major risk factor for developing cancers and other preventable diseases. Quitting smoking can help regain your health to the same level as those of non-smokers. It is never too late to stop smoking and start a healthy lifestyle!

-Ying Yu

Killed by comfort

We keep tinkering with our world, trying to make it better, more comfortable to live in. How we work, communicate, have fun and even the way we grow our food are constantly evolving. We are trying to create a utopia, but Dr. John Calhoun’s 1973 study suggests we might be in for a not-so-happy ending.

After the Second World War, population started rising frighteningly quickly, and it became obvious that such growth can’t go on forever. So, where does it stop? What will happen when it does?

Worries about overpopulation stimulated studies about the effect population density has on individual’s behaviour and perhaps the most famous was Dr. Calhoun’s mouse study, explained in the video below.

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Youtube video courtesy of: tamerahunt.

Mice were put in an environment where they faced no predation or scarcity of food or water. The only limiting factor was the space, which could still support around 3000 mice. But the population never come close to that number.

To begin the study, 4 pairs of breeding mice were introduced to their new environment (called Universe 1) and after an initial period of about three months, the population started rising exponentially. By day 315, there were already 620 mice. This is still far from the predicted 3000, but the growth stopped there. The animals were becoming increasingly aggressive and anti-social.

By day 600, society broke. The young were expelled before reaching maturity and were attacked by dominant males. Females also became more aggressive while non-dominant males became passive. Rather than reproduce, the mice started attacking each other. This escalated to the point where there were no new births, or if there were, the females would kill their own pups. Mortality rose dramatically.

One might think that once the population fell below some threshold, the behaviour might normalize, but it didn’t. The change that occurred in mice was irreversible and they were heading for doom. Dr. Calhoun called the tipping point the “Behavioral Sink”.

In this sick society, a subgroup emerged that seemed almost a separate species and Dr. Calhoun called them the “Beautiful Ones”. They were kept secluded from birth and were spared the insanity at the cost of no social interactions. They were hermits of sorts but because they lacked social interactions, they were also less intelligent. They weren’t violent, but they didn’t procreate either.

In the end, the colony died off. The research team made 25 such “Universes” and got the same result every time.

Dr. Calhoun in Universe 1. Source: Wikimedia commons, courtesy of Yoichi R Okamoto

Dr. Calhoun in Universe 1.
Source: Wikimedia commons, courtesy of Yoichi R Okamoto

These were studies on mice, but parallels can be made with our own species. In the developed world, countries are facing negative natural growth. In Europe for example, an average couple only has 1.4 children. If it weren’t for immigration, the population would already be in irreversible decline. Random violence? The shootings at schools don’t even shock us anymore. Mothers killing their young? Just last week, there was a pro-life demonstration on campus, I’m sure they’d love to tell you all about that.

Maybe these examples seem contrived, but perhaps there is something to it. Perhaps,  it would be best if we all went live in the woods and be merry. 🙂

Jan