Category Archives: Issues in Science

Brainless slime mold grows in pattern like Tokyo’s subway system

Physarum polycephalum, literally the “many-headed slime”

You may have spotted these yellow slime mold in your backyard, they flourish in shady, moist areas, such as decaying leaves. It is a single-celled organism that is not an animal, plant nor fungus. Scientists classify them to the taxonomic group named Protist, which is a group of organisms that are unicellular or unicellular-colonial and form no tissues. Slime mold isn’t capable of forming tissues, let alone organs or body systems. But surprisingly, a group of scientists from Japan found the brainless slime mold, Physarum polycephalum, to be able to remember, decide and solve complex optimization problems.

A group of researchers led by Toshiyuki Nakagaki from the Hokkaido University in Japan, placed Physarum polycephalum in a petri-dish scattered with oat flakes. The position of food scraps was deliberately placed to replicate the locations of some of the most visited site in Tokyo. In the first few hours, the slime mold’s size grew exponentially, and it branched out through the entire edible map. Within a few days, the size of its branches started to shrink, and the slime mold established a complex branching network between the oats on the petri-dish. Despite growing and expanding without a central coordination system like the brain, the mould had re-created an interconnected network made of slimes that looks almost exactly like the efficient, well-designed Tokyo subway system.

Comparison of the Physarum branching networks with the Tokyo subway networks

As you may know, the Tokyo’s rail system is one of the best in the world. With 102 train lines, it serves an estimated 14 billion passengers per year. Such a legendary metro system is the fruit of collaboration between community dwellings, civil engineering, urban planning over decades. However, the lowly slime mold solve this complex spatial problem in a matter of just a few days.

A beautiful map of the complex Tokyo subway system

Slime mold has been evolving on our planet for an estimation of at least 600 million years, and has survived through countless rounds of evolutionary competition. If we could capture the essence of this ancient adaptive network formation system and summarize it in to engineering and biological models, it will certainly inspire new algorithms that guides network construction many domains.

—-Ran Bi

Overstudying can actually cause your death

If you are a student and a month has passed since the last time that you checked your mails, hung out with your friends, or played your favourite game, you may be in danger of dying. Although studying itself does not sound very fatal, it comes with consequences. Sitting for a long time, lacking sleep, and overstressing, are three serious consequences of overstudying which can actually lead to death.

According to CNN “sitting too long can kill you, even if you exercise”. With no doubt school needs hard work. As a science student most of us may spend our days sitting in the library studying for the next test or doing our assignments, feeling productive and delighted while it could be not as much beneficial as we think. According to Thomas Jefferson School of Law sitting for a long time is a source of Pulmonary Embolisms (P.E.) which can lead to sudden cardiac death. In simple words sitting for a long time can lead to formation of blood clots which movement in body can cause sudden death.

Blood Clots in Veins / Thomas Jefferson School of Law website

 

The other fatal consequence of overstudying is lack of sleep. During exam periods student usually experience sleep deprivation. According to a study at Chicago Medical Institute sleep deprivation which simply is lack of sleep can cause serious diseases, such as heart disease and mental illness and in extreme cases it can cause death.

A neuroscience researcher, sleeping at work / The Connectome Website

Finally the most serious and the most common danger threatening students is overstressing. Almost all of the student will get stressed for their upcoming exams and deadlines which are many in each term. As stated in Boston Magazine Stress may take a toll on your mind, body, and heart. Researchers observed a strong correlation between activity in the brain and subsequent cardiac events, such as heart attack, stroke, and angina. An 18-year-old girl from Lahore passed away due to exam stress regarding to PARHLO.

As the last and interesting real example, in 1900, Harvard Law School student William T. Parker Jr. went crazy during an exam. He was then sent to a hospital, where he died several days later of “an abscess on the brain caused by overstudy,” according to the New York Times.

New York Times

As a conclusion studying may be the most important job that a student have but immoderation in anything can be harmful. An organized and moderate daily plan can be solution for a excellent academical and personal life. Overstuding can cause serious mental and physical problems which in extreme cases can lead to death. It may sound like a joke but understudying can be better than overstudying.

Author: Asana Khajavi

 

Eat less, live longer?

Did you know that eating less could extend your life? That sounds impossible, but eating less relates to restricting food intake, which to some extent, could benefit people’s health in preventing age-related diseases. Although there’s still no answer to the secret of a long life, scientists have made great efforts in the past years on studying the effect of calorie restriction on lives of animals and humans.

Monkeys as subjects: 

In the late 1980’s, two studies were conducted on rhesus macaques, human-like primates. One study was done by scientists at the Wisconsin National Primate Research Center(WNPRC).The researchers recruited young rhesus monkeys, aged 7 to 14. In 2009, they published a preliminary study in the journal science. At the age of 27, ordinary rhesus macaques had a hump, and the hair on their faces turned gray. By contrast, the calorie-restricted rhesus macaques, with their brown fur, are still energetic. The monkeys’ ability to resist age-related diseases has also increased by three times, and the incidence of cancer, diabetes, brain shrinkage and cardiovascular disease has dropped significantly. The result implies that calorie-restriction contributes to monkeys’ health and survival. Another study was done by scientists at the National Institute on Aging(NIH). In contrast, the research team reported in 2012 that calorie restriction can’t prolong the life of monkeys.

Humans as subjects:

One study followed a group of people who adopted caloric restriction diets, with men consuming 1400 calories a day and women consuming 1120 calories a day.

“Most of the benefits of caloric restriction in animal experiments are reflected in the human body. Those who started eating in the middle of their lives for eight years maintained a very good cardiovascular system. ” said Luigi Fontana, a biogerontologist at the university of Washington School of Medicine. According to Fontana’s team, calorie restriction can prevent atherosclerosis, and people who stick to calorie-restricted diets are healthier and have better heart elasticity and heart rhythm variability.

In brief, there are many unknowns about the study of calorie restriction. Let us expect scientists’ future discoveries in the effect of calorie restriction on prevention in aged-related diseases in human, somehow contributed to the increase of humans’ life expectancy.

Author: Xinwei Kuang

 

Negative Side Effects of Caffeine

What is the first thing you do to make yourself less tired? In order to stay awake to work or study, most people consume caffeine for mental alertness . Caffeine is not only included in coffee, but also included in tea, coke, chocolates, energy drinks, and other products that we regularly consume in our daily lives. Caffeine works by stimulating the adrenaline production and blocking sleep-inducing chemicals. 

Image credit: Pete

Although caffeine can help people by energizing them instantly, it can also affect people negatively. If more than 300 mg of caffeine consumed in one day, which are approximately three cups of coffee or three to four cans of soda, it may allow people to stay fully awake. However, the most frightening side effect of excessive amount of caffeine is insomnia, which can caused by six or more cups of coffee (approximately 250 mg of caffeine). From insomnia, one’s work performance and quality of life may be affected negatively.

Image credit: Michael Burger

Caffeine can also cause an increase in stress hormones because when a heart beats faster by the consumption of caffeine, it decreases the blood supply to the intestines. Due to the decrease in the blood supply, it may lead to the indigestion.

Can there be any other severe negative effects of caffeine that may have on humans’ health? In 2011, a study by British Journal of Pharmacology stated that caffeine could possibly reduce the chance of fertility in women because caffeine crosses the placenta and reaches the fetus. Also, University of Nevada School of Medicine showed that caffeine can reduce a woman’s fertility rate by about 27%. Therefore, due to immature metabolism of caffeine in fetus, caffeine can build up toxic levels in fetus, which leads to a higher chance of miscarriage and low birth weight of newborn babies.

What can we do to minimize the possible negative consequences from excessive caffeine consumption? Most people unconsciously become addicted to caffeine due to the desire for wide awakeness. Instead of searching for caffeine-containing drinks or food, it is better to get more sleep or consume other essential nutrients that make you less tired. Therefore, your eating or exercise pattern can be modified in the replacement of excess consumption of caffeine.

Author: Victoria Park

How Does Carbon Dioxide Cycle Through the Oceans?

Have you guys ever wondered where carbon dioxide (CO2) molecule goes after you exhale? A lot of carbon dioxide on the Earth, including what we exhale and carbon from our factories or cars, actually ends up in the ocean. Once CO2 molecule is in the ocean, it might travel in through the surface for a while before going back to the air above or it can travel deep down into the ocean and stay there for hundreds of years. A computer model was made to track CO2 in the ocean in order to find out where it travels and the time duration it stays at the bottom of the ocean. Research has shown that carbon dioxide cycles in different levels of the ocean. This information enables us to find out how the ocean responds to and contributes to global climate change.
 
The oceans play an important role to the Earth’s climate change because it can take in a huge amount of carbon above and store carbon in the atmosphere. In fact, more than 93% of the carbon dioxide (CO2) in the world is stored in the oceans. Fortunately, most of the CO2 is stored in the oceans, which leaves less CO2 in the atmosphere. The reason is that Greenhouse gases such as CO2 can trap heat that is radiated back to the Earth, which can overheat our planet. Thus, oceans help to store a large amount of CO2.
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Tiny plants called phytoplankton live on the surface of the water where they can be exposed to sun. They gather CO2 from the atmosphere to build their bodies. When they die, phytoplankton sink into the bottom of the oceans and bacteria break them down to release the stored carbon dioxide back into the seawater. This process is called biological carbon pump, which pumps carbon dioxide into the bottom of the oceans for many years.
 
Study has shown that phytoplankton are usually bigger in colder areas compared to warmer areas and stick together into large clumps when they die. This will make them heavier and sink down into the ocean further and faster before they get decomposed by bacteria. The colder area of the oceans also slows down the bacteria growth, which allows phytoplankton to sink further down before their carbon dioxide be decomposed and released by bacteria.
If humans keep continuing to pollute the Earth and emit CO2 to the atmosphere, the oceans and the world will become warmer. The warm oceans can not store more CO2, which will cause CO2 to be released into the atmosphere and further heat up the Earth. In order to break this cycle, humans need to work together to save our planet and reduce the use of fossil fuels and factory waste into the atmosphere. Also, human beings can avoid many natural disasters such as hurricane, blizzard, and volcanic eruptions resulted from the effect of Global Warming.

Cell-stretching robots and the importance of revisiting old ideas with new technology

People are great at coming up with terrible ideas, even when those people are scientists. Bad ideas can be harmless, like Lamarck’s theory of inheritance, or more sinister, like eugenics, an idea which inspired forced sterilizations and worse. The beauty of science lies in how these bad ideas are replaced by newer and better ideas. These bad ideas are old ideas like all old ideas, right?

Wrong. The history of science is overflowing with terrible ideas but a few gems remain hidden among the asininity.

A new robot, designed by Dr. Dana Damian at the University of Sheffield is based on one of these gems. The robot connects to a pig’s esophagus with two rings. Soft, wrinkled skin protects the robot’s position sensors and motors that slowly stretch the robot and the tissue it’s attached to. The robot was built with diseases like short bowel disease or esophageal atresia in mind. The robot elongated a pig’s esophagus by 77% over nine days and this elongation was almost entirely due cell division, not cells being stretched. By stretching the pig’s tissue, the robot encouraged cells to divide and build a longer esophagus.

Dr. David Mooney, a professor of Bioengineering at Harvard University, explained the ideas behind Dr. Damian’s robot are not new.

“We have long appreciated physical forces regulate biology,” he said in the Science Friday interview. He cites prescribing weight lifting regimen to osteoporosis patients as lifting weights has been shown to increase bone density and strength, helping combat the disease.

Robots like Dr. Damian’s could be implanted into newborns to treat physical ailments like atresia but the possibilities these robots raise are more far more exciting and wide reaching.

Robots applying steady and long-lasting mechanical stress could be used to stimulate stem cells to divide and specialize. This would simplify processes required to work with stem cells today which are expensive and potentially dangerous. A robot that could mechanically stimulate new stem cells for use in healing and recovering, while years away from clinical use, is now has proof of concept.

What other ideas has science relegated to dusty book shelves that could prove to be revolutionary today?

Using leeches and maggots in medicine are the best known examples of science breathing new life into old ideas. Scientists need to look back at old ideas, theories, and research with the benefits of modern knowledge and technology. Retrospective research could lead to new (but old) ideas of how our world works, avenues of research, or treatments for disease.

Oliver Sack’s, the late neurologist and writer, ended his essay Scotoma: Forgetting and Neglect in Science by exploring the nature of ideas in science. “Ideas, like loving creatures, may arise and flourish, going in all directions, or abort and become extinct, in completely unpredictable ways,” he wrote. “[This] brings home a sense that science is not an ineluctable process but contingent in the extreme.”

– Koby Michaels