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Stephen Hawking and the ALS disease

Dr Stephen Hawking Physics professor and author at Cambridge University

Less than a week ago, beloved cosmologist and theoretical physicist Stephen Hawking, science’s brightest star, died at the age of 76 in the morning on Mar.14. His brilliance and persistence has inspired people around the world. People who are not specialist in physics may have not heard of his four laws of black hole mechanics or the Hawking radiation, but often have heard of his courageous story and lifelong battle with the amyotrophic lateral sclerosis disease (ALS).

While studying at Oxford, the young Stephen Hawking was diagnosed with ALS – a disease that causes death of neurons and gradually paralyses voluntary muscles – at the age of 21, in 1963. The doctor gave him a life expectancy of less than three years, but Stephen Hawking have defied the odds and coped with the daunting disease for over half a century. He spent 30 years as mathematics professors at the University of Cambridge, published the world-renowned The Universe in a Nutshell and A Briefer History of Time, which introduced cutting edge findings in theoretical physics to millions of readers. While Lou Gehrig and other people that suffer from ALS usually succumb in less than ten years, why has Hawking beat the odds and lived with the formidable disease?

Illustration of a normal nerve structure (left) and an ALS affected nerve cell (right)

Amyotrophic lateral sclerosis is a highly variable disorder and can be classified a few different ways: by where the motor neuron is first affected, and by how fast the disease progresses. Hawking was an outlier, the neurons that control the diaphragm and swallowing muscle are not severely deteriorated, that means breathing muscle functions properly, malnutrition and dehydration which are often found in other cases would not be seen on Hawking.

The disorder progression also tends to be slower in people with onset at less than 40 years old, the reason behind this remains unknown. Hawking’s case is very similar to juvenile amyotrophic lateral sclerosis, which progresses very slowly and have a life expectancy of more than 30 years. And like his mind, Hawking’s illness seems to be singular. Hawking’s longevity is partly due to the excellent care that he received, and more importantly – the biology of his form of the neurodegenerative disease. Stephen Hawking’s case is a unique example of the variability of the disease, he not only gives hope to patient who also suffer from the ALS disease, but also inspires millions for his determination to fight against the odds.

Stephen Hawking’s contribution to physics and cosmology will live in the annals of science forever.

Video Video

Graphics Processing Unit (GPU): The protagonist of the new computing era

Most people know the Moore’s Law in Computer Science:  the number of transistors in a Central Processing Unit (CPU) doubles approximately every two years. However, this speed will stop in several years because of physical limitations. In contrast, Graphics Processing Unit (GPU) will keep this rate for a long time.

8:36pm Match 3 of AlphaGo vs Lee Sedol. The confidence of the human commentary is fascinating.

The rapid development of GPU is not the main reason why some people say the new GPU era is coming. The most important reason is the world is changing by deep learning. You may be not familiar with this term, but it is very possible for you to know AlphaGo, one computer program developed by Google, that beat the world No.1 ranked player of the board game. The program uses the algorithm of deep learning to know how to play the game (There is a short introduction video of deep learning below). What is the “brain ” of deep learning? The answer is GPU! You may hear that CPU is the “brain” of one computer, but GPU plays a more important role in artificial intelligence because its structure is perfect for the features of these algorithms.

“Deep learning involves a huge amount of matrix multiplications and other operations which can be massively parallelized and thus sped up on GPU-s.”, One Ph.D. in Computer Science said on Quora. Most people know one CPU usually have two to four cores, and the high-end CPU i7-8700k has up to six cores. However, GPU can have more than five thousand cores that are able to do operations parallelly.

In summary, because of the high-speed development of GPU and its huge advantages on deep learning, the nex computing era will be lead by it, so now you can understand why the prices of GPUs always are increasing 🙂


-Xiangshuo Li