Author Archives: samin shadravan

Robots Can Help Children with Autism Learn

About 1 in every  160 children globally has autism spectrum disorder. Most of them face developmental delays such as behavioral challenges and difficulties with social interaction. This makes learning new skills a serious challenge for them, especially in traditional schools.

It has been reported that socially assistive robots can help autistic children learn, but only if the robot can accurately interpret their behavior and react appropriately. In 2020, researchers at the University of Southern California developed a personalized learning robot called Kiwi for children with autism.

Kiwi, a personalized learning robot for autistic children. Source: kcet.org

Kiwi Teaching Math and Social Skills

Kiwi uses math games and an algorithm that monitors the child’s math performance to provide appropriate feedback and change the games’ level of difficulty accordingly.

While the content of the game focuses on math, the main purpose is to teach the kids fundamental social skills through their interactions with the robot, such as turn-taking (is it my turn or Kiwi’s turn to talk?) and eye contact (should I look at Kiwi when I’m talking?). Kiwi also uses data such as dialogue and eye contact to predict whether children are engaged in a given activity. If it detects that the child is not engaged, it tries to re-engage them for an extended period of time. When tested, Kiwi managed to reach a 90% accuracy in predicting the child’s engagement.

Collecting Data from a Realistic Environment

The study is based on the information collected after leaving Kiwi with 17 autistic children for a month in their homes. Participants regularly played the games on Kiwi’s attached tablet. The robot would then give personalized feedback through a reinforcement-learning algorithm. This algorithm enables Kiwi to elicit the best possible feedback by modifying its response based on each child’s reaction in the same way as the study’s lead author describes:

“If you think of a real learning environment, the teacher is going to learn things about the child, and the child will learn things from them. It’s a bidirectional process and that doesn’t happen with current robotic systems. This study aims to make robots smarter by understanding the child’s behavior and responding to it in real-time.”

The following video shows the robot, its interaction with an autistic child, and the researchers’ insights about it:

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Source: NSF|YouTube

Surprising Results

Assessments were conducted for each participant before and after the month-long interventions. The results surpassed the researchers’ expectations of participants’ improvement. At the end of the study, 100% of the participants demonstrated improved math skills; 92% of them also improved in social skills.

Despite having promising results, such interventions are typically inaccessible to most people due to their high costs. The hope is that in the future, such socially assistive robots become affordable and turn into personalized therapeutic companions for all autistic children to improve their development.

I’ll leave you with the following short film telling the story of an autistic boy improving his social skills with the help of Kiwi:

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Source: USCViterbi|YouTube

-Samin Shadravan

Combating Antibiotic Resistance with “Nanoparticles”

The Centers for Disease Control and Prevention (CDC) calls antibiotic resistance “one of the biggest public health challenges of our time.” But what is antibiotic resistance? How is it affecting our lives? and How can we use nanoparticles to fight it?

Antibiotic Resistance Crisis:

Antibiotics are powerful medications that are widely used for the treatment of infections caused by bacteria. However, taking antibiotics too often or for the wrong purpose caused bacteria to evolve various antibiotic resistance mechanisms.
Some bacteria have developed resistance to nearly all the antibiotic treatments available and can cause serious fatal diseases that were once easily treatable with antibiotics.

Without the invention of new strategies to counteract drug-resistant infections, they are likely to kill more than 10 million people each year by 2050. This is more than the number of  people currently dying from cancer.

Ongoing studies are analyzing the ways nanoparticles (small particles ranging between 1 to 100 nanometres in size) can be used to defeat antibiotic-resistant bacteria. The size of nanoparticles and their flexible antibacterial properties make them a favorable solution to this problem since they can be used to not only deliver antibiotics but also to fight bacteria themselves.

The following video explains what nanoparticles are, how they are produced, and how they can enter and kill the bacterial cells:

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Source: TCTTPC YouTube

Nanoparticles as Antibiotic Carriers:

According to this study conducted by Zhang and his colleague in late 2020, some nanoparticles can penetrate into the bacterial cells while carrying and protecting the antibiotic agents. These nanoparticles —developed using materials such as metals and chitosan (a type of fiber)— can save the antibiotic from chemicals released by bacteria that can otherwise destroy them.

 Chitosan nanoparticle possesses a positive charge making it able to attach to bacterial cells that have a negative charge on their membrane (outer layer of the cell). Source: ResearchGate

Nanoparticles as Antibiotic Drugs: 

Nanoparticles can also defeat bacteria directly using mechanisms such as the generation of reactive oxygen species (ROS). ROS are unstable molecules that can easily react with other biomolecules (DNA, protein, etc.) in a cell, disrupt them, and cause cell death.

Silver nanoparticles (SNPs), for instance, can destroy the bacterial membrane and interact with interior components of the bacterium by releasing silver ions that can generate ROS inside the cell. Indeed, severe cellular damages in 5 different types of bacteria were reported when treated with SNPs.

Effect of Nanoparticles on Bacteria

E.coli (a type of bacteria) (left) is severely damaged when treated with a  silver nanoparticle (right). Source: pubs.acs.org

Nanoparticles appear to be a promising solution to address the problem
of antibiotic resistance; however, the main factor that limits their application in treatments is that researchers often face side-effects related to nanoparticle toxicity when interacted with biological systems like human cells. For instance, the ROS generated by a high dose of SNPs can damage the human cell components.

New strategies are being investigated to direct the target of nanoparticles to bacterial cells only and reduce their toxicity in order to develop safe and efficient antibacterial nanoparticles.

– Samin Shadravan

Combating Antibiotic Resistance with “Nanoparticles”

The Centers for Disease Control and Prevention (CDC) calls antibiotic resistance “one of the biggest public health challenges of our time.” But what is antibiotic resistance? How is it affecting our lives? and How can we use nanoparticles to fight it?

Antibiotic Resistance Crisis:

Antibiotics are powerful medications that are widely used for the treatment of infections caused by bacteria by either killing them or inhibiting their reproduction. However, taking antibiotics too often or for the wrong purpose caused bacteria to evolve various antibiotic resistance mechanisms that defeat the actions of antibiotics.
Some bacteria have developed resistance to nearly all the antibiotic treatments available. Infections by these antibiotic-resistant bacteria can result in serious fatal diseases that were once easily treatable with antibiotics.

Without the invention of new strategies to counteract drug-resistant infections, they are likely to kill more than 10 million people each year by 2050. This is more than the number of  people currently dying from cancer.

Bacterial Resistance to Antibiotic Drugs, Source: phys.org

Ongoing researches are analyzing the ways nanoparticles (small particles ranging between 1 to 100 nanometres in size) can be used to defeat antibiotic-resistant bacteria. The size of nanoparticles which is about 1/100 of bacteria and their flexible antibacterial properties make them a favorable solution to this problem since they can be used to not only deliver antibiotics but also to fight bacteria themselves.

Using Nanoparticles as Antibiotic Carriers:

According to this research, some nanoparticles have the ability to penetrate into the bacterial cells while carrying the antibiotic agents. They protect the carried antibiotic physically against the bacterial resistance mechanisms, for example by saving the antibiotic from bacterial released chemicals that can otherwise destroy them.

Chitosan (a type of fiber) nanoparticle can be used to deliver antibiotics to inside the bacterial cells. This nanoparticle possesses a positive charge making it able to attach to bacterial cells that have a negative charge on their membrane (outer layer of the cell). Source: ResearchGate

Using Nanoparticles as Antibiotic Drugs: 

Nanoparticles can also defeat bacteria directly by themselves using mechanisms such as the generation of reactive oxygen species (ROS). ROS are unstable molecules that can easily react with other biomolecules (DNA, protein, etc.) in a cell, disrupt them, and cause cell death.

Recent research recorded severe cellular damage in 5 different types of bacteria when treated with silver nanoparticles. As they reported, an increase in ROS formation leads to damage to bacterial biomolecules resulting in the death of bacteria.

Effect of Nanoparticles on Bacteria

E.coli (a type of bacteria) (left) is severely damaged when treated with a special virus-like nanoparticle (right). Source: pubs.acs.org

Nanoparticles appear to be a promising solution to address the problem
of antibiotic resistance; however, the main factor that limits the use of nanoparticles in treatments is that researchers often face side-effects related to nanoparticle toxicity for living organisms. For instance, some metal nanoparticles can cause heart problems or even cancer when inhaled.

The ways through which nanoparticles can produce toxicity need to be investigated in future researches in order to develop safe and efficient antibacterial nanoparticles.

– Samin Shadravan