How Safe is Your Data in a Quantum Computer Era?

Quantum computers have recently gone from science fiction to science fact. The tech has the potential to advance countless fields with its unparalleled computing power, but it may also spell the end of internet security as we know it. You are likely wondering what the heck is a quantum computer? And what does it have to do with internet security? 

Quantum Computer, Processor, Computer, Technology

Source: pxhere.com

Quantum Vs. Classical

In simple terms, classical computers use a system of 1’s and 0’s called bits in order to store information. Each bit can either be a 1 or a 0, and when you string lots of bits together, you can form complex information. Computing power is limited by how fast these bits can be read.

binary code, binary, binary system, byte, bits, administrator, virus, trojan, computer, digital, 1, software, code, developer, software development, program, hacker, blue, green, text, technology, line, pattern, font, mesh, energy, electric blue, net

Source: pxhere.com

Qubits are like bits, but instead of being limited as either a 1 or a 0, they can be both a 1, a 0, and anything in between all at the same time. While this concept may make your brain hurt, the important takeaway is that qubits allow quantum computers to skip step by step computing.

Let’s say you take a test. You answer the first question, then the second, and so on. This is how a normal computer works, but a quantum computer would be able to answer all the questions simultaneously. 

Understanding the basics, let’s figure out why internet security might be in the crosshairs of quantum computers.

Encryption for Everyone

You rely on encryption every day to keep your personal information safe online. While different encryption methods vary, the most common of these are public key encryptions

Computer, Encrypt, Encryption, Security, Green Computer

Source: pixabay.com

If I told you to multiply 556 by 632, you could easily use a calculator to find 351,392. But if I gave you that number and asked you to find two specific factors, you could come up with a bunch of different answers. 

Public key encryption jumbles up information and hides it behind a really large number like a “door”. To unlock this door you need the right factors or the “key”. Use a large enough number, and even the most powerful conventional computers would need thousands of years to crack the code.

Quantum Codebreaking

Factoring these large numbers would be easy for a quantum computer, as it would be able to guess every answer at the same time. A recent study published by the International Journal of Advanced Computer Science and Applications concluded that:

The consequence of this technological advancement is the absolute collapse of the present public key algorithms that are considered secure…” (IJACSA)

Using qubits, computers could break a code that would take normal computers thousands of years to crack in mere hours. For a more complete understanding of how this could work check out this video:

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Thankfully quantum computers still have a ways to go before they pose a real threat to our online security. Researchers are also developing quantum proof encryption, but who knows if it will be able to protect us from the coming quantum era. 

– Declan O’Driscoll

A Promising Treatment in the Fight Against Microplastics

Over the past few years, there has been a global effort by scientists to develop a treatment that is able to limit the pollution of microplastics into marine environments. Fortunately, Marthe Kiendrebeogo and her research team may have found a solution. They discovered that they were able to effectively break down a sample of microplastics through anodic oxidation. 

Now you may ask, what are microplastics?

Microplastics are pieces of plastic less than 5 mm in length. The three main sources of microplastics are the breakdown of larger plastics, cosmetics and laundry washes. All three of these sources have contaminated marine environments all over the Earth. To put this into perspective, a recent study has suggested that there are approximately 12-125 trillion microplastics floating in the oceans today. 

A collection of mainly plastic material that washed ashore. Plastics, such as a water bottle, can be degraded and become a source of microplastics.

Credit: unsplash.com/john_cameron

The Effect of Microplastics on Life:

The buildup of microplastics in aquatic life through ingestion can lead to toxic (harmful) effects. These effects were studied by a different research team led by Dr. Kogel where they found the toxic effects included infertility, decreased growth rate, shorter lifespans, and internal damage. Furthermore, microplastics are known to travel up the food chain and eventually reach humans. There is currently a lack of information regarding the effects of microplastics in humans, but several studies are in progress.

YouTube Preview ImageFor those interested, Drs. Sarah Dudas and Peter Ross show the presence of microplastics in aquatic life in this video.

And now to the study:

With the background information out of the way, I’m going to explain how Marthe Kiendrebeogo and her team created a potential solution to tackle the rising issue of microplastics.

This research team found that the process of anodic oxidation breaks down microplastics efficiently. Anodic oxidation involves a lot of chemistry, but the main thing to know is that it creates hydroxyl radicals (OH-) without adding extra chemicals into the water. These hydroxyl radicals are very good at attacking and breaking down microplastics. The full mechanism is in the article for those interested. This study found that with their proposed mechanism, 58 ± 21% of microplastics broke down in 1 hour which reached approximately 80% in 3 hours. 

I think that the most significant result in this study is that 58 ± 21% of polystyrene was degraded in 1 hour because an hour is close to the time of a normal laundry cycle. A laundry cycle puts a lot of stress on clothing fabrics which leads to the release of microplastics. In fact, a recent study has estimated that 35% of microplastics in oceans can be contributed to laundry. Thus, this mechanism would be very effective at decreasing the amount of microplastic production if it was implemented into laundry machines.

The addition of this treatment into laundry machines can limit the number of microplastics released at the initial source.

Credit: unsplash.com/scottsweb

Based on the results of this study, the future of treatments for microplastics sounds more promising. Nevertheless, there still is a lot of work to be done. The next step for this promising treatment would be to test the effectiveness of the proposed mechanism on samples consisting of other microplastics. 

-Karnvir Dhillon

Use of Nanotechnology in Cancer Therapy

Would you believe someone if they told you that there is a type cancer therapy that is more effective and has less negative effects than chemotherapy, yet is less commonly used?

Cancer is characterized by the rapid division of cells anywhere in the body.  Every day, your body produces many potentially cancerous cells that are later destroyed. Moreover, every year, over 10 million people are diagnosed with cancer. With such a large amount of diagnoses, cancer remains one of leading causes of human death as it is generally incurable due to the metastasis of cancer cells.

Microtubules in breast cancer cells leading to rapid cell division.

Credit: National cancer institute. Downloaded from: Unsplash.com

An article by Ranjita Misra and her research team  describes a new yet promising technique in cancer treatment and early detection known as nanotechnology cancer therapy.  Today, treating cancer through radiation and chemotherapy is the most popular option. Chemotherapy has numerous negative effects like drug resistance and an insufficient amount of drug reaching tumour sites. This can lead to insufferable side effects as both cancerous cells and healthy cells are destroyed. 

The use of nanotechnology in cancer therapy involves the production of small particles called nanoparticles that are effective in transporting anticancer drugs to target cells while minimizing damage to healthy cells. Nanoparticles target cancer cells through active targeting and passive targeting. Examples of nanoparticles approved by the FDA include nanoparticle-liposome and albumin nanoparticles. Liposomes in particular are vital in nanotechnology cancer therapy as drugs transported through nanoparticle-liposomes have shown to have significantly longer half lives, upwards of 55 hours. This is important as the drug is able to stay in the body for a longer time meaning less drug is needed, which reduces damage to healthy cells. Another reason liposomes are favourable is because of their composition. Their hydrophobic composition allows appreciable amounts of anticancer drug  to reach the tumour site as the body cannot destroy the drug . This is important in cancer therapy as damaging healthy cells due to excess drug is the main reason why chemotherapy has numerous side effects.  The mechanisms and benefits of nanotechnology cancer therapy talked about above are explained in more detail by Joy Wolfram (2018) in the video below.

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TEDtalk by Joy Wolfram in 2018 about nanotechnology in cancer therapy.

 

Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer - ScienceDirect

Liposome nanoparticle structure that is used for cancer therapy.

Credit: ScienceDirect. Downloaded from Unsplash.com

This breakthrough in cancer therapy shows that science is forever evolving and that in the future it is possible there will be a cure for cancer.  Although nanotechnology cancer therapy is a relatively new area of research it shows tremendous potential and over time it is expected that larger advancements in preventing and treating cancer will be seen. Lastly, it is believed by researchers that nanotechnology cancer therapy has the potential to be the main form of treating cancer in the future due to the fact that it has less side effects and is more effective than chemotherapy (Gharpure et al. 2015).

Balkaran Dhaliwal

Itching Towards a Solution to Eczema’s Problem

For those who are living with atopic dermatitis, commonly known as eczema, it’s not always fun.

Imagine that one minute you’re going on about your day, then suddenly your skin flares into an itchy, dry and blistering rash. The skin irritation becomes agonizing as soon as you start to feel your skin throb and burn, almost as if a million fire ants endlessly crawl all over your skin.

According to the Canadian Dermatology Association, this is what 17 percent of Canadians deal with throughout their lives. 

Source: flickr.com

Recent Research

A recent study published in the Journal of Investigative Dermatology examined the relationship between an enzyme known as Granzyme B and the symptoms associated with eczema. According to Dr. David Granville, UBC’s Faculty of Medicine professor and researcher, increased Granzyme B secretion causes the enzymes to “eat away” cell-adhesion proteins that function in holding skin cells together. As a result, the skin barrier is weakened which increases skin sensitivity, thereby introducing symptoms like skin inflammation, dryness and itchiness. 

So what would happen if these enzyme levels were decreased?

Granville and his team discovered that by lowering Granzyme B secretion levels with inhibitors, skin cell layers were more likely to remain intact as fewer cell-adhesion proteins were eaten by these enzymes. Symptoms such as inflammation and lesion growth were shown to be greatly reduced compared to such increasing symptoms associated with high Granzyme B secretion levels. As these observed symptoms contribute to dryness and itchiness, these findings ultimately introduces a newer approach towards treating eczema.

A Step Closer to Newer Treatments

How can these findings be implemented into future treatments for individuals who have eczema?

Former UBC postdoctoral fellow and lead author of the study Dr. Chris Turner, suggests that with further research and clinical trials, these findings can potentially introduce topical creams or lotions that can inhibit Granzyme B levels in the future, ultimately reducing symptoms of itchiness and inflammation on affected skin. This potentially brings in treatments that avoid damaging the skin.

“Corticosteroid creams are a common treatment for individuals with AD who experience more severe itching and rashes. However, these can thin the skin when used over a prolonged period of time, which can make skin more prone to damage and infection.” (VCH Research Institute)

Source: med.ubc.ca

As further research opens up more information about eczema and the enzyme that aggravates its symptoms, hopefully it’ll help researchers get closer towards developing potential treatments. Perhaps one day a Granzyme B-inhibiting cream will become available in the market.

After all, no one likes to have itchy, dry skin.

– Tina Huynh

Catnip Magic was a Protection Against Mosquitoes (old)

Catnip is a plant that can bring about a euphoric state and cause most cats to act unusually as if they are drunk. If you own a cat, you may have used catnip products and witnessed your cat rolling, flipping, and rubbing. Some cats even zone out. The responses to catnip are also observed in other felids such as lions and bobcats.

“For cats, catnip may be a recreational drug but it’s totally harmless. […] After about 10 minutes, the cats come back down to Earth” (Wild At Heart, BBC Earth)

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Credit: Wild At Heart | BBC Earth

Why do cats behave in this way?

Since the first feline response was reported by a British botanist back in 1759, this behaviour remained mysterious for a long time. It was generally thought that the responses were purely driven by the euphoric experience. However, in January 2021, a team of scientists from multiple universities in Japan and The University of Liverpool found that the responses allow cats to protect themselves from mosquito bites.

The team found that in the silver vine plant (which has the same effects as catnip), the significant component that induces the characteristic behaviour is called nepetalactol. The team also found that it has mosquito repellent activity. In catnip, the corresponding chemical is called nepetalactone and has similar properties.

When cats sniff these chemicals, it stimulates the brain system u-opioid. In humans, this system controls the rewarding effects. Researchers confirmed that the stimulation induces cats to rub their bodies and face against the chemical. This rubbing and rolling behaviour transfer the chemical onto their fur, allowing the cat to gain a chemical defence against mosquitoes.

The neurophysiological and functional significance of silver vine response in cats.
Image Credit: Chie Nakayama adapted from Uenoyama, Reiko, et al. doi:10.1126/sciadv.abd9135.

Their findings confirmed that the euphoric experience drove the behaviour. At the same time, it showed that what seemed like a crazy behaviour was surprisingly a functional one. The research sheds light on developing new mosquito repellents for humans in the hope of gaining protection from the transmission of malaria and yellow fever.

– Chie Nakayama

From Recreational to Pharmaceutical – Promising Party Drugs in Research

Source: Unsplash.com

3,4-Methylenedioxymethamphetamine, more commonly known as MDMA, ecstasy, E, M, or Molly, is an infamous psychoactive drug often associated with nightclub and rave scenes. Hours of partying are fueled by intense feelings of pleasure, emotional warmth, and an abundance of energy owed to this little pill with so many names. The negative stigma attached to recreational drug use has given MDMA a bad rep, but a team of researchers in California are repurposing this synthetic drug to treat anxiety in people suffering from life-threatening illnesses (LTI).

In one of the first clinical trials of its kind, Dr. Philip Wolfson and his team explored how using MDMA during psychotherapy sessions impacted anxiety levels. The team found that the study participants who took MDMA had improved mindfulness and a more positive outlook towards their traumatic experiences. Depression, sleep quality, and anxiety levels also improved, but these improvements couldn’t conclusively be attributed to the MDMA. The findings of this small pilot study suggest MDMA could still have potential to reduce anxiety associated with LTI and may also have positive long-term effects.

MDMA is only one of many drugs currently being researched for therapeutic applications. LSD, famously tested for mind control by the CIA in the 1950’s and 60’s as a part of the MK-ULTRA Program, shows potential for treating alcoholism and could also treat PTSD. Another psychedelic drug called psilocybin, the active compound in magic mushrooms, is being investigated to treat a myriad of mental health disorders: from depression, to anxiety, to OCD, to certain substance use disorders. A horse tranquillizer called ketamine, which doubles as a club drug, is being researched to treat depression and (so far) shows potential.

Although current studies show promising results, could the stigma surrounding hard drugs like MDMA and ketamine deter patients from taking them once/if they become approved for clinical use? Or would the existing stigma dwindle once they get a doctor’s stamp of approval? Or maybe it’s simply why the drugs are used that give recreational use a bad name. Whatever your beliefs and convictions, scientifically, hard drugs may have a place in medicine in the (potentially near) future.

Source: GoodRx.com

By Maya Bird

Protein Folding: Solved

Just as the turmoil of 2020 was coming to a wrap, a scientific breakthrough came about. On November 30th, AlphaFold, coming out of DeepMind, claimed to have solved the protein folding problem using artificial intelligence.

The Problem

Proteins perform the majority of work done in our cells from synthesizing DNA to getting rid of waste. Of course, the way a protein functions is largely dependent on its structure. This can include characterizations such as what parts of the protein are exposed versus tucked away. The proteomics field is dedicated to studying these, what is currently estimated to be, 80,000 to 400,000 proteins in our bodies and use two main strategies to determine their structure in the lab: X-ray crystallography and NMR. And yet, even in the midst of these complex protocols and high-tech machinery, a structure can take between a week to a few months to piece together according to UCONN Health.

The Game Changer

This is where AlphaFold sneaks into the picture. AlphaFold chose to take a different approach to this nominal problem: artificial intelligence.

Artificial intelligence has taken the world by storm and has improved the accuracy and efficiency of processes in almost every industry. From self-driving cars to artificial voices the possibilities are endless. 

General scheme for developing an artificial intelligence model.

Put very simply by the diagram above, artificial intelligence, more specifically machine learning, trains a computer to look for patterns within a given dataset. Once trained, this program can use the patterns it learned to make predictions of its own. In the case of AlphaFold, their model was trained off of amino acid sequences and their predetermined structures.

Just one of the many protein folding predictions generated by AlphaFold’s model.

In comparison to the time it takes in the lab, AlphaFold’s model was able to predict protein structure in a mere half an hour with an accuracy of 90% according to their statement. In fact, it has already helped an evolutionary biologist named Andrei Lupis with piecing together a protein his team has been stuck on for a decade. In an interview for nature, Lupis even said: 

“This is a game changer, this will change medicine. It will change research. It will change bioengineering. It will change everything”

Beyond AlphaFold

Of course, while AlphaFold may be a hot-topic, beyond protein folding, AI has also been used for a variety of tasks including interpreting MRI images, predicting climate change, or even sifting through astronomical data. The applications seem to be limitless so make sure to keep an eye out, the next breakthrough could be coming up just around the corner!

Jessica Petrochuk

 

 

Welcome to SCIE 300 Blogging!

Welcome to the SCIE 300 course blog!

Here are some things to note before you start posting. First, you should read the blogging resources page in the Create menu. This will help if you’re new to using WordPress; you’ll find video tutorials about writing posts on this blog, adding media to your posts, tagging, and categorizing. You’ll also find a link to the grading rubric for your blog posts.

Next, check out the blogging guidelines. Here you’ll find the answer to the question: “What are we supposed to blog about?” You can also check out one of last term’s blogs for some additional inspiration.

There are a few important things to keep in mind when blogging. Please do not assume that just because something is online, it is OK for you to use it. For example, unless it is explicitly stated, an image on the internet can not just be copied, saved, and used in your own post without permission to do so. We’ve provided you with a lot more detail about properly using online content, but if you have questions, let us know.

This blog also contains a lot of resources for you. For example, also under the Create menu, there is a list of suggested software to use for your projects. We’ve also collected some writing and presentation resources. Basic audio/visual equipment can be borrowed from SCIE300. Contact the course coordinator for more info.

Under the Explore menu, you’ll find some sample podcasts and videos, links that may be of interest or assistance, a list of groups and associations related to communicating science, as well as a list of local museums and science centres. The Explore menu also contains a library resources page, which you should definitely have a look at. Finally, there is a bookshelf that lists relevant books that are on reserve for you in Woodward Library.

Let us know if you have any questions about the blog or would like to see any other resources made available. Or, if you find something that you think would be useful to the rest of the class, tell us, and we can add it to the resources. Better yet — write a post about it!

Happy blogging!

The Science 300 Team