Tag Archives: exploration

How Does AI Change Drug Development? Evidence from Clinical Trial Phases and Drug Types

Kwon, Angela Eunyoung, Jaecheok Park, Gene Moo Lee. “How Does AI Change Drug Development? Evidence from Clinical Trial Phases and Drug Types,” Working Paper.

  • Presentations: KrAIS (2025), CIST (2025), INFORMS (2025), UBC (2025), WISE (2025)

We examine how pharmaceutical firms’ AI capabilities influence drug development outcomes, focusing on clinical trials. Clinical trials progress through three phases that differ in regulatory scrutiny and evidentiary requirements. We measure firm-level AI capabilities using job postings and clinical trial outcomes using the number of trials initiated across phases. We find no significant overall effect of AI capabilities on clinical trial activity. However, this average relationship masks meaningful heterogeneity. AI capabilities are associated with increases in incremental innovation (refinement trials) but not radical innovation (new trials). These effects are stronger for biologics, where market incentives are high, than for small-molecule drugs, where learning hurdles are relatively low. AI capabilities also matter more in early-phase trials, where regulatory barriers are lower, and have no detectable influence in Phase III. This study contributes to the healthcare IS literature by identifying the nuanced and context-dependent business value of AI in drug development. It also offers practical guidance for pharmaceutical firms and policymakers on where AI investments are most likely to enhance R&D productivity.

Exploring the Influence of Machine Learning on Organizational Learning: An Empirical Analysis of Publicly Listed Organizations

Lee, Myunghwan, Timo Sturm, Gene Moo Lee “Exploring the Influence of Machine Learning on Organizational Learning: An Empirical Analysis of Publicly Listed Organizations”, Work-in-Progress.

  • Presentations: JUSWIS 2024, KrAIS Summer 2024
  • Best Short Paper Award at KrAIS Summer Workshop 2024.

We contribute to the literature on the role of machine learning (ML) in organizational learning by examining two key learning tendencies: exploitation and exploration. We analyze the effect of ML investments on organizations’ learning tendency, which in turn influences firm performance and survival. Our findings suggest that ML primarily shifts organizations towards exploration and that ML-induced learning tendency fully mediates the positive relationship between ML investments and organization survival. Notably, we find that non-IT organizations with exploitative tendencies can effectively shift towards exploration through ML investments. To our knowledge, this study provides the first large-scale empirical insights into ML’s impact on organizations’ learning tendency and performance outcomes, offering valuable insights for rethinking organizational learning in the age of ML.