Tag Archives: AI

How Does AI Change Drug Development? Evidence from Clinical Trial Phases and Drug Types

Kwon, Angela Eunyoung, Jaecheok Park, Gene Moo Lee. “How Does AI Change Drug Development? Evidence from Clinical Trial Phases and Drug Types,” Working Paper.

  • Presentations: KrAIS (2025), INFORMS (2025)

We examine how the AI capability of pharmaceutical firms affects drug development processes, with a particular focus on clinical trials. Clinical trials test the safety and efficacy of drug candidates on human subjects across four phases. While early phases (Phases I & II) assess preliminary safety and efficacy in smaller populations, later phases (Phases III & IV) investigate thorough effectiveness in larger populations. To examine the effect of the AI capability of firms on clinical trial outcomes (total trials, new trials, and retrials), we utilize job postings data and ClinicalTrials.gov. Our preliminary findings suggest that AI capability has significant effects on clinical trial outcomes in the early phases of clinical trials, but not in the later phases. Moreover, we find the heterogeneous effects across drug types, where the effect of AI capability on retrials is greater for biologics. This study contributes to the healthcare IS literature by empirically demonstrating the business value of AI in enhancing drug development processes. Our study also provides practical guidance on AI investment and implementation for pharmaceutical firms, regulatory agencies, and policymakers.

The New Industrial Revolution: AI, Labor Unions, and the Future of Work

Park, Jiyong, Myunghwan Lee, Yoonseock Son, Gene Moo Lee “The New Industrial Revolution: AI, Labor Unions, and the Future of Work”, Work-in-Progress.

  • The first three authors equally contributed to the work.
  • Presentations: CIST (2024), WISE (2024).
  • Nominated for Best Paper Award at WISE 2024

As a general-purpose technology, Artificial Intelligence (AI) has profoundly transformed the human labor landscape with its capability to perform complex tasks. Despite ongoing debates about AI’s role in the future of work, there remains a limited understanding of how a firm’s endeavors to strengthen its AI capabilities interweave with its workforce. Reflecting on the ongoing role of labor unions in responding to technological advancements, we investigate the impact of unionization on AI investments and their subsequent effects on firm value. Utilizing datasets on labor elections and AI-skilled labor, we construct measures for unionization and AI investment. Based on a regression discontinuity design framework, our results indicate that while AI investments lead to an improvement in firm value, unionization decreases AI investments in the following 5 years, implying that labor unions have an indirect negative impact on firm value by hampering AI investments. We also provide suggestive evidence of the competition between firms and labor unions in resource allocation between AI investments and employment as a potential mechanism through which labor unions may hinder AI investments. This research advances our understanding of corporate AI strategies by recognizing labor unions as a crucial stakeholder, enriching the discourse on the literature on the business value of AI and IT.

Jaecheol Park’s PhD Proposal: Strategic Roles of AI and Mobile Management on Performance: Evidence from U.S. Public Firms

Jaecheol Park (2024) “Strategic Roles of AI and Mobile Management on Performance: Evidence from U.S. Public Firms”, Ph.D. Dissertation Proposal, University of British Columbia. https://jaecheol-park.github.io/

Supervisor: Gene Moo Lee

Supervisory Committee Members: J. Frank Li, Jiyong Park (Georgia)

The integration of emerging technologies such as Artificial Intelligence (AI) and mobile IT into the workplace is transforming how businesses operate. Despite the increasing prevalence and importance of AI and mobile IT, there is limited research on how firms can strategically manage these technologies to achieve competitive advantage and enhance performance. This dissertation consists of two large-scale empirical studies on U.S. public firms, aiming to provide new theoretical and managerial insights into how firms can harness the power of these technologies to drive success.

The first chapter investigates the impact of mobile device management (MDM) on firm performance during the recent pandemic, highlighting the importance of MDM in digital resilience. Drawing on the resource-based view and a novel proprietary dataset from a global MDM provider for U.S. public firms, we find that firms with MDM have better financial performance during the pandemic, demonstrating greater resilience to the shock. Additionally, we explore the moderating role of external and internal factors, revealing that firms with high environmental munificence or those with low IT capabilities experience greater resilience effects from MDM. This study contributes to the work-from-home and hybrid work literature by emphasizing the business value of MDM and its crucial role in building digital resilience.

The second chapter investigates the effect of AI strategic orientation on firm performance with a dual lens on product and process orientation. We create a novel measure of AI orientation by employing a large language model to assess business descriptions in Form 10-K filings, and identify an increasing trend of AI disclosure among U.S. public firms. By dissecting firms’ AI disclosure into AI washing and AI (product and process) orientation, our long-difference analyses show that AI orientation significantly affects costs, sales, and market value but AI washing does not, showing the importance of strategic deployment of AI to create business value. Moreover, we find the heterogeneous effects between AI product and process orientation on performance. This study contributes to the recent AI management literature by providing the strategic role of AI orientation on firm performance.

The findings of the dissertation offer valuable insights for academics, practitioners, and policymakers seeking to understand and leverage these emerging technologies’ full potential. From an academic perspective, this dissertation contributes to the literature on the business value of IT and AI by empirically demonstrating the business value of MDM and AI strategies. From an industry perspective, this research provides actionable guidance for businesses looking to leverage the power of MDM and AI to achieve strategic goals and drive success in the digital age.

News Quality vs. Promptness: Investigating Large Language Models’ Impact on Modern Journalism

Zhang, Xiaoke, Myunghwan Lee, Mi Zhou, Gene Moo Lee “News Quality vs. Promptness: Investigating Large Language Models’ Impact on Modern Journalism,” Working Paper.

  • Presentations: UBC (2024), DS (2024), CIST (2024), BIGS (2024)
  • Industry partner: Muhayu

The advancement of digital technologies has transformed the news industry, with large language models (LLMs) introducing new opportunities and challenges for the institutional press. Utilizing a unique setting where two major news institutions in South Korea introduced LLM-based news writing assistants, this study investigates how LLM assistance affects journalists’ news production and readers’ engagement using a mixed-method approach. We first conduct interviews and surveys with journalists to identify key constructs in journalism and develop a research model on the emerging phenomenon. We then empirically examine the impacts of LLM assistance on news production and engagement using a unique dataset of 941 LLM-assisted articles and 7,230 human-written articles on identical events. Notably, we develop a novel framework using GPT-4o to extract information sources from a large number of news articles. Our results show that LLM assistance reduces the diversity and uniqueness of information sources in news articles but increases publication promptness. Furthermore, LLM-assisted news is associated with decreased reader engagement, a trend exacerbated by reduced source diversity and uniqueness despite faster publication. This study contributes to the understanding of generative AI’s role in journalism and provides implications for the institutional press navigating the integration of AI technologies in journalistic practices.

Exploring the Influence of Machine Learning on Organizational Learning: An Empirical Analysis of Publicly Listed Organizations

Lee, Myunghwan, Timo Sturm, Gene Moo Lee “Exploring the Influence of Machine Learning on Organizational Learning: An Empirical Analysis of Publicly Listed Organizations”, Work-in-Progress.

  • Presentations: JUSWIS 2024, KrAIS Summer 2024
  • Best Short Paper Award at KrAIS Summer Workshop 2024.

We contribute to the literature on the role of machine learning (ML) in organizational learning by examining two key learning tendencies: exploitation and exploration. We analyze the effect of ML investments on organizations’ learning tendency, which in turn influences firm performance and survival. Our findings suggest that ML primarily shifts organizations towards exploration and that ML-induced learning tendency fully mediates the positive relationship between ML investments and organization survival. Notably, we find that non-IT organizations with exploitative tendencies can effectively shift towards exploration through ML investments. To our knowledge, this study provides the first large-scale empirical insights into ML’s impact on organizations’ learning tendency and performance outcomes, offering valuable insights for rethinking organizational learning in the age of ML.

Unpacking AI Transformation: The Impact of AI Strategies on Firm Performance from the Dynamic Capabilities Perspective

Park, Jaecheol, Myunghwan Lee, J. Frank Li, Gene Moo Lee “Unpacking AI Transformation: The Impact of AI Strategies on Firm Performance from the Dynamic Capabilities Perspective,” Work-in-Progress.

  • Presentations: UBC (2024), CIST (2024), INFORMS (2024), SNU (2024), UMass (2024), BIGS (2024), KrAIS (2024), CityU Hong Kong (2025), NTU (2025), AIM (2025)
  • Best Paper Award at BIGS 2024
  • Best Student Paper Award at KrAIS 2024

Artificial intelligence (AI) technologies hold great potential for large-scale economic impact. Aligned with this trend, recent studies explore the adoption impact of AI technologies on firm performance. However, they predominantly measure firms’ AI capabilities with input (e.g., labor/job posting) or output (e.g., patents), neglecting to consider the strategic direction toward AI in business operations and value creation. In this paper, we empirically examine how firms’ AI strategic orientation affects firm performance from the dynamic capabilities perspective. We create a novel firm-year AI strategic orientation measure by employing a large language model to analyze business descriptions in Form 10-K filings and identify an increasing trend and changing status of AI strategies among U.S. public firms. Our long-difference analysis shows that AI strategic orientation is associated with greater operating cost, capital expenditure, and market value but not sales, showing the importance of strategic direction toward AI to create business value. By further dissecting firms’ AI strategic orientation into AI awareness, AI product orientation, and AI process orientation, we find that AI awareness is generally not related to performance, that AI product orientation is associated with short-term increased operating expenses and long-term market value, and that AI process orientation is associated with long-term increased costs and sales. Moreover, we find the negative moderating effect of environmental dynamism on AI process orientation. This study contributes to the recent AI strategy and management literature by providing the strategic role of AI orientation on firm performance. 

Xiaoke Zhang’s Master’s Thesis

Xiaoke Zhang (2023). “How Does AI-Generated Voice Affect Online Video Creation? Evidence from TikTok”, Master’s Thesis, University of British Columbia

Supervisors: Gene Moo Lee, Mi Zhou

The rising demand for online video content has fostered one of the fastest-growing markets as evidenced by the popularity of platforms like TikTok. Because video content is often difficult to create, platforms have attempted to leverage recent advancements in artificial intelligence (AI) to help creators with their video creation process. However, surprisingly little is known about the effects of AI on content creators’ productivity and creative patterns in this emerging market. Our paper investigates the adoption impact of AI-generated voice – a generative AI technology creating acoustic artifacts – on video creators by empirically analyzing a unique dataset of 4,021 creators and their 428,918 videos on TikTok. Utilizing multiple audio and video analytics algorithms, we detect the adoption of AI voice from the massive video data and generate rich measurements for each video to quantify its characteristics. We then estimate the effects of AI voice using a difference-in-differences model coupled with look-ahead propensity score matching. Our results suggest that the adoption of AI voice increases creators’ video production and that it induces creators to produce shorter videos with more negative words. Interestingly, creators produce more novel videos with less self-disclosure when using AI voice. We also find that AI-voice videos received less viewer engagement unintendedly. Our paper provides the first empirical evidence of how generative AI reshapes video content creation on online platforms, which provides important implications for creators, platforms, and policymakers in the digital economy.

 

Myunghwan Lee’s PhD Proposal: Three Essays on AI Strategies and Innovation

Myunghwan Lee (2023) “Three Essays on AI Strategies and Innovation”, Ph.D. Dissertation Proposal, University of British Columbia. https://sites.google.com/view/myunghwanlee/home

Supervisor: Gene Moo Lee

Artificial Intelligence (AI) technologies, along with the explosive growth of digitized data, are transforming many industries and our society. While both academia and industry consider AI closely intertwined with innovation, we still have limited knowledge of the business and economic values of AI on innovation. This three-essay dissertation seeks to address this gap (i) by proposing a novel firm-level measure to identify strategically innovative firms; (ii) by examining how firm-level AI capabilities affect knowledge innovation; and (iii) by investigating the impact of robotics, embodied AI with a physical presence, on operational innovation.

In the first essay, we propose a novel firm-level measure, Strategic Competitive Positioning (SCP), to identify distinctive strategic positioning (i.e., first-movers, second-movers) and competition relationships. Drawing on network theory, we develop a structural hole-based, dynamic, and firm-specific SCP measure. Notably, this SCP measure is constructed using unsupervised machine-learning and network analytics approaches with minimal human intervention. Using a large dataset of 10-K annual reports from 13,476 public firms in the U.S., we demonstrate the value of the proposed measure by examining the impact of SCP on subsequent IPO performance.

In the second essay, we study the impact of firm-level AI capabilities on exploratory innovation to determine how AI’s value-creation process can facilitate knowledge innovation. Drawing on March and Simon (1958), we theorize how AI capabilities can help firms overcome bounded rationality and pursue exploratory innovation. We compiled a unique dataset consisting of 54,649 AI conference publications, 3 million patent filings, and 1.9 million inter-firm transactions to test the hypotheses. The findings show that a firm’s AI capabilities have a positive impact on exploratory innovation, and interestingly that conventional exploratory innovation-seeking approaches (e.g., traditional data management capabilities and inter-firm technology collaborations) negatively moderate the positive impact of AI capabilities on exploratory innovation.

The impact of AI technologies can be beyond knowledge innovation. Embodied AI technologies, specifically robotics, are driving operational innovation in manufacturing and service industries. While industrial robots designed for pre-defined tasks in controlled environments are extensively studied, little is known about the impact of AI-based service robots designed for customer-facing dynamic environments. In the third essay, we seek to examine how service robots can affect operational efficiency and service quality using the case of the hospitality industry. The preliminary results from a difference-in-differences model using a dataset of 4,610 restaurants in Singapore demonstrate that service robot adoption increases customer satisfaction, specifically through perceived service quality. To validate the initial result and further explore underlying mechanisms, we plan to collect additional datasets from different geographic areas and industries.

 

Disrupt with AI: The Impact of Deep Learning Capabilities on Exploratory Innovation

Lee, Myunghwan, Victor Cui, Gene Moo Lee. “Disrupt with AI: The Impact of Deep Learning Capabilities on Exploratory Innovation”, AOM 2023

Given the importance of exploratory innovation in fostering firms’ sustainable competitive advantages, firms often depend on technological assets or inter-firm relationships to pursue exploration. Regarded as a general-purpose technology, deep learning (DL)-based artificial intelligence (AI) can be an exploratory innovation-seeking instrument for firms in searching unexplored resources and thereby broadening their boundary. Drawing on the theories of organizational learning and path dependence, we hypothesize the impact of a firm’s DL capabilities on exploratory innovation and how DL capabilities interact with conventional pathbreaking activities such as technical assets and inter-firm relationships. Our empirical investigations, based on a novel DL capabilities measure constructed from comprehensive datasets on AI conferences and patents, show that DL capabilities have positive impacts on exploratory innovation. The results also show that extant technological assets (i.e., structured data management capabilities) and inter-firm relationships remedy the constraints on a firm’s innovation-seeking behaviors and that these path-breaking activities negatively moderate the positive impact of DL capabilities on exploratory innovation. To our knowledge, this is the first large-scale empirical study to investigate how DL affects exploratory innovation, contributing to the emerging literature on AI and innovation.

AI Voice in Online Video Platforms: A Multimodal Perspective on Content Creation and Consumption

Zhang, Xiaoke, Mi Zhou, Gene Moo Lee “AI Voice in Online Video Platforms: A Multimodal Perspective on Content Creation and Consumption,” Working Paper.

  • Previous title: How Does AI-Generated Voice Affect Online Video Creation? Evidence from TikTok
  • Presentations: INFORMS DS (2022), UBC (2022), WITS (2022), Yonsei (2023), POSTECH (2023), ISMS MKSC (2023), CSWIM (2023), KrAIS Summer (2023), Dalhousie (2023), CIST (2023), Temple (2024), Santa Clara U (2024), Wisconsin Milwaukee (2024)
  • Best Student Paper Nomination at CIST 2023; Best Paper Runner-Up Award at KrAIS Summer Workshop 2023
  • Media coverage: [UBC News] [Global News]
  • API sponsored by Ensemble Data
  • SSRN version: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4676705

Major user-generated content (UGC) platforms like TikTok have introduced AI-generated voice to assist creators in complex multimodal video creation. AI voice in videos represents a novel form of partial AI assistance, where AI augments one specific modality (audio), whereas creators maintain control over other modalities (text and visuals). This study theorizes and empirically investigates the impacts of AI voice adoption on the creation, content characteristics, and consumption of videos on a video UGC platform. Using a unique dataset of 554,252 TikTok videos, we conduct multimodal analyses to detect AI voice adoption and quantify theoretically important video characteristics in different modalities. Using a stacked difference-in-differences model with propensity score matching, we find that AI voice adoption increases creators’ video production by 21.8%. While reducing audio novelty, it enhances textual and visual novelty by freeing creators’ cognitive resources. Moreover, the heterogeneity analysis reveals that AI voice boosts engagement for less-experienced creators but reduces it for experienced creators and those with established identities. We conduct additional analyses and online randomized experiments to demonstrate two key mechanisms underlying these effects: partial AI process augmentation and partial AI content substitution. This study contributes to the UGC and human-AI collaboration literature and provides practical insights for video creators and UGC platforms.