Author Archives: OliviaGaiaTanuseputra

Exercise- A New Way to Prevent Alzheimer’s Disease.

As the global population is aging, the number of elderly suffering from Alzheimer’s disease or dementia are predicted to increase to an estimated 75.6 million in 2030 and 135.5 million in 2050. Every 67 seconds, someone in the United States develops Alzheimer’s disease. Today, it is ranked the sixth leading cause of deaths in America. Although a growing number of researchers are studying the disease, Alzheimer’s disease is still the only cause of death in the top 10 that cannot be prevented, cured or slowed.

Alzheimer’s Disease Facts. Source: Alzheimer’s Association

A recently published study in the Journal of Alzheimer’s Disease showed that calories-burning activities are linked with greater gray matter volume in brain areas responsible for cognition and memory. Gray matter in the brain consists of most of the brain’s neurons responsible for muscle control, emotions, speech and memory. Patients suffering from Alzheimer’s disease or dementia have decreasing gray matter volume in the brain, thus affecting their cognition and memory. Halting the reduction in gray matter volume might be the effective way in preventing dementia and Alzheimer’s disease.

Normal brain vs. Alzheimer’s brain. Source: Bioinformatics

The study conducted by scientists at UCLA and the University of Pittsburgh School of Medicine revealed that participants who suffer from Alzheimer’s disease or dementia who are physically more active experience less reduction in gray matter volume than those who are physically inactive. Participants who are physically active also experience less cognitive and memory declines.

Researchers gathered five years of data from 876 participants aged 65 and older. Brain scans, cognitive tests and interviews were conducted to gather accurate data about their cognitive health, physical health and physical activities over the period of five years. Participants filled questionnaires to evaluate their leisure time, physical activities and cognitive abilities.

Scientists revealed that those who exercise the most have a 5% larger gray matter volume than those who exercise the least. 5% decrease in gray matter volume corresponds to 50% lost in cognitive and memory functions. The brain scans revealed that participants who exercised the most have denser gray matter in the frontal, temporal and parietal lobes, which are the areas responsible for learning, cognitive tasks and memory.

Frontal, parietal and temporal lobes of the brain and their functions. Source: My Brain Tests

Scientists are encouraging doctors to start dementia and Alzheimer’s disease prevention by encouraging regular physical exercise instead of waiting for memory loss to start. Past studies have shown that delaying the development of Alzheimer’s disease by ten years would eliminate the disease as the elderly would die of other causes first before developing the disease.

Even though scientists have no fixed number of how much exercise it takes to prevent dementia, researchers estimated that the people need about an extra 500 calories per day to be burnt. Luckily, it doesn’t matter how the extra calories are burnt, as long as they are burnt.

Organisms Inside Us

Have you ever wondered how many micro organisms are living inside us? Micro organisms are living organisms that cannot be seen with our naked eyes. They may be multicellular (made out of more than one cell) or unicellular (made out of one cell). Our human body is packed with trillions of microbes (or micro organisms). In fact, our own body cells are out numbered with a ratio of 1:10. So, we are technically 90% germs and 10% human. Microbes are found in all parts of our body in different proportions. Our lung has approximately 1000x less microbes than our mouth and has approximately 1 billion times less microbes than our intestines. Although most microbes are harmless to us, some may cause bacterial infections in humans.

The Human Body = 90% Germs + 10% Human

Top three functions microbes in our body:

  1. Defense mechanism: Microbes in our lungs, intestines and our skin provide the first line of defense against harmful bacteria that enters our body. Good microbes found in these areas play an essential role in preventing the spread of harmful microbes by occupying space so less space are available for harmful microbes to settle down inside us. Thus, preventing us from bacterial infections that may cause fever, diarrhea or other problems. Other than that, researchers have found evidence that microbes that live inside us help promote our immune system cells to grow and replicate.
  2. Keeping us in shape: The trillions of microbe colonies in our intestines help digest fats and carbohydrates, facilitating the absorption of nutrients in cells. Our intestinal microbes also ferment food that we consume. The fermentation process produces chemicals that speeds up our metabolic processes. As a result, the microbes in our gut helps us keep in shape by increasing our metabolism.
  3. Detoxifies us: Microbes living in us are also capable of digesting toxins that we accidently ingest into less harmful substances. Therefore, preventing us from being poisoned. For example, the microbe Lacrobacillus probiotics found in food help the human body detoxify heavy toxic metals such as aluminum.

Good microbes that keep us healthy

Where do we get microbes that live in our body? Most of our microbes that inhabit our intestines comes from the food we ingest. Our skin and lung microbes come from the air we are exposed to. Recently, researchers discovered that newborn infants get their microbes from their mother’s breast milk and vagina. Researchers found that the method of delivery may have an effect on the diversity of intestinal microbes in newborns. They discovered that infants born vaginally and infants born by caesarean section have different intestinal microbe composition. This indicates that we start to develop our microbe colonies from the day we were born.

Microbes inside our body

Eating Turkey Makes You Sleepy: True or False?

https://www.youtube.com/watch?v=aa1_CeUAQIc#action=share

Many of us have probably heard or even experienced the famous phenomenon known as food coma. If you have no idea what food coma is, you most probably have experienced it before unknowingly. Food coma is a state of lethargy or sleepiness experienced after consuming a large portion of food. Despite its informal name, it is a medically recognized condition called post-prandial comnolence.

Food coma generally hits harder at the most festive times of the year- the holiday seasons. The thanksgiving turkey is no exception. You stack your plates with turkey, sweet potatoes, dressing, cranberries and all the other old-fashioned foods, then fill your stomach up to the brim. Then, of course, you go for a second, then third round. It’s the holiday seasons after all. Not long after, you start to feel lethargic, energy-less and sleepy. Unknowingly, you have fallen into the food-coma trap.

For many years, urban myths have blamed the turkey for the main cause of the sleepiness. But is the turkey really to be blamed?

Where did the myth come from?  Many of you might have heard about the amino acid called tryptophan. Tryptophan is one of the components of the hormone serotonin. Serotonin is converted to the sleep-inducing hormone melatonin. Without melatonin, we will all be always wide awake. This chemical is essential in our body to give us enough rest at night for proper bodily functions. Hence, yes, tryptophan is an essential chemical in our body. However, our body does not produce tryptophan. Tryptophan is obtained by our body from the food we eat.

The tryptophan we ingest competes with other amino acids in our body to enter our brain through the blood-brain barrier. The blood-brain barrier is an interface that separates the brain from the rest of the body. It protects the brain from harmful chemicals that enters the body by filtering them. The blood-brain barrier will only allow certain chemicals to enter the brain. Only a portion of the tryptophan we ingest successfully enters our brain. Most of them are broken down in our liver. The myth that turkeys make us sleepy began when tryptophan were found in turkey meat.

So, do turkeys make us sleepy? The answer to this question is- yes and no. Turkey meat contains tryptophan-yes. However, according to Standford neuroimmunologist Lawrence Steinman, MD, the levels of tryptophan  in turkey “is not higher than in most other muscle tissue from other animals, more commonly known as meats”. It is not the turkey that makes us sleepy but it is the enormous amounts of carbohydrates and often alcohol consumed on the holiday seasons.

Carbohydrates such as the dressing or mashed potatoes induces the release of insulin into the bloodstream compared to other amino acids present. As a result, higher levels of tryptophan are concentrated at the brain-blood barrier.

In conclusion, it is not the turkey that makes you sleepy after Thanksgiving. So, take a quick nap on Thanksgiving, but be sure to wake up in time for the dishes!